Prof James P O'Gara

BSc, PhD

Contact Details

Personal Professor
Microbiology
School of Natural Sciences
NUI Galway

T: Ext. 2250
E: JAMESP.OGARA@nuigalway.ie
 
researcher

Biography


2012-Present: Personal Professor of Microbiology, National University of Ireland, Galway.

2013- 2016:    Head of Microbiology, National University of Ireland, Galway.

2007-2012:     Head of Graduate Studies, School of Biomolecular and Biomedical Science, UCD.

                           Conway Fellow, Conway Institute of Biomolecular & Biomedical Research, UCD.

2005-2012:     Senior Lecturer (Microbiology), University College Dublin

2004-2005:     Senior Lecturer (Microbiology), Royal College of Surgeons in Ireland

1999-2004:     College Lecturer (Microbiology), Royal College of Surgeons in Ireland

1997-1999:     Postdoctoral Research Fellow, Department of Microbiology, Trinity College Dublin

1994-1997:     Postdoctoral Research Fellow, The University of Texas Medical School, Houston, TX.

1990-1994:      PhD (Microbiology), National University of Ireland, Galway  

Research Interests

HRB Press Release - 15th November 2016


Galway researchers find penicillin aids MRSA fight



https://www.rte.ie/news/2016/1115/831844-mrsa/



http://www.hrb.ie/about/in-the-news/?no_cache=1&tx_ttnews%5BbackPid%5D=19&tx_ttnews%5Btt_news%5D=830...61d86160b9



HRB Press Release - 9th July 2015

Breaking up MRSA - new discovery could reduce device-related infections in hospitals

 
http://www.hrb.ie/home/media/press-release/

 

Research Projects

  Project Start Date End Date
REDUCING RESISTANCE TO BETA-LACTAM ANTIBIOTICS; A NEW TREATMENT STRATEGY FOR MRSA INFECTIONS 01-OCT-16 30-NOV-19
IRC POSTGRADUATE SCHOLARSHIP 2016 CLAIRE FINGLETON - New frontiers in the treatment of MRSA infections: Using amino acid analogues to overcome resistance to beta-lactam antibiotics 01-OCT-16 30-SEP-20
NEW TREATMENTS FOR TREATMENT OF MRSA INFECTIONS J O GARA 01-OCT-14 30-SEP-18
BIOFLUX MICROFLUIDICS SYSTEM FOR CELL ANALYSIS UNDER J O GARA 01-JAN-13 31-DEC-14
JIM O GARA INVESTIGATING THE RELATIONSHIP BETWEEN METHICILLIN RESISTANCE , BIOFILM AND VIRULENCE IN STAPHLOCCUS AUREAUS 01-NOV-12 31-OCT-15
TOWARDS IMPROVED PREVENTION AND TREATMENT OF DEVICE RELATED INFECTIONS(DVIS) JIM O GARA 01-OCT-13 30-SEP-14
TOWARDS IMPROVED PREVENTION AND TREATMENT OF DEVICE RELATED INFECTIONS(DVIS) JIM O GARA 01-FEB-13 30-SEP-13

Contract Researchers

  Researcher Name Project Role Funding Body
Dr Elaine Waters New drug combinations for the treatment of MRSA infections Senior Postdoctoral Fellow Science Foundation Ireland (SFI)
Dr Laura Gallagher New antibiotic combinations for the treatment of MRSA infections Postdoctoral Fellow Health Research Board (HRB)

