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Dr Ted Vaughan

B.Eng., Ph.D

 
researcher
 

Biography


Dr. Ted Vaughan is a Senior Lecturer in Biomedical Engineering and Principal Investigator at the Biomechanics Research Centre at the National University of Ireland, Galway. Dr. Ted Vaughan graduated with a First Class Honours Degree in Mechanical Engineering from the University of Limerick in 2007. He was awarded a PhD in Mechanical Engineering in 2011, also from the University of Limerick, for research in the area of computational micromechanics of composite materials, funded through a scholarship from the Irish Research Council for Science Engineering and Technology (IRCSET). Between 2011-2015, he held a position as a postdoctoral researcher in the Centre for Biomechanics Research (BMEC) here at NUI, Galway. During this time, he also held a position as a Visiting Postdoctoral Scholar at the University of Notre Dame, funded through a Postdoctoral Mobility Grant awarded by the Royal Irish Academy.

His research focusses on the development of multiscale modelling approaches to enhance our understanding of tissue biomechanics, biomaterials and medical implants. He was awarded a European Research Council Starter Grant that seeks to understand the biomechanical basis for bone fragility in Type-2 Diabetes. Dr. Vaughan is also project coordinator of BioImplant ITN, a programme that is developing next-generation bioresorbable material technologies for orthopaedic and cardiovascular implants. He works collaboratively with a range of industrial and clinical partners in the area medical device testing and development using in-silico modelling. He has authored more than 30 publications in peer-reviewed journals, an invited book chapter and more than 70 contributions to International and National Conferences.

 Career History
2019- Present: Senior Lecturer, Biomedical Engineering, NUI Galway 

2015 - 2019: Lecturer, Biomedical Engineering, NUI Galway 

Teaching Activities: Tissue Engineering BME405; Biomechanics & Mechanobiology BME503; Engineering Computing (Introduction to Matlab) CT1110; 
 
2011 - 2015: Postdoctoral Researcher, Centre for Biomechanics Research (BMEC), NUI Galway 

2007-2011: PhD in Mechanical Engineering, Irish Centre for Composites Research, University of Limerick 


Research Interests

Dr. Ted Vaughan's current research is focused on the development of multiscale computational models that facilitate a better understand of different aspects of bone biomechanics and mechanobiology. His research has also developed multiscale finite element damage models for composite materials. Some of his research interests include,

  • Multiscale finite element modeling to understand the hierarchical structure of bone tissue
  • Multiscale finite element models to predict mechanical stimulation of bone cells in their native environment
  • Fluid-structure interaction modelling of bone cells and their mechanosensors under in vitro and in vivo fluid flow stimulation
  • Continuum damage modelling and failure prediction of composite materials 
  • Micromechanical modelling of damage and failure in fibre reinforced composite materials
  • Nanoindentation of fibre reinforced composite materials 

