Dr Aaron Liew

MB Bch BAO LRCP & SI, MRCPI, Ph.D

 
researcher
 

Biography

Dr. Aaron Liew was appointed as a Consultant Physician in Diabetes, Endocrinology and General Internal Medicine at Portiuncula University Hospital and Galway University Hospital, and a Senior Lecturer in Endocrinology at National University of Galway (NUIG) in November 2015. He runs the diabetes clinics and provides inpatient service with oncalls in Portiuncula University Hospital. He also has an endocrinology clinic in Galway University Hospital.

Dr. Liew graduated from the Royal College of Surgeons in Ireland (RCSI) in 2000, and completed his Higher Specialist Training (HST) in Diabetes and Endocrinology with General Internal Medicine in 2010. During his Higher Specialist Training in Ireland, Dr Liew was awarded the Clinical Research Training Fellowship from the Health Research Board and completed a PhD, in the Regenerative Medicine Institute, NUIG in 2008 under the supervision of Professor Timothy O’Brien. His PhD thesis was entitled ‘Diabetes related dysfunction of endothelial progenitor and mature endothelial cells’.

Following his HST in 2010, he continued his research in cell therapy in critical limb ischaemia as a post-doctoral researcher under the supervision of Professor O'Brien in NUIG. He obtained the Ulysses Grant which allowed him learn the novel electrogene transfer method for human mesenchymal stromal cell in Gustave Roussy, Laboratoire de Vectorologie et Therapeutiques Anticancereuses, Villejuif, France in 2011. He was involved in the first clinical trial conducted in Ireland to examine the safety and feasibility of autologous intramuscular transplantation of bone marrow derived mesenchymal stromal cells as a novel therapy for people with no-option critical limb ischemia (EudraCT number: 2013-003447-37).

In 2014, Dr. Liew was appointed as the Principal Research Associate in the Institute of Cellular Medicine, Newcastle University and Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust. His research included the Diabetes UK funded Project, entitled ‘Biomedical and Psychosocial Outcomes of Islet Transplantation’, led by Professor James Shaw. He was also involved in the first phase 3, double-blind, randomised controlled trial which evaluates the efficacy of an investigational anti-inflammatory small molecule (reparixin) in preventing graft dysfunction following pancreatic islet transplantation in people with Type 1 Diabetes Mellitus.


Research Interests

Dr. Liew’s current research interests focus on diabetes mellitus and frailty. His other research interest includes the management of diabetes mellitus and its related vascular complications, in particularly regenerative medicine with cell therapy and gene therapy, as well as anti-thrombotic therapy for venous and arterial thrombosis. He is involved in multiple collaborative network for systematic reviews and meta-analyses.

Dr. Liew and Dr. O'Caoimh are Co-Principal Investigators from NUIG for the ADVANTAGE Joint Action (JA) on the prevention of frailty. This Joint Action involves 22 Member States (MS) and over 35 organizations and it is co-funded by the European Union (EU) and the MS. NUIG-HSE leads the Work Package 5 (Knowing frailty at population level) of this project (http://www.advantageja.eu/index.php/project/content-research/wp5).

The ADVANTAGE Joint Action Research Team (NUIG/HSE):
Dr. Aaron Liew (Work Package 5 Leader/NUIG)
Dr. Ronan O'Caoimh (Work Package 7 Task Leader/NUIG)
Dr. Duygu Sezgin (Post-Doctoral researcher/NUIG)
Mr. Mark O'Donovan (Research Assistant/NUIG)
Dr. Siobhan Kennelly (National Clinical Advisory Group Lead Older Persons/HSE)
Dr. Helen Whitty (Programme Manager for National Clinical Programme for Older People/RCPI)

Results of the ADVANTAGE Joint Action:
http://advantageja.eu/index.php/home-3

Face Up to Frailty! Campaign:
https://www.inrca.it/inrca/advantage/faceupToolkit.asp

Dr. Liew is also a Co-Principal Investigator for the EMERGE trial (NCT02980276) for Portiuncula University Hospital site, with the Lead Principal Investigator, Professor Fidelma Dunne for GUH site. This is a very important double blind placebo controlled phase 3 randomised controlled trial with a specific aim to determine whether metformin plus usual care, when compared with placebo plus usual care (introduced at the time of initial diagnosis of GDM), reduces: a) the need for insulin use, or hyperglycemia (primary outcome measure); b) excessive maternal weight gain; c) maternal and neonatal morbidities and, d) cost of treatment for women with Gestational Diabetes Mellitus.

Book Chapters

  Year Publication
(2015) 'Chapter 5: Isolation of Endothelial Progenitor Cells (EPCs)'
Liew A, O'Brien T (2015) 'Chapter 5: Isolation of Endothelial Progenitor Cells (EPCs)' In: Handbook of Vascular Biology Techniques. Springer: Springer. [DOI] [Details]
(2012) 'Mesenchymal Stem Cells: Clinical Applications (An Overview)'
Liew A, O’Brien T. (2012) 'Mesenchymal Stem Cells: Clinical Applications (An Overview)' In: Stem Cells and Cancer Stem Cells, Volume 6. U.S.A: Springer. [Details]

