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Medicine
Dr. Emer Bourke
PhD, BSc
Contact Details
LECTURER ABOVE THE BAR
Discipline of Pathology, School
Lambe Translational Research Fac
Costello Road
National University of Ireland,
T: 494416
E: emer.bourke@nuigalway.ie
Discipline of Pathology, School
Lambe Translational Research Fac
Costello Road
National University of Ireland,
T: 494416
E: emer.bourke@nuigalway.ie
Biography
Research Interests
Peer Reviewed Journals
Year | Publication | |
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(2019) | 'Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer'
Casey, MC;Prakash, A;Holian, E;McGuire, A;Kalinina, O;Shalaby, A;Curran, C;Webber, M;Callagy, G;Bourke, E;Kerin, MJ;Brown, JA (2019) 'Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer'. BMC Cancer, 19 [DOI] [Details] |
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(2019) | 'Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer'
Casey, MC,Prakash, A,Holian, E,McGuire, A,Kalinina, O,Shalaby, A,Curran, C,Webber, M,Callagy, G,Bourke, E,Kerin, MJ,Brown, JA (2019) 'Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer'. BMC Cancer, 19 [DOI] [Details] |
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(2018) | 'Clinically Applicable Inhibitors Impacting Genome Stability'
Prakash A, Garcia-Moreno JF, Brown JAL, Bourke E. (2018) 'Clinically Applicable Inhibitors Impacting Genome Stability'. Molecules (Basel, Switzerland), [DOI] [Details] |
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(2010) | 'Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis'
Mohrin M, Bourke E, Alexander D, Warr M, Barry-Holson K,, LeBeau M, Morrison CG and Passegué E. (2010) 'Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis'. Cell Stem Cell Impact Factor 24, 7 (2):174-185 [Details] |
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(2007) | 'DNA damage induces Chk1-dependent centrosome amplification'
Bourke E, Dodson H, Merdes A, Cuffe L, Zachos G, Walker M, Gillespie D, Morrison CG. (2007) 'DNA damage induces Chk1-dependent centrosome amplification'. Embo Reports, 8 (6):603-609 [Details] |
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(2004) | 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'
Dodson H, Bourke E, Jeffers LJ, Vagnarelli P, Sonoda E, Takeda S, Earnshaw WC, Merdes A, Morrison C. (2004) 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'. Embo Journal, 23 (19):3864-3873 [Details] |
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(2019) | 'Quantifying Tip60 (Kat5) stratifies breast cancer'
McGuire, A,Casey, MC,Shalaby, A,Kalinina, O,Curran, C,Webber, M,Callagy, G,Holian, E,Bourke, E,Kerin, MJ,Brown, JAL (2019) 'Quantifying Tip60 (Kat5) stratifies breast cancer'. Scientific Reports, 9 [DOI] [Details] |
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(2018) | 'Clinically Applicable Inhibitors Impacting Genome Stability'
Prakash A, Garcia-Moreno JF, Brown JAL, Bourke E. (2018) 'Clinically Applicable Inhibitors Impacting Genome Stability'. Molecules (Basel, Switzerland), 23 (5) [DOI] [Details] |
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(2017) | 'Practical Bioinformatics Analysis of MiRNA Data Using Online Tools'
Brown, JAL;Bourke, E (2017) 'Practical Bioinformatics Analysis of MiRNA Data Using Online Tools'. Methods in Molecular Biology, 1509 :195-208 [DOI] [Details] |
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(2016) | 'Targeting cancer using KAT inhibitors to mimic lethal knockouts'
Brown, J. A.,Bourke, E.,Eriksson, L. A.,Kerin, M. J. (2016) 'Targeting cancer using KAT inhibitors to mimic lethal knockouts'. Biochem Soc Trans, 44 (44):979-86 [Details] |
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(2015) | 'ROCK activity and the G beta gamma complex mediate chemotactic migration of mouse bone marrow-derived stromal cells'
Ryan, CM,Brown, JAL,Bourke, E,Prendergast, AM,Kavanagh, C,Liu, ZL,Owens, P,Shaw, G,Kolch, W,O'Brien, T,Barry, FP (2015) 'ROCK activity and the G beta gamma complex mediate chemotactic migration of mouse bone marrow-derived stromal cells'. Stem Cell Research & Therapy, 6 [DOI] [Details] |
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(2014) | 'Rational design and validation of a Tip60 histone acetyltransferase inhibitor'
