Howard Oliver Fearnhead

Lecturer Above The Bar PhD

Contact Details

Lecturer Above The Bar
Dept of Pharmacology
NUI, Galway

T: 5115 / 5240
E: howard.fearnhead@nuigalway.ie
 
researcher

Biography

In 1991 Dr Fearnhead completed a BSc. in Pharmacology and Toxicology at the London School of Pharmacy, before completing a PhD. in apoptosis at the MRC-Toxicology Centre, Leicester, UK in 1995. In 1999 Dr Fearnhead completed a post-doctoral fellowship at Cold Spring Harbor Laboratory, NY before moving to the National Cancer Institute in Maryland as a tenure track principle investigator. In 2004 Dr Fearnhead moved to the National Centre of Biomedical Engineering Science (NCBES), National University of Ireland, Galway (http://www.nuigalway.ie/ncbes) and in 2006 was appointed a lecturer in Pharmacology and Therapeutics (http://www.nuigalway.ie/pharmacology).

Peer Reviewed Journals

  Year Publication
(2014) 'Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues'
Monaghan, D,O'Connell, E,Cruickshank, FL,O'Sullivan, B,Giles, FJ,Hulme, AN,Fearnhead, HO (2014) 'Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues'. Biochemical And Biophysical Research Communications, 443 :761-767 [DOI] [Details]
(2014) 'Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers'
Elliman SJ, Howley BV, Mehta DS, Fearnhead HO, Kemp DM, Barkley LR (2014) 'Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers'. Oncogene, 3 [DOI] [Details]
(2014) 'New roles for old enzymes: killer caspases as the engine of cell behavior changes'
Connolly PF, Jäger R, Fearnhead HO (2014) 'New roles for old enzymes: killer caspases as the engine of cell behavior changes'. Frontiers in physiology, 5 [DOI] [Details]
(2012) 'Dead Cells Talking: The Silent Form of Cell Death Is Not so Quiet'
Jäger R, Fearnhead HO (2012) 'Dead Cells Talking: The Silent Form of Cell Death Is Not so Quiet'. Biochem, 2012 [DOI] [Details]
(2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'
Colleran, A,Ryan, A,O'Gorman, A,Mureau, C,Liptrot, C,Dockery, P,Fearnhead, H,Egan, LJ (2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'. Journal Of Biological Chemistry, 286 :22886-22893 [DOI] [Details]
(2010) 'TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase'
Fabian, Z.,Fearnhead, H. O. (2010) 'TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase'. Biochem Biophys Res Commun, 395 (44):458-64 [Details]
(2010) 'p53-mediated induction of Noxa and p53AIP1 requires NFkappaB'
O'Prey J, Crighton D, Martin AG, Vousden KH, Fearnhead HO, Ryan KM (2010) 'p53-mediated induction of Noxa and p53AIP1 requires NFkappaB'. Cell Cycle, 9 (5):947-952 [Details]
(2009) 'Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B'
Martin, A. G.,Trama, J.,Crighton, D.,Ryan, K. M.,Fearnhead, H. O. (2009) 'Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B'. Aging (Albany NY), 1 (33):335-49 [Details]
(2009) 'The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer'
Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB (2009) 'The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer'. Embo Journal, 28 (13):1916-1925 [DOI] [Details]
(2008) 'A non-apoptotic role for caspase-9 in muscle differentiation'
Murray TV, McMahon JM, Howley BA, Stanley A, Ritter T, Mohr A, Zwacka R, Fearnhead HO (2008) 'A non-apoptotic role for caspase-9 in muscle differentiation'. Journal Of Cell Science, 121 (Pt 22):3786-3793 [DOI] [Details]
(2008) 'Caspases as therapeutic targets'
Howley B, Fearnhead HO (2008) 'Caspases as therapeutic targets'. Journal Of Cellular And Molecular Medicine, 12 (5A):1502-1516 [DOI] [Details]
(2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'
Samali, A,O'Mahoney, M,Reeve, J,Logue, S,Szegezdi, E,McMahon, J,Fearnhead, HO (2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'. Apoptosis, 12 :465-474 [DOI] [Details]
(2006) 'Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome'
Chandra, D., Bratton, S. B., Person, M. D., Tian, Y., Martin, A. G., Ayres, M., Fearnhead, H. O., Gandhi, V. and Tang, D. G. (2006) 'Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome'. Cell, 125 :1333-1346 [Details]
(2006) 'Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis'
Malet G, Martín AG, Orzáez M, Vicent MJ, Masip I, Sanclimens G, Ferrer-Montiel A, Mingarro I, Messeguer A, Fearnhead HO, Pérez-Payá E (2006) 'Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis'. Cell Death And Differentiation, 13 (9):1523-1532 [DOI] [Details]
(2004) 'Apo cytochrome c inhibits caspases by preventing apoptosome formation'
Martin AG, Nguyen J, Wells JA, Fearnhead HO (2004) 'Apo cytochrome c inhibits caspases by preventing apoptosome formation'. Biochem, 319 (3):944-950 [DOI] [Details]
