Dr. Howard Oliver Fearnhead PhD
Contact Details
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Biography:
| In 1991 Dr Fearnhead completed a BSc. in Pharmacology and Toxicology at the London School of Pharmacy, before completing a PhD. in apoptosis at the MRC-Toxicology Centre, Leicester, UK in 1995. In 1999 Dr Fearnhead completed a post-doctoral fellowship at Cold Spring Harbor Laboratory, NY before moving to the National Cancer Institute in Maryland as a tenure track principle investigator. In 2004 Dr Fearnhead moved to the National Centre of Biomedical Engineering Science (NCBES), National University of Ireland, Galway (http://www.nuigalway.ie/ncbes) and in 2006 was appointed a lecturer in Pharmacology and Therapeutics (http://www.nuigalway.ie/pharmacology). |
Peer Reviewed Journals
| Ormerod, M. G., Sun, X. M., Snowden, R. T., Davies, R., Fearnhead, H. O. & Cohen, G. M. (1993) 'Increased membrane permeability of apoptotic thymocytes: a flow cytometric study'. Cytometry, 14 :595-602. [Details] |
| Fearnhead, H. O., Chwalinski, M., Snowden, R. T., Ormerod, M. G. & Cohen, G. M. (1994) 'Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle'. Biochemical Pharmacology, 48 :1073-1079. [Details] |
| Cohen G. M., X.M.Sun, X. M., Fearnhead, H. O., MacFarlane, M., Brown, D. G., Snowden, R. T. & Dinsdale, D. (1994) 'Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes'. Journal of Immunology, 153 :507-516. [Details] |
| Norbury, C., MacFarlane, M., Fearnhead, H. & Cohen, G. M. (1994) 'Cdc2 activation is not required for thymocyte apoptosis'. Biochemical & Biophysical Research Communications, 202 :1400-1406. [Details] |
| Fearnhead, H. O., Dinsdale, D. & Cohen, G. M. (1995) 'An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes'. FEBS Letters, 375 :283-288. [Details] |
| Fearnhead, H. O., MacFarlane, M., Dinsdale, D. and Cohen, G. M. (1995) 'DNA degradation and proteolysis in thymocyte apoptosis'. Toxicology Letters, :135-83141. [Details] |
| Zhu, H., Fearnhead, H. O. & Cohen, G. M. (1995) 'An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells'. FEBS Letters, 374 :303-308. [Details] |
| Fearnhead, H. O., Rivett, A. J., Dinsdale, D. and Cohen, G. M. (1995) 'A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli'. EMBO Journal/ FEBS Letters, 357 :242-246. [Details] |
| Cohen, G. M., MacFarlane, M., Fearnhead, H. O., Sun, X. M. and Dinsdale, D. (1995) 'Mechanisms of Cell Death, with Particular Reference to Apoptosis'. Molecular and Cellular Mechanisms of Toxicity, . [Details] |
| Faleiro, L., Kobayashi, R., Fearnhead, H. O. and Lazebnik, Y. A. (1997) 'Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells'. 16 :2271-2281. [Details] |
| Fearnhead, H. O., McCurrach, M. E., O'Neill, J., Zhang, K., Lowe, S. W. and Lazebnik, Y. A. (1997) 'Oncogene-dependent apoptosis in extracts from drug-resistant cells'. Genes and Development, 11 :1266-1276. [Details] |
| Fearnhead, H. O., Rodriguez, J., Govek, E., Guo, W., Kobayashi, R., Hannon, G. and Lazebnik, Y. A. (1998) 'Oncogene-dependent caspase activation is mediated by caspase-9'. Proceedings of the National Academy of Sciences, 95 :13664-13669. [Details] |
| Fearnhead, H. O. (2001) 'Cell-free systems to study apoptosis'. Methods in Cell Biology, 66 :167-185. [Details] |
| Richter, B. W. M., Mir, S. S., Eiben, L. J., Lewis, J., Berkey Reffey, S., Frattini, A., Tian, L., Frank, S., Youle, R. J., Nelson, D. L., Notarangelo, L. D., Vezzoni, P., Fearnhead, H. O. and Duckett, C. S. (2001) 'Molecular Cloning of ILP-2, a novel member of the Inhibitor of Apoptosis Protein family'. 13 :4292-4301. [Details] |
