John Laffey

Professor of Anaesthesia, BSc, MB, Bch, BAO, MD, MA, FFARCSI

Contact Details

Professor of Anaesthesia,
ANAESTHESIA
CLINICAL SCIENCE BUILDING
NUI
GALWAY

T: 5662 / 87-4608
E: john.laffey@nuigalway.ie
 
researcher

Biography

John Laffey is the Professor of Anaesthesia at the School of Medicine of the National University of Ireland, and a Consultant in Anaesthesia and Intensive Care Medicine at Galway University Hospitals.

Research Interests

Professor Laffey’s major research interest is centred on investigation of the pathophysiology of, and development of therapeutic strategies for Acute Respiratory Distress Syndrome (ARDS), a devastating disease which causes severe respiratory failure in critically ill patients, and for which there are currently no specific therapies. More people die every year from ARDS than from other better known diseases such as HIV, Breast Cancer or Asthma.

Professor Laffey founded and lead the lung biology group at NUI Galway. His research group are currently conducting studies into the pathogenesis of ventilation and sepsis Acute Lung Injury. The current focus is on the investigation of the therapeutic potential of gene and stem cell based therapies for Acute Lung Injury. This work is being done in collaboration with colleagues from the Regenerative Medicine Institute (REMEDI) at NUI Galway. A long term focus of Professor Laffey’s work had been on determining the safety and therapeutic potential of hypercapnic acidosis in septic and inflammatory disease models of Acute Lung Injury.

Professor Laffey is a principal investigator at the National Centre for Biomedical Engineering Sciences, and a Clinical Trials Investigator at the HRB Clinical Research Facility at the National University of Ireland, Galway. The translation of promising therapeutic strategies emerging from these pre-clinical studies to the clinical setting, through the Clinical Research Facility, and in collaboration with the Irish Critical Care Trials group, is a priority.

Professor Laffey is co-principal investigator in the first investigator led multi-centre trial conducted in critically ill patients in Ireland. This study, termed the HARP-2 study, aims to determine whether statin therapy might help people suffering from ARDS.

Additional clinical research interests include the investigation of the utility of novel devices and technologies for management of the airway, and investigation of novel approaches to postoperative analgesia.