Peer Reviewed Journals

  Year Publication
(2020) 'Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies'
O'Caoimh R;Sezgin D;O'Donovan MR;Molloy DW;Clegg A;Rockwood K;Liew A; (2020) 'Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies'. Age And Ageing, [DOI] [Details]
(2020) 'Efficacy and safety of a sodium-glucose co-transporter-2 inhibitor vs placebo as an add-on therapy for people with type 2 diabetes inadequately treated with metformin and a dipeptidyl peptidase-4 inhibitor: a systematic review and meta-analysis of randomized controlled trials'
De Buitléir C;O' Connor E;Satti M;Shaw J;Liew A; (2020) 'Efficacy and safety of a sodium-glucose co-transporter-2 inhibitor vs placebo as an add-on therapy for people with type 2 diabetes inadequately treated with metformin and a dipeptidyl peptidase-4 inhibitor: a systematic review and meta-analysis of randomized controlled trials'. Diabetic Medicine, [DOI] [Details]
(2020) 'Characterization of pre-transplant psychosocial burden in an integrated national islet transplant program'
Liew AY;Holmes-Truscott E;Flatt AJ;Bennett D;Crookston R;Pimkova M;Birtles L;Casey J;Pernet A;Wood RC;Choudhary P;Forbes S;Rutter MK;Rosenthal M;Johnson P;Shaw JA;Speight J; (2020) 'Characterization of pre-transplant psychosocial burden in an integrated national islet transplant program'. Islets, [DOI] [Details]
(2020) 'Autoreactive T-cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function'
Sabbah S;Liew A;Brooks AM;Kundu R;Reading JL;Flatt A;Counter C;Choudhary P;Forbes S;Rosenthal MJ;Rutter MK;Cairns S;Johnson P;Casey J;Peakman M;Shaw JA;Tree TIM; (2020) 'Autoreactive T-cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function'. American Journal Of Transplantation, [DOI] [Details]
(2020) 'Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes'
Maffi P;Lundgren T;Tufveson G;Rafael E;Shaw JAM;Liew A;Saudek F;Witkowski P;Golab K;Bertuzzi F;Gustafsson B;Daffonchio L;Ruffini PA;Piemonti L; ; ; (2020) 'Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes'. Diabetes Care, [DOI] [Details]
(2020) 'Routine screening and rates of metabolic syndrome in patients treated with clozapine and long-acting injectable antipsychotic medications: a cross-sectional study'
Lydon A;Vallely J;Tummon A;Maher S;Sabri S;McLoughlin J;Liew A;McDonald C;Hallahan B; (2020) 'Routine screening and rates of metabolic syndrome in patients treated with clozapine and long-acting injectable antipsychotic medications: a cross-sectional study'. Irish Journal of Psychological Medicine, [DOI] [Details]
(2020) 'Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine'
Gerotziafas GT;Catalano M;Colgan MP;Pecsvarady Z;Wautrecht JC;Fazeli B;Olinic DM;Farkas K;Elalamy I;Falanga A;Fareed J;Papageorgiou C;Arellano RS;Agathagelou P;Antic D;Auad L;Banfic L;Bartolomew JR;Benczur B;Bernardo MB;Boccardo F;Cifkova R;Cosmi B;De Marchi S;Dimakakos E;Dimopoulos MA;Dimitrov G;Durand-Zaleski I;Edmonds M;El Nazar EA;Erer D;Esponda OL;Gresele P;Gschwandtner M;Gu Y;Heinzmann M;Hamburg NM;Hamadé A;Jatoi NA;Karahan O;Karetova D;Karplus T;Klein-Weigel P;Kolossvary E;Kozak M;Lefkou E;Lessiani G;Liew A;Marcoccia A;Marshang P;Marakomichelakis G;Matuska J;Moraglia L;Pillon S;Poredos P;Prior M;Salvador DRK;Schlager O;Schernthaner G;Sieron A;Spaak J;Spyropoulos A;Sprynger M;Suput D;Stanek A;Stvrtinova V;Szuba A;Tafur A;Vandreden P;Vardas PE;Vasic D;Vikkula M;Wennberg P;Zhai Z; ; (2020) 'Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine'. Journal Of Thrombosis And Haemostasis, [DOI] [Details]
(2020) 'Autologous bone marrow mesenchymal stromal cell therapy for no-option critical limb ischemia is limited by karyotype abnormalities'
Mohamed SA;Howard L;McInerney V;Hayat A;Krawczyk J;Naughton S;Finnerty A;Holohan M;Duffy A;Moloney T;Kavanagh E;Burke P;Liew A;Tubassam M;Walsh SR;O'Brien T; (2020) 'Autologous bone marrow mesenchymal stromal cell therapy for no-option critical limb ischemia is limited by karyotype abnormalities'. Cytotherapy, [DOI] [Details]
(2020) 'Assessing Global Frailty Scores: Development of a Global Burden of Disease-Frailty Index (GBD-FI)'
O'Donovan M;Sezgin D;Kabir Z;Liew A;O'Caoimh R; (2020) 'Assessing Global Frailty Scores: Development of a Global Burden of Disease-Frailty Index (GBD-FI)'. International Journal Of Environmental Research And Public Health, 17 (16) [DOI] [Details]
(2020) 'The effectiveness of intermediate care including transitional care interventions on function, healthcare utilisation and costs: a scoping review'
Sezgin, D;O'Caoimh, R;Liew, A;O'Donovan, MR;Illario, M;Salem, MA;Kennelly, S;Carriazo, AM;Lopez-Samaniego, L;Carda, CA;Rodriguez-Acuna, R;Inzitari, M;Hammar, T;Hendry, A (2020) 'The effectiveness of intermediate care including transitional care interventions on function, healthcare utilisation and costs: a scoping review'. European Geriatric Medicine, [DOI] [Details]
(2020) 'European Collaborative and Interprofessional Capability Framework for Prevention and Management of Frailty-a consensus process supported by the Joint Action for Frailty Prevention (ADVANTAGE) and the European Geriatric Medicine Society (EuGMS)'