| Martin, A. G. and Fearnhead, H. O. (2002) 'Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis'. Journal of Biological Chemistry, . [Details] |
| Davydov, I. V., Woods, D., Safiran, Y. J., Oberoi, P., Fearnhead, H. O., Fang, S., Jensen, J., Weissman, A. M. , Kenten, J. H. and Vousden, K. H. (2004) 'Assay for ubiquitin Ligase activity: High Throughput screen for inhibitors of MDM2'. Journal of Biomolecular Screening, 8 :695-703. [Details] |
| Fearnhead, H. O. (2004) 'Getting Back on Track, or What to Do When Apoptosis Is De-Railed: Recoupling Oncogenes to the Apoptotic Machinery'. Cancer Biology & Therapy, 3 (1):21-28. [Details] |
| Martin, A. G., Nguyen, J., Wells, J. and Fearnhead, H. O. (2004) 'Apo cytochrome c inhibits caspases by preventing apoptosome formation'. Biochemical & Biophysical Research Communications 2, 319 (3):944-950. [Details] |
| Malet, G., Martin, A. G., Orzaez, M., Vicent, M. J., Masip, I., Sanclimens, G., Ferrer-Montiel, A., Mingarro, I., Messeguer, A., Fearnhead, H. O. & Perez-Paya, E. (2005) 'Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis'. Cell Death Differ, . [Details] |
| Chandra, D., Bratton, S. B., Person, M. D., Tian, Y., Martin, A. G., Ayres, M., Fearnhead, H. O., Gandhi, V. and Tang, D. G. (2006) 'Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome'. Cell, 125 :1333-1346. [Details] |
| Samali, A., O'Mahony, M., Reeve, J., Logue, S, Svegezdi, E, McMahon, J. & Fearnhead, H. O. (2006) 'Identification of an inhibitor of caspase activation from heart extracts: ATP blocks apoptosome activation'. Apoptosis, 12 (3):465-474. [Details] |
| Samali, A., O'Mahony, M., Reeve, J., Logue, S, Svegezdi, E, McMahon, J. : Fearnhead, H.O* (2006) 'Identification of an inhibitor of caspase activation from heart extracts: ATP blocks apoptosome activation. . (2006)'. Apoptosis, 12 (3):465-474. [Details] |
| Howley B, Fearnhead HO (2008) 'Caspases as therapeutic targets'. J Cell Mol Med Review, 12 (5a):1502-1516. [Details] |
| Murray, T.V.,McMahon, J.M.,Howley, B.A, Stanley A, Ritter T, Mohr A, Zwacka R, Fearnhead HO (2008) 'A non-apoptotic role for caspase-9 in muscle differentiation'. J Cell Sci, 121 (pt 22):3786-3793. [DOI] [Details] |
| Howley, B. & Fearnhead, H. O. (2008) 'Caspases as therapeutic targets'. Journal of Cellular & Molecular Medicine, . [Details] |
| Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB. (2009) 'The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer'. EMBO J, 28 (13):1916-1925. [DOI] [Details] |
| kappa B. Martin AG, Trama J, Crighton D, Ryan KM, Fearnhead HO (2009) 'Activation of p73 and induction of Noxa by DNA damage requires NF-'. Aging, 1 (3):275-349. [Details] |
| Fabian Z, O’Brien P, Pajęcka K, Fearnhead HO* (2009) 'TPCK-induced apoptosis and labelling of the largest subunit of RNA polymerase II in Jurkat cells. '. Apoptosis, 14 (10):1154-1164. [DOI] [Details] |
| Fearnhead, O. (2010) 'TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase. Fabian Z, Fearnhead HO*'. Biochem Biophys Res Commun, 395 (4):458-464. [DOI] [Details] |
| NFkappaB. O'Prey J, Crighton D, Martin AG, Vousden KH, Fearnhead HO, Ryan KM. (2010) 'p53-mediated induction of Noxa and p53AIP1 requires'. Cell Cycle, 9 (5):947-952. [Details] |
Invited papers
| Fearnhead (2004) Oncogene dependent caspase activation. MRC Toxicology Unit, University of Leicester. Invited papers [Details] |
| Fearnhead, H (2005) Oncogene dependent caspase activation. NA Rockville, Maryland, USA. Invited papers [Details] |
| Fearnhead, H (2005) Oncogene dependent caspase activation. Univeristy of Texas, Austin. Invited papers [Details] |