Peer Reviewed Journals

  Year Publication
(2013) 'Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia'
Devaney, J,Curley, GF,Hayes, M,Masterson, C,Ansari, B,O'Brien, T,O'Toole, D,Laffey, JG (2013) 'Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia'. Critical care (London, England), 17 [DOI] [Details]
(2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'
Curley, GF,Ansari, B,Hayes, M,Devaney, J,Masterson, C,Ryan, A,Barry, F,O'Brien, T,O' Toole, D,Laffey, JG (2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'. Anesthesiology, 118 :924-933 [DOI] [Details]
(2013) 'Comparison of the Baska (R) mask with the single-use laryngeal mask airway in low-risk female patients undergoing ambulatory surgery'
Alexiev, V,Ochana, A,Abdelrahman, D,Coyne, J,McDonnell, JG,O'Toole, DP,Neligan, P,Laffey, JG (2013) 'Comparison of the Baska (R) mask with the single-use laryngeal mask airway in low-risk female patients undergoing ambulatory surgery'. Anaesthesia, 68 :1026-1032 [DOI] [Details]
(2012) 'Hypercapnia Induces Cleavage and Nuclear Localization of RelB Protein, Giving Insight into CO2 Sensing and Signaling'
Oliver, KM,Lenihan, CR,Bruning, U,Cheong, A,Laffey, JG,McLoughlin, P,Taylor, CT,Cummins, EP (2012) 'Hypercapnia Induces Cleavage and Nuclear Localization of RelB Protein, Giving Insight into CO2 Sensing and Signaling'. Journal Of Biological Chemistry, 287 :14004-14011 [DOI] [Details]
(2012) 'An observational study of the Baska (R) mask: a novel supraglottic airway'
Alexiev, V,Salim, A,Kevin, LG,Laffey, JG (2012) 'An observational study of the Baska (R) mask: a novel supraglottic airway'. Anaesthesia, 67 :640-645 [DOI] [Details]
(2012) 'Studies on the pathogenesis and survival of different culture forms of Listeria monocytogenes to pulsed UV-light irradiation after exposure to mild-food processing stresses'
Bradley, D,McNeil, B,Laffey, JG,Rowan, NJ (2012) 'Studies on the pathogenesis and survival of different culture forms of Listeria monocytogenes to pulsed UV-light irradiation after exposure to mild-food processing stresses'. Food Microbiology, 30 :330-339 [DOI] [Details]
(2012) 'Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial'
McAuley, DF,Laffey, JG,O'Kane, CM,Cross, M,Perkins, GD,Murphy, L,McNally, C,Crealey, G,Stevenson, M (2012) 'Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial'. Trials, 13 [DOI] [Details]
(2012) 'Ischemia-reperfusion-induced lung injury: Could hypercapnia have a therapeutic role?*'
Ansari B, Laffey JG (2012) 'Ischemia-reperfusion-induced lung injury: Could hypercapnia have a therapeutic role?*'. Critical Care Medicine, 40 (2):688-690 [DOI] [Details]
(2012) 'Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype?'
Hayes M, Curley G, Ansari B, Laffey JG (2012) 'Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype?'. Critical care (London, England), 16 (2) [DOI] [Details]
(2012) 'Relationship between growth of food-spoilage yeast in high-sugar environments and sensitivity to high-intensity pulsed UV light irradiation'
Hayes, JC,Laffey, JG,McNeil, B,Rowan, NJ (2012) 'Relationship between growth of food-spoilage yeast in high-sugar environments and sensitivity to high-intensity pulsed UV light irradiation'. International Journal Of Food Science And Technology, 47 :1925-1934 [DOI] [Details]
(2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'
Curley, GF,Hayes, M,Ansari, B,Shaw, G,Ryan, A,Barry, F,O'Brien, T,O'Toole, D,Laffey, JG (2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'. Thorax, 67 :496-501 [DOI] [Details]
(2012) 'Mesenchymal stem cells - a promising therapy for Acute Respiratory Distress Syndrome'
Hayes M, Curley G, Laffey JG (2012) 'Mesenchymal stem cells - a promising therapy for Acute Respiratory Distress Syndrome'. F1000 Medicine Reports, 4 [DOI] [Details]
(2012) 'Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-kappa B dependent mechanism'
Contreras, M,Ansari, B,Curley, G,Higgins, BD,Hassett, P,O'Toole, D,Laffey, JG (2012) 'Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-kappa B dependent mechanism'. Critical Care Medicine, 40 :2622-2630 [DOI] [Details]
(2011) 'Selective Gut Decontamination: The authors reply'
Quigley, E.M., Laffey, J.G. (2011) 'Selective Gut Decontamination: The authors reply'. Critical Care Medicine, 39 (12) [Details]
(2011) 'Overexpression of pulmonary extracellular uperoxide dismutase attenuates endotoxin induced acute lung injury'
Hassett P, Curley GF, Contreras M, Masterson C, Higgins BD, O'Brien T, Devaney J, O'Toole D, Laffey JG. (2011) 'Overexpression of pulmonary extracellular uperoxide dismutase attenuates endotoxin induced acute lung injury'. Intensive Care Medicine, 37 (10):1680-1687 [Details]
(2011) 'Studies on the relationship between pulsed UV light irradiation and the simultaneous occurrence of molecular and cellular damage in clinically-relevant Candida albicans'
Farrell, H,Hayes, J,Laffey, J,Rowan, N (2011) 'Studies on the relationship between pulsed UV light irradiation and the simultaneous occurrence of molecular and cellular damage in clinically-relevant Candida albicans'. Journal Of Microbiological Methods, 84 :317-326 [DOI] [Details]
(2011) 'Placebo blocks in local anaesthesia studies: the need for balance'
Laffey J (2011) 'Placebo blocks in local anaesthesia studies: the need for balance'. Anaesthesia, 66 (5):390-31 [DOI] [Details]
(2011) 'Studies on the spread of local anaesthetic solution in transversus abdominis plane blocks'
Carney, J,Finnerty, O,Rauf, J,Bergin, D,Laffey, JG,Mc Donnell, JG (2011) 'Studies on the spread of local anaesthetic solution in transversus abdominis plane blocks'. Anaesthesia, 66 :1023-1030 [DOI] [Details]
(2011) 'Lung stem cells - from an evolving understanding to a paradigm shift?'
Hayes, M,Curley, GF,Laffey, JG (2011) 'Lung stem cells - from an evolving understanding to a paradigm shift?'. Stem Cell Research & Therapy, 2 [DOI] [Details]
(2011) 'Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat'
Curley, GF,Contreras, M,Higgins, B,O'Kane, C,McAuley, DF,O'Toole, D,Laffey, JG (2011) 'Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat'. Anesthesiology, 115 :1022-1032 [DOI] [Details]
(2011) 'Stellate ganglion blockade for analgesia following upper limb surgery'
McDonnell, JG,Finnerty, O,Laffey, JG (2011) 'Stellate ganglion blockade for analgesia following upper limb surgery'. Anaesthesia, 66 :611-614 [DOI] [Details]
(2011) 'Comparison of the C-MAC (R), Airtraq (R), and Macintosh laryngoscopes in patients undergoing tracheal intubation with cervical spine immobilization'
McElwain, J,Laffey, JG (2011) 'Comparison of the C-MAC (R), Airtraq (R), and Macintosh laryngoscopes in patients undergoing tracheal intubation with cervical spine immobilization'. British Journal Of Anaesthesia, 107 :258-264 [DOI] [Details]
(2011) 'Comparison of three cuffed emergency percutaneous cricothyroidotomy devices to conventional surgical cricothyroidotomy in a porcine model'
Murphy, C,Rooney, SJ,Maharaj, CH,Laffey, JG,Harte, BH (2011) 'Comparison of three cuffed emergency percutaneous cricothyroidotomy devices to conventional surgical cricothyroidotomy in a porcine model'. British Journal Of Anaesthesia, 106 :57-64 [DOI] [Details]
(2011) 'Special Populations - Critical illness and pregnancy'
Neligan P, Laffey JG (2011) 'Special Populations - Critical illness and pregnancy'. Critical Care, 15 [DOI] [Details]
(2011) 'Strengthening the evidence base for airway equipment: time to become more ‘ADEPT’?'
Laffey, JG (2011) 'Strengthening the evidence base for airway equipment: time to become more ‘ADEPT’?'. Anaesthesia, 66 (8):656-658 [Details]
(2011) 'Casual bystander or active participant? New clues about adiponectin and traumatic injury'
White MB, Laffey JG, Kevin LG (2011) 'Casual bystander or active participant? New clues about adiponectin and traumatic injury'. Critical Care Medicine, 39 (8):2007-2008 [Details]
(2011) 'Gene based therapies for ALI/ARDS: where are we now?'
Devaney J, Contreras M, Laffey JG. (2011) 'Gene based therapies for ALI/ARDS: where are we now?'. Critical Care, 15 (3) [Details]
(2011) 'A comparison of three novel cuffed emergency percutaneous cricothyroidotomy devices to conventional surgical cricothyroidotomy in experienced Anaesthetists'
Murphy, C, Rooney, SJ, Maharaj CH, Laffey JG, Harte BH. (2011) 'A comparison of three novel cuffed emergency percutaneous cricothyroidotomy devices to conventional surgical cricothyroidotomy in experienced Anaesthetists'. British Journal Of Anaesthesia, 106 (1):57-64 [Details]
(2011) 'Hypocapnia and the injured brain: Evidence for harm'
Curley G, Kavanagh BP, Laffey JG (2011) 'Hypocapnia and the injured brain: Evidence for harm'. Critical Care Medicine, 39 (1):229-230 [DOI] [Details]
(2011) 'Can ‘permissive’ hypercapnia modulate sepsis induced ALI/ARDS'
Curley G, Hayes M, Laffey JG. (2011) 'Can ‘permissive’ hypercapnia modulate sepsis induced ALI/ARDS'. Critical Care, 15 (2) [Details]
(2011) 'A rude awakening after our fourth ‘NAP’: lessons for Airway Management'
O'Sullivan E, Laffey J, Pandit JJ. (2011) 'A rude awakening after our fourth ‘NAP’: lessons for Airway Management'. Anaesthesia, 66 (5):390-392 [DOI] [Details]
(2011) 'A Comparison of the C-MAC®, Airtraq®, and Macintosh Laryngoscopes in Patients undergoing tracheal intubation with Cervical Spine Immobilisation'
McElwain J, Laffey JG (2011) 'A Comparison of the C-MAC®, Airtraq®, and Macintosh Laryngoscopes in Patients undergoing tracheal intubation with Cervical Spine Immobilisation'. British Journal Of Anaesthesia, 107 (2):258-264 [Details]
(2011) 'Clinical review: Special populations--critical illness and pregnancy'
Neligan PJ, Laffey JG (2011) 'Clinical review: Special populations--critical illness and pregnancy'. Critical care (London, England), 15 (4) [DOI] [Details]
(2011) 'Hypocapnia induced cerebral ischaemia during therapeutic hypothermia-Potential for harm?'
Curley G, Laffey JG (2011) 'Hypocapnia induced cerebral ischaemia during therapeutic hypothermia-Potential for harm?'. Resuscitation, 82 (9):1122-1123 [DOI] [Details]
(2011) 'Clinical review: gene-based therapies for ALI/ARDS: where are we now?'
Devaney J, Contreras M, Laffey JG (2011) 'Clinical review: gene-based therapies for ALI/ARDS: where are we now?'. Critical care (London, England), 15 (3) [DOI] [Details]
(2011) 'Can 'permissive' hypercapnia modulate the severity of sepsis-induced ALI/ARDS?'
Curley G, Hayes M, Laffey JG (2011) 'Can 'permissive' hypercapnia modulate the severity of sepsis-induced ALI/ARDS?'. Critical care (London, England), 15 (2) [DOI] [Details]
(2010) 'Hypocapnia and the injured brain: more harm than benefit'
Curley G, Kavanagh BP, Laffey JG (2010) 'Hypocapnia and the injured brain: more harm than benefit'. Critical Care Medicine, 38 (5):1348-1359 [DOI] [Details]
(2010) 'Comparison of the C-MAC (R) videolaryngoscope with the Macintosh, Glidescope (R), and Airtraq (R) laryngoscopes in easy and difficult laryngoscopy scenarios in manikins'
McElwain, J,Malik, MA,Harte, BH,Flynn, NM,Laffey, JG (2010) 'Comparison of the C-MAC (R) videolaryngoscope with the Macintosh, Glidescope (R), and Airtraq (R) laryngoscopes in easy and difficult laryngoscopy scenarios in manikins'. Anaesthesia, 65 :483-489 [DOI] [Details]
(2010) 'Ipsilateral Transversus Abdominis Plane Block Provides Effective Analgesia After Appendectomy in Children: A Randomized Controlled Trial'
Carney, J,Finnerty, O,Rauf, J,Curley, G,McDonnell, JG,Laffey, JG (2010) 'Ipsilateral Transversus Abdominis Plane Block Provides Effective Analgesia After Appendectomy in Children: A Randomized Controlled Trial'. Anesthesia And Analgesia, 111 :998-1003 [DOI] [Details]
(2010) 'Determination of the optimal stylet strategy for the C-MAC (R) videolaryngoscope'
McElwain, J,Malik, MA,Harte, BH,Flynn, NH,Laffey, JG (2010) 'Determination of the optimal stylet strategy for the C-MAC (R) videolaryngoscope'. Anaesthesia, 65 :369-378 [DOI] [Details]
(2010) 'Bench to Bedside Review: Carbon Dioxide'
Curley G, Laffey JG, Kavanagh BP. (2010) 'Bench to Bedside Review: Carbon Dioxide'. Critical Care, 14 (220) [Details]
(2010) 'Comparison of the C-MAC Videolaryngoscope with the Glidescope, Airtraq and Macintosh laryngoscope in easy and difficult laryngoscopy scenarios in manikins'
McElwain, J., Malik, M.A.,Harte, B.H., Flynn, N.M.,Laffey, J.G. (2010) 'Comparison of the C-MAC Videolaryngoscope with the Glidescope, Airtraq and Macintosh laryngoscope in easy and difficult laryngoscopy scenarios in manikins'. Anaesthesia, [DOI] [Details]
(2010) 'Hypercapnia and acidosis in sepsis: a double-edged sword?'
Curley G, Contreras MM, Nichol AD, Higgins BD, Laffey JG (2010) 'Hypercapnia and acidosis in sepsis: a double-edged sword?'. Anesthesiology, 112 (2):462-472 [DOI] [Details]
(2010) 'Determination of the optimal stylet strategy for use with the C-MAC laryngoscope - A manikin study'
McElwain J, Malik MA, Harte BH, Flynn NH, Laffey JG, (2010) 'Determination of the optimal stylet strategy for use with the C-MAC laryngoscope - A manikin study'. Anaesthesia, 65 (4):369-378 [DOI] [Details]
