Research Interests

My research has centred on preclinical animal models of depression, most particularly investigating the olfactory bulbectomized and whether this myriad of changes associated with this model can be attenuated by chronic treatment with antidepressants, both established and novel treatments. This research has demonstrated how valuable the integrated approach can be in ascertaining interactions between behavioural, physiological, neurochemical and immune changes. A similar approach has been taken with other animal models under my direction, such as the Forced Swim Test and lipopolysaccharide models. This research has resulted in over 100 peer-reviewed publications. More recently, I have become interested in exploring the integrative nature of my research in the realms of antinociceptive properties of psychotropic drugs.

 

Books

Dr John Patrick Kelly (2010) Principles of CNS Drug Development: From Test Tube to Patient Wiley UK. [Details]

   

Peer Reviewed Journals

Song, C., Kelly, J. and Leonard, B.E. (1993) 'Is the state of leucocyte adhesiveness/aggregation an immune marker of stress in the olfactory bulbectomized rat?'. Stress Medicine, 9 :255-258. [Details]

Nsimba, S.E.D, Kelly, J.P. and Leonard, B.E. (1994) 'Dose-dependent behavioural effects of phencyclidine (PCP)'. Medical Science Research, 22 :207-209. [Details]

Nsimba, S.E.D, Kelly, J.P. and Leonard, B.E. (1994) 'Effects of acute phencyclidine (PCP) on different routes of administration on behavioural parameters in rats'. Medical Science Research, 22 :399-401. [Details]

Song, C., Kelly, J.P. and Leonard, B.E. (1994) 'Alterations in immune and endocrine parameters following olfactory bulbectomy'. Medical Science Research, 22 :593-595. [Details]

KELLY, JP,LEONARD, BE (1994) 'THE EFFECT OF TIANEPTINE AND SERTRALINE IN 3 ANIMAL-MODELS OF DEPRESSION'. Neuropharmacology, 33 :1011-1016. [Details]

Song, C., Kelly, J.P. and Leonard, B.E. (1994) 'The effect of stressful behavioural exposure on endocrine and immune parameters in the rat'. Stress Medicine, 10 :239-245. [Details]

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1995) 'Effects of olfactory bulbectomy and chronic amitriptyline treatment on phencyclidine (PCP)-induced hyperactivity'. Medical Science Research, 23 :351-352. [Details]

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1995) 'Effects of chronic antidepressant administration on the conditioned taste aversion to 8-OHDPAT in the olfactory bulbectomised rat model of depression'. Medical Science Research, 23 :487-488. [Details]

O’Neill, M., Caldwell, M., Earley, B., Canney, M., O’Halloran, A., Kelly, J., Leonard, B.E. and Junien, J.L. (1995) 'The  receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia'. European Journal Of Pharmacology, 283 :217-225. [Details]

MacSweeney, C.P., Kelly, J.P. and Leonard, B.E. (1995) 'The influence of route of administration on the diabetogenic effects of streptozotocin in the rat'. Medical Science Research, 23 :811-812. [Details]

Caldwell, M., O'Neill, M., Earley, B., Kelly, J.P. and Leonard, B.E. (1995) 'NG-Nitro-L-arginine methyl ester protects against lipid peroxidation in the gerbil following cerebral ischaemia'. European Journal Of Pharmacology, 285 :203-206. [Details]

Maginn, M., Caldwell, M., Kelly, J.P. and Leonard, B.E. (1995) 'The effect of 2-amino-phospho propionic acid (AP-3) in the gerbil model of ischaemia'. European Journal Of Pharmacology, 282 :259-262. [Details]

McNamara, M.G., Kelly, J.P. and Leonard, B.E. (1995) 'The effect of acute MDMA administration on body temperature, serum corticosterone and neurotransmitter concentrations in male and female rats'. Human Psychopharmacology-Clinical And Experimental, 10 :373-383. [Details]

