Dr Cynthia Coleman

PhD

 
researcher
 

Biography

Cynthia Coleman currently leads a research program 1) investigating the aetiology of diabetes-induced osteopathy; 2) applying adult human marrow-derived mesenchymal stem cells to repair diabetic long bone fractures; 3) identifying the impact of gender on mesenchymal stem cell capacity and 4) investigating the efficacy of coral as a biocompatible bone graph substitute.  These investigations are conducted in collaboration with 10+ domestic and international academic and industrial partners, a clinical team at Galway University Hospital and the patient advocacy group Diabetes Ireland. This program has resulted in establishing a new in vivo model of fracture repair at NUIG and the creation of a highly sensitive high-throughput, regulatory body approved methodology to detect the biodistribution of therapeutic progenitor cells.  This assay was employed in regulatory submissions in support of clinical trials in wound repair (Endura CT#2015-005580-16) and critical limb ischemia (Endura CT#2013-003447-37).

Research Interests

Diabetes Induced Osteopathy
Bone Fracture Repair
Cartilage Repair
Skeletal Development
Joint Development
Patient Perceptions of Diabetes-Induced Osteopathy
Impact of Diabetes on the Outcome of Fragility Fracture Procedures in Irish Patients
Coral as a Bone Substitute

Research Projects

  Project Start Date End Date
A STUDY ON THE OSTEO-STIMULATIVE EFFECTS OFOCTACALCIUM PHOSPHATE (OCP) ON A MAMMALIAN CELL LINE . 03-JUL-18 02-JUL-19
Identifying the Aetiology of Diabetic Progenitor Cell Dysfunction in Osteoporosis 01-NOV-16 31-OCT-18
Investigating Cell Ingrowth into a Natural Bone Replacement Scaffold 01-NOV-16 31-OCT-17
PURESTEM: Utilization of the Mesenchymal Stem Cell Receptome for Rational Development of Uniform, Serum-free Conditions and Tools for Cell Characterization 01-NOV-08 01-NOV-10
REDDSTAR: Repair of Diabetic Damage by Stromal Cell Administration 01-NOV-12 01-NOV-15