Gao C*, Bourke E*, Scobie M, Famme MA, Koolmeister T, Helleday T, Eriksson LA, Lowndes NF, Brown JA. (2014) 'Rational design and validation of a Tip60 histone acetyltransferase inhibitor'. Scientific Reports, [Details] |
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(2010) | 'Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis'
Mohrin, M;Bourke, E;Alexander, D;Warr, MR;Barry-Holson, K;Le Beau, MM;Morrison, CG;Passegue, E (2010) 'Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis'. Cell Stem Cell, 7 :174-185 [DOI] [Details] |
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(2010) | 'DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2'
Bourke, E., Brown J.A., Takeda, S., Hochegger, H. and Morrison C.G. (2010) 'DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2'. Oncogene, 29 :616-624 [Details] |
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(2010) | 'MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification'
Brown, JAL,Bourke, E,Liptrot, C,Dockery, P,Morrison, CG (2010) 'MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification'. Oncogene, 29 :5537-5544 [DOI] [Details] |
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(2009) | 'Centriole separation in DNA damage-induced centrosome amplification'
Saladino C, Bourke E, Conroy PC, Morrison CG (2009) 'Centriole separation in DNA damage-induced centrosome amplification'. Environmental And Molecular Mutagenesis, 50 (8):725-732 [DOI] [Details] |
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(2007) | 'DNA damage induces Chk1-dependent centrosome amplification'
Bourke, E;Dodson, H;Merdes, A;Cuffe, L;Zachos, G;Walker, M;Gillespie, D;Morrison, CG (2007) 'DNA damage induces Chk1-dependent centrosome amplification'. Embo Reports, 8 :603-609 [DOI] [Details] |
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(2008) | 'Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line'
Faure, V,Wenner, T,Cooley, C,Bourke, E,Farr, CJ,Takeda, S,Morrison, CG (2008) 'Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line'. Dna Repair, 7 :713-724 [DOI] [Details] |
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(2004) | 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'
Dodson, H;Bourke, E;Jeffers, LJ;Vagnarelli, P;Sonoda, E;Takeda, S;Earnshaw, WC;Merdes, A;Morrison, C (2004) 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'. Embo Journal, 23 :3864-3873 [DOI] [Details] |
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(2003) | 'The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells'
Bourke E, Bosisio, D, Golay, J, Polentarutti, N & Mantovani, A (2003) 'The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells'. Blood, 102 (3):956-963 [Details] |
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(2003) | 'IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils'
Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A (2003) 'IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils'. Journal Of Immunology, 170 (12):5999-6005 [Details] |
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(2000) | 'Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells'
Bourke E, Kennedy, EJ & Moynagh, PN (2000) 'Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells'. Journal Of Biological Chemistry, 275 (51):39996-40002 [Details] |
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(1999) | 'Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B'
Bourke E. & Moynagh PN (1999) 'Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B'. Journal Of Immunology, 163 (4):2113-2119 [Details] |
Book Chapters
Year | Publication | |
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(2017) | 'Practical Bioinformatics Analysis of MiRNA Data Using Online Tools'
Brown, JAL,Bourke, E,Rani, S (2017) 'Practical Bioinformatics Analysis of MiRNA Data Using Online Tools' In: MicroRNA profiling. Switzerland: Springer Nature. [DOI] [Details] |
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(2012) | 'Centrosomes, DNA Damage and Aneuploidy'
Chiara Saladino, Emer Bourke, Ciaran Morrison (2012) 'Centrosomes, DNA Damage and Aneuploidy' In: The Centrosome. Springer. [Details] |
Abstract
Year | Publication | |
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(2015) | Assessing Argonaute-2 as A Biomarker For Breast Cancer.