McNamara, M.G., Kelly, J.P. and Leonard, B.E. (1995) 'Some behavioural and neurochemical aspects of subacute (+) 3,4-methylenedioxymethamphetamine administration in rats'. Pharmacology Biochemistry And Behavior, 52 :479-484. [Details]

McNamara, M.G., Kelly, J.P. and Leonard, B.E. (1995) 'Some behavioural effects of methiothepin in the olfactory bulbectomised rat model of depression'. Medical Science Research, 23 :583-585. [Details]

Mullen, A.M., Kelly, J. and Leonard, B.E. (1995) 'Effects of dietary l-histidine administration on trimethyltin-induced behavioural changes in the rat'. Medical Science Research, 23 :403-404. [Details]

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1995) 'The behavioural effects of milnacipran in the olfactory bulbectomised rat model of depression'. Medical Science Research, 23 :533-534. [Details]

Kelly, JP,Leonard, BE (1995) 'An investigation of the hyperactive response in the olfactory bulbectomised rat model of depression'. Medical Science Research, 23 :837-838. [Details]

Redrobe, J.P., Kelly, J.P., Chambers, P.L. and Leonard, B.E. (1995) 'Effect of chronic antidepressant treatment following acute administration of the neurotoxin trimethyltin in the rat'. Medical Science Research, 23 :407-408. [Details]

McGrath, C., Kelly, J.P., McHugh, M.F. and Leonard, B.E. (1995) 'Effect of acute administration of 3,4-methylenedioxymethamphetamine (MDMA) on temperature and locomotor activity in the olfactory bulbectomised rat model of depression'. Medical Science Research, 23 :199-201. [Details]

Kelly, JP,Leonard, BE (1996) 'Effects of chronic desipramine on waiting behaviour for a food reward in olfactory bulbectomized rats'. Journal Of Psychopharmacology, 10 :153-156. [Details]

Kelly, JP,Norman, TR,OHalloran, A,Leonard, BE (1996) 'Home cage and open-field locomotor activity responses in singly housed olfactory bulbectomised rats'. Medical Science Research, 24 :335-337. [Details]

Ryan, P.M., Kelly, J.P., Chambers, P.L. and Leonard, B.E. (1996) 'The characterization of oxotremorine-induced hypothermic response in the rat'. Pharmacology And Toxicology, 79 :238-240. [Details]

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1996) 'Behavioural effects of chronic glycine in the olfactory bulbectomised rat in the “open field” test and on phencyclidine (PCP)-induced hyperactivity'. Medical Science Research, 24 :55-56. [Details]

Redrobe, J.P., Kelly, J.P., Chambers, P.L. and Leonard, B.E. (1996) 'The effect of chronic antidepressant treatment on alcohol intake in rats'. Medical Science Research, 24 :25-26. [Details]

MacSweeney, C.P., McGarvey, C., Kelly, J.P. and Leonard, B.E. (1996) 'The plasma glucose profile of individual rats in response to a single subcutaneous injection of streptozotocin'. Medical Science Research, 24 :13-14. [Details]

McNamara, M.G., Kelly, J.P. and Leonard, B.E. (1996) 'Some behavioural and neurochemical effects of ipsapirone in two rodent models of depression'. Journal Of Psychopharmacology, 10 :126-133. [Details]

Cryan, J.F., Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1996) 'Does the serenic eltoprazine have antidepressant potential? -an investigation in three rodent paradigms'. Medical Science Research, 24 :719-720. [Details]

Maginn, M., Kelly, J.P. and Leonard, B.E. (1997) 'Protective effects of vanoxeamine (GBR 12909) against ischaemia-induced hyperactivity and neurodegeneration in gerbil model of cerebral ischaemia'. Pharmacology Biochemistry And Behavior, 56 :727-735. [Details]

Borsini, F., Cesana, R., Kelly, J., Leonard, B.E., McNamara, M., Richards, J. and Seiden, L. (1997) 'BIMT 17: a putative antidepressant with a fast onset of action?'. Psychopharmacology, 134 :378-386. [Details]

