Prof James P O'Gara

BSc, PhD

Contact Details

Personal Professor
Microbiology
School of Natural Sciences
NUI Galway

T: Ext. 2250
E: JAMESP.OGARA@nuigalway.ie
 
researcher

Biography

2013-Present:   Head of Microbiology, National University of Ireland, Galway.

2012-Present:   Personal Professor of Microbiology, National University of Ireland, Galway.

2007-2012:        Head of Graduate Studies, School of Biomolecular and Biomedical Science, University College Dublin.

                             Conway Fellow
, Conway Institute of Biomolecular & Biomedical Research, University College Dublin.

2005-2012:        Senior Lecturer (Microbiology), University College Dublin

2004-2005:        Senior Lecturer (Microbiology), Royal College of Surgeons in Ireland

1999-2004:        College Lecturer (Microbiology), Royal College of Surgeons in Ireland

1997-1999:        Postdoctoral Research Fellow, Department of Microbiology, Trinity College Dublin

1994-1997:        Postdoctoral Research Fellow, Department of Microbiology &Molecular Genetics, The University of Texas, Houston.

1990-1994:        PhD (Microbiology), National University of Ireland, Galway

 

Research Interests

HRB Press Release - 9th July 2015
 

http://www.hrb.ie/home/media/press-release/

https://www.youtube.com/watch?v=Jqa9WkL7KuY
 
Breaking up MRSA - new discovery could reduce device-related infections in hospitals
 

A new discovery which reveals how bacteria cling to the surfaces of medical devices, could have potential to significantly reduce infections from devices like catheters and other lines inserted into the body.

The HRB-funded research, published today in The Journal of Infectious Diseases, was conducted by Professor James O'Gara in NUI Galway and Dr Eoghan O'Neill in the Royal College of Surgeons in Ireland.

According to Professor O'Gara, from the Department of Microbiology at NUIG,

We've discovered a new way that bacteria can attach themselves to the walls of a medical device and create a protective coating that stops our immune system and antibiotics from attacking them. MRSA can secrete an enzyme, called coagulase, that converts a component of our blood, fibrinogen, into fibrin. Fibrin is the protein that helps our blood to clot.

This then acts as a scaffold onto which the bacteria attach themselves to the walls of the device, usually a plastic tube or catheter, and they also create a protective barrier with the fibrin that keep out antibiotics and our own immune system'.

Dr O'Neill takes up the story,

'We've tested some drugs that are known to break up blood clots and have found that they can break up the biofilms protecting these dangerous bacteria.

This opens the possibility of us getting in early and disrupting the bacteria in the initial stages of an infection. When we break up the biofilm, we expose the bacteria to the patient's own immune system response as well as allow us to try antibiotics against it'.

'This discovery could make a significant global contribution to reducing device-related infections in hospitals', according to Dr Graham Love, Chief Executive at the Health Research Board.

'This is the second major discovery by Professor O'Gara and Dr O'Neill and their teams at NUIG and the Royal College of Surgeons about how bacteria form biofilms. They are world leaders in their fields and the HRB is determined to keep them, and researchers like them, in Ireland. We are committed to creating the right environment in which people can both conduct top quality health research, and quickly convert those findings into new advances in patient care and patient outcomes'.

A video recording of Professor O'Gara explaining his discovery is available at the link below. A high quality photo image is also available on request.

The results are published in The Journal of Infectious Diseases, and available at their website.

For more information, please contact, Gillian Markey, HRB, 087228514, egmarkey(at)hrb.ie

Research Projects

  Project Start Date End Date
NEW TREATMENTS FOR TREATMENT OF MRSA INFECTIONS J O GARA 01-OCT-14 30-SEP-18
BIOFLUX MICROFLUIDICS SYSTEM FOR CELL ANALYSIS UNDER J O GARA 01-JAN-13 31-DEC-14
JIM O GARA INVESTIGATING THE RELATIONSHIP BETWEEN METHICILLIN RESISTANCE , BIOFILM AND VIRULENCE IN STAPHLOCCUS AUREAUS 01-NOV-12 31-OCT-15
TOWARDS IMPROVED PREVENTION AND TREATMENT OF DEVICE RELATED INFECTIONS(DVIS) JIM O GARA 01-OCT-13 30-SEP-14
TOWARDS IMPROVED PREVENTION AND TREATMENT OF DEVICE RELATED INFECTIONS(DVIS) JIM O GARA 01-FEB-13 30-SEP-13

