Dr William Ronan

BE, PhD

Contact Details

Lecturer Below The Bar
Biomedical Engineering,
ENG-2023,
New Engineering Building,
NUI Galway.

T: Ext. 3460
E: WILLIAM.RONAN@nuigalway.ie
 
researcher

Biography

I completed my Ph.D. in Mechanical Engineering at NUI Galway (graduating in 2013 and funded by the Irish Research Council for Science, Engineering and Technology Embark Scholarship) on the mechanics of cells. This research primarily focused on development and implementation of constitutive material models and adhesion models using the finite element method. During this time, I spent one year as a visiting scholar in the University of California, Santa Barbara. In 2013, I was awarded a SFI Short-Term Travel Fellowship which I used to visit the University of Cambridge. This research collaboration expanded on my previous doctoral work to examine the kinetics and mechanics of cell adhesion. In 2014, I began a post-doctoral research project at the Cambridge Centre for Micromechanics on the tensile ductility and toughness of lattice materials & polymer foams. I returned to NUI Galway in 2016, originally as a faculty member in Mechanical Engineering, before moving to my current role in Biomedical Engineering.

For more information, please see my personal website http://www.mechbio.ie/

Research Interests

Finite Element modelling
Solid mechanics
biomechanics
cell mechanics
biomedical engineering
mechanical engineering
numerical simulations

Peer Reviewed Journals

  Year Publication
(2016) 'Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds'
Shirazi, RN,Ronan, W,Rochev, Y,McHugh, P (2016) 'Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds'. Journal Of The Mechanical Behavior Of Biomedical Materials, 54 :48-59 [DOI] [Details]
(2016) 'Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance'
Shirazi RN;Aldabbagh F;Ronan W;Erxleben A;Rochev Y;McHugh P; (2016) 'Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance'. Journal Of Materials Science-Materials In Medicine, 27 (10) [DOI] [Details]
(2015) 'A thermodynamically motivated model for stress-fiber reorganization'
Vigliotti, A and Ronan, W and Baaijens, FPT and Deshpande, VS (2015) 'A thermodynamically motivated model for stress-fiber reorganization'. Biomechanics and modeling in mechanobiology, :1-29 [Details]
(2015) 'Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions'
Ronan, W,McMeeking, RM,Chen, CS,McGarry, JP,Deshpande, VS (2015) 'Cooperative contractility: The role of stress fibres in the regulation of cell-cell junctions'. Journal Of Biomechanics, 48 :520-528 [DOI] [ARAN Link] [Details]
(2014) 'Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion'
Ronan, W,Deshpande, VS,McMeeking, RM,McGarry, JP (2014) 'Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion'. Biomechanics And Modeling In Mechanobiology, 13 :417-435 [DOI] [ARAN Link] [Details]
(2014) 'On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells'
Reynolds, NH,Ronan, W,Dowling, EP,Owens, P,McMeeking, RM,McGarry, JP (2014) 'On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells'. Biomaterials, 35 :4015-4025 [DOI] [ARAN Link] [Details]
(2013) 'Experimental and Computational Investigation of the Role of Stress Fiber Contractility in the Resistance of Osteoblasts to Compression'
Weafer, PP,Ronan, W,Jarvis, SP,McGarry, JP (2013) 'Experimental and Computational Investigation of the Role of Stress Fiber Contractility in the Resistance of Osteoblasts to Compression'. Bulletin Of Mathematical Biology, 75 :1284-1303 [DOI] [ARAN Link] [Details]
(2013) 'Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading'
Dowling, EP,Ronan, W,McGarry, JP (2013) 'Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading'. Acta Biomaterialia, 9 :5943-5955 [DOI] [ARAN Link] [Details]
(2013) 'Simulation of the Mechanical Response of Cells on Micropost Substrates'
Ronan, W,Pathak, A,Deshpande, VS,McMeeking, RM,McGarry, JP (2013) 'Simulation of the Mechanical Response of Cells on Micropost Substrates'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 135 [DOI] [ARAN Link] [Details]
(2012) 'Stability enhancement of an atomic force microscope for long-term force measurement including cantilever modification for whole cell deformation'
Weafer, PP,McGarry, JP,van Es, MH,Kilpatrick, JI,Ronan, W,Nolan, DR,Jarvis, SP (2012) 'Stability enhancement of an atomic force microscope for long-term force measurement including cantilever modification for whole cell deformation'. Review Of Scientific Instruments, 83 [DOI] [ARAN Link] [Details]
(2012) 'Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells'
Ronan, W,Deshpande, VS,McMeeking, RM,McGarry, JP (2012) 'Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells'. Journal Of The Mechanical Behavior Of Biomedical Materials, 14 :143-157 [DOI] [Details]
(2012) 'The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation'
Dowling, EP,Ronan, W,Ofek, G,Deshpande, VS,McMeeking, RM,Athanasiou, KA,McGarry, JP (2012) 'The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation'. Journal Of The Royal Society Interface, 9 :3469-3479 [DOI] [ARAN Link] [Details]