McGrath, C., Kelly, J.P., McHugh, M.F. and Leonard, B.E. (1997) 'Effect of phencyclidine and apomorphine administration in the olfactory bulbectomised rat'. Medical Science Research, 25 :829-831. [Details]

Martin, F., Corrigan, F.M., Donard, O.F.X., Kelly, J., Besson, J.A.O. and Horrobin, D.F. (1997) 'Organotin comopunds in trimethyltin-treated rats and in human brain in Alzheimer’s Disease'. Human & Experimental Toxicology, 16 :512-515. [Details]

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1997) 'Behavioural and neurochemical effects of dizocilpine in the olfactory bulbectomized rat model of depression'. Pharmacology Biochemistry And Behavior, 58 :355-359. [Details]

Cryan, J.F., Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1997) 'The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat'. European Neuropsychopharmacology, 7 :109-114. [Details]

Connor, T.J., Kelly, J.P. and Leonard, B.E. (1997) 'Effect of acute desipramine treatment on immune parameters in the rat'. Medical Science Research, 25 :209-211. [Details]

De Souza, I., Kelly, J.P., Harkin, A.J. and Leonard, B.E. (1997) 'An appraisal of the pharmacological and toxicological effects of a single oral administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat'. Pharmacology And Toxicology, 80 :207-210. [Details]

Kelly, J.P., Wrynn, A.S. and Leonard, B.E. (1997) 'The olfactory bulbectomized rat as a model of depression: an update'. Pharmacology And Therapeutics, 74 :299-316. [Details]

Connor, T.J., Kelly, J.P. and Leonard, B.E. (1997) 'Forced swim test-induced neurochemical, endocrine and immune changes in the rat'. Pharmacology Biochemistry And Behavior, 58 :961-968. [Details]

Kelly, J.P. and Leonard, B.E. (1998) 'Models and responses in depression and aggression'. Biochemical Society Transactions, 26 :61-65. [Details]

Dredge, K., Kelly, J.P. and Leonard, B.E. (1998) 'Effect of single dose imipramine on some immunotoxicological parameters in the rat'. Medical Science Research, 26 :789-792. [Details]

Connor, T.J., McNamara, M.G., Finn, D., Currid, A., O' Malley, M., Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1998) 'Acute 3,4-methlyenedioxymethamphetamine (MDMA) administration produces a rapid and sustained suppression of immune function in the rat'. Immunopharmacology, 38 :253-260. [Details]

67. Harkany, T., O’Mahony, S., Kelly, J.P., Soos, K., Toro, I., Penke, B., Luiten, P.G.M., Nyakas, C., Gulya, K. and Leonard, B.E. (1998) '-amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation'. Behavioural Brain Research, 90 :133-145. [Details]

Connor, T.J., Kelly, J.P. and Leonard, B.E. (1998) 'Forced swim test-induced endocrine and immune changes in the rat: Effect of subacute desipramine treatment'. Pharmacology Biochemistry And Behavior, 59 :171-178. [Details]

KELLY, JP et al. (1999) 'The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients'. JOURNAL OF AFFECTIVE DISORDERS, 55 :231-235. [Details]

Kelly, JP,Leonard, BE (1999) 'An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression'. European Neuropsychopharmacology, 9 :101-105. [Details]

Redmond, A., Harkin, A., Kelly, J.P. and Leonard, B.E. ( (1999) 'Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity'. European Neuropsychopharmacology, 9 :165-170. [Details]

Healy, D., Harkin, A., Cryan, J., Kelly, J.P. and Leonard, B.E. (1999) 'Metyrapone displays antidepressant-like properties in preclinical paradigms of antidepressant activity'. Psychopharmacology, 145 :303-308. [Details]

Dredge, K., Connor, T.J., Kelly, J.P. and Leonard, B.E. (1999) 'Comparative effects of various antidepressant drugs and the known immunosuppressant dexamethasone on the T-lymphocyte proliferative response in vitro'. Medical Science Research, 27 :773-774. [Details]