(2010) 'Letter regarding IDS score'
McElwain J, Malik MA, Laffey JG. (2010) 'Letter regarding IDS score'. Br J Anaes 2010 (in press), [Details]
(2010) 'Investigation of critical inter-related factors affecting the efficacy of pulsed light for inactivating clinically relevant bacterial pathogens'
Farrell, HP,Garvey, M,Cormican, M,Laffey, JG,Rowan, NJ (2010) 'Investigation of critical inter-related factors affecting the efficacy of pulsed light for inactivating clinically relevant bacterial pathogens'. Journal Of Applied Microbiology, 108 :1494-1508 [DOI] [Details]
(2009) 'Mechanical ventilation: taking its toll on the lung'
Curley GF, Kevin LG, Laffey JG (2009) 'Mechanical ventilation: taking its toll on the lung'. Anesthesiology, 111 (4):701-703 [DOI] [Details]
(2009) 'A comparison of the Glidescope, Pentax AWS, and Macintosh laryngoscopes when used by novice personnel: a manikin study'
Malik MA, Hassett P, Carney J, Higgins BD, Harte BH, Laffey JG (2009) 'A comparison of the Glidescope, Pentax AWS, and Macintosh laryngoscopes when used by novice personnel: a manikin study'. Canadian Journal Of Anaesthesia-Journal Canadien D Anesthesie, 56 (11):802-811 [DOI] [Details]
(2009) 'Lung Injury and is Impact in ACS'
Laffey, J. G. (2009) 'Lung Injury and is Impact in ACS'. Acta Clinica Belgica, 64 (33):248-248 [Details]
(2009) 'Randomized controlled trial of the Pentax AWS (R), Glidescope (R), and Macintosh laryngoscopes in predicted difficult intubation'
Malik, MA,Subramaniam, R,Maharaj, CH,Harte, BH,Laffey, JG (2009) 'Randomized controlled trial of the Pentax AWS (R), Glidescope (R), and Macintosh laryngoscopes in predicted difficult intubation'. British Journal Of Anaesthesia, 103 :761-768 [DOI] [Details]
(2009) 'Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism'
O'Toole, D,Hassett, P,Contreras, M,Higgins, BD,McKeown, STW,McAuley, DF,O'Brien, T,Laffey, JG (2009) 'Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism'. Thorax, 64 :976-982 [DOI] [Details]
(2009) 'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries'
Maharaj, CH,O'Toole, D,Lynch, T,Carney, J,Jarman, J,Higgins, BD,Morrison, JJ,Laffey, JG (2009) 'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries'. Reproductive Biology And Endocrinology, 7 [DOI] [Details]
(2009) 'Comparison of the Glidescope (R), the Pentax AWS (R), and the Truview EVO2 (R) with the Macintosh laryngoscope in experienced anaesthetists: a manikin study'
Malik, MA,O'Donoghue, C,Carney, J,Maharaj, CH,Harte, BH,Laffey, JG (2009) 'Comparison of the Glidescope (R), the Pentax AWS (R), and the Truview EVO2 (R) with the Macintosh laryngoscope in experienced anaesthetists: a manikin study'. British Journal Of Anaesthesia, 102 :128-134 [DOI] [Details]
(2009) 'A comparison of the Glidescope (R), Pentax AWS (R), and Macintosh laryngoscopes when used by novice personnel: a manikin study'
Malik, MA,Hassett, P,Carney, J,Higgins, BD,Harte, BH,Laffey, JG (2009) 'A comparison of the Glidescope (R), Pentax AWS (R), and Macintosh laryngoscopes when used by novice personnel: a manikin study'. Canadian Journal Of Anaesthesia-Journal Canadien D Anesthesie, 56 :802-811 [DOI] [Details]
(2009) 'Differential Effects of Buffered Hypercapnia versus Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis'
Higgins, BD,Costello, J,Contreras, M,Hassett, P,O'Toole, D,Laffey, JG (2009) 'Differential Effects of Buffered Hypercapnia versus Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis'. Anesthesiology, 111 :1317-1326 [Details]
(2009) 'A comparison of the Glidescope ®, the Pentax AWS ® and the Truview ® EVO2 to the Macintosh laryngoscope in experienced Anaesthetists - A manikin study'
Carney J, Finnerty O, Rauf J, Curley G, McDonnell JG, Laffey JG.  (2009) 'A comparison of the Glidescope ®, the Pentax AWS ® and the Truview ® EVO2 to the Macintosh laryngoscope in experienced Anaesthetists - A manikin study'. Br J Anaes, 102 :128-134 [DOI] [Details]
(2009) 'Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation'
Jarman J, Maharaj CH, Higgins BD, Farragher RF, Laffey CD, Flynn NM, Laffey JG (2009) 'Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation'. BMC Anesthesiol, 9 [DOI] [Details]
(2009) 'Comparison of the Airtraq and Truview laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation in manikins'
Nasim S, Maharaj CH, Butt I, Malik MA, O' Donnell J, Higgins BD, Harte BH, Laffey JG (2009) 'Comparison of the Airtraq and Truview laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation in manikins'. BMC Emerg Med, 9 [DOI] [Details]
(2009) 'Tracheal intubation in patients with cervical spine immobilization: A comparison of the Airwayscope, LMA CTrach, and the Macintosh laryngoscopes. '
Murphy C, Rooney SJ, Maharaj CH, Laffey JG, Harte BH.  (2009) 'Tracheal intubation in patients with cervical spine immobilization: A comparison of the Airwayscope, LMA CTrach, and the Macintosh laryngoscopes. '. Br J Anaesth, 102 (5):654-661 [DOI] [Details]
(2008) 'Determination of the efficacy and side-effect profile of lower doses of Intrathecal Morphine in Patients undergoing Total Knee Replacement'
Higgins BD, Costello J, Contreras M, Hassett P, O' Toole D, Laffey JG.  (2008) 'Determination of the efficacy and side-effect profile of lower doses of Intrathecal Morphine in Patients undergoing Total Knee Replacement'. BMC Anesthesiology, 8 (5) [Details]
(2008) 'Determination Of The Efficacy And Side-effect Profile Of Lower Doses Of Intrathecal Morphine In Patients Undergoing Total Knee Arthroplasty'
Hassett P, Ansari B, Gnanamoorthy P, Kinirons B, Laffey JG (2008) 'Determination Of The Efficacy And Side-effect Profile Of Lower Doses Of Intrathecal Morphine In Patients Undergoing Total Knee Arthroplasty'. BMC Anesthesiol, 8 [DOI] [Details]
(2008) 'Carbon monoxide: from poison to therapy for cardiopulmonary bypass-induced lung injury?'
Kevin LG, Laffey JG (2008) 'Carbon monoxide: from poison to therapy for cardiopulmonary bypass-induced lung injury?'. Anesthesiology, 108 (6):977-978 [DOI] [Details]
(2008) 'Evaluation of the Airtraq and Macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation'
Maharaj CH, Costello JF, Harte BH, Laffey JG (2008) 'Evaluation of the Airtraq and Macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation'. Anaesthesia, 63 (2):182-188 [DOI] [Details]
(2008) 'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids'
Farragher, R,Maharaj, CH,Higgins, BD,Crowe, S,Burke, P,Laffey, CD,Flynn, NM,Laffey, JG (2008) 'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids'. Anesthesia And Analgesia, 107 :171-177 [DOI] [Details]
(2008) 'Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury'
O'Croinin, DF,Nichol, AD,Hopkins, N,Boylan, J,O'Brien, S,O'Connor, C,Laffey, JG,McLoughlin, P (2008) 'Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury'. Critical Care Medicine, 36 :2128-2135 [DOI] [Details]
(2008) 'A Comparison of Macintosh, Truview EV02â, Glidescope® and Airwayscope® Laryngoscopes in Patients with Cervical Spine Immobilization'
Higgins BD, Costello J, Contreras M, Hassett P, O' Toole D, Laffey JG.  (2008) 'A Comparison of Macintosh, Truview EV02â, Glidescope® and Airwayscope® Laryngoscopes in Patients with Cervical Spine Immobilization'. Br J Anaesth, 101 (5):723-730 [DOI] [Details]
(2008) 'Comparison of Macintosh, Truview EVO2 (R), Glidescope (R), and Airwayscope (R) laryngoscope use in patients with cervical spine immobilization'
Malik, MA,Maharaj, CH,Harte, BH,Laffey, JG (2008) 'Comparison of Macintosh, Truview EVO2 (R), Glidescope (R), and Airwayscope (R) laryngoscope use in patients with cervical spine immobilization'. British Journal Of Anaesthesia, 101 :723-730 [DOI] [Details]
(2008) 'The analgesic efficacy of transversus abdominis plane block after cesarean delivery: A randomized controlled trial'
McDonnell, JG,Curley, G,Carney, J,Benton, A,Costello, J,Maharaj, CH,Laffey, JG (2008) 'The analgesic efficacy of transversus abdominis plane block after cesarean delivery: A randomized controlled trial'. Anesthesia And Analgesia, 106 :186-191 [DOI] [Details]
(2008) 'Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury'
Kennedy MT, Higgins BD, Costello JF, Curtin WA, Laffey JG (2008) 'Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury'. BMC pulmonary medicine, 8 [DOI] [Details]
(2008) 'Hypercapnic acidosis attenuates the severity of severe pulmonary sepsis by a neutrophil independent mechanism'
Malik MA, Maharaj CH, Harte BH, Laffey JG. (2008) 'Hypercapnic acidosis attenuates the severity of severe pulmonary sepsis by a neutrophil independent mechanism'. Critical Care Medicine, 36 (12):3135-3144 [DOI] [Details]
(2008) 'Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia'
Chonghaile MN, Higgins BD, Costello J, Laffey JG (2008) 'Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia'. Anesthesiology, 109 (5):837-848 [DOI] [Details]
(2008) 'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism'
Chonghaile, MN,Higgins, BD,Costello, JF,Laffey, JG (2008) 'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism'. Critical Care Medicine, 36 :3135-3144 [DOI] [Details]
(2007) 'Meralgia Paraesthetica [Letter] (in press)'
Lynch T, Kinirons B, Laffey JG (2007) 'Meralgia Paraesthetica [Letter] (in press)'. IRISH MEDICAL JOURNAL, [Details]
(2007) 'Transversus abdominis plane block'
McDonnell JG, Laffey JG (2007) 'Transversus abdominis plane block'. Anesthesia And Analgesia, 105 (3) [DOI] [Details]
(2007) 'Permissive hypercapnia: Balancing risks and benefits in the peripheral microcirculation'
Hassett P, Laffey JG (2007) 'Permissive hypercapnia: Balancing risks and benefits in the peripheral microcirculation'. Critical Care Medicine, 35 (9):2229-2231 [DOI] [Details]
(2007) 'Implementing scientific advances into clinical practice in critical care--new challenges and new insights'
Costello JF, Laffey JG (2007) 'Implementing scientific advances into clinical practice in critical care--new challenges and new insights'. Critical Care Medicine, 35 (7):1779-1780 [DOI] [Details]
(2007) 'Transversus abdominis plane block: A cadaveric and radiological evaluation'
McDonnell, JG,O'Donnell, BD,Farrell, T,Gough, N,Tuite, D,Power, C,Laffey, JG (2007) 'Transversus abdominis plane block: A cadaveric and radiological evaluation'. Regional Anesthesia And Pain Medicine, 32 :399-404 [DOI] [Details]
(2007) 'Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane'
Mahajan, VA,Ni Chonghaile, M,Bokhari, SA,Harte, BH,Flynn, NM,Laffey, JG (2007) 'Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane'. European Journal Of Anaesthesiology, 24 :505-510 [DOI] [Details]
(2007) 'Endotracheal intubation in patients with cervical spine immobilization - A comparison of Macintosh and Airtraq laryngoscopes'
Maharaj, CH,Buckley, E,Harte, BH,Laffey, JG (2007) 'Endotracheal intubation in patients with cervical spine immobilization - A comparison of Macintosh and Airtraq laryngoscopes'. Anesthesiology, 107 :53-59 [Details]
(2007) 'The Airtraq (R) as a rescue airway device following failed direct laryngoscopy: a case series'
Maharaj, CH,Costello, JF,McDonnell, JG,Harte, BH,Laffey, JG (2007) 'The Airtraq (R) as a rescue airway device following failed direct laryngoscopy: a case series'. Anaesthesia, 62 :598-601 [DOI] [Details]
(2007) 'Retention of tracheal intubation skills by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscopes'
Maharaj, CH,Costello, J,Higgins, BD,Harte, BH,Laffey, JG (2007) 'Retention of tracheal intubation skills by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscopes'. Anaesthesia, 62 :272-278 [DOI] [Details]
(2007) 'A comparison of direct and indirect laryngoscopes and the ILMA in novice users: a manikin study'
Maharaj, CH,McDonnell, JG,Harte, BH,Laffey, JG (2007) 'A comparison of direct and indirect laryngoscopes and the ILMA in novice users: a manikin study'. Anaesthesia, 62 :1161-1166 [DOI] [Details]
(2006) 'Evaluation of ease of intubation with the Airtraq® or Macintosh laryngoscope in routine airway management: a randomized, controlled clinical trial'
Maharaj CH, O' Croinin D, Curley G, Harte BH, Laffey JG (2006) 'Evaluation of ease of intubation with the Airtraq® or Macintosh laryngoscope in routine airway management: a randomized, controlled clinical trial'. [Details]
(2006) 'Hypercapnia: permissive and therapeutic'
Kavanagh BP, Laffey JG (2006) 'Hypercapnia: permissive and therapeutic'. Minerva anestesiologica, 72 (6):567-576 [Details]
(2006) 'Sildenafil for pulmonary hypertension in pregnancy?'
Lynch TD, Laffey JG (2006) 'Sildenafil for pulmonary hypertension in pregnancy?'. Anesthesiology, 104 (2) [Details]
(2006) 'Tracheal intubation by inexperienced medical residents using the Airtraq and Macintosh laryngoscopes - a manikin study'
Maharaj, CH,Chonghaile, MN,Higgins, BD,Harte, BH,Laffey, JG (2006) 'Tracheal intubation by inexperienced medical residents using the Airtraq and Macintosh laryngoscopes - a manikin study'. American Journal Of Emergency Medicine, 24 :769-774 [DOI] [Details]
(2006) 'Evaluation of intubation using the Airtraq (R) or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy - a manikin study'
