Linda Howard

Lecturer

Contact Details

Lecturer
Medicine
NUI Galway

T: Ext. 5268
E: linda.howard@nuigalway.ie
 
researcher

Biography

Research Interests

Adult stem cells, Regulation of Stem Cell Differentiation, micro RNA regulation of cell proliferation and differentiation

Peer Reviewed Journals

  Year Publication
(2015) 'Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells'
Sanz-Nogués C, Horan J, Thompson K, Howard L, Ryan G, Kassem M, O'Brien T (2015) 'Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells'. Journal Of Biomedical Materials Research Part A, [DOI] [Details]
(2014) 'The Reduction in Immunogenicity of Neurotrophin Overexpressing Stem Cells after Intra-Striatal Transplantation by Encapsulation in an In Situ Gelling Collagen Hydrogel'
Hoban D, Newland B, Moloney T, Howard L, Pandit A, Dowd, E. (2014) 'The Reduction in Immunogenicity of Neurotrophin Overexpressing Stem Cells after Intra-Striatal Transplantation by Encapsulation in an In Situ Gelling Collagen Hydrogel'. Biomaterials, 34 (37):9420-9429 [Details]
(2014) 'A chondromimetic microsphere for in situ spatially controlled chondrogenic differentiation of human mesenchymal stem cells'
Ansboro, S,Hayes, JS,Barron, V,Browne, S,Howard, L,Greiser, U,Lalor, P,Shannon, F,Barry, FP,Pandit, A,Murphy, JM (2014) 'A chondromimetic microsphere for in situ spatially controlled chondrogenic differentiation of human mesenchymal stem cells'. J Control Release, 179 :42-51 [DOI] [Details]
(2013) 'Allogeneic Murine Mesenchymal Stem Cells: Migration to Inflamed Joints In Vivo and Amelioration of Collagen Induced Arthritis When Transduced to Express CTLA4Ig'
Sullivan, C,Barry, F,Ritter, T,O'Flatharta, C,Howard, L,Shaw, G,Anegon, I,Murphy, M (2013) 'Allogeneic Murine Mesenchymal Stem Cells: Migration to Inflamed Joints In Vivo and Amelioration of Collagen Induced Arthritis When Transduced to Express CTLA4Ig'. Stem Cells And Development, 22 :3203-3213 [DOI] [Details]
(2013) 'The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel'
Hoban, DB,Newland, B,Moloney, TC,Howard, L,Pandit, A,Dowd, E (2013) 'The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel'. Biomaterials, 34 :9420-9429 [DOI] [Details]
(2013) 'Growth differentiation factor-5 enhances in vitro mesenchymal stromal cell chondrogenesis and hypertrophy'
Coleman CM, Vaughan EE, Browe DC, Mooney E, Howard L, Barry F (2013) 'Growth differentiation factor-5 enhances in vitro mesenchymal stromal cell chondrogenesis and hypertrophy'. Stem Cells and Development, 22 (13):1968-1976 [DOI] [Details]
(2012) 'Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells'
Moloney, TC,Hoban, DB,Barry, FP,Howard, L,Dowd, E (2012) 'Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells'. Protein Science, 21 :904-909 [DOI] [Details]
(2010) 'Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain'
Moloney, TC,Rooney, GE,Barry, FP,Howard, L,Dowd, E (2010) 'Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain'. Brain Research, 1359 :33-43 [DOI] [Details]
(2010) 'Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain'
Moloney TC, Dockery P, Windebank AJ, Barry FP, Howard L, Dowd E (2010) 'Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain'. Neurorehabil Neural Repair, 24 (7):645-656 [DOI] [Details]
(2010) 'immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain'
Moloney TC, Dockery P, Windebank AJ, Barry FP, Howard L, Dowd E. Survival and (2010) 'immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain'. Neurorehabil Neural Repair, 24 (7):645-656 [DOI] [Details]
(2010) 'Survival and Immunogenicity of Mesenchymal Stem Cells From the Green Fluorescent Protein Transgenic Rat in the Adult Rat Brain'
Moloney, TC,Dockery, P,Windebank, AJ,Barry, FP,Howard, L,Dowd, E (2010) 'Survival and Immunogenicity of Mesenchymal Stem Cells From the Green Fluorescent Protein Transgenic Rat in the Adult Rat Brain'. Neurorehabilitation And Neural Repair, 24 :645-656 [DOI] [Details]
(2009) 'Elevation of cAMP in Mesenchymal Stem Cells Transiently Upregulates Neural Markers Rather than Inducing Neural Differentiation'
Rooney, GE,Howard, L,O'Brien, T,Windebank, AJ,Barry, FP (2009) 'Elevation of cAMP in Mesenchymal Stem Cells Transiently Upregulates Neural Markers Rather than Inducing Neural Differentiation'. Stem Cells And Development, 18 :387-398 [DOI] [Details]
(2009) 'Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord Without Differentiating into Neural Cells'
Rooney, GE,McMahon, SS,Ritter, T,Garcia, Y,Moran, C,Madigan, NN,Flugel, A,Dockery, P,O'Brien, T,Howard, L,Windebank, AJ,Barry, FP (2009) 'Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord Without Differentiating into Neural Cells'. Tissue Engineering Part A, 15 :3049-3059 [DOI] [ARAN Link] [Details]
(2009) 'Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without differentiating into neural cells'
Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Madigan NN, Flügel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP (2009) 'Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without differentiating into neural cells'. Tissue Engineering, 15 (10):3049-3059 [DOI] [Details]
(2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'
Kealy, B,Liew, A,McMahon, JM,Ritter, T,O'Doherty, A,Hoare, M,Greiser, U,Vaughan, EE,Maenz, M,O'Shea, C,Barry, F,O'Brien, T (2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'. Tissue Engineering Part C-Methods, 15 :223-231 [DOI] [Details]
(2009) 'Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells'
Molloy, AP,Martin, FT,Dwyer, RM,Griffin, TP,Murphy, M,Barry, FP,O'Brien, T,Kerin, MJ (2009) 'Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells'. International Journal Of Cancer, 124 :326-332 [DOI] [Details]
(2009) 'Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells'