Peer Reviewed Journals

  Year Publication
(2017) 'Into the Storm: Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life threatening infections'
O'Gara, James P. (2017) 'Into the Storm: Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life threatening infections'. Environmental Microbiology, In Press [Details]
(2017) 'Redeploying β-lactam antibiotics as a novel anti-virulence strategy for the treatment of MRSA infections'
Waters, E.M., Rudkin, J.K., Coughlan, S., Clair, G.C., Adkins, J.N., Gore, S., Xia, G., Black, N.S., Downing, T., O'Neill, E., Kadioglu, A., and O’Gara, J.P. (2017) 'Redeploying β-lactam antibiotics as a novel anti-virulence strategy for the treatment of MRSA infections'. Journal Of Infectious Disease, 215 :80-87 [Details]
(2017) 'Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm related infections'
Hogan, S., Zapotaczna, M., Stevens, N., Humphreys, H., O'Gara, J.P., O'Neill, E. (2017) 'Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm related infections'. Journal Of Hospital Infection, In Press [Details]
(2017) 'Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds; MMV665953 (1-(3-Chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea) and MMV665807 (5-Chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide'
Zapotoczna, M., Boksmati, N., Donohue, S., Bahtiar, B., Boland, A., Al Somali, M., Cox, A., Humphreys, H., O'Gara, J.P., Brennan, M., O'Neill, E. (2017) 'Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds; MMV665953 (1-(3-Chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea) and MMV665807 (5-Chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide'. Journal Of Medical Microbiology, In Press [Details]
(2017) 'Eradication of Staphylococcus aureus biofilm infections using synthetic antimicrobial peptides'
Marta Zapotoczna, Eanna Forde, Siobhan Hogan, Hilary Humphreys, James P O’Gara, Deirdre Fitzgerald-Hughes, Marc Devocelle, Eoghan O’Neill (2017) 'Eradication of Staphylococcus aureus biofilm infections using synthetic antimicrobial peptides'. Journal Of Infectious Diseases, In Press [Details]
(2016) 'Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?'
Waters, EM,Rowe, SE,O'Gara, JP,Conlon, BP (2016) 'Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?'. Plos Pathogens, 12 [DOI] [Details]
(2016) '5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus'
Marta Zapotoczna, Ewan Murray, Siobhan Hogan, James P. O’Gara, Siri Ram Chhabra, Weng C. Chan, Eoghan O’Neill and Paul Williams (2016) '5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus'. Journal Of Antimicrobial Chemotherapy, [Details]
(2016) 'AraC-type regulator Rbf controls the Staphylococcus epidermidis biofilm phenotype by negatively regulating the icaADBC repressor SarR'
Rowe SE;Campbell C;Lowry C;O'Donnell ST;Olson ME;Lindgren JK;Waters EM;Fey PD;O'Gara JP; (2016) 'AraC-type regulator Rbf controls the Staphylococcus epidermidis biofilm phenotype by negatively regulating the icaADBC repressor SarR'. Journal Of Bacteriology, [DOI] [Details]
(2016) 'Untangling the diverse and redundant mechanisms of Staphylococcus aureus biofilm formation'
Marta Zapotoczna, Eoghan O’Neill and James P. O'Gara (2016) 'Untangling the diverse and redundant mechanisms of Staphylococcus aureus biofilm formation'. Plos Pathogens, [Details]
(2016) 'Eradication of Staphylococcus aureus catheter-related biofilm infections using ML:8 and Citrox'
Siobhan Hogan, Marta Zapotoczna, Niall Stevens, Hilary Humphreys, James P. O'Gara and Eoghan O'Neill (2016) 'Eradication of Staphylococcus aureus catheter-related biofilm infections using ML:8 and Citrox'. Antimicrobial Agents And Chemotherapy, [Details]
(2016) 'The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation'
Khodaparast, L,Shahrooei, M,Stijlemans, B,Merckx, R,Baatsen, P,O'Gara, JP,Waters, E,Van Mellaert, L,Van Eldere, J (2016) 'The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation'. Plos One, 11 [DOI] [Details]
(2016) 'In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus'
Hogan, S,Zapotoczna, M,Stevens, NT,Humphreys, H,O'Gara, JP,O'Neill, E (2016) 'In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus'. Antimicrobial Agents And Chemotherapy, 60 :2923-2931 [DOI] [Details]
(2016) 'The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model'
McCarthy, H,Waters, EM,Bose, JL,Foster, S,Bayles, KW,O'Neill, E,Fey, PD,O'Gara, JP (2016) 'The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model'. Fems Microbiology Letters, 363 [DOI] [Details]