Maharaj, CH,Higgins, BD,Harte, BH,Laffey, JG (2006) 'Evaluation of intubation using the Airtraq (R) or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy - a manikin study'. Anaesthesia, 61 :469-477 [DOI] [Details]
(2006) 'A comparison of tracheal intubation using the Airtraq (R) or the Macintosh laryngoscope in routine airway management: a randomised, controlled clinical trial'
Maharaj, CH,O'Croinin, D,Curley, G,Harte, BH,Laffey, JG (2006) 'A comparison of tracheal intubation using the Airtraq (R) or the Macintosh laryngoscope in routine airway management: a randomised, controlled clinical trial'. Anaesthesia, 61 :1093-1099 [DOI] [Details]
(2006) 'Learning and performance of tracheal intubation by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscope'
Maharaj, CH,Costello, JF,Higgins, BD,Harte, BH,Laffey, JG (2006) 'Learning and performance of tracheal intubation by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscope'. Anaesthesia, 61 :671-677 [DOI] [Details]
(2006) 'Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection'
Hopkins, N,Gunning, Y,O'Croinin, DF,Laffey, J,McLoughlin, P (2006) 'Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection'. Journal Of Pathology, 209 :198-205 [DOI] [Details]
(2005) 'Maternal brain death and somatic support'
Farragher RA, Laffey JG (2005) 'Maternal brain death and somatic support'. Critical care (London, England), 3 (2):99-106 [DOI] [Details]
(2005) 'Preoperative intravenous fluid therapy decreases postoperative nausea and pain in high risk patients'
Maharaj CH, Kallam SR, Malik A, Hassett P, Grady D, Laffey JG (2005) 'Preoperative intravenous fluid therapy decreases postoperative nausea and pain in high risk patients'. Anesthesia And Analgesia, 100 (3):675-61 [DOI] [Details]
(2005) 'Permissive hypercapnia: role in protective lung ventilatory strategies'
Ni Chonghaile M, Higgins B, Laffey JG (2005) 'Permissive hypercapnia: role in protective lung ventilatory strategies'. Critical care (London, England), 11 (1):56-62 [Details]
(2005) 'Maternal Brain Death'
Farragher R, Laffey JG (2005) 'Maternal Brain Death'. Neurocritical Care, [Details]
(2005) 'Maternal Brain Death - an Irish Perspective'
Farragher R, Marsh B, Laffey JG (2005) 'Maternal Brain Death - an Irish Perspective'. IRISH JOURNAL OF MEDICAL SCIENCE, [Details]
(2005) 'Bench-to-bedside review: Permissive hypercapnia'
O'Croinin D, Ni Chonghaile M, Higgins B, Laffey JG (2005) 'Bench-to-bedside review: Permissive hypercapnia'. Critical care (London, England), 9 (1):51-59 [DOI] [Details]
(2005) 'Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury'
O'Croinin, DF,Hopkins, NO,Moore, MM,Boylan, JF,McLoughlin, P,Laffey, JG (2005) 'Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury'. Critical Care Medicine, 33 :2606-2612 [DOI] [Details]
(2004) 'New strategies to control the inflammatory response in cardiac surgery'
Maharaj C, Laffey JG (2004) 'New strategies to control the inflammatory response in cardiac surgery'. Current opinion in anaesthesiology, 17 (1):35-48 [Details]
(2004) 'Therapeutic hypercapnia is not protective in the in vivo surfactant-depleted rabbit lung'
Rai S, Engelberts D, Laffey JG, Frevert C, Kajikawa O, Martin TR, Post M, Kavanagh BP (2004) 'Therapeutic hypercapnia is not protective in the in vivo surfactant-depleted rabbit lung'. Pediatric research, 55 (1):42-49 [DOI] [Details]
(2004) 'Maternal brain death: medical, ethical and legal issues'
Lane, A,Westbrook, A,Grady, D,O'Connor, R,Counihan, TJ,Marsh, B,Laffey, JG (2004) 'Maternal brain death: medical, ethical and legal issues'. Intensive Care Medicine, 30 :1484-1486 [DOI] [Details]
(2004) 'Hypercapnic acidosis attenuates endotoxin-induced acute lung injury'
Laffey JG, Honan D, Hopkins N, Hyvelin JM, Boylan JF, McLoughlin P (2004) 'Hypercapnic acidosis attenuates endotoxin-induced acute lung injury'. Critical Care Medicine, 169 (1):46-56 [DOI] [Details]
(2004) 'Strategies that attenuate the Inflammatory response to Cardiac Surgery. Current Opinion in Anaesthesiology'
Maharaj C, Laffey JG (2004) 'Strategies that attenuate the Inflammatory response to Cardiac Surgery. Current Opinion in Anaesthesiology'. Current Opinion in Anaesthesiology, [Details]
(2004) 'Permissive Hypercapnia - Role in Protective Lung Ventilatory Strategies'
Croinin D, McLoughlin P, Kavanagh BP, Laffey JG (2004) 'Permissive Hypercapnia - Role in Protective Lung Ventilatory Strategies'. Intensive Care Medicine, [Details]
(2004) 'Therapeutic Hypercapnia Improves Oxygenation but does not Protect Against Stretch-Induced Injury in the in vivo Saline-Lavaged Rabbit'
S Rai, Engelberts D, Laffey JG, Frevert C, Kajikawa O, Martin TR, Post M, Kavanagh BP (2004) 'Therapeutic Hypercapnia Improves Oxygenation but does not Protect Against Stretch-Induced Injury in the in vivo Saline-Lavaged Rabbit'. Pediatric Research, [Details]
(2003) 'Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation'
Laffey JG, Engelberts D, Duggan M, Veldhuizen R, Lewis JF, Kavanagh BP (2003) 'Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation'. Critical Care Medicine, 31 (11):2634-2640 [DOI] [Details]
(2003) 'Assessment of a simple artificial neural network for predicting residual neuromuscular block'
Laffey JG, Tobin E, Boylan JF, McShane AJ (2003) 'Assessment of a simple artificial neural network for predicting residual neuromuscular block'. Br J Anaesth, 90 (1):48-52 [Details]
(2003) 'Optimizing the dose of intrathecal morphine in older patients undergoing hip arthroplasty'
Murphy, PM,Stack, D,Kinirons, B,Laffey, JG (2003) 'Optimizing the dose of intrathecal morphine in older patients undergoing hip arthroplasty'. Anesthesia And Analgesia, 97 :1709-1715 [DOI] [Details]
(2003) 'A simple artificial neural network can help predict residual neuromuscular blockade'
Tobin E, Boylan J, McShane AJ, Laffey JG (2003) 'A simple artificial neural network can help predict residual neuromuscular blockade'. British Journal of Anaesthesia, :48-52 [Details]
(2003) 'Perioperative control of CO2'
BP Kavanagh, Laffey JG (2003) 'Perioperative control of CO2'. Canadian Journal of Anesthesia (Supplement), [Details]
(2003) 'Effects of Therapeutic Hypercapnia on Mesenteric Ischemia - Reperfusion Injury'
Jankov R, Engelberts D, Tanswell AK, Post M, Lindsay T, Mullen JB, Romaschin A, Stephens D, McKerlie C, Kavanagh BP, Laffey JG (2003) 'Effects of Therapeutic Hypercapnia on Mesenteric Ischemia - Reperfusion Injury'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDIC, [Details]
(2003) 'Interleukin-1ß Rapidly inhibits Aortic Endothelium-Dependent relaxation by a DNA Transcription-Dependent mechanism'
Loughrey J, Laffey JG, Moore B, Lynch F, McLoughlin P, Boylan J (2003) 'Interleukin-1ß Rapidly inhibits Aortic Endothelium-Dependent relaxation by a DNA Transcription-Dependent mechanism'. Critical Care Medicine, :910-915 [Details]
(2002) 'The systemic inflammatory response to Cardiac Surgery - implications for the Anesthesiologist'
Boylan JF, Cheng, DCH, Laffey JG (2002) 'The systemic inflammatory response to Cardiac Surgery - implications for the Anesthesiologist'. Anesthesiology, :215-252 [Details]
(2002) 'Cyclizine and droperidol have comparable efficacy and side effects during patient-controlled analgesia'
Laffey JG, Boylan JF (2002) 'Cyclizine and droperidol have comparable efficacy and side effects during patient-controlled analgesia'. Ir J Med Sci, 171 (3):141-144 [Details]
(2002) 'Isoprostanes--markers of ischaemia reperfusion injury'
Sakamoto H, Corcoran TB, Laffey JG, Shorten GD (2002) 'Isoprostanes--markers of ischaemia reperfusion injury'. European Journal Of Anaesthesiology, 19 (8):550-559 [Details]
(2002) 'Droperidol and Cyclizine have comparable antiemetic efficacy and side effects during patient controlled analgesia'
Boylan JF, Laffey JG (2002) 'Droperidol and Cyclizine have comparable antiemetic efficacy and side effects during patient controlled analgesia'. IRISH JOURNAL OF MEDICAL SCIENCE, :141-144 [Details]
(2002) 'Acid-base disorders in the critically ill'
Laffey JG (2002) 'Acid-base disorders in the critically ill'. Anaesthesia, 57 (2) [Details]
(2002) 'Mechanisms of Disease: Hypocapnia'
Kavanagh BP, Laffey JG (2002) 'Mechanisms of Disease: Hypocapnia'. NEW ENGLISH JOURNAL OF MEDICINE, :43-53 [Details]
(2002) 'An audit of activity patterns in a HDU and its impact on ICU utilization'
Curran E, O' Gorman D. Phelan D, Laffey JG (2002) 'An audit of activity patterns in a HDU and its impact on ICU utilization'. Clinical Intensive Care, :13-20 [Details]
(2002) 'Hypocapnia'
Laffey JG, Kavanagh BP (2002) 'Hypocapnia'. The New England journal of medicine, 347 (1):43-53 [DOI] [Details]
(2001) 'Protective effects of acidosis'
Laffey JG (2001) 'Protective effects of acidosis'. Anaesthesia, 56 (10):1013-1014 [Details]
(2001) 'Patient compliance with pre-operative day case instructions'
Laffey JG, Boylan JF (2001) 'Patient compliance with pre-operative day case instructions'. Anaesthesia, 56 (9) [Details]
(2001) 'Low-dose spinal morphine for postoperative analgesia following knee arthroplasty'
Laffey JG, Flynn N (2001) 'Low-dose spinal morphine for postoperative analgesia following knee arthroplasty'. Br J Anaesth, 86 (1):152-153 [Details]
(2000) 'Injurious effects of Hypocapnic Alkalosis in the Lung'
Engelberts D, Kavanagh BP, Laffey JG (2000) 'Injurious effects of Hypocapnic Alkalosis in the Lung'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDIC, :399-405 [Details]
(2000) 'Patients' knowledge of perioperative care'
Laffey JG, Coleman M, Boylan JF (2000) 'Patients' knowledge of perioperative care'. Ir J Med Sci, 169 (2):113-118 [Details]
(2000) 'Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury'
Laffey JG, Kavanagh BP (2000) 'Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury'. The New England journal of medicine, 343 (11):1-4 [DOI] [Details]
(2000) 'The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia'
Fagan C, Frizelle HP, Laffey J, Hannon V, Carey M (2000) 'The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia'. Anesthesia And Analgesia, 91 (1):201-205 [Details]
(2000) 'Biological effects of hypercapnia'
Laffey JG, Kavanagh BP (2000) 'Biological effects of hypercapnia'. Intensive care medicine, 26 (1):133-138 [Details]
(2000) 'Postoperative neurological deficit despite normal cerebral oximetry during carotid endarterectomy'
Mehigan D, Boylan, Laffey JG (2000) 'Postoperative neurological deficit despite normal cerebral oximetry during carotid endarterectomy'. Journal of Clinical Anaesthesia, :573-574 [Details]
(2000) 'Effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena following general anaesthesia'
Fagan C, Frizelle HP, Laffey JG, Hannon V, Carey M (2000) 'Effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena following general anaesthesia'. Anaesthesia and Analgesia, :201-205 [Details]
(2000) 'Buffering hypercapnic acidosis worsens acute lung injury'
Laffey JG, Engelberts D, Kavanagh BP (2000) 'Buffering hypercapnic acidosis worsens acute lung injury'. Critical Care Medicine, 161 (1):141-146 [Details]
(2000) 'Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion'
Laffey JG, Tanaka M, Engelberts D, Luo X, Yuan S, Tanswell AK, Post M, Lindsay T, Kavanagh BP (2000) 'Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion'. Critical Care Medicine, 162 (6):2287-2294 [Details]
(2000) 'Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxin'
Murphy DB, Cregg N, Tremblay L, Engelberts D, Laffey JG, Slutsky AS, Romaschin A, Kavanagh BP (2000) 'Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxin'. Critical Care Medicine, 162 (1):27-33 [Details]
(1999) 'Carbon dioxide and the critically ill--too little of a good thing?'
Laffey JG, Kavanagh BP (1999) 'Carbon dioxide and the critically ill--too little of a good thing?'. Lancet, 354 (9186):1283-1286 [DOI] [Details]
(1999) 'Efficacy of spinal cord stimulation for neuropathic pain following idiopathic acute transverse myelitis: a case report'
Laffey JG, Murphy D, Regan J, O'Keeffe D (1999) 'Efficacy of spinal cord stimulation for neuropathic pain following idiopathic acute transverse myelitis: a case report'. Clinical neurology and neurosurgery, 101 (2):125-127 [Details]
(1999) 'Prolonged perioperative myocardial ischemia in a young male: due to topical intranasal cocaine?'
Laffey JG, Neligan P, Ormonde G (1999) 'Prolonged perioperative myocardial ischemia in a young male: due to topical intranasal cocaine?'. Journal Of Clinical Anesthesia, 11 (5):419-424 [Details]
(1998) 'Instructions for ambulatory surgery--patient comprehension and compliance'
Laffey JG, Carroll M, Donnelly N, Boylan JF (1998) 'Instructions for ambulatory surgery--patient comprehension and compliance'. Ir J Med Sci, 167 (3):160-163 [Details]
(1998) 'Cost-benefit analysis of spinal cord stimulation for intractable angina pectoris: a win-win scenario?'
Laffey J, Murphy D, Regan J, O'Keeffe D (1998) 'Cost-benefit analysis of spinal cord stimulation for intractable angina pectoris: a win-win scenario?'. Hospital Medicine, 59 (10):820-821 [Details]