Shen, Y., Connor, T.J., Nolan, Y., Kelly, J.P. and Leonard, B.E. (1999) 'Differential effect of chronic antidepressant treatments on LPS-induced depressive-like behavioural symptoms in the rat'. Life Sciences, 65 :1773-1786. [Details]

Dredge, K., Connor, T.J., Kelly, J.P. and Leonard, B.E. (1999) 'Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1 and tumor necrosis factor-secretion following an in vivo lipopolysaccharide challenge in rats'. International Journal Of Immunopharmacology, 21 :663-673. [Details]

Darcy, P., Dredge, K., Kelliher, P., Kelly, J.P., Leonard, B.E. and Chambers, P.L. (1999) 'Acute toxcity profile of maprotiline in the rat'. Pharmacology And Toxicology, 85 :276-281. [Details]

Connor, T.J., Kelliher, P., Harkin, A., Kelly, J.P. and Leonard, B.E. (1999) 'Reboxetine attenuates forced swim test-induced behavioural and neurochemical alterations in the rat'. European Journal Of Pharmacology, 379 :125-133. [Details]

Cryan, J.F., Kelliher, P., Kelly, J.P. and Leonard, B.E. (1999) 'Comparative effects of serotonergic agonists with varying efficacy at the 5-HT1A receptor on core body temperature: modification by the selective 5-HT1A receptor antagonist WAY 100635'. Journal Of Psychopharmacology, 13 :278-283. [Details]

Shen, Y., Connor, T.J., Kelly, J.P. and Leonard, B.E. (1999) 'Effects of chronic dietary supplementation with 3 and 6 fatty acid rich oils on lipopolysaccharide-induced behavioural responses and interleukin-1 secretion in the rat'. Medical Science Research, 27 :291-294. [Details]

Connor, T.J., McNamara, M.G., Kelly, J.P. and Leonard, B.E. (1999) '3,4-methlyenedioxymethamphetamine (MDMA; Ecstasy) administration produces dose-dependent neurochemical, endocrine and immune changes in the rat'. Human Psychopharmacology-Clinical And Experimental, 14 :95-104. [Details]

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1999) 'The determination of the optimal dose of milnacipran in the olfactory bulbectomized rat model of depression'. Pharmacology Biochemistry And Behavior, 62 :619-623. [Details]

Harkin, A., Kelly, J.P., McNamara, M., Connor, T.J., Dredge, K., Redmond, A. and Leonard, B.E. (1999) 'Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression'. European Journal Of Pharmacology, 364 :123-132. [Details]

Connor, T.J., Kelly, J.P., McGee, M. and Leonard, B.E. (2000) 'Methylenedioxymethamphetamine (MDMA; ecstasy) suppresses IL-1? and TNF-? secretion following an in vivo lipopolysaccharide challenge'. Life Sciences, 67 :1601-1612. [Details]

Harkin, A., Kelly, J.P., Frawley, J., O'Donnell, J.M. and Leonard, B.E. (2000) 'Test conditions influence the response to a drug challenge in rodents. '. Pharmacol. Biochem. Behav, 65 :389-398. [Details]

Connor, T.J., Kelly, J.P. and Leonard, B.E. (2000) 'An assessment of the acute effects of the serotonin releasers methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on immunity in rats'. Immunopharmacology, 46 :223-235. [Details]

Kelly, J. (2000) 'Olfactory bulbectomy provokes a suppression of interleukin-1? and tumour necrosis factor-? production following an in vivo challenge with lipopolysaccharide: Effect of chronic desipramine treatment'. Neuroimmunomodulation, 7 :27-35. [Details]

Harkin, A., Nally, R., Kelly, J.P. and Leonard, B.E. (2000) 'Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and ?1-adrenergic receptors in an animal model of depression'. J. Neural Trans, 107 :1213-1227. [Details]

Kelly, J.P. (2000) 'The role of animal models in the development of anti-depressants'. J. Depression and Anxiety, 3 :22-27. [Details]