Conference Publications

  Year Publication
(2014) ANALYSIS OF THE ACTIVE RESPONSE OF CELLS TO CYCLIC LOADING USING A MODIFIED AFM SYSTEM
Weafer, P,Reynolds, N,Ronan, W,Dowling, E,Jarvis, S,McGarry, P, (2014) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT B ANALYSIS OF THE ACTIVE RESPONSE OF CELLS TO CYCLIC LOADING USING A MODIFIED AFM SYSTEM [Details]
(2012) INVESTIGATION OF THE ROLE OF STRESS FIBER CONTRACTILITY AND NUCLEUS GEOMETRY IN THE RESPONSE OF CELLS TO MICROPIPETTE ASPIRATION
Reynolds, NH,Ronan, W,Dowling, EP,McGarry, JP, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B INVESTIGATION OF THE ROLE OF STRESS FIBER CONTRACTILITY AND NUCLEUS GEOMETRY IN THE RESPONSE OF CELLS TO MICROPIPETTE ASPIRATION , pp.699-700 [Details]
(2012) INVESTIGATION OF STRESS FIBER AND FOCAL ADHESION EVOLUTION UNDER APPLIED MECHANICAL LOADING
Ronan, W,Deshpande, VS,McMeeking, RM,McGarry, JP, (2012) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B INVESTIGATION OF STRESS FIBER AND FOCAL ADHESION EVOLUTION UNDER APPLIED MECHANICAL LOADING , pp.689-690 [Details]
(2011) Contribution Of Stress Fiber Remodeling To The Response Of Cells To Micropipette Aspiration. Biomedical Engineering Society 2011 Annual Meeting, Hartford, CT, USA
Ronan, W.H., Reynolds, N.H., McGarry, J.P. (2011) Contribution Of Stress Fiber Remodeling To The Response Of Cells To Micropipette Aspiration. Biomedical Engineering Society 2011 Annual Meeting, Hartford, CT, USA [Details]
(2010) FINITE ELEMENT ANALYSIS OF CYTOSKELETAL REMODELING DURING MICROPIPETTE ASPIRATION
Ronan, W,Deshpande, VS,McMeeking, RM,McGarry, P, (2010) PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010 FINITE ELEMENT ANALYSIS OF CYTOSKELETAL REMODELING DURING MICROPIPETTE ASPIRATION , pp.433-434 [Details]