(2016) 'Electrophoretic Mobility Shift Assays'
Rowe SE, O'Gara JP (2016) 'Electrophoretic Mobility Shift Assays'. Methods in molecular biology (Clifton, N.J.), 1373 :155-167 [DOI] [Details]
(2016) 'A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA'
Ramundo MS;Beltrame CO;Botelho AM;Coelho LR;Silva-Carvalho MC;Ferreira-Carvalho BT;Nicolás MF;Guedes IA;Dardenne LE;O'Gara JP;Figueiredo AM; (2016) 'A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA'. International Journal Of Medical Microbiology : Ijmm, [DOI] [Details]
(2015) 'An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections'
Zapotoczna, M; McCarthy, H; Rudkin, JK; O’Gara, JP; and O’Neill, E. (2015) 'An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections'. Journal Of Infectious Diseases, [Details]
(2015) 'Methicillin resistance and the biofilm phenotype in Staphylococcus aureus'
McCarthy, H,Rudkin, JK,Black, NS,Gallagher, L,O'Neill, E,O'Gara, JP (2015) 'Methicillin resistance and the biofilm phenotype in Staphylococcus aureus'. Frontiers In Cellular And Infection Microbiology, 5 [DOI] [Details]
(2015) 'Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation'
Laura E. Spoor, Emily Richardson, Amy C. Richards​, Gillian J. Wilson, Chriselle Mendonca​, Ravi Kr. Gupta, Paul R. McAdam​, Stephen Nutbeam-Tuffs​, Nikki S. Black​, James P. O'Gara​, Chia Y. Lee, Jukka Corander, J. Ross Fitzgerald (2015) 'Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation'. Microbial Genomics, 1:mgen.0.000036 [Details]
(2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis Under Static Growth Conditions'
Waters, EM,McCarthy, H,Hogan, S,Zapotoczna, M,O'Neill, E,O'Gara, JP,Fey, PD (2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis Under Static Growth Conditions'. Methods Mol Biol, 1106 :157-166 [DOI] [Details]
(2014) 'Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus'
Rudkin, JK,Laabei, M,Edwards, AM,Joo, HS,Otto, M,Lennon, KL,O'Gara, JP,Waterfield, NR,Massey, RC (2014) 'Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus'. Antimicrobial Agents And Chemotherapy, 58 :1100-1107 [DOI] [Details]
(2014) 'Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype'
Conlon BP, Geoghegan JA;Waters EM;McCarthy H;Rowe SE;Davies JR;Schaeffer CR;Foster TJ;Fey PD;O'Gara JP (2014) 'Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype'. Journal Of Bacteriology, 196 (24):4268-4275 [DOI] [Details]
(2014) 'Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin- resistant Staphylococcus aureus strain LAC'
McCourt, J, D.P. O'Halloran, H. McCarthy, J.P. O'Gara and J.A. Geoghegan (2014) 'Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin- resistant Staphylococcus aureus strain LAC'. Fems Microbiology Letters, 353 :157-164 [DOI] [Details]
(2014) 'Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections'
Hogan S, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. (2014) 'Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections'. Current Pharmaceutical Design, In Press [Details]
(2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis under Static Growth Conditions'
Waters, E.M, McCarthy, H., Hogan, S., Zapotoczna, M., O’Neill, E., and O’Gara, J.P. (2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis under Static Growth Conditions'. Methods Mol Biol, :157-166 [DOI] [Details]
(2013) 'Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms'
Geoghegan, J.A., I.R. Monk, J.P. O'Gara and T.J. Foster (2013) 'Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms'. Journal Of Bacteriology, 195 :2675-2683 [DOI] [Details]
(2012) 'Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections'
Pozzi, C,Waters, EM,Rudkin, JK,Schaeffer, CR,Lohan, AJ,Tong, P,Loftus, BJ,Pier, GB,Fey, PD,Massey, RC,O'Gara, JP (2012) 'Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections'. Plos Pathogens, 8 [DOI] [Details]
(2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'
Stevens, NT,Greene, CM,O'Gara, JP,Bayston, R,Sattar, MTA,Farrell, M,Humphreys, H (2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'. British Journal Of Neurosurgery, 26 :792-797 [DOI] [Details]
(2012) 'Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3'
Michael A Sharkey, James P O'Gara, Stephen V Gordon, Frauke Hackenberg, Claire Healy, Francesca Paradisi, Siddappa Patil, Bettina Schaible, Matthias Tacke (2012) 'Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3'. Journal Of Antibiotics, 1 (1):25-28 [Details]