Nolan, Y., Connor, T.J., Kelly, J.P. and Leonard, B.E. (2000) 'Lipopolysaccharide administration produces time-dependent and region-specific alterations in tryptophan and tyrosine hydroxylase activities in rat brain'. J. Neural Trans, 107 :1393-1401. [Details]

Cryan, J.F., Harkin, A., Naughton, M., Kelly, J.P. and Leonard, B.E. (2000) 'Characterization of D-fenfluramine-induced hypothermia evidence for multiple sites of action'. Eur. J. Pharmacol, 390 :275-285. [Details]

Connor, T.J., Kelliher, P., Shen, Y., Harkin, A., Kelly, J.P. and Leonard, B.E. (2000) 'Effect of subchronic antidepressant treatments on behavioural, neurochemical and endocrine changes following forced swim test exposure in the rat'. Pharmacol. Biochem. Behav, 65 :591-597. [Details]

Kelliher, P., Connor, T.J., Harkin, A., Sanchez, C., Kelly, J.P. and Leonard, B.E. (2000) 'Varying responses to the rat forced swim test under diurnal and nocturnal conditions'. Physiol. Behav, 69 :531-539. [Details]

Harkin, A., Morris, K., Kelly, J.P., O'Donnell, J.M. and Leonard, B.E. (2001) 'Modulation of MK-801-induced behaviour by noradrenergic agents in mice'. Psychopharmacology, 154 :177-188. [Details]

O'Loinsigh, E.D., Boland, G., Kelly, J.P. and O'Boyle K.M. (2001) 'Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat'. Prog Neuropsychopharmacol Biol Psychiatry, 25 :621-638. [Details]

Connor, T.J., Connelly, D.B. and Kelly, J.P. (2001) 'Methylenedioxy-methamphetamine (MDMA; 'Ecstasy') suppresses antigen specific IgG(2a) and IFN-gamma production'. Immunol Lett, 78 :67-73. [Details]

Connor, T.J., Dennedy, M.C., Harkin, A. and Kelly, J.P. (2001) 'Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin'. Eur J Pharmacol, 418 :147-152. [Details]

Ryan, P.M., Kelly, J.P., Chambers, P.L. and Leonard, B.E. (2001) 'The toxicity profile of a single dose of paroxetine: an alternative approach to acute toxicity testing in the rat'. Pharmacology and Toxicology, 88 :59-66. [Details]

Harkin, A., Connor, T.J., Mulrooney, J., Kelly, J.P. and Leonard, B.E. (2001) 'Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats'. Life Sciences, 68 :1367-1382. [Details]

Kelly, J.P. (2002) 'Animal models of depression'. Brain Pharmacol, 1 :267-284. [Details]

Harkin, A., Houlihan, D. D. and Kelly, J. P. (2002) 'Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine'. Journal of Psychopharmacology, 16 :115-123. [Details]

Harkin, A. J., O'Donnell, J. and Kelly, J. P. (2002) 'A study of VitalView for behavioural and physiological monitoring in laboratory rats'. Physiology & Behavior, 77 :65-77. [Details]

Darcy, P., Kelly, J. P., Leonard, B. E. and Henry, J. A. (2002) 'The effect of lofepramine and other related agents on the motility of Tetrahymena pyriformis'. Toxicology Letters, 128 :207-214. [DOI] [Details]

Harkin, A., Connor, T. J., O'Donnell, J. M. and Kelly, J. P. (2002) 'Physiological and behavioral responses to stress: what does a rat find stressful?'. Laboratory Animals, 31 :42-50. [Details]

Connor, T. J. and Kelly, J. P. (2002) 'Fenfluramine-induced immunosuppression: an in vivo analysis'. European Journal of Pharmacology, 455 :175-185. [DOI] [Details]

Harkin, A ., Kelly, J. P. and Leonard, B. E. (2003) 'A review of the relevance and validity of olfactory bulbectomy as a model of depression'. Clinical Neuroscience Research, 3 :253-262. [Details]

Kelly, J. P. (2003) 'Novel therapeutic targets for the treatment of depression'. Current Medicinal Chemistry, 3 :311-322. [Details]