Peer Reviewed Journals

  Year Publication
(2016) 'Untangling the diverse and redundant mechanisms of Staphylococcus aureus biofilm formation'
Marta Zapotoczna, Eoghan O’Neill and James P. O'Gara (2016) 'Untangling the diverse and redundant mechanisms of Staphylococcus aureus biofilm formation'. Plos Pathogens, [Details]
(2016) 'The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model'
McCarthy H, Waters EM;Bose JL;Foster S;Bayles KW;O'Neill E;Fey PD;O'Gara JP (2016) 'The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model'. Fems Microbiology Letters, [DOI] [Details]
(2016) 'In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus'
Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. (2016) 'In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus'. Antimicrob Agents Chemother, 60 (5):2923-2931 [Details]
(2016) 'A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA'
Mariana Severo Ramundo, Cristiana Ossaille Beltrame, Ana Maria Nunes Botelho, Leonardo Rocchetto Coelho, Maria Cicera Silva-Carvalho, Bernadete Teixeira Ferreira-Carvalho, Marisa Fabiana Nicolás, Isabella Alvim Guedes, Laurent Emmanuel Dardenne, James P. O’Gara, and Agnes Marie Sá Figueiredo (2016) 'A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA'. International Journal Of Medical Microbiology, [Details]
(2016) 'The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation'
Khodaparast, L,Shahrooei, M,Stijlemans, B,Merckx, R,Baatsen, P,O'Gara, JP,Waters, E,Van Mellaert, L,Van Eldere, J (2016) 'The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation'. Plos One, 11 [DOI] [Details]
(2015) 'Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation'
Laura E. Spoor, Emily Richardson, Amy C. Richards​, Gillian J. Wilson, Chriselle Mendonca​, Ravi Kr. Gupta, Paul R. McAdam​, Stephen Nutbeam-Tuffs​, Nikki S. Black​, James P. O'Gara​, Chia Y. Lee, Jukka Corander, J. Ross Fitzgerald (2015) 'Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation'. Microbial Genomics, 1:mgen.0.000036 [Details]
(2015) 'Electrophoretic Mobility Shift Assays'
Rowe SE, O'Gara JP (2015) 'Electrophoretic Mobility Shift Assays'. Methods in molecular biology (Clifton, N.J.), 1373 :155-167 [DOI] [Details]
(2015) 'An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections'
Zapotoczna, M; McCarthy, H; Rudkin, JK; O’Gara, JP; and O’Neill, E. (2015) 'An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections'. Journal Of Infectious Diseases, [Details]
(2015) 'Methicillin resistance and the biofilm phenotype in Staphylococcus aureus'
McCarthy, H,Rudkin, JK,Black, NS,Gallagher, L,O'Neill, E,O'Gara, JP (2015) 'Methicillin resistance and the biofilm phenotype in Staphylococcus aureus'. Frontiers In Cellular And Infection Microbiology, 5 [DOI] [Details]
(2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis Under Static Growth Conditions'
Waters, EM,McCarthy, H,Hogan, S,Zapotoczna, M,O'Neill, E,O'Gara, JP,Fey, PD (2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis Under Static Growth Conditions'. Methods Mol Biol, 1106 :157-166 [DOI] [Details]
(2014) 'Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype'
Conlon BP, Geoghegan JA;Waters EM;McCarthy H;Rowe SE;Davies JR;Schaeffer CR;Foster TJ;Fey PD;O'Gara JP (2014) 'Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype'. Journal Of Bacteriology, 196 (24):4268-4275 [DOI] [Details]
(2014) 'Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus'
Rudkin, JK,Laabei, M,Edwards, AM,Joo, HS,Otto, M,Lennon, KL,O'Gara, JP,Waterfield, NR,Massey, RC (2014) 'Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus'. Antimicrobial Agents And Chemotherapy, 58 :1100-1107 [DOI] [Details]
(2014) 'Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin- resistant Staphylococcus aureus strain LAC'
McCourt, J, D.P. O'Halloran, H. McCarthy, J.P. O'Gara and J.A. Geoghegan (2014) 'Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin- resistant Staphylococcus aureus strain LAC'. Fems Microbiology Letters, 353 :157-164 [DOI] [Details]
(2014) 'Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections'
Hogan S, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. (2014) 'Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections'. Current Pharmaceutical Design, In Press [Details]
(2013) 'Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms'
Geoghegan, J.A., I.R. Monk, J.P. O'Gara and T.J. Foster (2013) 'Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms'. Journal Of Bacteriology, 195 :2675-2683 [DOI] [Details]
(2012) 'Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections'