Peer Reviewed Journals

  Year Publication
(2020) 'Impact of type 2 diabetes mellitus on human bone marrow stromal cell number and phenotypic characteristics'
F. Cassidy, C. Shortiss, C. Murphy, S. Kearnes, W. Curtin, C. DeBuitleir, T. O’Brien, C.M. Coleman (2020) 'Impact of type 2 diabetes mellitus on human bone marrow stromal cell number and phenotypic characteristics'. International Journal Of Molecular Sciences, 21 [Details]
(2020) 'Knowledge and Perceptions and Concerns of Diabetes-Associated Complications Among Individuals Living with Type 1 and Type 2 Diabetes Mellitus'
C. Sanz-Nogues, M. Mustafa, H. Burke, T. O’Brien, C.M. Coleman (2020) 'Knowledge and Perceptions and Concerns of Diabetes-Associated Complications Among Individuals Living with Type 1 and Type 2 Diabetes Mellitus'. Healthcare, 9 (1) [Details]
(2019) 'Mineral Heterogeneity is Altered in the Femoral Heads of Osteoporotic and Diabetic Human Patients'
E. Parle, S. Tio, A. Behre, J. Carey, C. Murphy, T. O’Brien, W. Curtin, S. Kearns, J. McCabe, C.M. Coleman, T. Vaughan, L. McNamara (2019) 'Mineral Heterogeneity is Altered in the Femoral Heads of Osteoporotic and Diabetic Human Patients'. Journal of Bone and Mineral Research Plus, 4 (2) [Details]
(2019) 'Hypoxia Stimulates PTHrP and Zfp521 to Attenuate Hypertrophy in Mesenchymal Stem Cell Derived Cartilage'
D.C. Browe, C.M. Coleman, F.P. Barry, S.J. Elliman (2019) 'Hypoxia Stimulates PTHrP and Zfp521 to Attenuate Hypertrophy in Mesenchymal Stem Cell Derived Cartilage'. Scientific Reports, 9 (1) [Details]
(2019) 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'
Galbraith AS;Sanz-Nogués C;Glynn S;Coleman CM;Murphy C; (2019) 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'. Journal Of Orthopaedic Research, [DOI] [ARAN Link] [Details]
(2017) 'Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction based detection of human DNA in murine organs'
Creane, M;Howard, L;O'Brien, T;Coleman, CM (2017) 'Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction based detection of human DNA in murine organs'. Cytotherapy, 19 :384-394 [DOI] [Details]
(2015) 'Evaluation of Cartilage Repair by Mesenchymal Stem Cells Seeded on a PEOT/PBT Scaffold in an Osteochondral Defect'
Barron, V,Merghani, K,Shaw, G,Coleman, CM,Hayes, JS,Ansboro, S,Manian, A,O'Malley, G,Connolly, E,Nandakumar, A,van Blitterswijk, CA,Habibovic, P,Moroni, L,Shannon, F,Murphy, JM,Barry, F (2015) 'Evaluation of Cartilage Repair by Mesenchymal Stem Cells Seeded on a PEOT/PBT Scaffold in an Osteochondral Defect'. Annals Of Biomedical Engineering, 43 :2069-2082 [DOI] [ARAN Link] [Details]
(2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'
Bulman, SE,Coleman, CM,Murphy, JM,Medcalf, N,Ryan, AE,Barry, F (2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'. Stem Cell Research & Therapy, 6 [DOI] [Details]
(2014) 'Chondrogenic Differentiation Increases Host Immune Response to Allogeneic Mesenchymal Stem Cell (MSC) Transplantation'
Ryan, A; Lohan, P; O'Flynn, L; Treacy, O; Chen, X; Coleman, CM; Shaw, G; Murphy, M; Barry, F; Griffin, M; Ritter, T (2014) 'Chondrogenic Differentiation Increases Host Immune Response to Allogeneic Mesenchymal Stem Cell (MSC) Transplantation'. Molecular Therapy, 22 (3):655-667 [Details]
(2013) 'Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy'
Coleman, CM,Vaughan, EE,Browe, DC,Mooney, E,Howard, L,Barry, F (2013) 'Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy'. Stem Cells And Development, 22 :1968-1976 [DOI] [Details]
(2012) 'A role for MRP8 in in stent restenosis in diabetes'
Stocca, A; O'Toole, D; Hynes, N; Hynes, S; Mashayekhi, K; McGinley, L; Coleman, C.M; Sultan, S; Duffy, A; Tuney, T; O'Brien, T (2012) 'A role for MRP8 in in stent restenosis in diabetes'. Atherosclerosis, 221 (2):325-332 [Details]
(2012) 'Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'
Vaughan, E; Liew, A; Mashayekhi, K; Dockery, P; McDermott, J; Kealy, B; Flynn, A; Duffy, A; Coleman, C.M.; O'Regan A; Barry, F; O'Brien, T. (2012) 'Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'. Cell Transplantation, 21 (6):1095-1107 [Details]
(2011) 'Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study'
Coleman, CM,Scheremeta, BH,Boyce, AT,Mauck, RL,Tuan, RS (2011) 'Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study'. Clinical Orthopaedics And Related Research, 469 :2915-2924 [DOI] [Details]
(2003) 'Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation'
Coleman, C.M; Tuan, R.S. (2003) 'Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation'. Developmental Dynamics, 228 (2):208-216 [Details]
(2003) 'Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos'
Chatterjee, B; Meyer, R; Loredo, G; Coleman, C.M; Tuan, R; Lo, C (2003) 'Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos'. Cell Adhesion and Communication, 10 (1):37-50 [Details]
(2003) 'Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development'
Coleman, C.M.; Loredo, G.A.; Lo, C.W.; Tuan, R (2003) 'Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development'. Anatomical Record, 275 (A):1117-1121 [Details]
(2003) 'Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells'
Coleman, C.M.; Tuan, R (2003) 'Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells'. Mechanisms Of Development, 120 (7):823-836 [Details]