Peer Reviewed Journals

  Year Publication
(2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'
Verbruggen, SW;Vaughan, TJ;McNamara, LM (2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'. Journal Of The Royal Society Interface, 9 :2735-2744 [DOI] [Details]
(2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'
Vaughan, TJ;McCarthy, CT;McNamara, LM (2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'. Journal Of The Mechanical Behavior Of Biomedical Materials, 12 :50-62 [DOI] [Details]
(2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'
Vaughan, TJ;Haugh, MG;McNamara, LM (2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'. Journal Of The Royal Society Interface, 10 [DOI] [Details]
(2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'
Dolan, EB;Vaughan, TJ;Niebur, GL;Casey, C;Tallon, D;McNamara, LM (2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 136 [DOI] [Details]
(2020) 'An experimental evaluation of the mechanics of bare and polymer-covered self-expanding wire braided stents'
McKenna, CG;Vaughan, TJ (2020) 'An experimental evaluation of the mechanics of bare and polymer-covered self-expanding wire braided stents'. Journal Of The Mechanical Behavior Of Biomedical Materials, 103 [DOI] [Details]
(2020) 'An experimental evaluation of the mechanics of bare and polymer-covered self-expanding wire braided stents'
McKenna, CG,Vaughan, TJ (2020) 'An experimental evaluation of the mechanics of bare and polymer-covered self-expanding wire braided stents'. Journal Of The Mechanical Behavior Of Biomedical Materials, 103 [DOI] [Details]
(2020) 'Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study'
Parle E;Tio S;Behre A;Carey JJ;Murphy CG;O'Brien TF;Curtin WA;Kearns SR;McCabe JP;Coleman CM;Vaughan TJ;McNamara LM; (2020) 'Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study'. Jbmr Plus, 4 (2) [DOI] [Details]
(2016) 'The effect of microscale residual stress from thermal cooldown on the nanoindentation properties of fibre-reinforced composites'
Hardiman, M,Vaughan, TJ,McCarthy, CT (2016) 'The effect of microscale residual stress from thermal cooldown on the nanoindentation properties of fibre-reinforced composites'. Journal Of Composite Materials, 50 :4147-4158 [DOI] [Details]
(2017) 'Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur'
Metzger, TA,Vaughan, TJ,McNamara, LM,Niebur, GL (2017) 'Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur'. Biomechanics And Modeling In Mechanobiology, 16 :841-850 [DOI] [Details]
(2017) 'The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells'
Virjula, S,Zhao, FH,Leivo, J,Vanhatupa, S,Kreutzer, J,Vaughan, TJ,Honkala, AM,Viehrig, M,Mullen, CA,Kallio, P,McNamara, LM,Miettinen, S (2017) 'The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells'. Journal Of The Mechanical Behavior Of Biomedical Materials, 72 :38-48 [DOI] [Details]
(2017) 'A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading'
Zhao, FH,Vaughan, TJ,Mc Garrigle, MJ,McNamara, LM (2017) 'A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading'. Computers in biology and medicine, 89 :181-189 [DOI] [Details]
(2018) 'In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm'
Zhao, FH,Mc Garrigle, MJ,Vaughan, TJ,McNamara, LM (2018) 'In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm'. Biomechanics And Modeling In Mechanobiology, 17 :5-18 [DOI] [Details]
(2018) 'Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates'
Haugh, MG,Vaughan, TJ,Madl, CM,Raftery, RM,McNamara, LM,O'Brien, FJ,Heilshorn, SC (2018) 'Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates'. Biomaterials, 171 :23-33 [DOI] [Details]
(2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'
Dolan, EB,Vaughan, TJ,Niebur, GL,Casey, C,Tallon, D,McNamara, LM (2014) 'How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 136 [DOI] [Details]
(2014) 'Cell morphology and focal adhesion location alters internal cell stress'
Mullen, CA,Vaughan, TJ,Voisin, MC,Brennan, MA,Layrolle, P,McNamara, LM (2014) 'Cell morphology and focal adhesion location alters internal cell stress'. Journal Of The Royal Society Interface, 11 [DOI] [Details]
(2015) 'The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior'
Mullen, CA,Vaughan, TJ,Billiar, KL,McNamara, LM (2015) 'The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior'. Biophysical journal, 108 :1604-1612 [DOI] [ARAN Link] [Details]
(2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'
Zhao, FH,Vaughan, TJ,McNamara, LM (2016) 'Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures'. Biomechanics And Modeling In Mechanobiology, 15 :561-577 [DOI] [ARAN Link] [Details]
(2016) 'The effects of pile-up, viscoelasticity and hydrostatic stress on polymer matrix nanoindentation'
Hardiman, M,Vaughan, TJ,McCarthy, CT (2016) 'The effects of pile-up, viscoelasticity and hydrostatic stress on polymer matrix nanoindentation'. Polymer Testing, 52 :157-166 [DOI] [Details]
(2016) 'Mechanisms of osteocyte stimulation in osteoporosis'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2016) 'Mechanisms of osteocyte stimulation in osteoporosis'. Journal Of The Mechanical Behavior Of Biomedical Materials, 62 :158-168 [DOI] [ARAN Link] [Details]
(2014) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2014) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'. Biomechanics And Modeling In Mechanobiology, 13 :85-97 [DOI] [ARAN Link] [Details]
(2013) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'
Verbruggen SW, Vaughan TJ, McNamara LM (2013) 'Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach'. Biomech Model Mechanobiol, [DOI] [Details]
(2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'
Vaughan, TJ,Verbruggen, SW,McNamara, LM (2013) 'Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes'. International Journal For Numerical Methods In Biomedical Engineering, 29 :1361-1372 [DOI] [Details]
(2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'
Vaughan, TJ,Haugh, MG,McNamara, LM (2013) 'A fluid-structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems'. Journal Of The Royal Society Interface, 10 [DOI] [Details]
(2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'
Verbruggen, SW,Vaughan, TJ,McNamara, LM (2012) 'Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes'. Journal Of The Royal Society Interface, 9 :2735-2744 [DOI] [ARAN Link] [Details]
(2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'
Vaughan, TJ,McCarthy, CT,McNamara, LM (2012) 'A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone'. Journal Of The Mechanical Behavior Of Biomedical Materials, 12 :50-62 [DOI] [ARAN Link] [Details]
(2011) 'A Micromechanical Study into the Effect of Intra-Ply Properties on the Transverse Shear Behaviour of Fibre Reinforced Composites”'
Vaughan, T.J., McCarthy, C.T. (2011) 'A Micromechanical Study into the Effect of Intra-Ply Properties on the Transverse Shear Behaviour of Fibre Reinforced Composites”'. Composites Part A: Applied Science and Manufacturing, 42 (9):1217-1228 [Details]
(2011) 'Micromechanical Modelling of the Transverse Damage Behaviour in Fibre Reinforced Composite Materials'
Vaughan, T.J., McCarthy, C.T. (2011) 'Micromechanical Modelling of the Transverse Damage Behaviour in Fibre Reinforced Composite Materials'. Composites Science and Technology, 71 (3):388-396 [Details]
(2010) 'A Combined Experimental-Numerical Approach for Generating Statistically Equivalent Fibre Distributions for High Strength Laminated Composite Materials'
Vaughan, T.J., McCarthy, C.T. (2010) 'A Combined Experimental-Numerical Approach for Generating Statistically Equivalent Fibre Distributions for High Strength Laminated Composite Materials'. Composites Science and Technology, 70 (2):291-297 [ARAN Link] [Details]

