Miss Clara Sanz Nogues

M.Sc

Contact Details

Post Doctoral Researcher
REMEDI
Bioscience building
NUI Galway
E: CLARA.SANZNOGUES@nuigalway.ie
 
researcher
 

Biography

Clara has a BSc Biotechnology from the Polytechnic University of Valencia (Spain) (2010), a MSc in Clinical Research from the University of Galway (2018), and a PhD in Medicine from the University of Galway (2015). Her research focuses on developing novel mesenchymal stromal cell (MSC)-based therapies for treating diabetic health complications. 

Research Interests

  • Mesenchymal stromal cell therapy
  • Translational research
  • Diabetes health complications
  • Skeletal muscle ischaemia
  • Muscle wasting
  • microRNAs
  • Biomaterials

Peer Reviewed Journals

  Year Publication
(2021) 'When Origin Matters: Properties of Mesenchymal Stromal Cells From Different Sources for Clinical Translation in Kidney Disease'
Sandra Calcat-I-Cervera, Clara Sanz-Nogués, Timothy O'Brien (2021) 'When Origin Matters: Properties of Mesenchymal Stromal Cells From Different Sources for Clinical Translation in Kidney Disease'. Frontiers In Medicine, eCollection 2021 [DOI] [Details]
(2021) 'Validation of ERICVA Risk Score as a Predictor of One Year Amputation-Free Survival of Patients with Critical Limb Ischemia'
Mohamed SA;Viknaswaran NL;Doran J;Sanz-Nogués C;Ahmed K;Howard L;Tubassam M;O'Brien T;Walsh SR; (2021) 'Validation of ERICVA Risk Score as a Predictor of One Year Amputation-Free Survival of Patients with Critical Limb Ischemia'. Annals Of Vascular Surgery, [DOI] [Details]
(2020) 'Knowledge, Perceptions and Concerns of Diabetes -Associated Complications Among Individuals Living with Type 1 and Type 2 Diabetes Mellitus'
Sanz-Nogués C;Mustafa M;Burke H;O'Brien T;Coleman CM; (2020) 'Knowledge, Perceptions and Concerns of Diabetes -Associated Complications Among Individuals Living with Type 1 and Type 2 Diabetes Mellitus'. Healthcare (Basel, Switzerland), 8 (1) [DOI] [Details]
(2020) 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'
Galbraith AS;Sanz-Nogués C;Glynn S;Coleman CM;Murphy C; (2020) 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'. Journal Of Orthopaedic Research, 38 (4):834-842 [DOI] [ARAN Link] [Details]
(2018) 'Anti-Donor Antibody Induction Following Intramuscular Injections of Allogeneic Mesenchymal Stromal Cells'
Alagesan, S., Sanz-Nogués, C., Chen, X-Z, Creane, M., Ritter, T., Ceredig, R., O'Brien, T., Griffin, M. (2018) 'Anti-Donor Antibody Induction Following Intramuscular Injections of Allogeneic Mesenchymal Stromal Cells'. Immunol Cell Biol, [DOI] [Details]
(2018) 'Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody'
Liew, A,Baustian, C,Thomas, D,Vaughan, E,Sanz-Nogues, C,Creane, M,Chen, X,Alagesan, S,Owens, P,Horan, J,Dockery, P,Griffin, MD,Duffy, A,O'Brien, T (2018) 'Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody'. Cell Transplantation, 27 :1210-1221 [DOI] [Details]
(2016) 'In vitro models for assessing therapeutic angiogenesis'
Sanz-Nogués C;O'Brien T; (2016) 'In vitro models for assessing therapeutic angiogenesis'. Drug Discovery Today, 21 (9) [DOI] [ARAN Link] [Details]
(2015) 'Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells'
Sanz-Nogués C;Horan J;Thompson K;Howard L;Ryan G;Kassem M;O'Brien T; (2015) 'Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells'. Journal Of Biomedical Materials Research Part A, 103 (11) [DOI] [ARAN Link] [Details]
(2014) 'A shape-controlled tuneable microgel platform to modulate angiogenic paracrine responses in stem cells'
Thomas D;Fontana G;Chen X;Sanz-Nogués C;Zeugolis DI;Dockery P;O'Brien T;Pandit A; (2014) 'A shape-controlled tuneable microgel platform to modulate angiogenic paracrine responses in stem cells'. Biomaterials, 35 (31) [DOI] [Details]
(2014) 'MSCs isolated from patients with ischemic vascular disease have normal angiogenic potential'
Sanz-Nogués C;O'Brien T; (2014) 'MSCs isolated from patients with ischemic vascular disease have normal angiogenic potential'. Molecular Therapy : The Journal Of The American Society Of Gene Therapy, 22 (11) [DOI] [Details]