Roller-Wirnsberger R;Lindner S;Liew A;O'Caoimh R;Koula ML;Moody D;Espinosa JM;van Durme T;Dimitrov P;Benjak T;Nicolaidou E;Hammar T;Vanhecke E;Junius-Walker U;Csizmadia P;Galluzzo L;Macijauskien¿ J;Salem M;Rietman L;Ranhoff AH;Targowski T;de Arriaga MT;Bozdog E;Gabrovec B;Hendry A;Martin FC;Rodriguez-Mañas L; (2020) 'European Collaborative and Interprofessional Capability Framework for Prevention and Management of Frailty-a consensus process supported by the Joint Action for Frailty Prevention (ADVANTAGE) and the European Geriatric Medicine Society (EuGMS)'. Aging Clinical and Experimental Research, [DOI] [Details]
(2020) 'Transitional palliative care interventions for older adults with advanced non-malignant diseases and frailty: a systematic review'
Duygu Sezgin, Anne Hendry, Aaron Liew, Mark O'Donovan, Mohamed Salem, Ana María Carriazo, Luz López-Samaniego, Rafael Rodríguez-Acuña, Siobhan Kennelly, Maddalena Illario, Cristina Arnal Carda, Marco Inzitari, Teija Hammar, Rónán O'Caoimh (2020) 'Transitional palliative care interventions for older adults with advanced non-malignant diseases and frailty: a systematic review'. Journal of Integrated Care, [DOI] [Details]
(2020) 'Defining the characteristics of intermediate care models including transitional care: an international Delphi study'
Sezgin, D;O'Caoimh, R;O'Donovan, MR;Salem, MA;Kennelly, S;Samaniego, LL;Carda, CA;Rodriguez-Acuna, R;Inzitari, M;Hammar, T;Holditchl, C;Bettger, JP;Vernon, M;Carroll, A;Gradinger, F;Perman, G;Wilson, M;Vella, A;Cherubini, A;Tucker, H;Fantini, MP;Onder, G;Roller-Wirnsberger, R;Gutierrez-Robledo, LM;Cesari, M;Bertoluci, P;Kieliszek, M;van der Vlegel-Brouwer, W;Nelson, M;Manas, LR;Antoniadou, E;Barriere, F;Lindblom, S;Park, G;Perez, I;Alguacil, D;Lowdon, D;Alkiza, ME;Bouzon, CA;Young, J;Carriazo, A;Liew, A;Hendry, A (2020) 'Defining the characteristics of intermediate care models including transitional care: an international Delphi study'. Aging Clinical and Experimental Research, [DOI] [Details]
(2020) 'Evidence of Inter-Professional and Multi-Professional Interventions for Geriatric Patients: A Systematic Review'
Elisabeth Platzer, Katrin Singler, Peter Dovjak, Gerhard Wirnsberger, Annemarie Perl, Sonja Lindner, Aaron Liew, Regina Elisabeth Roller-Wirnsberger (2020) 'Evidence of Inter-Professional and Multi-Professional Interventions for Geriatric Patients: A Systematic Review'. International Journal Of Integrated Care, 20 (1) [Details]
(2020) 'Thrombotic risk following video-assisted thoracoscopic surgery versus open thoracotomy: a systematic review and meta-analysis'
Spiezia L;Liew A;Campello E;Di Gregorio G;Zuin A;Simioni P; (2020) 'Thrombotic risk following video-assisted thoracoscopic surgery versus open thoracotomy: a systematic review and meta-analysis'. Interactive cardiovascular and thoracic surgery, [DOI] [Details]
(2020) 'The safety and efficacy of steroid treatment for acute spinal cord injury: A Systematic Review and meta-analysis'
Sultan I;Lamba N;Liew A;Doung P;Tewarie I;Amamoo JJ;Gannu L;Chawla S;Doucette J;Cerecedo-Lopez CD;Papatheodorou S;Tafel I;Aglio LS;Smith TR;Zaidi H;Mekary RA; (2020) 'The safety and efficacy of steroid treatment for acute spinal cord injury: A Systematic Review and meta-analysis'. Heliyon, 6 (2) [DOI] [Details]
(2020) 'The Efficacy of Prophylactic Negative Pressure Wound Therapy for Closed Incisions in Breast Surgery: A Systematic Review and Meta-Analysis'
Cagney D;Simmons L;O'Leary DP;Corrigan M;Kelly L;O'Sullivan MJ;Liew A;Redmond HP; (2020) 'The Efficacy of Prophylactic Negative Pressure Wound Therapy for Closed Incisions in Breast Surgery: A Systematic Review and Meta-Analysis'. World Journal Of Surgery, [DOI] [Details]
(2019) 'An Irish National Diabetes in Pregnancy Audit: aiming for best outcomes for women with diabetes'
Egan AM;Brassill MJ;Brosnan E;Carmody L;Clarke H;Coogan Kelly C;Culliney L;Durkan M;Fenlon M;Ferry P;Hanlon G;Higgins T;Hoashi S;Khamis A;Kinsley B;Kinsley T;Kirwan B;Liew A;McGurk C;McHugh C;Murphy MS;Murphy P;O'Halloran D;O'Mahony L;O'Sullivan E;Nolan M;Peter M;Roberts G;Smyth A;Todd M;Tuthill A;Wan Mahmood WA;Yousif O;P Dunne F; ; (2019) 'An Irish National Diabetes in Pregnancy Audit: aiming for best outcomes for women with diabetes'. Diabetic Medicine, [DOI] [Details]
(2019) 'The Effectiveness of Antiepileptic Medications as Prophylaxis of Early Seizure in Patients with Traumatic Brain Injury Compared with Placebo or No Treatment: A Systematic Review and Meta-Analysis'
Wat R;Mammi M;Paredes J;Haines J;Alasmari M;Liew A;Lu VM;Arnaout O;Smith TR;Gormley WB;Aglio LS;Mekary RA;Zaidi H; (2019) 'The Effectiveness of Antiepileptic Medications as Prophylaxis of Early Seizure in Patients with Traumatic Brain Injury Compared with Placebo or No Treatment: A Systematic Review and Meta-Analysis'. World neurosurgery, 122 [DOI] [Details]
(2019) 'Burden of disease, disability-adjusted life years and frailty prevalence'
O'Donovan MR;Sezgin D;Liew A;O'Caoimh R; (2019) 'Burden of disease, disability-adjusted life years and frailty prevalence'. Qjm-An International Journal Of Medicine, 112 (4) [DOI] [Details]
(2019) 'Non-pharmacological treatments for sleep disturbance in mild cognitive impairment and dementia: A systematic review and meta-analysis'