(2012) 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system'
Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters EM, Chan WC, Williams P, O'Gara JP, Massey RC (2012) 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system'. Journal Of Infectious Diseases, 205 (5):798-806 [DOI] [Details]
(2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'
Stevens NT, Greene CM, O'Gara JP, Bayston R, Sattar MT, Farrell M, Humphreys H (2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'. Journal of neurosurgery, 26 (6):792-797 [DOI] [Details]
(2012) 'Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study'
Galvin S, Boyle M, Russell RJ, Coleman DC, Creamer E, O'Gara JP, Fitzgerald-Hughes D, Humphreys H (2012) 'Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study'. J Hosp Infect, 80 (1):67-70 [DOI] [Details]
(2012) 'Evaluation of protein adsorption on atmospheric plasma deposited coatings exhibiting superhydrophilic to superhydrophobic properties'
Stallard CP, McDonnell KA, Onayemi OD, O'Gara JP, Dowling DP (2012) 'Evaluation of protein adsorption on atmospheric plasma deposited coatings exhibiting superhydrophilic to superhydrophobic properties'. Biointerphases, 7 (1-4) [DOI] [Details]
(2011) 'A novel role for SarX in Staphylococcus epidermidis biofilm regulation'
Rowe SE, Mahon V, Smith SG, O'Gara JP (2011) 'A novel role for SarX in Staphylococcus epidermidis biofilm regulation'. Microbiology, 157 (Pt 4):1042-1049 [DOI] [Details]
(2011) 'Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype'
Houston P, Rowe SE, Pozzi C, Waters EM, O'Gara JP (2011) 'Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype'. Infection And Immunity, 79 (3):1153-1165 [DOI] [Details]
(2011) 'Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development'
Holland LM, Conlon B, O'Gara JP (2011) 'Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development'. Microbiology, 157 (Pt 2):408-418 [DOI] [Details]
(2011) 'Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma'
Cotter JJ, Maguire P, Soberon F, Daniels S, O'Gara JP, Casey E (2011) 'Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma'. J Hosp Infect, 78 (3):204-207 [DOI] [Details]
(2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'
Rawlinson LA, O'Gara JP, Jones DS, Brayden DJ (2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'. Journal Of Medical Microbiology, 60 (Pt 7):968-976 [DOI] [Details]
(2010) 'Role of surface protein SasG in biofilm formation by Staphylococcus aureus'
Geoghegan JA, Corrigan RM, Gruszka DT, Speziale P, O'Gara JP, Potts JR, Foster TJ (2010) 'Role of surface protein SasG in biofilm formation by Staphylococcus aureus'. Journal Of Bacteriology, 192 (21):5663-5673 [DOI] [Details]
(2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'
Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, Massey RC (2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'. The ISME journal, 4 (4):577-584 [DOI] [Details]
(2010) 'Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus'
Oduwole KO, Glynn AA, Molony DC, Murray D, Rowe S, Holland LM, McCormack DJ, O'Gara JP (2010) 'Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus'. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 28 (9):1252-1256 [DOI] [Details]
(2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'
Cotter JJ, O'Gara JP, Stewart PS, Pitts B, Casey E (2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'. Journal Of Applied Microbiology, 109 (6):2105-2117 [DOI] [Details]
(2009) 'Hydrogen peroxide induced repression of icaADBC transcription and biofilm development in Staphylococcus epidermidis'
Glynn AA, O'Donnell ST, Molony DC, Sheehan E, McCormack DJ, O'Gara JP (2009) 'Hydrogen peroxide induced repression of icaADBC transcription and biofilm development in Staphylococcus epidermidis'. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27 (5):627-630 [DOI] [Details]
(2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis'
Cotter JJ, O'Gara JP, Mack D, Casey E (2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis'. Applied And Environmental Microbiology, 75 (1):261-264 [DOI] [Details]
(2009) 'Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2'
Stevens NT, Sadovskaya I, Jabbouri S, Sattar T, O'Gara JP, Humphreys H, Greene CM (2009) 'Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2'. Cellular Microbiology, 11 (3):421-432 [DOI] [Details]
