Dr JESSICA SCHIAVI

PhD

 
researcher
 

Biography

Dr Jessica Schiavi is graduated from the University of Lorraine, Nancy, France. After a Bachelor in Biology (2006), she completed her Master in Bioengineering (Honors). Then, she started her PhD thanks to a fellowship from the doctoral school BioSE (2008), in the cartilage engineering group at the UMR CNRS 7561 headed by Pr. Stoltz (France). Jessica’s research was focus on developing a new strategy to repair whole osteochondral defects, from articular cartilage up to the sub-chondral bone. She validated a stratified scaffold based on alginate hydrogel laden with human mesenchymal stem cells from bone marrow where those cells were differentiated into chondrocyte and hypertrophic chondrocyte in the different layers. Moreover, she performed mechanical test on the stratified scaffold to check its behaviour for a high load bearing area as the articular cartilage is. In parallel, she taught during 4 years (2008-2012) in the Bachelor and Master of Health Science (biostatistics, ergonomic and biochemistry) in the college of medicine in Nancy, France. After completing her PhD in Cell Biology in November 2011, she started a post-doctoral position in the Regenerative Nanomedicine group of Dr Nadia Jessel in Strasbourg (France), where she worked on providing a smart biosubstitut to fill bone and osteochondral defects during surgery. The aim was to accelerate tissue regeneration by adsorbing growth factors and/or seeding human mesenchymal stem cells on the biomaterial. Currently, she is working in the group of Professor Laoise McNamara on an innovative approach to treat osteoporosis. The project is to look at a mechanobiology based approach for the treatment of osteoporosis by looking at changes in bone cells mechanosensing under an osteoporotic condition. Since 2010, she published 13 peer-reviewed articles and several congress abstracts.

Contract Researchers

  Researcher Name Project Role Funding Body
Postdoctoral researcher Mechanobiology based approaches for treatment of osteoporosis Investigating the effect of estrogen withdrawal on bone cells under mechanical stimulations
Postdoctoral researcher Nanomedicine regenerative applied to bone Development of a biomaterial functionalised with growth factors to regenerate large bone defect