Book Chapters

  Year Publication
(2012) 'Permissive Hypercapnia'
Laffey J.G, Kavanagh, B.P. (2012) 'Permissive Hypercapnia' In: Principles & Practice of Mechanical Ventilation. US: McGraw-Hill Companies Inc. [Details]
(2011) 'Acute Respiratory Distress Syndrome'
Walshe C, Kevin L, Laffey JG, Kavanagh BP (2011) 'Acute Respiratory Distress Syndrome' In: Postoperative Cardiac Care. A Society of Cardiovascular Anesthesiologists Monograph. Baltimore, US: Lippincott Williams & Wilkins. [Details]
(2011) 'Can ‘permissive’ hypercapnia modulate sepsis induced ALI/ARDS?'
Curley G, Hayes M, Laffey JG (2011) 'Can ‘permissive’ hypercapnia modulate sepsis induced ALI/ARDS?' In: 2011 Yearbook of Intensive Care and Emergency Medicine. Belgium: Springer-Verlag. [Details]
(2009) 'Permissive Hypercapnia'
Hassett P, Laffey JG (2009) 'Permissive Hypercapnia' In: Il Malato Critico. (The Critically Ill Patient.). Torino, Italy: UTET Scienze Mediche. [Details]
(2009) 'Is Permissive Hypercapnia helpful or harmful?'
Contreras M, Hassett P, Laffey JG. (2009) 'Is Permissive Hypercapnia helpful or harmful?' In: Evidence-Based Practice of Critical Care. United States: Elselvier. [Details]
(2008) 'Hypercapnia - Permissive, Therapeutic or not at all?'
Contreras M, Hassett P, Laffey JG (2008) 'Hypercapnia - Permissive, Therapeutic or not at all?' In: 2008 Yearbook of Intensive Care and Emergency Medicine. Belgium: Springer-Verlag. [Details]
(2006) 'Permissive Hypercapnia'
Laffey JG, Kavanagh BP. (2006) 'Permissive Hypercapnia' In: Principles & Practice of Mechanical Ventilation. New York, US: McGraw-Hill Companies Inc. [Details]
(2006) 'Modulation of Lung Injury by Hypercapnia'
Laffey JG, Kavanagh BP (2006) 'Modulation of Lung Injury by Hypercapnia' In: Ventilator-Induced Lung injury (Series on Lung Biology in Health and Disease). New York, US: Marcel Dekker Inc. [Details]
(2006) 'Analgesia following Caesarean Section'
Farragher R, Laffey JG. (2006) 'Analgesia following Caesarean Section' In: Postoperative Pain Management: An Evidence-Based Guide to Practice. Amsterdam, The Netherlands: Elsevier Press Inc. [Details]
(2006) 'Permissive Hypercapnia: Role in Protective Lung ventilatory strategies'
Laffey JG, O'Croinin D, McLoughlin P, Kavanagh BP. (2006) 'Permissive Hypercapnia: Role in Protective Lung ventilatory strategies' In: Applied Physiology in Intensive Care. Berlin, Germany: Springer Verlag. [Details]

