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About NUI Galway
About NUI Galway
Since 1845, NUI Galway has been sharing the highest quality teaching and research with Ireland and the world. Find out what makes our University so special – from our distinguished history to the latest news and campus developments.
Colleges & Schools
Colleges & Schools
NUI Galway has earned international recognition as a research-led university with a commitment to top quality teaching across a rang of key areas of expertise.
Business & Industry
Guiding Breakthrough Research at NUI Galway
We explore and facilitate commercial opportunities for the research community at NUI Galway, as well as facilitating industry partnership.
- Alumni, Friends & Supporters
At NUI Galway, we believe that the best learning takes place when you apply what you learn in a real world context. That's why many of our courses include work placements or community projects.
Dr Karen Doyle B.Sc., Ph.D.
My research focuses on understanding the causes of neuronal death, and novel neuroprotective strategies to
prevent neuronal death. My previous work has touched on an array of neurological and psychiatric
conditions including epilepsy, Parkinson’s disease, bipolar depression and the brain damage caused
by drugs of abuse. In particular I have made a substantial contribution to the field of polyamine research.
Peer Reviewed Journals
|Mnich, K,Carleton, LA,Kavanagh, ET,Doyle, KM,Samali, A,Gorman, AM (2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'. Cell Death & Disease, 5 . [DOI] [Details]|
|Butler, RK,Ford, GK,Hogan, M,Roche, M,Doyle, KM,Kelly, JP,Kendall, DA,Chapman, V,Finn, DP (2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, 26 :83-91. [DOI] [Details]|
|Debnath, M,Doyle, KM,Langan, C,McDonald, C,Leonard, B,Cannon, DM (2011) 'RECENT ADVANCES IN PSYCHONEUROIMMUNOLOGY: INFLAMMATION IN PSYCHIATRIC DISORDERS'. Translational Neuroscience, 2 :121-137. [DOI] [Details]|
|Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. Journal Of Cellular And Molecular Medicine, . [Details]|
|Gorman, A. M.,Doyle, K. M. (2009) 'Considerations and recent advances in neuroscience'. Biochemical Society Transactions, 37 :299-302. [Details]|
|Li J, Doyle, K.M. & Tatlisumak T (2007) 'Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia'. Curr Med Chem, 14 (17):1807-1813. [Details]|
|Kavanagh, ET,Loughlin, JP,Herbert, KR,Dockery, P,Samall, A,Doyle, KM,Gorman, AM (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochemical And Biophysical Research Communications, 351 :890-895. [DOI] [Details]|
|Li, J,Henman, MC,Atkinson, J,Fixon-Owoo, S,Tatlisumak, T,Shaw, GG,Doyle, KM (2006) 'The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice'. Brain Research, 1076 :209-215. [DOI] [Details]|
|Doyle, K.M., Kirby, B.P., Murphy, D. & Shaw, G.G. (2005) 'Effect of L-type calcium channel antagonists on spermine induced CNS excitation in vivo'. Neuroscience Letters, 380 :247-251. [Details]|
|Doyle, KM,Kirby, BP,Murphy, D,Shaw, GG (2005) 'Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo'. Neuroscience Letters, 380 :247-251. [DOI] [Details]|
|Li, J,Henman, MC,Tatlisumak, T,Shaw, GG,Doyle, KM (2005) 'The pre-ischaemic neuroprotective effects of N-1-dansyl-spermine in a transient focal cerebral ischaemia model in mice'. Brain Research, 1055 :180-185. [DOI] [Details]|
|Sales, KM,Kingston, ST,Doyle, KM,Purcell, WM (2004) 'Preliminary characterisation of an in vitro paradigm for the study of the delayed effects of organophosphorus compounds: hen embryo brain spheroids'. Toxicology, 195 :187-202. [DOI] [Details]|
|Doyle, K.M.,Shaw, G.G. (1998) 'Investigation of the actions and antagonist activity of some polyamine analogues in vivo'. British Journal Of Pharmacology, 124 :386-390. [Details]|
|Doyle, K.M., Feerick, S., Kirkby, D.L., Eddleston, A. & Higgins, G.A. (1998) 'Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour'. Behavioural Pharmacology, 9 :671-681. [Details]|
|Doyle, K.M. : Shaw, G.G. (1996) 'Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo'. British Journal Of Pharmacology, 117 :1803-1808. [Details]|
|Purcell, W.M., Doyle, K.M., Westgate, C. : Atterwill, C.K (1996) 'Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex'. Journal Of Neuroimmunology, 65 :49-53. [Details]|
|Purcell, W.M., Doyle, K.M., Bagga, L. : Derks, M. (1994) 'Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?'. Biochemical Society Transactions, 22 . [Details]|
|Doyle, K.M.,Shaw, G.G. (1994) 'The mechanism of the neurotoxic effects of spermidine'. Biochemical Society Transactions, 22 . [Details]|
|Doyle KM, Gorman AM (2009) 'Considerations and recent advances in neuroscience. Meeting report of 2nd Neuroscience Ireland Conference' Biochem Soc Trans 37 :299-302. [Details]|
|Gorman, AM,Doyle, KM (2009) BIOCHEMICAL SOCIETY TRANSACTIONS Considerations and recent advances in neuroscience , pp.299-302 [DOI] [Details]|
|Santos, AM,Kelly, JP,Doyle, KM (2010) METHAMPHETAMINE EFFECTS ON CELL VIABILITY, BDNF LEVELS AND NEURITE OUTGROWTH IN PC12 CELLS. Abstract [Details]|
|Devadasan, C,Starr, BS,Doyle, KM (2001) The effect of the co-administration of eliprodil with memantine in naive and reserpinised mice. Abstract [Details]|
|Li, J,Doyle, KM,Tatlisumak, T (2007) Polyamines in the brain: Distribution, biological interactions, and their potential therapeutic role in brain ischaemia. Reviews [Details]|
|Murphy, DH,Shaw, GG,Atkinson, J,Fixon-Owoo, S,Henman, M,Doyle, KM (2003) Investigation of the antagonist action of novel polyamine analogues on spermine induced CNS excitation in mice in vivo. Meeting [Details]|