O'Caoimh R;Mannion H;Sezgin D;O'Donovan MR;Liew A;Molloy DW; (2019) 'Non-pharmacological treatments for sleep disturbance in mild cognitive impairment and dementia: A systematic review and meta-analysis'. Maturitas, 127 [DOI] [Details]
(2019) 'Pre-frailty as a multi-dimensional construct: A systematic review of definitions in the scientific literature'
Sezgin D;Liew A;O'Donovan MR;O'Caoimh R; (2019) 'Pre-frailty as a multi-dimensional construct: A systematic review of definitions in the scientific literature'. Geriatric Nursing (New York, N.Y.), [DOI] [Details]
(2019) 'Interventions to Promote Early Discharge and Avoid Inappropriate Hospital (Re)Admission: A Systematic Review'
Coffey A;Leahy-Warren P;Savage E;Hegarty J;Cornally N;Day MR;Sahm L;O'Connor K;O'Doherty J;Liew A;Sezgin D;O'Caoimh R; (2019) 'Interventions to Promote Early Discharge and Avoid Inappropriate Hospital (Re)Admission: A Systematic Review'. International Journal Of Environmental Research And Public Health, 16 (14) [DOI] [Details]
(2019) 'Defining frailty for healthcare practice and research: A qualitative systematic review with thematic analysis'
Sezgin D;O'Donovan M;Cornally N;Liew A;O'Caoimh R; (2019) 'Defining frailty for healthcare practice and research: A qualitative systematic review with thematic analysis'. International Journal Of Nursing Studies, 92 [DOI] [Details]
(2019) 'Integrated Care Models for Managing and Preventing Frailty: A Systematic Review for the European Joint Action on Frailty Prevention (ADVANTAGE JA)'
Hendry A;Vanhecke E;Carriazo AM;López-Samaniego L;Espinosa JM;Sezgin D;O'Donovan M;Hammar T;Ferry P;Vella A;Bacaicoa OA;Braga M;Ciutan M;Velivasi A;Lamprini Koula M;Van der Heyden J;Liew A;O'Caoimh R; (2019) 'Integrated Care Models for Managing and Preventing Frailty: A Systematic Review for the European Joint Action on Frailty Prevention (ADVANTAGE JA)'. Translational Medicine At Unisa, 19 [Details]
(2019) 'Computed Tomography Angiography Versus Digital Subtraction Angiography for Postclipping Aneurysm Obliteration Detection A Meta-Analysis'
Uricchio, M,Gupta, S,Jakowenko, N,Levito, M,Vu, N,Doucette, J,Liew, A,Papatheodorou, S,Khawaja, AM,Aglio, LS,Aziz-Sultan, MA,Zaidi, H,Smith, TR,Mekary, RA (2019) 'Computed Tomography Angiography Versus Digital Subtraction Angiography for Postclipping Aneurysm Obliteration Detection A Meta-Analysis'. Stroke, 50 :381-388 [DOI] [Details]
(2018) 'Thrombin Generation Profile in Patients With Steady State Peripheral Arterial Disease'
Liew A, Failla G, Molinari G, Prior M, Zalunardo B, Pergolini D, Knavs K, Kozak M, Cortelazzo A, Van Dreden P, Elalamy I, Catalano M, Gerotziafas GT. (2018) 'Thrombin Generation Profile in Patients With Steady State Peripheral Arterial Disease'. Clinical And Applied Thrombosis-Hemostasis, 24 (1):193-194 [DOI] [Details]
(2018) 'Prevalence of frailty at population level in European ADVANTAGE Joint Action Member States: a systematic review and meta-analysis'
O'Caoimh R;Galluzzo L;Rodríguez-Laso Á;Van der Heyden J;Ranhoff AH;Lamprini-Koula M;Ciutan M;López-Samaniego L;Carcaillon-Bentata L;Kennelly S;Liew A; ; (2018) 'Prevalence of frailty at population level in European ADVANTAGE Joint Action Member States: a systematic review and meta-analysis'. Annali dell'Istituto superiore di sanita, 54 (3) [DOI] [Details]
(2018) 'Population screening, monitoring and surveillance for frailty: three systematic reviews and a grey literature review'
Rodríguez-Laso Á;O'Caoimh R;Galluzzo L;Carcaillon-Bentata L;Beltzer N;Macijauskiene J;Albaina Bacaicoa O;Ciutan M;Hendry A;López-Samaniego L;Liew A; ; (2018) 'Population screening, monitoring and surveillance for frailty: three systematic reviews and a grey literature review'. Annali dell'Istituto superiore di sanita, 54 (3) [DOI] [Details]
(2018) 'Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE'
O'Caoimh R;Galluzzo L;Rodríguez-Laso Á;Van der Heyden J;Ranhoff AH;Carcaillon-Bentata L;Beltzer N;Kennelly S;Liew A; ; (2018) 'Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE'. Annali dell'Istituto superiore di sanita, 54 (3) [DOI] [Details]
(2018) 'Incidence of frailty: a systematic review of scientific literature from a public health perspective'
Galluzzo L;O'Caoimh R;Rodríguez-Laso Á;Beltzer N;Ranhoff AH;Van der Heyden J;Lamprini-Koula M;Ciutan M;López-Samaniego L;Liew A; ; (2018) 'Incidence of frailty: a systematic review of scientific literature from a public health perspective'. Annali dell'Istituto superiore di sanita, 54 (3) [DOI] [Details]
(2018) 'Gene therapy for peripheral arterial disease'
Forster R;Liew A;Bhattacharya V;Shaw J;Stansby G; (2018) 'Gene therapy for peripheral arterial disease'. Cochrane Database Of Systematic Reviews , 10 [DOI] [Details]
(2018) 'Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation'
Keighron C;Lyons CJ;Creane M;O'Brien T;Liew A; (2018) 'Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation'. Frontiers In Medicine, 5 [DOI] [Details]
(2018) 'The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1 beta'
Chambers, SEJ,O'Neill, CL,Guduric-Fuchs, J,McLoughlin, KJ,Liew, A,Egan, AM,O'Brien, T,Stitt, AW,Medina, RJ (2018) 'The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1 beta'. Stem Cells, 36 :834-843 [DOI] [Details]