Pozzi, C,Waters, EM,Rudkin, JK,Schaeffer, CR,Lohan, AJ,Tong, P,Loftus, BJ,Pier, GB,Fey, PD,Massey, RC,O'Gara, JP (2012) 'Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections'. Plos Pathogens, 8 [DOI] [Details]
(2012) 'Evaluation of protein adsorption on atmospheric plasma deposited coatings exhibiting superhydrophilic to superhydrophobic properties'
Stallard CP, McDonnell KA, Onayemi OD, O'Gara JP, Dowling DP (2012) 'Evaluation of protein adsorption on atmospheric plasma deposited coatings exhibiting superhydrophilic to superhydrophobic properties'. Biointerphases, 7 (1-4) [DOI] [Details]
(2012) 'Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study'
Galvin S, Boyle M, Russell RJ, Coleman DC, Creamer E, O'Gara JP, Fitzgerald-Hughes D, Humphreys H (2012) 'Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study'. J Hosp Infect, 80 (1):67-70 [DOI] [Details]
(2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'
Stevens NT, Greene CM, O'Gara JP, Bayston R, Sattar MT, Farrell M, Humphreys H (2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'. Journal of neurosurgery, 26 (6):792-797 [DOI] [Details]
(2012) 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system'
Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters EM, Chan WC, Williams P, O'Gara JP, Massey RC (2012) 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system'. Journal Of Infectious Diseases, 205 (5):798-806 [DOI] [Details]
(2012) 'Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3'
Michael A Sharkey, James P O'Gara, Stephen V Gordon, Frauke Hackenberg, Claire Healy, Francesca Paradisi, Siddappa Patil, Bettina Schaible, Matthias Tacke (2012) 'Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3'. Journal Of Antibiotics, 1 (1):25-28 [Details]
(2011) 'A novel role for SarX in Staphylococcus epidermidis biofilm regulation'
Rowe SE, Mahon V, Smith SG, O'Gara JP (2011) 'A novel role for SarX in Staphylococcus epidermidis biofilm regulation'. Microbiology, 157 (Pt 4):1042-1049 [DOI] [Details]
(2011) 'Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma'
Cotter JJ, Maguire P, Soberon F, Daniels S, O'Gara JP, Casey E (2011) 'Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma'. J Hosp Infect, 78 (3):204-207 [DOI] [Details]
(2011) 'Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype'
Houston P, Rowe SE, Pozzi C, Waters EM, O'Gara JP (2011) 'Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype'. Infection And Immunity, 79 (3):1153-1165 [DOI] [Details]
(2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'
Rawlinson LA, O'Gara JP, Jones DS, Brayden DJ (2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'. Journal Of Medical Microbiology, 60 (Pt 7):968-976 [DOI] [Details]
(2011) 'Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development'
Holland LM, Conlon B, O'Gara JP (2011) 'Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development'. Microbiology, 157 (Pt 2):408-418 [DOI] [Details]
(2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'
Cotter JJ, O'Gara JP, Stewart PS, Pitts B, Casey E (2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'. Journal Of Applied Microbiology, 109 (6):2105-2117 [DOI] [Details]
(2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'
Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, Massey RC (2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'. The ISME journal, 4 (4):577-584 [DOI] [Details]
(2010) 'Role of surface protein SasG in biofilm formation by Staphylococcus aureus'
Geoghegan JA, Corrigan RM, Gruszka DT, Speziale P, O'Gara JP, Potts JR, Foster TJ (2010) 'Role of surface protein SasG in biofilm formation by Staphylococcus aureus'. Journal Of Bacteriology, 192 (21):5663-5673 [DOI] [Details]
(2010) 'Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus'
Oduwole KO, Glynn AA, Molony DC, Murray D, Rowe S, Holland LM, McCormack DJ, O'Gara JP (2010) 'Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus'. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 28 (9):1252-1256 [DOI] [Details]
(2009) 'Hydrogen peroxide induced repression of icaADBC transcription and biofilm development in Staphylococcus epidermidis'
Glynn AA, O'Donnell ST, Molony DC, Sheehan E, McCormack DJ, O'Gara JP (2009) 'Hydrogen peroxide induced repression of icaADBC transcription and biofilm development in Staphylococcus epidermidis'. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27 (5):627-630 [DOI] [Details]
(2009) 'Carriage of both the fnbA and fnbB genes and growth at 37 degrees C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates'
O'Neill E, Humphreys H, O'Gara JP (2009) 'Carriage of both the fnbA and fnbB genes and growth at 37 degrees C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates'. Journal Of Medical Microbiology, 58 (Pt 4):399-402 [DOI] [Details]