Peer Reviewed Journals

  Year Publication
(2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'
Freeman, FE;Schiavi, J;Brennan, MA;Owens, P;Layrolle, P;McNamara, LM (2017) 'Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells'. Tissue Engineering Part A, 23 :1466-1478 [DOI] [Details]
(2017) 'Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold'
Schiavi, J.,Reppel, L.,Charif, N.,de Isla, N.,Mainard, D.,Benkirane-Jessel, N.,Stoltz, J. F.,Rahouadj, R.,Huselstein, C. (2017) 'Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold'. J Tissue Eng Regen Medj Tissue Eng Regen Med, [DOI] [Details]
(2017) 'The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids'
Griffin, F.E.; Schiavi, J.; McDevitt, T.C.; McGarry, J.P.; McNamara, L.M. (2017) 'The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids'. Journal Of Biomechanics, [DOI] [Details]
(2016) 'PRIMARY CILIA EXPRESSION IN BONE MARROW IN RESPONSE TO MECHANICAL STIMULATION IN EXPLANT BIOREACTOR CULTURE'
Coughlin, TR;Schiavi, J;Varsanik, MA;Voisin, M;Birmingham, E;Haugh, MG;McNamara, LM;Niebur, GL (2016) 'PRIMARY CILIA EXPRESSION IN BONE MARROW IN RESPONSE TO MECHANICAL STIMULATION IN EXPLANT BIOREACTOR CULTURE'. European Cells & Materials, 32 :111-122 [DOI] [Details]
(2015) 'Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine'
Schiavi, J;Keller, L;Morand, DN;De Isla, N;Huck, O;Lutz, JC;Mainard, D;Schwinte, P;Benkirane-Jessel, N (2015) 'Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine'. Nanomedicine, 10 :753-763 [DOI] [Details]
(2015) 'Chondrogenic induction of mesenchymal stromal/stem cells from Wharton's jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering'
Reppel, L;Schiavi, J;Charif, N;Leger, L;Yu, H;Pinzano, A;Henrionnet, C;Stoltz, JF;Bensoussan, D;Huselstein, C (2015) 'Chondrogenic induction of mesenchymal stromal/stem cells from Wharton's jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering'. Stem Cell Research & Therapy, 6 [DOI] [Details]
(2015) 'A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration'
Eap, S;Keller, L;Schiavi, J;Huck, O;Jacomine, L;Fioretti, F;Gauthier, C;Sebastian, V;Schwinte, P;Benkirane-Jessel, N (2015) 'A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration'. International Journal Of Nanomedicine, 10 :1061-1074 [DOI] [Details]
(2014) 'Collagen implants equipped with 'fish scale'-like nanoreservoirs of growth factors for bone regeneration'
Eap, S;Ferrand, A;Schiavi, J;Keller, L;Kokten, T;Fioretti, F;Mainard, D;Ladam, G;Benkirane-Jessel, N (2014) 'Collagen implants equipped with 'fish scale'-like nanoreservoirs of growth factors for bone regeneration'. Nanomedicine, 9 :1253-1261 [DOI] [Details]
(2012) 'Constitutive equations for Ca2+-alginate gels'
Magnenet, V;Schiavi-Tritz, J;Huselstein, C;Rahouadj, R (2012) 'Constitutive equations for Ca2+-alginate gels'. Journal Of The Mechanical Behavior Of Biomedical Materials, 5 :90-98 [DOI] [Details]
(2012) 'Human Stem Cells and Articular Cartilage Tissue Engineering'
Stoltz, JF;Huselstein, C;Schiavi, J;Li, YY;Bensoussan, D;Decot, V;De Isla, N (2012) 'Human Stem Cells and Articular Cartilage Tissue Engineering'. Current Pharmaceutical Biotechnology, 13 :2682-2691 [Details]
(2010) 'Designing a three-dimensional alginate hydrogel by spraying method for cartilage tissue engineering'
Tritz, J;Rahouadj, R;de Isla, N;Charif, N;Pinzano, A;Mainard, D;Bensoussan, D;Netter, P;Stoltz, JF;Benkirane-Jessel, N;Huselstein, C (2010) 'Designing a three-dimensional alginate hydrogel by spraying method for cartilage tissue engineering'. Soft Matter, 6 :5165-5174 [DOI] [Details]

Book Chapters

  Year Publication
(2012) 'Articular cartilage engineering'
Huselstein, C.,De Isla, N.,Tritz, J,Stoltz, J. F. (2012) 'Articular cartilage engineering' In: Biomedical and Health Research - Regenerative medicine and cells therapyBiomedical and Health Research - Regenerative medicine and cells therapy. book: IOS Press. [Details]

Conference Publications

  Year Publication
(2010) BIO-MEDICAL MATERIALS AND ENGINEERING
Tritz-Schiavi, J;Charif, N;Henrionnet, C;de Isla, N;Bensoussan, D;Magdalou, J;Benkirane-Jessel, N;Stoltz, JF;Huselstein, C (2010) Original approach for cartilage tissue engineering with mesenchymal stem cells BIO-MEDICAL MATERIALS AND ENGINEERING , pp.167-174 [DOI] [Details]

Other Journals

  Year Publication
(2012) 'Does Making Method of Alginate Hydrogel Influence the Chondrogenic Differentiation of Human Mesenchymal Stem Cells?'
Jessica Schiavi, Naceur Charif, Natalia de Isla, Danièle Bensoussan, Jean-François Stoltz, Nadia Benkirane-Jessel, Céline Huselstein (2012) 'Does Making Method of Alginate Hydrogel Influence the Chondrogenic Differentiation of Human Mesenchymal Stem Cells?' engineering, 4 (10B) :110-113. [DOI] [Details]

Education

  Year Institution Qualification Subject
2011 Lorraine University PhD Cell Biology
2008 Lorraine University (University Henri Poincaré) Master in Biology Bioengineering

Languages

  Language
English
French
German
Italian