(2018) 'Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody'
Liew, A,Baustian, C,Thomas, D,Vaughan, E,Sanz-Nogues, C,Creane, M,Chen, X,Alagesan, S,Owens, P,Horan, J,Dockery, P,Griffin, MD,Duffy, A,O'Brien, T (2018) 'Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody'. Cell Transplantation, 27 :1210-1221 [DOI] [Details]
(2018) 'KEY MESSAGES FOR A FRAILTY PREVENTION AND MANAGEMENT POLICY IN EUROPE FROM THE ADVANTAGE JOINT ACTION CONSORTIUM'
Manas, LR,Garcia-Sanchez, I,Hendry, A,Bernabei, R,Roller-Wirnsberger, R,Gabrovec, B,Liew, A,Carriazo, AM,Redon, J,Galluzzo, L,Vina, J,Antoniadou, E,Targowski, T,di Furia, L,Lattanzio, F,Bozdog, E,Telo, M,ADVANTAGE Joint Action Partners (2018) 'KEY MESSAGES FOR A FRAILTY PREVENTION AND MANAGEMENT POLICY IN EUROPE FROM THE ADVANTAGE JOINT ACTION CONSORTIUM'. Journal Of Nutrition Health & Aging, 22 :892-897 [DOI] [Details]
(2018) 'Screening For Pulmonary Hypertension With Multidetector Computed Tomography Among Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation'
O'Sullivan, CJ,Montalbetti, M,Zbinden, R,Kurz, DJ,Bernheim, AM,Liew, A,Meyer, MR,Tuller, D,Eberli, FR (2018) 'Screening For Pulmonary Hypertension With Multidetector Computed Tomography Among Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation'. Frontiers In Cardiovascular Medicine, 5 [DOI] [Details]
(2018) 'Epidemiology of peripheral artery disease in Europe: VAS Educational Paper'
Olinic, DM,Spinu, M,Olinic, M,Homorodean, C,Tataru, DA,Liew, A,Schernthaner, GH,Stanek, A,Fowkes, G,Catalano, M (2018) 'Epidemiology of peripheral artery disease in Europe: VAS Educational Paper'. International Angiology, 37 :327-334 [DOI] [Details]
(2017) 'Extended-duration versus short-duration pharmacological thromboprophylaxis in acutely Ill hospitalized medical patients: a systematic review and meta-analysis of randomized controlled trials'
Liew, AYL,Piran, S,Eikelboom, JW,Douketis, JD (2017) 'Extended-duration versus short-duration pharmacological thromboprophylaxis in acutely Ill hospitalized medical patients: a systematic review and meta-analysis of randomized controlled trials'. Journal Of Thrombosis And Thrombolysis, 43 :291-301 [DOI] [Details]
(2017) 'Focused parathyroidectomy versus open parathyroidectomy for primary hyperparathyroidism: a meta-analysis'
Jinih, M,O'Connell, E,O'leary, DP,Liew, A,Redmond, HP (2017) 'Focused parathyroidectomy versus open parathyroidectomy for primary hyperparathyroidism: a meta-analysis'. Ann Surg Oncol, [Details]
(2016) '4 risk assessment models had good calibration but poor discrimination for VTE in hospitalized medical patients'
Liew A;Douketis J; (2016) '4 risk assessment models had good calibration but poor discrimination for VTE in hospitalized medical patients'. Annals Of Internal Medicine, 165 (6) [DOI] [Details]
(2016) 'Portal vein thrombosis in patients with cirrhosis: underdiagnosis and undertreatment?'
Liew A;Douketis J; (2016) 'Portal vein thrombosis in patients with cirrhosis: underdiagnosis and undertreatment?'. Internal And Emergency Medicine, [DOI] [Details]
(2016) 'Catheter-directed thrombolysis for extensive iliofemoral deep vein thrombosis: review of literature and ongoing trials'
Liew A;Douketis J; (2016) 'Catheter-directed thrombolysis for extensive iliofemoral deep vein thrombosis: review of literature and ongoing trials'. Expert Review Of Cardiovascular Therapy, 14 (2) [DOI] [Details]
(2016) 'Can HbA1c detect undiagnosed diabetes in acute medical hospital admissions?'
Manley SE;O'Brien KT;Quinlan D;Round RA;Nightingale PG;Ali F;Durrani BK;Liew A;Luzio SD;Stratton IM;Roberts GA; (2016) 'Can HbA1c detect undiagnosed diabetes in acute medical hospital admissions?'. Diabetes Research & Clinical Practice, 115 [DOI] [Details]
(2016) 'Gene therapy for peripheral arterial disease (Protocol)'
Liew A, Bhattacharya V, Shaw J, Stansby G (2016) 'Gene therapy for peripheral arterial disease (Protocol)'. Cochrane Database Of Systematic Reviews, (1) [DOI] [Details]
(2015) 'New oral anticoagulants versus vitamin K antagonists for treatment of acute venous thromboembolism: do they really increase the incidence of myocardial infarction?'
Liew A;Piran S;Douketis J; (2015) 'New oral anticoagulants versus vitamin K antagonists for treatment of acute venous thromboembolism: do they really increase the incidence of myocardial infarction?'. Internal And Emergency Medicine, 10 (4) [DOI] [Details]
(2015) 'Cell Therapy for Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials'
Liew A, Bhattacharya V, Shaw J, Stansby G (2015) 'Cell Therapy for Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials'. Angiology, [DOI] [Details]
(2015) 'De Novo Donor-Specific HLA Antibodies Are Associated With Rapid Loss of Graft Function Following Islet Transplantation in Type 1 Diabetes'
Brooks AM, Carter V, Liew A, Marshall H, Aldibbiat A, Sheerin NS, Manas DM, White SA, Shaw JA (2015) 'De Novo Donor-Specific HLA Antibodies Are Associated With Rapid Loss of Graft Function Following Islet Transplantation in Type 1 Diabetes'. American Journal Of Transplantation, 15 (12):3239-3246 [DOI] [Details]