Harkin, A., Shanahan, E., Kelly, J. P. and Connor, T. J. (2003) 'Methylenendioxyamphetamine produces serotonin nerve terminal loss and diminished behavioural and neurochemical responses to the antidepressant fluoxetine'. European Journal of Neuroscience, 18 :1021-1027. [DOI] [Details]

Harkin, A., Hynes, M. J., Masterson, E., Kelly, J. P., O'Donnell, J. M. and Connor, T. J. (2003) 'A toxicokinetic study of nickel-induced immunosuppression in rats'. Immunopharmacology. Immunotoxicology, 25 :655-670. [DOI] [Details]

Harkin, A. J., O'Donnell, J. and Kelly, J. P. (2003) 'A combined and comparative study of physiologic and behavioral parameters in a systemic toxicity test'. Contemporary Topics in Laboratory Animal Science, 42 :30-37. [Details]

Connor, T.J., O'Sullivan, J., Nolan, Y. and Kelly, J.P. (2003) 'Inhibition of constitutive nitric oxide production increases the severity of lipopolysaccharide-induced sickness behaviour: a role for TNF-alpha'. Neuroimmunomodulation, 10 :367-368. [Details]

Harkin, A., Connor, T.J., Walsh, M., St. John, N. and Kelly, J.P. ( (2003) 'Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors'. Neuropharmacology, 44 :616-623. [DOI] [Details]

Kelliher, P., Kelly, J.P., Leonard, B.E. and Sanchez, C. (2003) 'Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test'. Psychoneuroendocrinology, 28 :332-347. [DOI] [Details]

Horrigan, L.A., Kelly, J.P. and Connor, T.J. (2004) 'Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway'. Int. Immunopharmacol, 4 :1409-1417. [Details]

Horrigan, L. A., Kelly, J. P. and Connor, T. J. (2004) 'Caffeine suppresses TNF-alpha production via activation of the cyclic AMP/protein kinase A pathway'. International Immunopharmacology, 4 :1409-1417. [DOI] [Details]

Harkin, A., Connor, T. J., Burns, M. P. and Kelly, J. P. (2004) 'Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test'. European Journal of Neuropsychopharmacology, 14 :274-281. [Details]

Horrigan, L.A., Diamond, M., Connor, T.J. and Kelly, J.P. (2004) 'Caffeine inhibits monocyte and neutrophil chemotaxis at concentrations relevant to normal human consumption. In:'. Int. Cytokine Soc, :49-54. [Details]

Connor, T. J., Harkin, A. and Kelly, J. P. (2005) 'Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor necrosis factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10'. Journal of Pharmacology & Experimental Therapeutics, 312 :134-143. [Details]

Connor, T. J., Brewer, C., Kelly, J. P. and Harkin, A. (2005) 'Acute stress suppresses cytokines TNF-alpha and IL-a beta independent of a catecholamine-driven increase in IL-10 production'. Journal of Neuroimmunology, 159 :119-128. [DOI] [Details]

Roche, M,Diamond, M,Kelly, JP,Finn, DP (2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'. Journal Of Neuroimmunology, 181 :57-67. [DOI] [Details]

Diamond, M., Kelly, J. P. and Connor, T. J. (2006) 'Antidepressants suppress production of the Th(1) cytokine interferon-gamma, independent of monoamine transporter blockade'. European Journal of Neuropsychopharmacology, 16 :481-490. [DOI] [Details]

Horrigan, L.A., Kelly, J.P. and Connor, T.J. (2006) 'Immodulatory effects of caffeine: friend or foe?'. Pharmacol. Ther, 111 :877-892. [Details]

Roche, M., Harkin, A. and Kelly J.P (2007) 'Chronic fluoxetine attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat'. Neuropsychopharmacology, 32 :1312-1320. [DOI] [Details]