Book Chapters

  Year Publication
(2015) '14 – Micromechanical failure analysis of advanced composite materials'
C. McCarthy, T.J Vaughan (2015) '14 – Micromechanical failure analysis of advanced composite materials' In: Numerical Modelling of Failure in Advanced Composite Materials. Cambridge: Woodhead Publishing. [DOI] [Details]

Conference Publications

  Year Publication
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Verbruggen, SW;Vaughan, TJ;McNamara, LM (2012) LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.517-518 [Details]
(2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
Gunning, PS;Harewood, FJ;Vaughan, TJ;McNamara, LM (2012) TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B , pp.1043-1044 [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A
Vaughan, TJ;Haugh, MG;McNamara, LM (2014) FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A [Details]
(2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B
Dolan, EB;Vaughan, TJ;Niebur, GL;Tallon, D;McNamara, LM (2014) UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B [Details]
(2014) FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW
Vaughan, TJ,Haugh, MG,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A FLUID-STRUCTURE INTERACTION MODELLING PREDICTS THAT STRAIN TRANSFER THROUGH FOCAL ATTACHMENTS OF OSTEOBLAST CELLS ARE THE PRIMARY MEDIATORS OF MECHANICAL STIMULATION UNDER FLUID FLOW [Details]
(2012) LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT
Verbruggen, SW,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B LOADING-INDUCED INTERSTITIAL FLUID FLOW IN BONE MECHANOBIOLOGY: AN FSI APPROACH TO THE OSTEOCYTE ENVIRONMENT , pp.517-518 [Details]
(2014) UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION
Dolan, EB,Vaughan, TJ,Niebur, GL,Tallon, D,McNamara, LM, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B UNDERSTANDING THE EFFECTS OF THERMAL ELEVATIONS ASSOCIATED WITH ORTHOPEDIC INTERVENTION: AN EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION [Details]
(2012) TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT
Gunning, PS,Harewood, FJ,Vaughan, TJ,McNamara, LM, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B TRANSCATHETER AORTIC VALVES: A FINITE ELEMENT STUDY OF LEAFLET STRESS DISTRIBUTION IN THE IN VIVO ENVIRONMENT , pp.1043-1044 [Details]
(2010) 4th European Conference of Computational Mechanics
Vaughan, T.J., McCarthy, C.T. (2010) Micromechanical Modelling of Transverse Damage in Fibre Reinforced Composites 4th European Conference of Computational Mechanics Paris, France, [Details]
(2010) 3rd Annual Materials Ireland Conference
Vaughan, T.J., McCarthy, C.T. (2010) Micromechanics based failure predictions for fibre reinforced composites 3rd Annual Materials Ireland Conference Dublin, Ireland, [Details]
(2010) 5th International Conference for Multiscale Materials Modelling
Vaughan, T.J., McCarthy, C.T. (2010) Micromechanics Based Failure Predictions for Fibre Reinforced Composite Materials 5th International Conference for Multiscale Materials Modelling Freiburg, Germany, [Details]
(2009) 2nd Annual Materials Ireland Conference
Vaughan, T.J., McCarthy, C.T. (2009) Micromechanical modelling of damage and failure in composite materials 2nd Annual Materials Ireland Conference Cork, Ireland, [Details]
(2009) 15th International Conference on Composite Structures
Vaughan, T.J., McCarthy, C.T. (2009) Generating Statistically Equivalent Fibre Distributions for High-Strength Composites 15th International Conference on Composite Structures Porto, Portugal, [Details]
(2008) 9th International Conference on Computational Structures Technology
Vaughan, T.J., McCarthy, C.T., Soutis, C. (2008) Development of a Statistically Equivalent Representative Volume Element for a Fibre Reinforced Composite 9th International Conference on Computational Structures Technology Athens, Greece, [Details]
(2008) 4th International Conference for Multiscale Materials Modelling
Vaughan, T.J., McCarthy, C.T. (2008) Development of Statistically Equivalent Representative Volume Elements for Multiscale Modelling of Composite Materials 4th International Conference for Multiscale Materials Modelling Tallahassee, Florida, [Details]

Conference Paper

  Year Publication
(2009) A Combined Experimental-Numerical Approach for Generating Statistically Equivalent Fibre Distributions for High Strength Laminated Composite Materials. 12th Annual Sir Bernard Crossland Symposium.
Vaughan, T.J. (2009) A Combined Experimental-Numerical Approach for Generating Statistically Equivalent Fibre Distributions for High Strength Laminated Composite Materials. 12th Annual Sir Bernard Crossland Symposium. Queens University Belfast: Conference Paper [Details]

Reviews

  Year Publication
(2017) A review of key developments and pertinent issues in nanoindentation testing of fibre reinforced plastic microstructures.
Hardiman, M;Vaughan, TJ;McCarthy, T (2017) A review of key developments and pertinent issues in nanoindentation testing of fibre reinforced plastic microstructures. OXFORD: Reviews [DOI] [Details]