(2014) 'Approach to the new oral anticoagulants in family practice: part 1: comparing the options'
Douketis J;Bell AD;Eikelboom J;Liew A; (2014) 'Approach to the new oral anticoagulants in family practice: part 1: comparing the options'. Canadian family physician Medecin de famille canadien, 60 (11) [Details]
(2014) 'Approach to the new oral anticoagulants in family practice: part 2: addressing frequently asked questions'
Douketis J;Bell AD;Eikelboom J;Liew A; (2014) 'Approach to the new oral anticoagulants in family practice: part 2: addressing frequently asked questions'. Canadian family physician Medecin de famille canadien, 60 (11) [Details]
(2014) 'Efficacy and safety of warfarin vs. antiplatelet therapy in patients with systolic heart failure and sinus rhythm: a systematic review and meta-analysis of randomized controlled trials'
Liew AY;Eikelboom JW;Connolly SJ;O' Donnell M;Hart RG; (2014) 'Efficacy and safety of warfarin vs. antiplatelet therapy in patients with systolic heart failure and sinus rhythm: a systematic review and meta-analysis of randomized controlled trials'. International Journal Of Stroke, 9 (2) [DOI] [Details]
(2014) 'Mesenchymal Stromal Cell Therapy for Crohn's Disease'
Liew, A,O'Brien, T,Egan, L (2014) 'Mesenchymal Stromal Cell Therapy for Crohn's Disease'. Digestive Diseases, 32 :50-60 [DOI] [Details]
(2014) 'The Potential of Cell-based Therapy for Diabetes and Diabetes-related Vascular Complications'
Liew, A,O'Brien, T (2014) 'The Potential of Cell-based Therapy for Diabetes and Diabetes-related Vascular Complications'. Current Diabetes Reports, 14 [DOI] [Details]
(2014) 'Extended-duration new oral anticoagulants for venous thromboprophylaxis in patients undergoing total hip arthroplasty: a meta-analysis of the randomized controlled trials'
Liew, A,Eikelboom, JW,O'Donnell, M (2014) 'Extended-duration new oral anticoagulants for venous thromboprophylaxis in patients undergoing total hip arthroplasty: a meta-analysis of the randomized controlled trials'. Journal Of Thrombosis And Haemostasis, 12 :107-109 [DOI] [Details]
(2014) 'Comparing mortality in patients with atrial fibrillation who are receiving a direct-acting oral anticoagulant or warfarin: a meta-analysis of randomized trials'
Liew, A,O'Donnell, M,Douketis, J (2014) 'Comparing mortality in patients with atrial fibrillation who are receiving a direct-acting oral anticoagulant or warfarin: a meta-analysis of randomized trials'. Journal Of Thrombosis And Haemostasis, 12 :1419-1424 [DOI] [Details]
(2013) 'Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model'
O'Loughlin A, Kulkarni M, Vaughan EE, Creane M, Liew A, Dockery P, Pandit A, O'Brien T (2013) 'Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model'. Stem Cell Research & Therapy, 4 (6) [DOI] [Details]
(2013) 'Perioperative management of patients who are receiving a novel oral anticoagulant'
Liew A;Douketis J; (2013) 'Perioperative management of patients who are receiving a novel oral anticoagulant'. Internal And Emergency Medicine, 8 (6) [DOI] [Details]
(2013) 'Is there a role for novel oral anticoagulants in patients with an acute coronary syndrome? A review of the clinical trials'
Liew A;Darvish-Kazem S;Douketis JD; (2013) 'Is there a role for novel oral anticoagulants in patients with an acute coronary syndrome? A review of the clinical trials'. Polskie Archiwum Medycyny Wewnetrznej, 123 (11) [Details]
(2013) 'Assessment of Anticoagulation Intensity and Management of Bleeding With Old and New Oral Anticoagulants'
Liew, A,Eikelboom, JW,O'Donnell, M,Hart, RG (2013) 'Assessment of Anticoagulation Intensity and Management of Bleeding With Old and New Oral Anticoagulants'. Canadian Journal Of Cardiology, 29 :34-44 [DOI] [Details]
(2013) 'Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury'
Riegler, J,Liew, A,Hynes, SO,Ortega, D,O'Brien, T,Day, RM,Richards, T,Sharif, F,Pankhurst, QA,Lythgoe, MF (2013) 'Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury'. Biomaterials, 34 :1987-1994 [DOI] [Details]
(2013) 'Initial and long-term treatment of deep venous thrombosis: recent clinical trials and their impact on patient management'
Liew A;Douketis J; (2013) 'Initial and long-term treatment of deep venous thrombosis: recent clinical trials and their impact on patient management'. Expert opinion on pharmacotherapy, 14 (4) [DOI] [Details]
(2013) 'Robust, Efficient, and Practical Electrogene Transfer Method for Human Mesenchymal Stem Cells Using Square Electric Pulses'
Liew, A,Andre, FM,Lesueur, LL,De Menorval, MA,O'Brien, T,Mir, LM (2013) 'Robust, Efficient, and Practical Electrogene Transfer Method for Human Mesenchymal Stem Cells Using Square Electric Pulses'. Human Gene Therapy Methods, 24 :289-297 [DOI] [Details]
(2012) 'Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia'
Liew A;O'Brien T; (2012) 'Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia'. Stem Cell Research & Therapy, 3 (4) [DOI] [Details]
(2012) 'Randomized controlled trials of new oral anticoagulants for stroke prevention in atrial fibrillation'
Liew, A,Eikelboom, JW,O'Donnell, M (2012) 'Randomized controlled trials of new oral anticoagulants for stroke prevention in atrial fibrillation'. Current Opinion In Cardiology, 27 :331-339 [DOI] [Details]