(2009) 'Carriage of both the fnbA and fnbB genes and growth at 37 degrees C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates'
O'Neill E, Humphreys H, O'Gara JP (2009) 'Carriage of both the fnbA and fnbB genes and growth at 37 degrees C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates'. Journal Of Medical Microbiology, 58 (Pt 4):399-402 [DOI] [Details]
(2009) 'Rapid depletion of dissolved oxygen in 96-well microtiter plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'
Cotter JJ, O'Gara JP, Casey E (2009) 'Rapid depletion of dissolved oxygen in 96-well microtiter plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'. Biotechnology and Bioengineering, 103 (5):1042-1047 [DOI] [Details]
(2009) 'Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis'
Stevens NT, Greene CM, O'Gara JP, Humphreys H (2009) 'Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis'. Journal Of Medical Microbiology, 58 (Pt 7):855-862 [DOI] [Details]
(2009) 'Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC'
Cue D, Lei MG, Luong TT, Kuechenmeister L, Dunman PM, O'Donnell S, Rowe S, O'Gara JP, Lee CY (2009) 'Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC'. Journal Of Bacteriology, 191 (20):6363-6373 [DOI] [Details]
(2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'
O'Neill E, Pozzi C, Houston P, Humphreys H, Robinson DA, Loughman A, Foster TJ, O'Gara JP (2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'. Journal Of Bacteriology, 190 (11):3835-3850 [DOI] [Details]
(2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP'
Holland LM, O'Donnell ST, Ryjenkov DA, Gomelsky L, Slater SR, Fey PD, Gomelsky M, O'Gara JP (2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP'. Journal Of Bacteriology, 190 (15):5178-5189 [DOI] [Details]
(2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis'
Stevens NT, Tharmabala M, Dillane T, Greene CM, O'Gara JP, Humphreys H (2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis'. Clin Microbiol Infect, 14 (7):719-722 [DOI] [Details]
(2007) 'ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus'
O'Gara JP (2007) 'ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus'. Fems Microbiology Letters, 270 (2):179-188 [DOI] [Details]
(2007) 'Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections'
O'Neill E, Pozzi C, Houston P, Smyth D, Humphreys H, Robinson DA, O'Gara JP (2007) 'Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections'. Journal Of Clinical Microbiology, 45 (5):1379-1388 [DOI] [Details]
(2007) 'SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis'
Handke LD, Slater SR, Conlon KM, O'Donnell ST, Olson ME, Bryant KA, Rupp ME, O'Gara JP, Fey PD (2007) 'SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis'. Canadian Journal Of Microbiology, 53 (1):82-91 [DOI] [Details]
(2006) 'Environmental regulation of biofilm development in methicillin-resistant and methicillin-susceptible Staphylococcus aureus clinical isolates'
Fitzpatrick F, Humphreys H, O'Gara JP (2006) 'Environmental regulation of biofilm development in methicillin-resistant and methicillin-susceptible Staphylococcus aureus clinical isolates'. J Hosp Infect, 62 (1):120-122 [DOI] [Details]
(2005) 'The genetics of staphylococcal biofilm formation--will a greater understanding of pathogenesis lead to better management of device-related infection?'
Fitzpatrick F, Humphreys H, O'Gara JP (2005) 'The genetics of staphylococcal biofilm formation--will a greater understanding of pathogenesis lead to better management of device-related infection?'. Clin Microbiol Infect, 11 (12):967-973 [DOI] [Details]
(2005) 'Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates'
Fitzpatrick F, Humphreys H, O'Gara JP (2005) 'Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates'. Journal Of Clinical Microbiology, 43 (4):1973-1976 [DOI] [Details]
(2005) 'The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?'
Fitzpatrick, F,Humphreys, H,O'Gara, JP (2005) 'The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?'. Clinical Microbiology And Infection, 11 :967-973 [DOI] [Details]
(2005) 'Evidence for low temperature regulation of biofilm formation in Staphylococcus epidermidis'
Fitzpatrick F, Humphreys H, O'gara JP (2005) 'Evidence for low temperature regulation of biofilm formation in Staphylococcus epidermidis'. Journal Of Medical Microbiology, 54 (Pt 5):509-510 [DOI] [Details]