(2009) 'Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2'
Stevens NT, Sadovskaya I, Jabbouri S, Sattar T, O'Gara JP, Humphreys H, Greene CM (2009) 'Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2'. Cellular Microbiology, 11 (3):421-432 [DOI] [Details]
(2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis'
Cotter JJ, O'Gara JP, Mack D, Casey E (2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis'. Applied And Environmental Microbiology, 75 (1):261-264 [DOI] [Details]
(2009) 'Rapid depletion of dissolved oxygen in 96-well microtiter plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'
Cotter JJ, O'Gara JP, Casey E (2009) 'Rapid depletion of dissolved oxygen in 96-well microtiter plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'. Biotechnology And Bioengineering, 103 (5):1042-1047 [DOI] [Details]
(2009) 'Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis'
Stevens NT, Greene CM, O'Gara JP, Humphreys H (2009) 'Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis'. Journal Of Medical Microbiology, 58 (Pt 7):855-862 [DOI] [Details]
(2009) 'Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC'
Cue D, Lei MG, Luong TT, Kuechenmeister L, Dunman PM, O'Donnell S, Rowe S, O'Gara JP, Lee CY (2009) 'Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC'. Journal Of Bacteriology, 191 (20):6363-6373 [DOI] [Details]
(2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP'
Holland LM, O'Donnell ST, Ryjenkov DA, Gomelsky L, Slater SR, Fey PD, Gomelsky M, O'Gara JP (2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP'. Journal Of Bacteriology, 190 (15):5178-5189 [DOI] [Details]
(2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis'
Stevens NT, Tharmabala M, Dillane T, Greene CM, O'Gara JP, Humphreys H (2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis'. Clin Microbiol Infect, 14 (7):719-722 [DOI] [Details]
(2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'
O'Neill E, Pozzi C, Houston P, Humphreys H, Robinson DA, Loughman A, Foster TJ, O'Gara JP (2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'. Journal Of Bacteriology, 190 (11):3835-3850 [DOI] [Details]
(2007) 'ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus'
O'Gara JP (2007) 'ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus'. Fems Microbiology Letters, 270 (2):179-188 [DOI] [Details]
(2007) 'Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections'
O'Neill E, Pozzi C, Houston P, Smyth D, Humphreys H, Robinson DA, O'Gara JP (2007) 'Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections'. Journal Of Clinical Microbiology, 45 (5):1379-1388 [DOI] [Details]
(2007) 'SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis'
Handke LD, Slater SR, Conlon KM, O'Donnell ST, Olson ME, Bryant KA, Rupp ME, O'Gara JP, Fey PD (2007) 'SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis'. Canadian Journal Of Microbiology, 53 (1):82-91 [DOI] [Details]
(2006) 'Environmental regulation of biofilm development in methicillin-resistant and methicillin-susceptible Staphylococcus aureus clinical isolates'
Fitzpatrick F, Humphreys H, O'Gara JP (2006) 'Environmental regulation of biofilm development in methicillin-resistant and methicillin-susceptible Staphylococcus aureus clinical isolates'. J Hosp Infect, 62 (1):120-122 [DOI] [Details]
(2005) 'The genetics of staphylococcal biofilm formation--will a greater understanding of pathogenesis lead to better management of device-related infection?'
Fitzpatrick F, Humphreys H, O'Gara JP (2005) 'The genetics of staphylococcal biofilm formation--will a greater understanding of pathogenesis lead to better management of device-related infection?'. Clin Microbiol Infect, 11 (12):967-973 [DOI] [Details]
(2005) 'Evidence for low temperature regulation of biofilm formation in Staphylococcus epidermidis'
Fitzpatrick F, Humphreys H, O'gara JP (2005) 'Evidence for low temperature regulation of biofilm formation in Staphylococcus epidermidis'. Journal Of Medical Microbiology, 54 (Pt 5):509-510 [DOI] [Details]
(2005) 'Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates'
Fitzpatrick F, Humphreys H, O'Gara JP (2005) 'Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates'. Journal Of Clinical Microbiology, 43 (4):1973-1976 [DOI] [Details]
(2005) 'Genomic diversity of Staphylococcus epidermidis isolates from the intensive care unit'
FitzGerald SF, Fitzpatrick F, Dillane T, Smith EG, Humphreys H, O'Gara JP (2005) 'Genomic diversity of Staphylococcus epidermidis isolates from the intensive care unit'. Clin Microbiol Infect, 11 (7) [DOI] [Details]