(2012) 'Pretreatment of Endothelial Progenitor Cells With Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'
Vaughan, EE,Liew, A,Mashayekhi, K,Dockery, P,McDermott, J,Kealy, B,Flynn, A,Duffy, A,Coleman, C,O'Regan, A,Barry, FP,O'Brien, T (2012) 'Pretreatment of Endothelial Progenitor Cells With Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'. Cell Transplantation, 21 :1095-1107 [DOI] [Details]
(2011) 'The prevalence of adrenal incidentaloma in routine clinical practice'
Davenport C;Liew A;Doherty B;Win HH;Misran H;Hanna S;Kealy D;Al-Nooh F;Agha A;Thompson CJ;Lee M;Smith D; (2011) 'The prevalence of adrenal incidentaloma in routine clinical practice'. Endocrine, 40 (1) [DOI] [Details]
(2011) 'Developing Cell-Specific Antibodies to Endothelial Progenitor Cells Using Avian Immune Phage Display Technology'
Bowes, T;Hanley, SA;Liew, A;Eglon, M;Mashayekhi, K;O'Kennedy, R;Barry, F;Taylor, WR;O'Brien, T;Griffin, MD;Finlay, WJJ;Greiser, U (2011) 'Developing Cell-Specific Antibodies to Endothelial Progenitor Cells Using Avian Immune Phage Display Technology'. Journal of biomolecular screening, 16 :744-754 [DOI] [Details]
(2010) 'Central pontine myelinolysis secondary to hypokalaemic nephrogenic diabetes insipidus'
Davenport C;Liew A;Vic Lau P;Smith D;Thompson CJ;Kearns G;Agha A; (2010) 'Central pontine myelinolysis secondary to hypokalaemic nephrogenic diabetes insipidus'. Annals Of Clinical Biochemistry, 47 (Pt 1) [DOI] [Details]
(2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'
Kealy, B,Liew, A,McMahon, JM,Ritter, T,O'Doherty, A,Hoare, M,Greiser, U,Vaughan, EE,Maenz, M,O'Shea, C,Barry, F,O'Brien, T (2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'. Tissue Engineering Part C-Methods, 15 :223-231 [DOI] [Details]
(2009) 'A case of progressive hypertension preceding gemcitabine-associated thrombotic microangiopathy complicated by acute kidney injury and stroke'
Phelan PJ;Liew A;Magee C; (2009) 'A case of progressive hypertension preceding gemcitabine-associated thrombotic microangiopathy complicated by acute kidney injury and stroke'. Renal failure, 31 (8) [DOI] [Details]
(2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'
Kealy, B;Liew, A;McMahon, JM;Ritter, T;O'Doherty, A;Hoare, M;Greiser, U;Vaughan, EE;Maenz, M;O'Shea, C;Barry, F;O'Brien, T (2009) 'Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells'. Tissue Engineering Part C-Methods, 15 :223-231 [DOI] [Details]
(2008) 'Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or Pandora's box?'
Liew A;McDermott JH;Barry F;O'Brien T; (2008) 'Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or Pandora's box?'. Diabetes Obesity & Metabolism, 10 (5) [DOI] [Details]
(2008) 'Is hypopituitarism predictable after traumatic brain injury?'
Liew A;Thompson CJ; (2008) 'Is hypopituitarism predictable after traumatic brain injury?'. Nature Clinical Practice. Endocrinology & Metabolism, 4 (3) [DOI] [Details]
(2008) 'Clinical insights into the safety and utility of the insulin tolerance test (ITT) in the assessment of the hypothalamo-pituitary-adrenal axis'
Finucane FM, Liew A, Thornton E, Rogers B, Tormey W, Agha A. (2008) 'Clinical insights into the safety and utility of the insulin tolerance test (ITT) in the assessment of the hypothalamo-pituitary-adrenal axis'. Clin Endocrinol (Oxf), 69 (4):603-607 [DOI] [Details]
(2006) 'Endothelial progenitor cells: diagnostic and therapeutic considerations'
Liew, A,Barry, F,O'Brien, T (2006) 'Endothelial progenitor cells: diagnostic and therapeutic considerations'. Bioessays, 28 :261-270 [DOI] [Details]
(2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'
Duffy A, Liew A, O'Sullivan J, Avalos G, Samali A, O'Brien T (2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'. Endothelium, 13 (1):9-16 [DOI] [Details]
(2006) 'The role of the combined diabetic nephropathy clinic'
McDermott, J., Liew, A., Dunne, F. & Lappin, D. (2006) 'The role of the combined diabetic nephropathy clinic'. DiabetesWise, [Details]
(2004) 'Conventional glucocorticoid replacement overtreats adult hypopituitary patients with partial ACTH deficiency'
Agha A, Liew A, Finucane F, Baker L, O'Kelly P, Tormey W, Thompson CJ. (2004) 'Conventional glucocorticoid replacement overtreats adult hypopituitary patients with partial ACTH deficiency'. Clin Endocrinol (Oxf), 60 (6):688-693 [DOI] [Details]
(2002) 'The expression of p53, p21, Bax and induction of apoptosis in normal volunteers in response to different doses of ultraviolet radiation'
Murphy M;Mabruk MJ;Lenane P;Liew A;McCann P;Buckley A;Billet P;Leader M;Kay E;Murphy GM; (2002) 'The expression of p53, p21, Bax and induction of apoptosis in normal volunteers in response to different doses of ultraviolet radiation'. British Journal Of Dermatology, 147 (1) [DOI] [Details]
(2002) 'Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation'
Murphy M;Mabruk MJ;Lenane P;Liew A;McCann P;Buckley A;O Flatharta C;Hevey D;Billet P;Robertson W;Javed S;Leader M;Kay E;Murphy GM; (2002) 'Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation'. Journal Of Clinical Pathology, 55 (11) [Details]