Conference Publications

  Year Publication
(2011) Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury
Hassett, P,Curley, GF,Contreras, M,Masterson, C,Higgins, BD,O'Brien, T,Devaney, J,O'Toole, D,Laffey, JG (2011) INTENSIVE CARE MEDICINE Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury , pp.1680-1687 [DOI] [Details]
(2009) Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis
Costello, J,Higgins, B,Contreras, M,Chonghaile, MN,Hassett, P,O'Toole, D,Laffey, JG (2009) CRITICAL CARE MEDICINE Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis , pp.2412-2420 [DOI] [Details]
(2008) Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia
Chonghaile, MN,Higgins, BD,Costello, J,Laffey, JG (2008) ANESTHESIOLOGY Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia , pp.837-848 [Details]
(2008) Society of Pediatric Anesthesia 2008 Winter Symposium
Laffey JG (2008) Hypercapnia: Permissive and Therapeutic Society of Pediatric Anesthesia 2008 Winter Symposium [Details]
(2008) Proceedings of the 14th Annual Conference of the Section of Bioengineering of Royal Academy of Medicine in Ireland
Heraty, K.B., Laffey, J.G., Quinlan, N.J. (2008) Fluid dynamics of gas exchange in high frequency oscillatory ventilation . In: Reilly, G.; Fitzpatrick, D eds. Proceedings of the 14th Annual Conference of the Section of Bioengineering of Royal Academy of Medicine in Ireland Sligo, Ireland, , 25-JAN-08 - 26-JAN-08 [Details]
(2008) Evaluation of the Airtraq (R) and Macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation
Maharaj, CH,Costello, JF,Harte, BH,Laffey, JG (2008) ANAESTHESIA Evaluation of the Airtraq (R) and Macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation , pp.182-188 [DOI] [Details]
(2007) The analgesic efficacy of transversus abdominis plane block after abdominal surgery: A prospective randomized controlled trial
McDonnell, JG,O'Donnell, B,Curley, G,Heffernan, A,Power, C,Laffey, JG (2007) ANESTHESIA AND ANALGESIA The analgesic efficacy of transversus abdominis plane block after abdominal surgery: A prospective randomized controlled trial , pp.193-197 [DOI] [Details]
(2005) Preoperative intravenous fluid therapy decreases postoperative nausea and pain in high risk patients
Maharaj, CH,Kallam, SR,Malik, A,Hassett, P,Grady, D,Laffey, JG (2005) ANESTHESIA AND ANALGESIA Preoperative intravenous fluid therapy decreases postoperative nausea and pain in high risk patients , pp.675-682 [DOI] [Details]

Other Journals

  Year Publication
(2004) 'The inflammatory response to Surgery'
Laffey JG (2004) 'The inflammatory response to Surgery' Proceedings of the 2004 Annual Winter Anaesthesia Symposium, . [Details]
(2003) 'The role of permissive hypercapnia in a concept of protective lung ventilation'
Laffey JG (2003) 'The role of permissive hypercapnia in a concept of protective lung ventilation' Journal fur Anasthesie und Intensivbehandlung, :100-102. [Details]
(2003) 'Permissive Hypercapnia - with or without Acidosis?'
Laffey JG (2003) 'Permissive Hypercapnia - with or without Acidosis?' Journal fur Anasthesie und Intensivbehandlung, :157-158. [Details]
(2003) 'Perioperative ACE Inhibitors and Outcome'
Laffey JG (2003) 'Perioperative ACE Inhibitors and Outcome' Proceedings of the College of Anaesthetists RCSI Annual Scientific Meeting, :30-33. [Details]
(2003) 'Attenuation of the Stress response to Cardiac Surgery is Beneficial'
Laffey JG (2003) 'Attenuation of the Stress response to Cardiac Surgery is Beneficial' Society of Cardiovascular Anaesthesia Newsletter, . [Details]

Abstract

  Year Publication
(2014) Selection of optimum Baska mask size in male patients, an initial study.
Alexiev, V,Ochana, A,Quinn, A,Foto, T,McDonnell, JG,Laffey, JG (2014) Selection of optimum Baska mask size in male patients, an initial study. Abstract [Details]
(2009) Lung Injury and is Impact in ACS.
Laffey, JG (2009) Lung Injury and is Impact in ACS. Abstract [Details]
(2009) INTRAPULMONARY DELIVERY OF EXTRACELLULAR SUPEROXIDE DISMUTASE AMELIORATES LIPO-POLYSACCHARIDE INDUCED LUNG INJURY IN RATS.
Hassett, P,Curley, G,O'Toole, D,O'Higgins, B,Laffey, J (2009) INTRAPULMONARY DELIVERY OF EXTRACELLULAR SUPEROXIDE DISMUTASE AMELIORATES LIPO-POLYSACCHARIDE INDUCED LUNG INJURY IN RATS. Abstract [Details]
(2008) Aerosol delivery of rAAV pseudotypes 2, 2/5 and 2/6. ISGCT Annual Conference.
MacLoughlin R, Higgins B, Laffey J, O'Brien T (2008) Aerosol delivery of rAAV pseudotypes 2, 2/5 and 2/6. ISGCT Annual Conference. UCC: Abstract [Details]
(2007) Optimization of aerosol delivery to the lungs of Sprague-Dawley rat, an in vitro study of aerosol performance. International Society for Aerosols in Medicine (ISAM), 16th Congress, Vinci Congress Center.
MacLoughlin R, Higgins B, Laffey J, O' Brien T (2007) Optimization of aerosol delivery to the lungs of Sprague-Dawley rat, an in vitro study of aerosol performance. International Society for Aerosols in Medicine (ISAM), 16th Congress, Vinci Congress Center. Tours, France: Abstract [Details]
(2007) A systematic approach to maximising aerosol delivery of adeno-associated viral (AAV) vector to the lungs. British Association for Lung Research (BALR), 'Gene and Stem Cell Therapies for Lung Diseases', National University of Ireland, Maynooth, Ireland.
MacLoughlin R, Higgins B, Laffey J, O'Brien T (2007) A systematic approach to maximising aerosol delivery of adeno-associated viral (AAV) vector to the lungs. British Association for Lung Research (BALR), 'Gene and Stem Cell Therapies for Lung Diseases', National University of Ireland, Maynooth, Ireland. Abstract [Details]

Conference Paper

  Year Publication
(2006) Session chair - ESICM Conference.
J.G. Laffey (2006) Session chair - ESICM Conference. Conference Paper [Details]
(2005) Succeeding in Basic Science Research. Intensive Care society Winter Meeting .
J.G. Laffey (2005) Succeeding in Basic Science Research. Intensive Care society Winter Meeting . Belfast, Northern Ireland: Conference Paper [Details]
(2004) Symposium Co-Chairman, Session ‘Mechanical Ventilation: New Experimental Insights’, Annual Scientific Meeting, American Thoracic Society.
J.G. Laffey (2004) Symposium Co-Chairman, Session ‘Mechanical Ventilation: New Experimental Insights’, Annual Scientific Meeting, American Thoracic Society. Conference Paper [Details]
(2003) Chairman, Ventilation Session, Autumn Scientific Meeting, Intensive Care Society of Ireland .
J.G. Laffey (2003) Chairman, Ventilation Session, Autumn Scientific Meeting, Intensive Care Society of Ireland . Galway, Ireland: Conference Paper [Details]
(2003) Permissive Hypercapnia - with or without Acidosis?'.
J.G. Laffey (2003) Permissive Hypercapnia - with or without Acidosis?'. Bremen, Germany: Conference Paper [Details]
(2003) 'The role of permissive hypercapnia in Protective Lung Ventilation strategies'. HAI 2003 Congress.
J.G. Laffey (2003) 'The role of permissive hypercapnia in Protective Lung Ventilation strategies'. HAI 2003 Congress. Berlin, Germany: Conference Paper [Details]
(2003) Scientific Programme Chair, 2003 West of Ireland Symposium in Anaesthesia .
J.G. Laffey (2003) Scientific Programme Chair, 2003 West of Ireland Symposium in Anaesthesia . Galway, Ireland: Conference Paper [Details]
(2001) Managing Care - Is there a role for step-down units?' .
J.G. Laffey (2001) Managing Care - Is there a role for step-down units?' . Geneva, Switzerland: Conference Paper [Details]