(2005) 'Genomic diversity of Staphylococcus epidermidis isolates from the intensive care unit'
FitzGerald SF, Fitzpatrick F, Dillane T, Smith EG, Humphreys H, O'Gara JP (2005) 'Genomic diversity of Staphylococcus epidermidis isolates from the intensive care unit'. Clin Microbiol Infect, 11 (7) [DOI] [Details]
(2004) 'Contribution of culture media and chemical properties of polystyrene tissue culture plates to biofilm development by Staphylococcus aureus'
Kennedy CA, O'Gara JP (2004) 'Contribution of culture media and chemical properties of polystyrene tissue culture plates to biofilm development by Staphylococcus aureus'. Journal Of Medical Microbiology, 53 (Pt 11):1171-1173 [Details]
(2004) 'Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis'
Conlon KM, Humphreys H, O'Gara JP (2004) 'Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis'. Journal Of Bacteriology, 186 (18):6208-6219 [DOI] [Details]
(2004) 'Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolates'
Handke LD, Conlon KM, Slater SR, Elbaruni S, Fitzpatrick F, Humphreys H, Giles WP, Rupp ME, Fey PD, O'Gara JP (2004) 'Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolates'. Journal Of Medical Microbiology, 53 (Pt 5):367-374 [Details]
(2002) 'Regulation of icaR gene expression in Staphylococcus epidermidis'
O'Gara JP, Conlon KM, Humphreys H (2002) 'Regulation of icaR gene expression in Staphylococcus epidermidis'. Fems Microbiology Letters, 216 (2):171-177 [Details]
(2002) 'Environmental regulation of biofilm formation in intensive care unit isolates of Staphylococcus epidermidis'
Fitzpatrick F, Humphreys H, Smyth E, Kennedy CA, O'Gara JP (2002) 'Environmental regulation of biofilm formation in intensive care unit isolates of Staphylococcus epidermidis'. J Hosp Infect, 52 (3):212-218 [Details]
(2002) 'icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis'
Conlon KM, Humphreys H, O'Gara JP (2002) 'icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis'. Journal Of Bacteriology, 184 (16):4400-4408 [Details]
(2001) 'Staphylococcus epidermidis biofilms: importance and implications'
O'Gara JP, Humphreys H (2001) 'Staphylococcus epidermidis biofilms: importance and implications'. Journal Of Medical Microbiology, 50 (7):582-587 [Details]
(2000) 'Effects of local transcription and H-NS on inversion of the fim switch of Escherichia coli'
O'Gara JP, Dorman CJ (2000) 'Effects of local transcription and H-NS on inversion of the fim switch of Escherichia coli'. Molecular Microbiology, 36 (2):457-466 [Details]
(1998) 'Control of photosystem formation in Rhodobacter sphaeroides'
Zeilstra-Ryalls J, Gomelsky M, Eraso JM, Yeliseev A, O'Gara J, Kaplan S. (1998) 'Control of photosystem formation in Rhodobacter sphaeroides'. Journal Of Bacteriology, 180 :2801-2809 [Details]
(1998) 'A redox-responsive pathway for aerobic regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Eraso JM, Kaplan S (1998) 'A redox-responsive pathway for aerobic regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1'. Journal Of Bacteriology, 180 (16):4044-4050 [Details]
(1997) 'Evidence for the role of redox carriers in photosynthesis gene expression and carotenoid biosynthesis in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Kaplan S (1997) 'Evidence for the role of redox carriers in photosynthesis gene expression and carotenoid biosynthesis in Rhodobacter sphaeroides 2.4.1'. Journal Of Bacteriology, 179 (6):1951-1961 [Details]
(1997) 'Identification and molecular genetic analysis of multiple loci contributing to high-level tellurite resistance in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Gomelsky M, Kaplan S (1997) 'Identification and molecular genetic analysis of multiple loci contributing to high-level tellurite resistance in Rhodobacter sphaeroides 2.4.1'. Applied And Environmental Microbiology, 63 (12):4713-4720 [Details]
(1995) 'Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase'
O'Gara JP, Dunican LK (1995) 'Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase'. Applied And Environmental Microbiology, 61 (12):4477-4479 [Details]
(1994) 'Direct evidence for a constitutive internal promoter in the tryptophan operon of Corynebacterium glutamicum'
O'Gara JP, Dunican LK (1994) 'Direct evidence for a constitutive internal promoter in the tryptophan operon of Corynebacterium glutamicum'. Biochem, 203 (2):820-827 [Details]