Reviews

  Year Publication
(2020) Evidence of Inter-Professional and Multi-Professional Interventions for Geriatric Patients: A Systematic Review.
Platzer, E;Singler, K;Dovjak, P;Wirnsberger, G;Perl, A;Lindner, S;Liew, A;Roller-Wirnsberger, RE (2020) Evidence of Inter-Professional and Multi-Professional Interventions for Geriatric Patients: A Systematic Review. LONDON: Reviews [DOI] [Details]

Teaching Interests

1) Senior Lecturer in Endocrinology at National University of Ireland, Galway (NUIG)
2) Medical trainer in 
Portiuncula University Hospital for:
a) Senior House Officer in Basic Specialist Training (Internal Medicine) 
b) Senior House Officer in General Practice Scheme (Internal Medicine)
c) Medical Intern Scheme
3) Research supervisor for Master Thesis

Postgraduate students:

MSc in Clinical Research (NUIG)
2020 Dr. Yogesh Acharya
2020 Mr. Mark O'Donovan (Co-supervision with Dr Rónán O'Caoimh)
2019 Dr. Shereen Mohamed Saleh Esmael
2018 Dr. Muniza Satti
2018 Dr. Ciara de Buitleir
2017 Ms. Michelle Conboy

MSc of Multidisciplinary Radiology (NUIG) 
2018 Dr. Arlene Weir (Co-supervision with Prof. Peter McCarthy)

MSc in Regenerative Medicine (NUIG)
2011 Dr. Rory Durcan

Prospective candidates can discuss their proposed PhD/MD/MSc projects and potential funding opportunities by email: aaron.liew@nuigalway.ie