(2004) 'Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2'
Davydov, I. V.,Woods, D.,Safiran, Y. J.,Oberoi, P.,Fearnhead, H. O.,Fang, S.,Jensen, J. P.,Weissman, A. M.,Kenten, J. H.,Vousden, K. H. (2004) 'Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2'. J Biomol Screen, 9 (88):695-703 [Details]
(2004) 'Getting Back on Track, or What to Do When Apoptosis Is De-Railed: Recoupling Oncogenes to the Apoptotic Machinery'
Fearnhead, H. O. (2004) 'Getting Back on Track, or What to Do When Apoptosis Is De-Railed: Recoupling Oncogenes to the Apoptotic Machinery'. Cancer Biology & Therapy, 3 (1):21-28 [Details]
(2004) 'Apo cytochrome c inhibits caspases by preventing apoptosome formation'
Martin, A. G.,Nguyen, J.,Wells, J. A.,Fearnhead, H. O. (2004) 'Apo cytochrome c inhibits caspases by preventing apoptosome formation'. Biochem Biophys Res Commun, 319 (33):944-50 [Details]
(2002) 'Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis'
Martin AG, Fearnhead HO (2002) 'Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis'. Journal Of Biological Chemistry, 277 (52):50834-50841 [DOI] [Details]
(2001) 'Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family'
Richter BW, Mir SS, Eiben LJ, Lewis J, Reffey SB, Frattini A, Tian L, Frank S, Youle RJ, Nelson DL, Notarangelo LD, Vezzoni P, Fearnhead HO, Duckett CS (2001) 'Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family'. Molecular And Cellular Biology, 21 (13):4292-4301 [DOI] [Details]
(2001) 'Cell-free systems to study apoptosis'
Fearnhead, H. O. (2001) 'Cell-free systems to study apoptosis'. Methods in Cell Biology, 66 :167-185 [Details]
(1998) 'Oncogene-dependent caspase activation is mediated by caspase-9'
Fearnhead, H. O., Rodriguez, J., Govek, E., Guo, W., Kobayashi, R., Hannon, G. and Lazebnik, Y. A. (1998) 'Oncogene-dependent caspase activation is mediated by caspase-9'. Proceedings of the National Academy of Sciences, 95 :13664-13669 [Details]
(1997) 'Oncogene-dependent apoptosis in extracts from drug-resistant cells'
Fearnhead, H. O., McCurrach, M. E., O'Neill, J., Zhang, K., Lowe, S. W. and Lazebnik, Y. A. (1997) 'Oncogene-dependent apoptosis in extracts from drug-resistant cells'. Genes and Development, 11 :1266-1276 [Details]
(1997) 'Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells'
Faleiro, L.,Kobayashi, R.,Fearnhead, H.,Lazebnik, Y. (1997) 'Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells'. EMBO J, 16 (99):2271-81 [Details]
(1995) 'DNA degradation and proteolysis in thymocyte apoptosis'
Fearnhead HO, MacFarlane M, Dinsdale D, Cohen GM (1995) 'DNA degradation and proteolysis in thymocyte apoptosis'. Toxicology letters, 82-83 :135-141 [Details]
(1995) 'An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes'
Fearnhead HO, Dinsdale D, Cohen GM (1995) 'An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes'. Febs Letters, 375 (3):283-288 [Details]
(1995) 'A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli'
Fearnhead, H. O.,Rivett, A. J.,Dinsdale, D.,Cohen, G. M. (1995) 'A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli'. FEBS Lett, 357 (33):242-6 [Details]
(1995) 'Mechanisms of Cell Death, with Particular Reference to Apoptosis'
Cohen, G. M., MacFarlane, M., Fearnhead, H. O., Sun, X. M. and Dinsdale, D. (1995) 'Mechanisms of Cell Death, with Particular Reference to Apoptosis'. Molecular and Cellular Mechanisms of Toxicity, [Details]
(1995) 'An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells'
Zhu, H.,Fearnhead, H. O.,Cohen, G. M. (1995) 'An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells'. FEBS Lett, 374 (22):303-8 [Details]
(1994) 'Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle'
Fearnhead, H. O., Chwalinski, M., Snowden, R. T., Ormerod, M. G. & Cohen, G. M. (1994) 'Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle'. Biochemical Pharmacology, 48 :1073-1079 [Details]
(1994) 'Cdc2 activation is not required for thymocyte apoptosis'
Norbury, C.,MacFarlane, M.,Fearnhead, H.,Cohen, G. M. (1994) 'Cdc2 activation is not required for thymocyte apoptosis'. Biochem Biophys Res Commun, 202 (33):1400-6 [Details]
(1994) 'Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes'
Cohen G. M., X.M.Sun, X. M., Fearnhead, H. O., MacFarlane, M., Brown, D. G., Snowden, R. T. & Dinsdale, D. (1994) 'Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes'. Journal of Immunology, 153 :507-516 [Details]
(1993) 'Increased membrane permeability of apoptotic thymocytes: a flow cytometric study'
Ormerod, M. G., Sun, X. M., Snowden, R. T., Davies, R., Fearnhead, H. O. & Cohen, G. M. (1993) 'Increased membrane permeability of apoptotic thymocytes: a flow cytometric study'. Cytometry, 14 :595-602 [Details]