Reviews

  Year Publication
(2019) Impact of Diabetes Mellitus on Bone Health.
C.E. Murray, C.M. Coleman (2019) Impact of Diabetes Mellitus on Bone Health. Reviews [Details]
(2014) Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?.
Lohan, P,Coleman, CM,Murphy, M,Griffin, MD,Ritter, T,Ryan, AE (2014) Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?. Reviews [DOI] [Details]
(2014) From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair.
Watson L;Elliman SJ;Coleman CM; (2014) From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair. Reviews [DOI] [Details]
(2016) Diabetic Bone Fracture Repair: A Progenitor Cell-Based Paradigm.
J. Hayes, C.M. Coleman (2016) Diabetic Bone Fracture Repair: A Progenitor Cell-Based Paradigm. Reviews [Details]
(2013) Enhancing the Mesenchymal Stem Cell Therapeutic Response: Cell Localization and Support for Cartilage Repair.
Bulman, SE,Barron, V,Coleman, CM,Barry, F (2013) Enhancing the Mesenchymal Stem Cell Therapeutic Response: Cell Localization and Support for Cartilage Repair. Reviews [DOI] [Details]
(2011) Mesenchymal chondroprogenitor cell origin and therapeutic potential.
O'Sullivan, J,D'Arcy, S,Barry, FP,Murphy, JM,Coleman, CM (2011) Mesenchymal chondroprogenitor cell origin and therapeutic potential. Reviews [DOI] [Details]
(2010) Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?.
Coleman, CM;Curtin, C;Barry, FP;O'Flatharta, C;Murphy, JM (2010) Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?. NEW ROCHELLE: Reviews [DOI] [Details]
(2008) Chicken Embryo as a Model for Regenerative Medicine.
Coleman, C.M; (2008) Chicken Embryo as a Model for Regenerative Medicine. Reviews [Details]
(2003) Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton.
Shum, L; Coleman, C.M; Hatakeyama, Y; Tuan, R (2003) Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton. Reviews [Details]

Honours and Awards

  Year Title Awarding Body
2020 Best New Postgraduate Programme Grad Ireland
2018 Invited speaker European Orthopaedic Research Society
2017 Invited speaker at Diabetes Ireland Conference & Exhibition Diabetes Ireland
2016 Invited speaker at Molecular Medicine Ireland Molecular Medicine Ireland
2013 Invited speaker at Trinity College Dublin Trinity College Dublin
2011 NCBES Post-Doctoral Research Award NCBES Faculty
2010 Cover Photograph Human Gene Therapy
2010 Best Abstract International Cartilage Repair Society (Barcelona)

Professional Associations

  Association Function From / To
Orthopaedic Research Society Member 01-JAN-05 / 27-JUN-17
Irish Endocrine Society member 01-JUN-17 / 27-JUN-17

Committees

  Committee Function From / To
CMNHS Graduate Research Committee member 01-AUG-18 /
SNS Postgraduate Research Committee member 01-JAN-18 / 31-DEC-19
REMEDI Executive Management Committee member 01-NOV-16 /
SoM Taught Post-Graduate Strategy Committee member 01-SEP-17 /

Employment

  Employer Position From / To
National Institutes of Health Post Doctoral Fellow 01-NOV-02 / 01-JAN-04
National University of Ireland Galway Lecturer in Cellular Manufacturing and Therapy 01-SEP-17 /
National University of Ireland Galway Senior Scientist in Orthobiologics 10-JAN-07 / 30-SEP-13
Johnson & Johnson Regenerative Therapeutics Senior Scientist in Cell Biology and Preclinical Evaluation 01-JAN-04 / 01-DEC-06
National University of Ireland Galway Research Fellow in Orthobiologics 01-OCT-13 / 31-AUG-17