Book Chapters

  Year Publication
(2013) 'Stem cell microencapsulation for therapeutic angiogenesis'
C. Sanz-Nogues, D. Thomas, A. Pandit, T. O'Brien (2013) 'Stem cell microencapsulation for therapeutic angiogenesis' In: Biomaterials for stem cell therapy. State of the art and vision for the future. :386-423 Florida: CRC Press. [Details]

Conference Publications

  Year Publication
(2022) International Society of Cell and Gene Therapy
17. Keane AJ, Sanz-Nogués C, Lyons CJ, Jayasooriya D, Goljanek-Whysall K, O¿Brien T. (2022) miR-1, miR-133A and miR-29b are potential regulators of skeletal muscle pathology in critical limb ischemia International Society of Cell and Gene Therapy [Details]
(2022) International Society of Cell and Gene Therapy
16. Sanz-Nogués C. Keane AJ, Chen X, Horan E, Creane M, Lyons C.J, Elliman E.J, Goljanek-Whysall K, O¿Brien T. (2022) Anti-CD362+ Selected Human Umbilical Cord-Derived Mesenchymal Stromal Cells Ameliorate Skeletal Muscle Damage Induced by Ischemia International Society of Cell and Gene Therapy [Details]
(2022) Irish Endocrine Society (IES) Annual Meeting
Sanz-Nogués C, Keane A, Creane M, Hynes S.O, Chen X, Horan E, Lyons CJ., Elliman SJ, Goljanek-Whysall K, O¿Brien T. (2022) Human Umbilical Cord-Derived Mesenchymal Stromal Cells Ameliorate Skeletal Muscle Damage Induced by Ischaemia Irish Endocrine Society (IES) Annual Meeting [Details]
(2018) International Society for Cell and Gene Therapy
Sanz-Nogués C, Chao J, O’Flynn L, Horan E, Chen X, Creane M, Elliman SJ, O’Brien T. (2018) Human umbilical cord-derived CD362+ mesenchymal stromal cells (ORBCEL-CTM) Improve skeletal muscle regeneration after ischemia injur International Society for Cell and Gene Therapy [Details]
(2017) International Society for Cell and Gene Therapy
Sanz-Nogués C. O’Flynn L, Costello P, Creane M., Elliman SJ, O’Brien T (2017) Angiogenic assessment of ORBCELTM, a novel stromal cell population for treating Critical Limb Ischaemia (CLI) International Society for Cell and Gene Therapy [DOI] [Details]
(2015) TERMIS world congress
Sanz-Nogués C. Alagesan S, Creane M, Conroy C, Chen X, Dockery P, Griffin M and O’Brien T. (2015) Tacrolimus co-administration suppresses anti-donor immune response to allogeneic MSCs but does not influence disease severity in a mouse model of HLI TERMIS world congress Boston, US, [Details]
(2014) International Society for Cell and Gene Therapy
Sanz-Nogués C, Horan J, Ryan G, Kassem M, O’Brien T. (2014) Encapsulation of human mesenchymal stem cells in sodium cellulose sulfate-based microcapsules requires immortalization International Society for Cell and Gene Therapy [Details]