Editorial

  Year Publication
(2012) Ischemia-reperfusion-induced lung injury: Could hypercapnia have a therapeutic role?.
Ansari, B,Laffey, JG (2012) Ischemia-reperfusion-induced lung injury: Could hypercapnia have a therapeutic role?. Editorial [DOI] [Details]
(2011) Hypocapnia induced cerebral ischaemia during therapeutic hypothermia-Potential for harm?.
Curley, G,Laffey, JG (2011) Hypocapnia induced cerebral ischaemia during therapeutic hypothermia-Potential for harm?. Editorial [DOI] [Details]
(2011) Casual bystander or active participant? New clues about adiponectin and traumatic injury.
White, M,Laffey, JG,Kevin, LG (2011) Casual bystander or active participant? New clues about adiponectin and traumatic injury. Editorial [DOI] [Details]
(2011) A rude awakening after our fourth 'NAP': lessons for airway management.
O'Sullivan, E,Laffey, J,Pandit, JJ (2011) A rude awakening after our fourth 'NAP': lessons for airway management. Editorial [DOI] [Details]
(2011) Strengthening the evidence base for airway equipment: time to be more 'ADEPT'?.
Laffey, JG (2011) Strengthening the evidence base for airway equipment: time to be more 'ADEPT'?. Editorial [DOI] [Details]
(2009) Mechanical Ventilation Taking Its Toll on the Lung.
Curley, GF,Kevin, LG,Laffey, JG (2009) Mechanical Ventilation Taking Its Toll on the Lung. Editorial [Details]
(2008) Carbon monoxide - From poison to therapy for cardiopulmonary bypass-induced lung injury?.
Kevin, LG,Laffey, JG (2008) Carbon monoxide - From poison to therapy for cardiopulmonary bypass-induced lung injury?. Editorial [Details]
(2007) Permissive hypercapnia: Balancing risks and benefits in the peripheral micro circulation.
Hassett, P,Laffey, JG (2007) Permissive hypercapnia: Balancing risks and benefits in the peripheral micro circulation. Editorial [DOI] [Details]
(2007) Implementing scientific advances into clinical practice in critical care - New challenges and new insights.
Costello, JF,Laffey, JG (2007) Implementing scientific advances into clinical practice in critical care - New challenges and new insights. Editorial [DOI] [Details]

Invited papers

  Year Publication
Permissive Hypercapnia at the Intensive Care Society UK, Annual State of the Art Conference London, UK.
J.G. Laffey Permissive Hypercapnia at the Intensive Care Society UK, Annual State of the Art Conference London, UK. Invited papers [Details]
(2006) ‘Buffering Hypercapnic Acidosis’ delivered at European Society of Intensive Care Medicine Annual conference Barcelona, Spain.
J.G. Laffey (2006) ‘Buffering Hypercapnic Acidosis’ delivered at European Society of Intensive Care Medicine Annual conference Barcelona, Spain. Invited papers [Details]
(2006) Ethylene Glycol Intoxication. ‘The critically ill Obstetric Patient’ delivered at European Society of Intensive Care Medicine Annual conference Barcelona, Spain.
J.G. Laffey (2006) Ethylene Glycol Intoxication. ‘The critically ill Obstetric Patient’ delivered at European Society of Intensive Care Medicine Annual conference Barcelona, Spain. Invited papers [Details]
(2006) ‘Advances in Mechanical Ventilation’, delivered at Association of Critical Care Nurses Annual Meeting, May 27th 2006.
J.G. Laffey (2006) ‘Advances in Mechanical Ventilation’, delivered at Association of Critical Care Nurses Annual Meeting, May 27th 2006. Galway, Ireland: Invited papers [Details]
(2006) Caring for the Critically ill Mother. 'Obstetric Critical Care' Dingle 2006 Conference Dingle, Ireland.
J.G. Laffey (2006) Caring for the Critically ill Mother. 'Obstetric Critical Care' Dingle 2006 Conference Dingle, Ireland. Invited papers [Details]
(2006) Low Tidal volume Ventilation - with or without permissive hypercapnia?. 'Role of hypercapnia in protective lung ventilatory strategies' at ICSI/SICS Meeting Dunblane, Scotland.
J.G. Laffey (2006) Low Tidal volume Ventilation - with or without permissive hypercapnia?. 'Role of hypercapnia in protective lung ventilatory strategies' at ICSI/SICS Meeting Dunblane, Scotland. Invited papers [Details]
(2006) ‘Ethylene Glycol Intoxication' delivered at European Society of Intensive Care Medicine Annual conference.
J.G. Laffey (2006) ‘Ethylene Glycol Intoxication' delivered at European Society of Intensive Care Medicine Annual conference. Barcelona, Spain: Invited papers [Details]
(2006) The critically ill child with Meningococcemia. Critical Care Nursing Conference .
J.G. Laffey (2006) The critically ill child with Meningococcemia. Critical Care Nursing Conference . Galway, Ireland: Invited papers [Details]
(2006) ‘The inflammatory response to Surgery’ delivered at Western anaesthesia Symposium.
J.G. Laffey (2006) ‘The inflammatory response to Surgery’ delivered at Western anaesthesia Symposium. Invited papers [Details]
(2006) ‘Meningococcemia’ delivered to Critical Care Nursing Conference .
J.G. Laffey (2006) ‘Meningococcemia’ delivered to Critical Care Nursing Conference . Galway, Ireland: Invited papers [Details]
(2005) Mechanical Ventilation - From Bench to Bedside' at the Dingle 2005 Annual Symposium .
J.G. Laffey (2005) Mechanical Ventilation - From Bench to Bedside' at the Dingle 2005 Annual Symposium . Dingle, Ireland: Invited papers [Details]
(2004) The inflammatory response to Cardiac Surgery, Annual Winter Anaesthesia Symposium.
J.G. Laffey (2004) The inflammatory response to Cardiac Surgery, Annual Winter Anaesthesia Symposium. University of Leuven, Belgium: Invited papers [Details]
(2003) Low Tidal volume Ventilation - with or without permissive hypercapnia? .
J.G. Laffey (2003) Low Tidal volume Ventilation - with or without permissive hypercapnia? . Berlin, Germany: Invited papers [Details]
(2003) Buffering that Acidosis - treating the patient or the physician?.
J.G. Laffey (2003) Buffering that Acidosis - treating the patient or the physician?. Galway, Ireland: Invited papers [Details]
(2003) Perioperative ACE Inhibitors and Patient Outcome .
J.G. Laffey (2003) Perioperative ACE Inhibitors and Patient Outcome . Dublin, Ireland: Invited papers [Details]
(2003) Maternal Brain Death in Ireland - Medical, Legal and Ethical issues. Submission to Roundtable Discussion Forum, Winter Scientific Meeting.
J.G. Laffey (2003) Maternal Brain Death in Ireland - Medical, Legal and Ethical issues. Submission to Roundtable Discussion Forum, Winter Scientific Meeting. Intensive Care Society of Ireland Dublin, Ireland: Invited papers [Details]
(2001) Hypercapnia - from ‘Permissive’ to Therapeutic’. Anaesthesia Grand Rounds.
J.G. Laffey (2001) Hypercapnia - from ‘Permissive’ to Therapeutic’. Anaesthesia Grand Rounds. Adelaide Meath and National Children?s Hospital: Invited papers [Details]
(2001) Therapeutic Hypercapnia - current insights, future prospects.Research Grand Rounds.
J.G. Laffey (2001) Therapeutic Hypercapnia - current insights, future prospects.Research Grand Rounds. University College Hospital Galway, Ireland: Invited papers [Details]
(2001) Carbon dioxide and Acute Organ Injury. Respiratory Research Rounds.
J.G. Laffey (2001) Carbon dioxide and Acute Organ Injury. Respiratory Research Rounds. St. Vincent?s University Hospital Dublin, Ireland: Invited papers [Details]
(2000) Carbon Dioxide and the critically ill - too little of a good thing. Critical Care Grand Rounds, University of Toronto, Hospital for Sick Children.
J.G. Laffey (2000) Carbon Dioxide and the critically ill - too little of a good thing. Critical Care Grand Rounds, University of Toronto, Hospital for Sick Children. Invited papers [Details]
(1998) The Post Anaesthesia Care Unit - the anaesthetists’ perspective, National symposium on Post-Anaesthesia Care, Mater Hospital Dublin, Ireland.
J.G. Laffey (1998) The Post Anaesthesia Care Unit - the anaesthetists’ perspective, National symposium on Post-Anaesthesia Care, Mater Hospital Dublin, Ireland. Invited papers [Details]

Letter

  Year Publication
(2011) Placebo blocks in local anaesthesia studies: the need for balance.
Laffey, J (2011) Placebo blocks in local anaesthesia studies: the need for balance. Letter [DOI] [Details]
(2011) Hypocapnia and the injured brain: Evidence for harm.
Curley, G,Kavanagh, BP,Laffey, JG (2011) Hypocapnia and the injured brain: Evidence for harm. Letter [DOI] [Details]
(2011) Selective digestive decontamination reduces bacteremia following eradication of gut overgrowth reply.
Quigley, EM,Laffey, JG (2011) Selective digestive decontamination reduces bacteremia following eradication of gut overgrowth reply. Letter [DOI] [Details]
(2010) The learning curve for videolaryngoscopy Reply.
McElwain, J,Laffey, JG (2010) The learning curve for videolaryngoscopy Reply. Letter [DOI] [Details]
(2010) Comparison of the C-MAC (R) videolaryngoscope with the Macintosh, Glidescope (R) and Airtraq (R) laryngoscopes in easy and difficult laryngoscopy scenarios in manikins reply.
McElwain, J,Laffey, JG (2010) Comparison of the C-MAC (R) videolaryngoscope with the Macintosh, Glidescope (R) and Airtraq (R) laryngoscopes in easy and difficult laryngoscopy scenarios in manikins reply. Letter [DOI] [Details]
(2008) Subcostal transversus abdominis plane block under ultrasound guidance - Reply.
Laffey, JG,McDonnell, JG (2008) Subcostal transversus abdominis plane block under ultrasound guidance - Reply. Letter [DOI] [Details]
(2007) Transversus abdominis plane block - Response.
McDonnell, JG,Laffey, JG (2007) Transversus abdominis plane block - Response. Letter [DOI] [Details]
(2007) The transversus abdominis plane block - Response.
McDonnell, JG,Laffey, JG (2007) The transversus abdominis plane block - Response. Letter [DOI] [Details]
(2006) Sildenafil for pulmonary hypertension in pregnancy?.
Lynch, TD,Laffey, JG (2006) Sildenafil for pulmonary hypertension in pregnancy?. Letter [Details]
(2002) Hypocapnia - Reply.
Laffey, J,Kavanagh, BP (2002) Hypocapnia - Reply. Letter [Details]
(2001) Low-dose spinal morphine for postoperative analgesia following knee arthroplasty.
Laffey, JG,Flynn, N (2001) Low-dose spinal morphine for postoperative analgesia following knee arthroplasty. Letter [Details]