Dunne, F., O'Halloran, A. and Kelly, J.P. (2007) 'Development of a home cage locomotor tracking system capable of detecting the stimulant and sedative properties of drugs in rats'. Prog. Neuropsychopharmacol. Biol. Psychiatry, 31 :1456-1463. [Details]

Cassidy, J.P., Caulfield, C., Jones, B.R., Worrall, S., Conlon, L., Palmer, A.C. and Kelly, J. (2007) 'Leukoencephalomyelopathy in specific pathogen-free cats'. Vet. Pathol, 44 :912-916. [Details]

Roche, M., Harkin, A. and Kelly J.P. (2008) 'A review of the neuropharmacological properties of khat'. Prog Neuropsychopharmacol Biol Psychiatry, 32 :1147-1166. [Details]

Roche, M., Shanahan, E., Harkin, A. and Kelly, J.P (2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'. Pharmacol Rep, 60 :404-408. [Details]

Roche, M., Kelly, J.P., O'Driscoll, M. and Finn D.P. (2008) 'Comparison of the behavioural pharmacology of the Lister-Hooded with 2 commonly utilised albino rat strains'. Prog Neuropsychopharmacol Biol Psychiatry, 32 :1816-1823. [Details]

Caulfield, C.D., Cassidy, J.P. and Kelly JP. (2008) 'Effects of gamma irradiation and pasteurization on the nutritive composition of commercially available animal diets'. J Am Assoc Lab Anim Sci, 47 :61-66. [Details]

Uma, S, Kelly, J.P. and Rajasekaran. S.K. (2008) 'An investigation of the value of the Tetrahymena pyriformis as a test organism for assessing the acute toxicity of antidepressants'. Biomed. Res, 19 :37-40. [Details]

Roche, M,Kelly, JP,O'Driscoll, M,Finn, DP (2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'. Immunology, 125 :263-271. [DOI] [Details]

Caulfield CD, Kelly JP, Jones BR, Worrall S, Conlon L, Palmer AC, Cassidy JP. (2009) 'The experimental induction of leukoencephalomyelopathy in cats'. VETERINARY PATHOLOGY, 46 (6):1258-1269. [DOI] [Details]

Kelly J. (2010) 'Complete Book: : Principles of CNS Drug Development: from test tube to patient'. . [Details]

Simpson, J., and Kelly, J.P. (2011) 'The impact of environmental enrichment in laboratory rats--behavioural and neurochemical aspects'. Behavioural Brain Research, 12 :246-264. [Details]

Simpson, J. and Kelly, J.P. (2012) 'An investigation of whether there are sex differences in certain behavioural and neurochemical parameters in the rat'. Behavioural Brain Research, . [Details]

Roche, M., Kerr, D.M., Hunt, S.P. and Kelly, J.P. (2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'. Behavioural Brain Research, 228 :91-98. [Details]

Butler, R.K., Ford, G.K., Hogan, M., Roche, M., Doyle, K.M., Kelly, J.P., Kendall, D.A., Chapman, V. and Finn, D.P. (2012) 'Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, 26 :83-91. [Details]

Other Journals

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1994) 'Effect of paroxetine and fluvoxamine on behavioural changes in a number of paradigms in the olfactory bulbectomized rat model of depression' Journal of Serotonin Research 3 :199-205. [Details]

Redrobe, J.P., Kelly, J.P., Chambers, P.L. and Leonard, B.E. (1994) 'The effect of acute and chronic antidepressant treatment on MDMA-induced behavioural changes in rats' Journal of Serotonin Research 3 :215-219. [Details]

Nsimba, S.E., Kelly, J.P. and Leonard, B.E. (1994) 'Effects of olfactory bulbectomy on phencyclidine (PCP) induced behavioural changes' Indian Journal of Pharmacology 26 :136-140. [Details]

Harkin, A., Kelly, J.P. and Leonard, B.E. (1995) 'The comparative effects of long-term administration of sertraline, paroxetine, citalopram, fluoxetine and amitriptyline on monoamine content in rat brain' Journal of Serotonin Research 2 :181-190. [Details]