Other Journals

  Year Publication
(2021) 'Current good manufacturing practice considerations for mesenchymal stromal cells as therapeutic agents'
Clara Sanz-Nogues and Timothy O'Brien (2021) 'Current good manufacturing practice considerations for mesenchymal stromal cells as therapeutic agents' Biomaterials and Biosystems, 2 . [DOI] [ARAN Link] [Details]
(2014) 'Macromolecular Crowding: The Next Frontier in Tissue Engineering'
P. Kumar, A. Satyam, D. Gaspar, D. Cigognini, C. Sanz-Nogués, T. O’Brien, A. Pandit, D. Zeugolis (2014) 'Macromolecular Crowding: The Next Frontier in Tissue Engineering' Advances in Science and Technology, 96 :1-8. [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2022 School of Medicine Early-Stage Researcher Support Fund 2022 University of Galway, Ireland
2021 AURORA Women¿s Leadership Development program University of Galway
2021 Athena SWAN Mid-Career Post-Doctoral Researcher Research Capacity Building Grant University of Galway
2016 Further Education Policy Scheme University of Galway, Ireland
2014 ALIVE Award University of Galway, Ireland
2012 First award Synergy Project 2012 University Poster Award at the College of Medicine, Nursing and Health Science, University of Galway, Ireland. University go Galway, Ireland
2010 best Research Graduation Project at the School of Agricultural engineering and environment, Polytechnic University of Valencia, Spain. Polytechnic University of Valencia, Spain.

Committees

  Committee Function From / To
Irish Research Staff Association Committee Member 01-SEP-22 / 28-FEB-23
School of Medicine Equality, Diversity and Inclusion (EDI) at the University of Galway (Ireland). Committee member, woking in the Culture Group. 01-MAY-22 / 28-FEB-23
College of Medicine, Nursing & Health Science (CMNHS) Research Ethics Committee at the University of Galway (Ireland) Reviewing applications and providing feedback to students. Approving applications. 01-JAN-21 / 01-JAN-23

Employment

  Employer Position From / To
University of Galway, Ireland Post-doctoral researcher 01-NOV-14 / 31-DEC-16
University of Galway, Ireland Post-Doctoral Researcher 31-AUG-21 / 31-AUG-23
University of Galway, Ireland Post-doctoral Researcher 01-JAN-17 / 31-DEC-18
University of Galway, Ireland Post-Doctoral Researcher 01-MAY-19 / 31-AUG-21
University of Galway, Ireland Post-Doctoral Researcher 01-JUL-09 / 31-MAY-10
University of Galway, Ireland Post-Doctoral Researcher 01-JAN-19 / 30-APR-19

Education

  Year Institution Qualification Subject
2015 University of Galway, Ireland PhD in Medicine Development of Next Generation Mesenchymal Stem Cell Therapeutics for Critical Limb Ischemia (CLI).
2010 Polytechnic University of Valencia (Spain) BSc in Biotechnology Biotechnology
2018 University of Galway, Ireland MSc in Clinical Research Clinical Research

Languages

  Language
English
Spanish

Community Engagement

  Title Type From / To
Research (e.g. Community based research) Engagement with individuals living with type I and type II diabetes and health care professionals /
Outreach Beach Cleaning Event /
Teaching (e.g. Service learning / comunity based learning) Transition year student mentoring, Galway /
Outreach Cell Explorers Fantastic DNA activity /
Teaching (e.g. Service learning / comunity based learning) Scientific writing for lay audience /
Outreach 2016 Patient information leaflet entitled `Diabetes Mellitus & Bone Health¿ /

Reviews

  Journal Role
Clinics And Practice Reviewer
Frontiers In Immunology Reviewer
Nutrients Reviewer
International Journal Of Environmental Research And Public Health Reviewer
Stem Cell Research & Therapy Reviewer

Teaching Interests

- Toxicology and Biodistribution Studies
- Stem Cell Potency Testing
- Preclinical studies for regenerative therapies
Investigational New Drug (IND) application dossier 
- Designing research projects for undergraduate and MSc students, detailed in supervisory activities, evaluation of a thesis, providing constructive feedback and submitting a supervisor¿s final report of student effort in the laboratory.
- Evaluation of poster and oral presentations, providing constructive feedback, marking achievement.

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2014 Callum Conroy Msc Y
2015 Timour Kaliyev Msc Y
2018 Tina Zhang Msc Y
2017 John Brennan Msc Y
2018 Jack Brady Msc Y
2022 Laura Fagan Msc Y