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2016 Colm Lowry Msc Y
2015 Hannah McCathy PhD Y
2013 Siobhan Hogan Msc Y
2012 Elaine Waters PhD Y
2011 Brian Conlon PhD Y
2010 Patrick Houston PhD Y
2010 Sarah Rowe PhD Y
2009 Clarissa Pozzi PhD Y
2009 Linda Holland PhD Y
2009 Kay Oduwole Msc Y
2008 Eoghan O'Neill PhD Y
2007 Sinead O'Donnell PhD Y
2007 Aaron Glynn Msc Y
2005 Fidelma Fitzpatrick Doctor of Medicine Y
2005 Ciara Kennedy PhD Y
2004 Kevin Conlon PhD Y
2009 John Cotter PhD
2008 Niall Stevens PhD
2007 Maria Boyle PhD

Current Postgraduate Students (Research)

  Student Degree Type Type
Nikki Black Doctorate - Structured PhD (Science) Supervisor
Claire Fingleton Doctorate - Structured PhD (Science) Supervisor
Laura Gallagher Doctorate - Structured PhD (Science) Supervisor
Christopher Campbell Doctorate - Structured PhD (Science) Supervisor
Andrea Flannery Doctorate - Structured PhD (Science) Co-supervisor (1)

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2016/2017 Microbial Infectious Diseases MI325 Microbiology
2016/2017 Biology BO101 Microbiology
2016/2017 Bacterial Pathogenesis MI437 Microbiology

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Eoghan O'Neill Royal College of Surgeons in Ireland IRELAND
Paul Fey University of Nebraska Medical Centre U.S.A.
Aras Kadioglu University of Liverpool UNITED KINGDOM
Ross Fitzgerald University of Edinburgh SCOTLAND
Josh Adkins Pacific Northwest National Laboratory U.S.A.
Tim Downing Dublin City University IRELAND