Casey, MC,McGuire, A,Shalaby, A,Webber, M,Curran, C,Callagy, G,Bourke, E,Brown, JAL,Kerin, MJ (2015) Assessing Argonaute-2 as A Biomarker For Breast Cancer. Abstract [Details] |
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(2010) | DNA damage-induced centriole disengagement.
Saladino, C,Conroy, P,Inanc, B,Dodson, H,Bourke, E,Morrison, C (2010) DNA damage-induced centriole disengagement. Abstract [Details] |
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(2008) | How Can Hematopoietic Stem Cells and Myeloid Progenitors Become Transformed?.
Mohrin, M,Bourke, E,Morrison, C,Passegue, E (2008) How Can Hematopoietic Stem Cells and Myeloid Progenitors Become Transformed?. Abstract [Details] |
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(2008) | DNA repair capacity of hematopoietic stem and myeloid progenitor cells.
Mohrin, M,Bourke, E,Morrison, C,Passegue, E (2008) DNA repair capacity of hematopoietic stem and myeloid progenitor cells. Abstract [Details] |
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(2007) | The role of apoptosis and DNA repair in normal and abnormal hematopoiesis.
Mohrin, ME,Bourke, E,Morrison, C,Passegue, EA (2007) The role of apoptosis and DNA repair in normal and abnormal hematopoiesis. Abstract [Details] |
Meeting
Year | Publication | |
---|---|---|
(2008) | DNA repair capacity of hematopoietic stem and myeloid progenitor cells.
Mohrin, M,Bourke, E,Morrison, C,Passegue, E (2008) DNA repair capacity of hematopoietic stem and myeloid progenitor cells. Meeting [Details] |
Honours and Awards
Year | Title | Awarding Body | |
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2012 | National University of Ireland Galway Millennium Research Fund Award | National University of Ireland Galway | |
2005 | Health Research Board Ireland, Senior Postdoctoral research fellowship | Health Research Board | |
2004 | European Commission Framework Programme 6, Marie Curie European Reintegration grant | European Commission | |
2000 | European Commission Framework Programme 5, Marie Curie Association European Individual Postdoctoral Fellowship | European Commission |
Committees
Committee | Function | From / To | |
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Irish Association for Cancer Research | Committee member responsible for organisation of annual IACR conference | / |
Education
Year | Institution | Qualification | Subject | |
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2012 | National University of Ireland Galway | Postgraduate Certificate in Higher Education Teaching | Teaching and Learning in Higher Education |
Modules Taught
Term/Year | Module Title | Module Code | Subject / Desc | |
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2011-Present Semester 2 | Health&Disease I | MD-201 | 2nd Year Medical Students will learn about the molecular, cellular, microbiological and environmental mechanisms which underpin the development and progression of disease | |
2011-Present: Semester 1 | Health & Disease II | MD-302 | 3rd year Medical Students will learn to understand the common disease processes affecting different organ systems and their clinical implications. | |
2012-Present: Semester 1 | MSc in Clinical Oncology and Haematology | BI-461 | Students will learn about the underlying pathogenesis of cancer, nomenclature of tumours, clinical diagnostics and the latest clinical treatments | |
2013 | Biomedical Science Seminar and Written Review | BM-201 | Students will perform a literature search on a current area of research in Biomedical Science using both library journals and web-based methods, and organize the information for a seminar presentation and for a written review. |
Internal Collaborators
Name | Description of Collaboration | |
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Internal Collaborators |
External Collaborators
Name | Organisation / Institute | Country | Description of Collaboration | |
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External Collaborators |