Education

  Year Institution Qualification Subject
2002 Thomas Jefferson University PhD Developmental Biology and Teratology
2018 National University of Ireland Galway Postgraduate Certificate Teaching and Learning in Higher Educaiton
1997 Saint Michael's College BSc Biology, Minor in Chemistry

Languages

  Language
English

Consultancy

  Client Description
Zoan Biomed
Scientific Advisory Board

Community Engagement

  Title Type From / To
Outreach Invited speaker at “Diabetes Ireland Conference & Exhibition" /
Outreach Clinical Research Facility Galway open day guide and educator /
Outreach Reel Life Science adjudicator /
Teaching (e.g. Service learning / comunity based learning) Transition year student mentoring /
Outreach Local judge in Debating Science Issues /
Outreach National judge in Debating Science Issues /
Outreach Invited speaker at “Diabetes: It’s Complicated” /

Reviews

  Journal Role
Scientific Reports Reviewer
Tissue Engineering Reviewer
Cells Tissues Organs Reviewer
Scientific Reports Reviewer
Journal Of Tissue Engineering And Regenerative Medicine Reviewer
Experimental Biology And Medicine Reviewer
Journal Of Orthopaedic Research Reviewer
Life Sciences Reviewer
Cell Transplantation Reviewer
Connective Tissue Research Reviewer
Irish Journal Of Medical Science Reviewer
Biomed Research International Reviewer
Regenerative Medicine Reviewer
Arthritis Research & Therapy Reviewer
Pnas Reviewer
Acta biochimica et biophysica Sinica Reviewer
Stem Cell Research & Therapy Reviewer

Other Activities

  Description

Review of grant proposals for: • Biotechnology & Bioresearch Sciences Research Council • Medical Research Council UK • Netherlands Organisation for Health Research and Development

Teaching Interests

Cellular manufacturing
MSC therapy
Supervising dissertations
Anatomy of bone or cartilage
Orthopaedic tissue regeneration

Current Postgraduate Students (Taught)

  Name Degree Primary Supervisor
Enya O'Connor Msc
Jordan Kennedy Msc
Megan Shanahan Msc

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2013 Sarah Flood Msc
2018 Ti Zhang Msc
2018 Anthony Sannicandro Msc
2019 Cliodhna Murray Msc
2019 Fiona O'Kelly Msc
2017 Sophie Maybury Msc
2014 Barry Murphy Msc
2018 Clara Sanz Nogues Msc
2013 Sarah Bulman PhD
2013 Janice O¿Sullivan PhD
2011 Rosanne Raftery Msc
2015 Gillian Sexton Msc
2015 Aine Fleming Msc
2012 Sinead D¿Arcy PhD
2013 Paul Loftus Msc
2012 Dave McCarthy Msc

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2019/20 Cellular Manufacturing 1 MD1524
2020/21 Independent Study MD1527
2019/20 Mesenchymal Stromal Cell Therapy MD1526
2019/20 Cellular Manufacturing & Therapy Dissertation MD1523

Internal Collaborators

  Name Description of Collaboration
Linda Howard
Co-investigation on HRB-Diabetes Ireland grant investigating the aetiology of diabetes-induced osteoporosis.
Sharon Glynn
Pilot study: Investigating the Impact of Diabetes on the Outcome of Fragility Fracture Procedures in Irish Patients
Timothy O'Brien
Co-investigation on HRB-Diabetes Ireland grant investigating the aetiology of diabetes-induced osteoporosis.

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Helen Burke Galway University Hospitals IRELAND
Investigating Patient Perceptions of Diabetes-Induced Osteopathy
Colin Murphy Galway University Hospitals IRELAND
Pilot study: Investigating the Impact of Diabetes on the Outcome of Fragility Fracture Procedures in Irish Patients
Declan Clarke Zoan Biomed IRELAND
Investigating the efficacy of coral as a bone void filler