Sharif F, Hynes SO, Cooney R, Howard L, McMahon J, Daly K, Crowley J, Barry F, O'Brien T. (2009) 'Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells'. Clin Exp Immunol, 156 (1):149-160 [DOI] [Details]
(2008) 'Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'
Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP (2008) 'Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'. Tissue Engineering, 14 (5):681-690 [DOI] [Details]
(2008) 'Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model'
Mohr, A,Lyons, M,Deedigan, L,Harte, T,Shaw, G,Howard, L,Barry, F,O'Brien, T,Zwacka, R (2008) 'Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model'. Journal Of Cellular And Molecular Medicine, 12 :2628-2643 [DOI] [Details]
(2008) 'Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'
Rooney, GE,Moran, C,McMahon, SS,Ritter, T,Maenz, M,Flugel, A,Dockery, P,O'Brien, T,Howard, L,Windebank, AJ,Barry, FP (2008) 'Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'. Tissue Engineering Part A, 14 :681-690 [DOI] [Details]
(2008) 'Gene Eluting Stents: Adenoviral-Mediated Delivery of eNOS to the Blood Vessel Wall Accelerates Re-Endothelialization and Inhibits Restenosis'
Sharif F, Hynes SO, Cooney R, Howard L, McMahon J, Daly K, Crowley J, Barry F, O'Brien, T (2008) 'Gene Eluting Stents: Adenoviral-Mediated Delivery of eNOS to the Blood Vessel Wall Accelerates Re-Endothelialization and Inhibits Restenosis'. Mol Ther, 16 (10):1674-1680 [DOI] [Details]
(2008) 'Elevation of cAMP Induces Transient Upregulation of Neural Markers in Mesenchymal Stem Cells Cultured in a Defined Element Serum-Free Environment'
Rooney, GE, Howard, L, O' Brien, T, Windebank, AJ, Barry, FP (2008) 'Elevation of cAMP Induces Transient Upregulation of Neural Markers in Mesenchymal Stem Cells Cultured in a Defined Element Serum-Free Environment'. Stem Cells Dev, [Details]
(2008) '6: Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'
Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP. (2008) '6: Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'. TISSUE ENGINEERING. PART A. TISSUE ENGINEERING, 14 (5):681-690 [Details]
(2008) 'Effects of plating density and culture time on bone marrow stromal cell characteristics'
Neuhuber B, Swanger SA, Howard L, Mackay A, Fischer I. (2008) 'Effects of plating density and culture time on bone marrow stromal cell characteristics'. Exp Hematol, 36 (9):1176-1185 [Details]
(2008) 'Gene-eluting stents: Adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis'
Sharif, F,Hynes, SO,Cooney, R,Howard, L,McMahon, J,Daly, K,Crowley, J,Barry, F,O'Brien, T (2008) 'Gene-eluting stents: Adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis'. Molecular Therapy, 16 :1674-1680 [DOI] [Details]
(2007) 'Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury'
Cooney, R,Hynes, SO,Sharif, F,Howard, L,O'Brien, T (2007) 'Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury'. Gene Therapy, 14 :396-404 [DOI] [Details]
(2007) 'Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells'
Ryan, JM,Barry, F,Murphy, JM,Mahon, BP (2007) 'Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells'. Clinical And Experimental Immunology, 149 :353-363 [DOI] [Details]
(2006) 'Gene transfer into rat mesenchymal stem cells: A comparative study of viral and nonviral vectors'
McMahon, JM,Conroy, S,Lyons, M,Greiser, U,O'Shea, C,Strappe, P,Howard, L,Murphy, M,Barry, F,O'Brien, T (2006) 'Gene transfer into rat mesenchymal stem cells: A comparative study of viral and nonviral vectors'. Stem Cells And Development, 15 :87-96 [Details]
(2004) 'Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype'
Neuhuber B, Gallo G, Howard L, Kostura L, Mackay A, Fischer I. (2004) 'Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype'. JOURNAL OF NEUROSCIENCE RESEARCH, 77 (2):192-204 [Details]
(2001) 'Catalytic activity of ADAM28'
Howard L, Zheng Y, Horrocks M, Maciewicz RA, Blobel C. (2001) 'Catalytic activity of ADAM28'. FEBS LETTERS, 498 (1):82-86 [Details]
(2000) 'Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28'
Howard L, Maciewicz RA, Blobel CP. (2000) 'Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28'. Biochem J, 348 (1):21-27 [Details]
(1999) 'Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1'
Howard L, Nelson KK, Maciewicz RA, Blobel CP. (1999) 'Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1'. J. BIOL. CHEM, 274 (44):31693-31699 [Details]
(1999) 'A novel protease-docking function of integrin at invadopodia'
Mueller SC, Ghersi G, Akiyama SK, Sang QX, Howard L, Pineiro-Sanchez M, Nakahara H, Yeh Y, Chen WT. (1999) 'A novel protease-docking function of integrin at invadopodia'. J. BIOL. CHEM, 274 (35):24947-24953 [Details]
(1997) 'Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion'
Nakahara H, Howard L, Thompson EW, Sato H, Seiki M, Yeh Y, Chen WT. (1997) 'Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 94 (15):7959-7964 [Details]
(1997) 'Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease'
Piñeiro-Sánchez ML, Goldstein LA, Dodt J, Howard L, Yeh Y, Tran H, Argraves WS, Chen WT. (1997) 'Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease'. J. BIOL. CHEM, 272 (12):7595-7601 [Details]
(1996) 'Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types'
Howard L, Lu X, Mitchell S, Griffiths S, Glynn P. (1996) 'Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types'. Biochem J, 317 (1):45-50 [Details]
(1995) 'Membrane-associated metalloproteinase recognized by characteristic cleavage of myelin basic protein: assay and isolation'
Howard L, Glynn P. (1995) 'Membrane-associated metalloproteinase recognized by characteristic cleavage of myelin basic protein: assay and isolation'. Methods in Emzymology, 248 :388-395 [Details]