Meeting

  Year Publication
(2013) In vivo inhibition of pulmonary nuclear factor kappa-B attenuates ventilator-induced lung injury in the rat.
Hayes, MB,Curley, GF,Devaney, J,O'Toole, DP,Laffey, JG (2013) In vivo inhibition of pulmonary nuclear factor kappa-B attenuates ventilator-induced lung injury in the rat. Meeting [Details]
(2013) Human mesenchymal stem cells enhance repair after ventilator-induced lung injury.
Hayes, M,Curley, G,Ansari, B,O'Toole, D,Laffey, J (2013) Human mesenchymal stem cells enhance repair after ventilator-induced lung injury. Meeting [Details]
(2012) Carbon dioxide (CO2) sensing at the axis of immunity and inflammation.
Oliver, KM,Lenihan, CR,Bruning, U,Cheong, A,Laffey, JG,McLoughlin, P,Fitzpatrick, SF,Scholz, CC,Slattery, C,Leonard, MO,Taylor, CT,Cummins, EP (2012) Carbon dioxide (CO2) sensing at the axis of immunity and inflammation. Meeting [Details]
(2010) Hypercapnic Acidosis Impairs Inflammatory Signalling Via Inhibition Of Multiple Points Of The NF-kappa B Pathway.
O'Toole, D,Masterson, C,Leo, A,Contreras, M,Hassett, P,Laffey, J (2010) Hypercapnic Acidosis Impairs Inflammatory Signalling Via Inhibition Of Multiple Points Of The NF-kappa B Pathway. Meeting [Details]
(2010) Hypercapnic Acidosis Attenuates Moderate And Severe Ventilator Induced Lung Injury By An NF-kB Dependent Mechanism.
Contreras, M,O'Toole, D,Higgins, B,Ansari, BM,Curley, GF,Masterson, C,Laffey, J (2010) Hypercapnic Acidosis Attenuates Moderate And Severe Ventilator Induced Lung Injury By An NF-kB Dependent Mechanism. Meeting [Details]
(2010) Time Course Of Lung Injury, Inflammation, Repair And Fibrosis Following Ventilator Induced Lung Injury.
Curley, GF,Contreras, M,Higgins, B,O'Toole, D,O'Kane, C,Laffey, J (2010) Time Course Of Lung Injury, Inflammation, Repair And Fibrosis Following Ventilator Induced Lung Injury. Meeting [Details]
(2010) MESENCHYMAL STEM CELLS ENHANCE REPAIR FOLLOWING VENTILATOR INDUCED LUNG INJURY.
Curley, GF,Contreras, M,Ansari, B,Masterson, C,McHale, P,Devaney, J,Higgins, BD,O'Toole, D,Laffey, JG (2010) MESENCHYMAL STEM CELLS ENHANCE REPAIR FOLLOWING VENTILATOR INDUCED LUNG INJURY. Meeting [Details]
(2010) HYPERCAPNIC ACIDOSIS REDUCES STRETCH-INDUCED INFLAMMATION BY AN NF-KAPPA B-DEPENDENT MECHANISM.
Ansari, BM,Contreras, M,O'Toole, D,Laffey, J (2010) HYPERCAPNIC ACIDOSIS REDUCES STRETCH-INDUCED INFLAMMATION BY AN NF-KAPPA B-DEPENDENT MECHANISM. Meeting [Details]
(2009) Molecular Effects of Hypercapnic Acidosis on the NF-kappa B Intracellular Signalling Pathway.
O'Toole, DP,Hassett, PD,Leo, AM,Higgins, BD,Laffey, JG (2009) Molecular Effects of Hypercapnic Acidosis on the NF-kappa B Intracellular Signalling Pathway. Meeting [Details]
(2009) Prolonged Hypercapnia Reduces the Severity of Acute Lung Injury in Chronic Polymicrobial Sepsis.
Contreras, M,Costello, J,Higgins, B,O'Tool, D,Hassett, P,Laffey, JG (2009) Prolonged Hypercapnia Reduces the Severity of Acute Lung Injury in Chronic Polymicrobial Sepsis. Meeting [Details]
(2009) Hypercapnic Acidosis Inhibits TNF alpha Induced Wound Healing in a Lung Cell Culture Model.
O'Toole, D,Hassett, P,Leo, A,Higgins, BD,Laffey, JG (2009) Hypercapnic Acidosis Inhibits TNF alpha Induced Wound Healing in a Lung Cell Culture Model. Meeting [Details]
(2008) Aerosol delivery of AAV5-gfp to the rodent lung.
Mac Loughlin, R,Higgins, B,Laffey, J,O'Brien, T (2008) Aerosol delivery of AAV5-gfp to the rodent lung. Meeting [Details]

Reviews

  Year Publication
(2012) Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype?.
Hayes, M,Curley, G,Ansari, B,Laffey, JG (2012) Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype?. Reviews [DOI] [Details]
(2011) Clinical review: Special populations - critical illness and pregnancy.
Neligan, PJ,Laffey, JG (2011) Clinical review: Special populations - critical illness and pregnancy. Reviews [DOI] [Details]
(2011) Clinical Review: Gene-based therapies for ALI/ARDS: where are we now?.
Devaney, J,Contreras, M,Laffey, JG (2011) Clinical Review: Gene-based therapies for ALI/ARDS: where are we now?. Reviews [DOI] [Details]
(2010) Bench-to-bedside review: Carbon dioxide.
Curley, G,Laffey, JG,Kavanagh, BP (2010) Bench-to-bedside review: Carbon dioxide. Reviews [DOI] [Details]
(2010) Hypocapnia and the injured brain: More harm than benefit.
Curley, G,Kavanagh, BP,Laffey, JG (2010) Hypocapnia and the injured brain: More harm than benefit. Reviews [DOI] [Details]
(2010) Hypercapnia and Acidosis in Sepsis A Double-edged Sword?.
Curley, G,Contreras, M,Nichol, AD,Higgins, BD,Laffey, JG (2010) Hypercapnia and Acidosis in Sepsis A Double-edged Sword?. Reviews [Details]
(2005) Bench-to-bedside review: Permissive hypercapnia.
O'Croinin, D,Chonghaile, MN,Higgins, B,Laffey, JG (2005) Bench-to-bedside review: Permissive hypercapnia. Reviews [DOI] [Details]
(2005) Permissive hypercapnia: role in protective lung ventilatory strategies.
Ni Chonghaile, M,Higgins, B,Laffey, JG (2005) Permissive hypercapnia: role in protective lung ventilatory strategies. Reviews [Details]
(2005) Maternal brain death and somatic support.
Farragher, RA,Laffey, JG (2005) Maternal brain death and somatic support. Reviews [DOI] [Details]
(2005) Maternal brain death - an Irish perspective.
Farragher, R,Marsh, B,Laffey, JG (2005) Maternal brain death - an Irish perspective. Reviews [Details]
(2004) Permissive hypercapnia - role in protective lung ventilatory strategies.
Laffey, JG,O'Croinin, D,McLoughlin, P,Kavanagh, BP (2004) Permissive hypercapnia - role in protective lung ventilatory strategies. Reviews [DOI] [Details]
(2002) The systemic inflammatory response to cardiac surgery - Implications for the anesthesiologist.
Laffey, JG,Boylan, JF,Cheng, DCH (2002) The systemic inflammatory response to cardiac surgery - Implications for the anesthesiologist. Reviews [Details]

Honours and Awards

  Year Title Awarding Body
2008 Keynote speaker, Drager Medal Lecture Association of Anaesthetists of Graeat Britain and Ireland
2000 Young Investigator Award American Society of Critical Care Anesthesiologists
1999 Hynek Rothbart Research Prize Dept of Anesthesia, University of Toronto

Professional Associations

  Association Function From / To
European Society of Intensive Care Medicine Deputy Chairman, Acute Respiratory Failure Section 01-OCT-11 / 30-SEP-13
Irish Critical Care Trials Group Deputy Chair 01-JAN-10 / 31-DEC-12

Committees

  Committee Function From / To
Final Fellowship Examination in Anaesthesia, College of Anaesthetists Examiner /
Academic Anaesthesia Committee, College of Anaesthetists Member /
Intensive Care Society of Ireland Council Member /
Anaesthesiology and Pain Medicine Expert Review Panel, F1000 Medicine Faculty Member /
Society for Education in Anesthesia Member /
Cochrane Anaesthesia Research Group Member /
Association of Anaesthetists of Great Britain and Ireland Member /
International Anaesthesia Research Society Member /
European Society of Intensive Care Medicine Member /
American Thoracic Society Member /
Intensive Care Society of Ireland Council Member /

Education

  Year Institution Qualification Subject
1989 NUI Galway BSc Biochemistry
1992 NUI Galway Bachelor of Medicine Medicine
2001 Institute Of Public Administration, Dublin Masters of Arts Healthcare Management
2001 NUI Galway Doctor of Medicine Medicine

Teaching Interests