Book Chapters

  Year Publication
(2013) 'Mitochondrial Regulation of Cell Death'
Richard Jaeger and Howard O. Fearnhead (2013) 'Mitochondrial Regulation of Cell Death' In: Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy. USA: Springer. [Details]

Conference Publications

  Year Publication
(2011) European Lab Automation Congress
Monaghan, D; Griffin, R; Regan, A; O’Connell, E; Fearnhead, H (2011) Repurposing Drugs For The Treatment of Multi-Drug Resistant Breast Cancer European Lab Automation Congress Hamburg, Germany, [Details]
(2011) Irish Association for Cancer Research
Monaghan, D; O’Connell, E; Fearnhead, HO. (2011) Repurposing the antifungal ciclopirox olamine for treatment of triple negative multi-drug resistant breast cancer Irish Association for Cancer Research Cork, [Details]

Conference Contributions

  Year Publication
(2014) Non-coding RNA: From in-situ hybridization to next generation sequencing,
Howard Fearnhead, Vladimir Benes, Donal O'Carroll (2014) EMBL-sponsored training course for international scientists. [Conference Organising Committee Chairperson], Non-coding RNA: From in-situ hybridization to next generation sequencing, NUI Galway , 06-JUN-14 - 13-JUN-14. [Details]
(2013) Mechanisms of Cell Death - The command to die,
Howard Fearnhead (2013) International Cell Death Society Meeting. [Invited Lecture], Mechanisms of Cell Death - The command to die, Spain , 01-JUN-13 - 06-JUN-13. [Details]
(2011) From in-situ hybridization to next-generation sequencing,
Howard Fearnhead, Vladimir Benes, Donal O'Carroll (2011) EMBL-sponsored training course for international scientists. [Conference Organising Committee Chairperson], From in-situ hybridization to next-generation sequencing, NUI Galway , 21-MAY-11 - 27-MAY-11. [Details]
(2010) MicroRNA profiling: From In-Situ Hybridization to New Gen Sequencing,
Howard Fearnhead (2010) MicroRNAs (miRNA) are short, noncoding regulatory RNAs involved in development, differentiation, and metabolism of most eukaryotic organisms. Investigating miRNA expression in these cellular processes is important for our understanding of fundamental biological processes and many different diseases. The course is designed to introduce researchers to the theoretical and practical aspects of the methods used for discovery and profiling of miRNA expression such as in-situ hybridization, microarray and qPCR analyses, fluorescent sorting and new-generation sequencing. [Invited Oral Presentation], MicroRNA profiling: From In-Situ Hybridization to New Gen Sequencing, EMBL-Montorontondo, Italy , 10-APR-10 - 16-APR-10. [Details]
(2002) ASCB-Meeting minisymposium: Stress Regulation and Programmed Cell Death,
Howard Fearnhead (2002) E3-ligase activity of Xplinked Inhibitor of Apoptosis Protein. [Invited Oral Presentation], ASCB-Meeting minisymposium: Stress Regulation and Programmed Cell Death, Washington DC , 08-DEC-02 - 12-DEC-01. [Details]
(1997) The Biology of Proteolysis,
Howard Fearnhead, Yuri Lazebnik (1997) Oncogene-dependent caspase activation. [Oral Presentation], The Biology of Proteolysis, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY , 23-APR-97 - 27-APR-97. [Details]

Abstract

  Year Publication
(2014) Linear diterpenes with anticancer activity from the irish brown alga Bifurcaria bifurcata.
Smyrniotopoulos, V,Firsova, D,Rae, M,Heesch, S,Fearnhead, H,Tasdemir, D (2014) Linear diterpenes with anticancer activity from the irish brown alga Bifurcaria bifurcata. Abstract [Details]

Invited papers

  Year Publication
(2005) Oncogene dependent caspase activation. Univeristy of Texas, Austin.
Fearnhead, H (2005) Oncogene dependent caspase activation. Univeristy of Texas, Austin. Invited papers [Details]
(2005) Oncogene dependent caspase activation. NA Rockville, Maryland, USA.
Fearnhead, H (2005) Oncogene dependent caspase activation. NA Rockville, Maryland, USA. Invited papers [Details]
(2004) Oncogene dependent caspase activation. MRC Toxicology Unit, University of Leicester.
Fearnhead (2004) Oncogene dependent caspase activation. MRC Toxicology Unit, University of Leicester. Invited papers [Details]

Reviews

  Year Publication
(2008) Caspases as therapeutic targets.
Howley, B,Fearnhead, HO (2008) Caspases as therapeutic targets. Reviews [DOI] [Details]