(2004) 'Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolates'
Handke LD, Conlon KM, Slater SR, Elbaruni S, Fitzpatrick F, Humphreys H, Giles WP, Rupp ME, Fey PD, O'Gara JP (2004) 'Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolates'. Journal Of Medical Microbiology, 53 (Pt 5):367-374 [Details]
(2004) 'Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis'
Conlon KM, Humphreys H, O'Gara JP (2004) 'Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis'. Journal Of Bacteriology, 186 (18):6208-6219 [DOI] [Details]
(2004) 'Contribution of culture media and chemical properties of polystyrene tissue culture plates to biofilm development by Staphylococcus aureus'
Kennedy CA, O'Gara JP (2004) 'Contribution of culture media and chemical properties of polystyrene tissue culture plates to biofilm development by Staphylococcus aureus'. Journal Of Medical Microbiology, 53 (Pt 11):1171-1173 [Details]
(2002) 'icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis'
Conlon KM, Humphreys H, O'Gara JP (2002) 'icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis'. Journal Of Bacteriology, 184 (16):4400-4408 [Details]
(2002) 'Regulation of icaR gene expression in Staphylococcus epidermidis'
O'Gara JP, Conlon KM, Humphreys H (2002) 'Regulation of icaR gene expression in Staphylococcus epidermidis'. Fems Microbiology Letters, 216 (2):171-177 [Details]
(2002) 'Environmental regulation of biofilm formation in intensive care unit isolates of Staphylococcus epidermidis'
Fitzpatrick F, Humphreys H, Smyth E, Kennedy CA, O'Gara JP (2002) 'Environmental regulation of biofilm formation in intensive care unit isolates of Staphylococcus epidermidis'. J Hosp Infect, 52 (3):212-218 [Details]
(2001) 'Staphylococcus epidermidis biofilms: importance and implications'
O'Gara JP, Humphreys H (2001) 'Staphylococcus epidermidis biofilms: importance and implications'. Journal Of Medical Microbiology, 50 (7):582-587 [Details]
(2000) 'Effects of local transcription and H-NS on inversion of the fim switch of Escherichia coli'
O'Gara JP, Dorman CJ (2000) 'Effects of local transcription and H-NS on inversion of the fim switch of Escherichia coli'. Molecular Microbiology, 36 (2):457-466 [Details]
(1998) 'A redox-responsive pathway for aerobic regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Eraso JM, Kaplan S (1998) 'A redox-responsive pathway for aerobic regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1'. Journal Of Bacteriology, 180 (16):4044-4050 [Details]
(1997) 'Evidence for the role of redox carriers in photosynthesis gene expression and carotenoid biosynthesis in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Kaplan S (1997) 'Evidence for the role of redox carriers in photosynthesis gene expression and carotenoid biosynthesis in Rhodobacter sphaeroides 2.4.1'. Journal Of Bacteriology, 179 (6):1951-1961 [Details]
(1997) 'Identification and molecular genetic analysis of multiple loci contributing to high-level tellurite resistance in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Gomelsky M, Kaplan S (1997) 'Identification and molecular genetic analysis of multiple loci contributing to high-level tellurite resistance in Rhodobacter sphaeroides 2.4.1'. Applied And Environmental Microbiology, 63 (12):4713-4720 [Details]
(1995) 'Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase'
O'Gara JP, Dunican LK (1995) 'Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase'. Applied And Environmental Microbiology, 61 (12):4477-4479 [Details]
(1994) 'Direct evidence for a constitutive internal promoter in the tryptophan operon of Corynebacterium glutamicum'
O'Gara JP, Dunican LK (1994) 'Direct evidence for a constitutive internal promoter in the tryptophan operon of Corynebacterium glutamicum'. Biochem, 203 (2):820-827 [Details]

Book Chapters

  Year Publication
(2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis under Static Growth Conditions'
Waters, E.M, McCarthy, H., Hogan, S., Zapotoczna, M., O’Neill, E., and O’Gara, J.P. (2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis under Static Growth Conditions' In: Staphylococcus epidermidis. United States of America: Springer. [DOI] [Details]

Reviews

  Year Publication
(2012) Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.
Stevens, NT,Greene, CM,O'Gara, JP,Bayston, R,Sattar, MTA,Farrell, M,Humphreys, H (2012) Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment. Reviews [DOI] [Details]
(2005) The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?.
Fitzpatrick, F,Humphreys, H,O'Gara, JP (2005) The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?. Reviews [DOI] [Details]