Conference Paper

  Year Publication
(2011) Simulation of Stress Fiber Remodeling and Mixed-Mode Focal Adhesion Assembly During Cell Spreading and for Cells Adhered to Elastic Substrates. Proceedings of the ASME 2011 Summer Bioengineering Conference, Famington, PA USA.
Ronan, W., Deshpande, V.S., McMeeking, R.M., McGarry, J.P. (2011) Simulation of Stress Fiber Remodeling and Mixed-Mode Focal Adhesion Assembly During Cell Spreading and for Cells Adhered to Elastic Substrates. Proceedings of the ASME 2011 Summer Bioengineering Conference, Famington, PA USA. Conference Paper [Details]
(2011) Influence of Actin Cytoskeletal Remodelling on the Shear Resistance of Single Chondrocytes: A Computational and Experimental Investigation. 17th Annual Conference of the Bioengineering Section of the Royal Academy of Medicine in Ireland, Galway.
Dowling E.P., Ronan, W., Athanasiou, K.A., McGarry J.P. (2011) Influence of Actin Cytoskeletal Remodelling on the Shear Resistance of Single Chondrocytes: A Computational and Experimental Investigation. 17th Annual Conference of the Bioengineering Section of the Royal Academy of Medicine in Ireland, Galway. Conference Paper [Details]
(2011) Remodeling and contractility of the actin cytoskeleton during the shear deformation of single chondrocytes. Proceedings of the ASME 2011 Summer Bioengineering Conference, PA, USA.
Dowling E.P., Ronan, W., Deshpande, V.S., McMeeking, R.M., Athanasiou, K.A., McGarry J.P. (2011) Remodeling and contractility of the actin cytoskeleton during the shear deformation of single chondrocytes. Proceedings of the ASME 2011 Summer Bioengineering Conference, PA, USA. Conference Paper [Details]
(2011) Active Computational Modelling of Cytoskeletal Remodeling During Compression & Spreading. Bioengineering In Ireland 17, Galway, Ireland.
Ronan, W., Deshpande, V.S., McMeeking, R.M., McGarry, J.P. (2011) Active Computational Modelling of Cytoskeletal Remodeling During Compression & Spreading. Bioengineering In Ireland 17, Galway, Ireland. Conference Paper [Details]
(2011) Active Computational Modelling of Cytoskeletal Remodelling During Cell Spreading. TERMIS-EU 2011, Granda, Spain.
Ronan, W., McGarry, J.P. (2011) Active Computational Modelling of Cytoskeletal Remodelling During Cell Spreading. TERMIS-EU 2011, Granda, Spain. Conference Paper [Details]
(2011) Computational Modeling of the Actin Myosin Cytoskeleton in Chondrocytes. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA.
Ronan, W., Dowling, E.P., McGarry, J.P. (2011) Computational Modeling of the Actin Myosin Cytoskeleton in Chondrocytes. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA. Conference Paper [Details]
(2010) Finite Element Analysis of Cytoskeletal Remodeling During Micropipette Aspiration. Proceedings of the ASME 2010 Summer Bioengineering Conference, Naples, Fl, USA.
Ronan, W., Deshpande, V.S., McMeeking, R.M., McGarry, J.P. (2010) Finite Element Analysis of Cytoskeletal Remodeling During Micropipette Aspiration. Proceedings of the ASME 2010 Summer Bioengineering Conference, Naples, Fl, USA. Conference Paper [Details]
(2010) Simulating the Role of Actin Cytoskeleton Remodeling in the Shearing of Chondrocytes. 18th Annual Symposium on Computational Methods in Orthopaedic Biomechanics, New Orleans, LA, USA.
Dowling E.P., Ronan, W., Athanasiou, K.A., McGarry J.P. (2010) Simulating the Role of Actin Cytoskeleton Remodeling in the Shearing of Chondrocytes. 18th Annual Symposium on Computational Methods in Orthopaedic Biomechanics, New Orleans, LA, USA. Conference Paper [Details]
(2009) Finite Element Modelling of Stress Fibre and Focal Adhesion Evolution Under Applied Mechanical Loading. Bioengineering In Ireland 15, Limerick, Ireland.
Ronan, W., McGarry, J.P., McMeeking, R.M., Deshpande, V.S. (2009) Finite Element Modelling of Stress Fibre and Focal Adhesion Evolution Under Applied Mechanical Loading. Bioengineering In Ireland 15, Limerick, Ireland. Conference Paper [Details]