McGarvey, C., O’Donnell, J.M., Kelly, J.P. and Leonard, B.E. (1995) 'MK-801 potentiated the acute neuroendocrine and behaviural effects of 3,4-methylenedioxymethamphetamine' Journal of Serotonin Research 3 :191-203. [Details]

Kelly, J.P. and Leonard, B.E. (1995) 'The contribution of pre-clinical drug evaluation in predicting the clinical profile of the selective serotonin reuptake inhibitor paroxetine' Journal of Serotonin Research 2 :27-46. [Details]

Redmond, A.M., Kelly, J.P. and Leonard, B.E. (1995) 'The effects of acute and chronic antidepressant treatments on temperature and locomotor activity responses to 8-OH-DPAT, clonidine and apomorphine' Journal of Serotonin Research 2 :139-148. [Details]

McNamara, M.G., Kelly, J.P. and Leonard, B.E. (1995) 'Effect of 8-OH-DPAT in the olfactory bulbectomized rat model of depression' Journal of Serotonin Research 2 :91-99. [Details]

McGarvey, C., Kelly, J., O'Donnell, J.M. and Leonard, B.E. (1995) 'Neuroendocrine and behavioural effects of the serotonin releasers 3,4-methylenedioxymethamphetamine and fenfluramine in rats' Journal of Serotonin Research 4 :257-265. [Details]

McNamara, M.G., Kelly, J.P. and Leonard, B.E. (1995) 'Thermoregulatory and locomotor activity responses of 3,4-methylenedioxymethamphetamine (MDMA) inmale and female rats' Journal of Serotonin Research 4 :275-282. [Details]

Harkin, A., Kelly, J.P., and Leonard, B.E. (1996) 'Single or repeated administration of selective serotonin reuptake inhibitors fail to modulate apomorphine-induced responses in the rat' Journal of Serotonin Research 3 :49-58. [Details]

Nsimba, S.E.D., Kelly, J.P. and Leonard, B.E. (1997) 'The interaction between chlorpromazine and apomorphine on temperature in the rat' Journal of Serotonin Research 3 :161-167. [Details]

Nsimba, S.E.D., Kelly, J.P. and Leonard, B.E. (1997) 'Effect of acute and chronic haloperidol administration and apomorphine challenge on the behavioural parameters in rats' Indian Journal of Pharmacology 29 :15-19. [Details]

Nsimba, S.E.D., Kelly, J.P. and Leonard, B.E. (1997) 'Effect of chronic rafoxanide administration on behavioural and physiological parameters in the rat' Indian Journal of Pharmacology 29 :289-295. [Details]

Kelly, J.P. (2011) 'Cathinone derivatives: a review of their chemistry, pharmacology and toxicology' Drug Testing and Analysis 3 :439-453. [Details]

Conference Publications

KELLY, JP et al. (1998) Models and responses in depression and aggression BIOCHEMICAL SOCIETY TRANSACTIONS , pp.61-65 [Details]

 

Abstract

KELLY, JP,LEONARD, BE (1990) THE EFFECT OF TIANEPTINE ON THE OLFACTORY BULBECTOMIZED (OB) RAT MODEL OF DEPRESSION. Abstract [Details]

KELLY, JP,LEONARD, BE (1993) DEXAMETHASONE SUPPRESSION OF CORTICOSTERONE SECRETION IN OLFACTORY BULBECTOMIZED RATS. Abstract [Details]

Kelly, J,Dwyer, RM,Murphy, M,Barry, FP,O'Brien, T,Kerin, MJ (2009) Mesenchymal Stem Cell (MSC) secretion of TGF beta and VEGF stimulates Epithelial to Mesenchymal Transition (EMT) in breast cancer cell lines. Abstract [Details]

Kelly, J,McDermott, C (2010) Comparative behavioural pharmacology of three rat strains. Abstract [Details]

                       

Reviews

KELLY, JP et al. (1997) The olfactory bulbectomized rat as a model of depression: An update. PHARMACOLOGY & THERAPEUTICS. Reviews [Details]