Abstract

  Year Publication
(2008) Glial-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells. Society for Neuroscience, Washington, USA.
Rooney, Gemma E, McMahon, S, Ritter, T, Garcia, Y, Madigan, N, Flugel, A, Nickander, Kim, Dockery, P, O'Brien, T, Howard, L, Windebank, AJ, Barry, F (2008) Glial-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells. Society for Neuroscience, Washington, USA. Abstract [Details]
(2007) A Tissue engineering strategies for spinal cord Injury using mesenchymal stem cells. Keystone Tissue Engineering and Developmental Biology conference Utah USA.
Rooney, GE, Moran, C, McMahon, SS, Ritter, T, Maenz, M, Fluegel, A, Dockery, P, O' Brien, T, Howard, L, Windebank, AJ, Barry, FP (2007) A Tissue engineering strategies for spinal cord Injury using mesenchymal stem cells. Keystone Tissue Engineering and Developmental Biology conference Utah USA. Abstract [Details]
(2006) Lentiviral vector transduction efficiency and biosafety profile of aldult mesenchymal stem cells. American Societ of Gene Therapy 2006 Meeting, Baltimore, Maryland, USA.
McGrath, BM, O'Shea, C, Howard, L, Murphy, M, Barry, F, O'Brien, T, Strappe, P (2006) Lentiviral vector transduction efficiency and biosafety profile of aldult mesenchymal stem cells. American Societ of Gene Therapy 2006 Meeting, Baltimore, Maryland, USA. Abstract [Details]

Meeting

  Year Publication
(2010) MESENCHYMAL STEM CELLS FROM THE GREEN FLUORESCENT PROTEIN TRANSGENIC RAT ARE HYPOIMMUNOGENIC FOLLOWING TRANSPLANTATION TO THE INTACT ADULT RAT STRIATUM.
Moloney, TC,Dockery, P,Barry, FP,Windebank, AJ,Howard, L,Dowd, E (2010) MESENCHYMAL STEM CELLS FROM THE GREEN FLUORESCENT PROTEIN TRANSGENIC RAT ARE HYPOIMMUNOGENIC FOLLOWING TRANSPLANTATION TO THE INTACT ADULT RAT STRIATUM. Meeting [Details]
(2007) An alternative strategy to reduce instent restenosis and prevent late stent thrombosis through enhanced endothelial regeneration using eNOS gene-eluting stents.
Sharif, F,Hynes, SO,Cooney, R,Howard, L,Mcmahon, J,Daly, K,Crowley, J,Barry, F,O'brien, T (2007) An alternative strategy to reduce instent restenosis and prevent late stent thrombosis through enhanced endothelial regeneration using eNOS gene-eluting stents. Meeting [Details]