Prof John Laffey BSc, MB, Bch, BAO, MD, MA, FFARCSI
Contact Details
|
 |
Biography:
John Laffey is the Professor of Anaesthesia at the School of Medicine of the National University of Ireland, and a Consultant in Anaesthesia and Intensive Care Medicine at Galway University Hospitals. |
Research Interests
| Professor Laffey’s major research interest is centred on investigation of the pathophysiology of, and development of therapeutic strategies for Acute Respiratory Distress Syndrome (ARDS), a devastating disease which causes severe respiratory failure in critically ill patients, and for which there are currently no specific therapies. More people die every year from ARDS than from other better known diseases such as HIV, Breast Cancer or Asthma. Professor Laffey founded and lead the lung biology group at NUI Galway. His research group are currently conducting studies into the pathogenesis of ventilation and sepsis Acute Lung Injury. The current focus is on the investigation of the therapeutic potential of gene and stem cell based therapies for Acute Lung Injury. This work is being done in collaboration with colleagues from the Regenerative Medicine Institute (REMEDI) at NUI Galway. A long term focus of Professor Laffey’s work had been on determining the safety and therapeutic potential of hypercapnic acidosis in septic and inflammatory disease models of Acute Lung Injury. Professor Laffey is a principal investigator at the National Centre for Biomedical Engineering Sciences, and a Clinical Trials Investigator at the HRB Clinical Research Facility at the National University of Ireland, Galway. The translation of promising therapeutic strategies emerging from these pre-clinical studies to the clinical setting, through the Clinical Research Facility, and in collaboration with the Irish Critical Care Trials group, is a priority. Professor Laffey is co-principal investigator in the first investigator led multi-centre trial conducted in critically ill patients in Ireland. This study, termed the HARP-2 study, aims to determine whether statin therapy might help people suffering from ARDS. Additional clinical research interests include the investigation of the utility of novel devices and technologies for management of the airway, and investigation of novel approaches to postoperative analgesia. |
Research Projects
|
Project: HRB HEALTH RESEARCH AWARDS HRA_POR/2010/131 PROF JOHN LAFFEY ( RHR913) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-10 / 01-OCT-13 |
|
Project: ERC HYPERCAPNIC ACIDOSIS LAFFEY ( RE7013) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-09 / 31-DEC-13 |
|
Project: MODULATING NF-KB 08/ERC/002 J LAFFEY ( RSF0885) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-09 / 31-DEC-13 |
|
Project: RP 2008 193 HRB JOHN LAFFEY ( RHB0811) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-MAY-09 / 30-APR-12 |
|
Project: HRB THERAPEUTIC STRATEGIES JOHN LAFFEY ( RHR889) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-05 / 31-JAN-09 |
|
Project: AAGBI ALI SGT DR J LAFFEY ANAESTHESIA ( RIB662) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-03 / 31-DEC-12 |
|
Project: ILF ACUTE LUNG INJ DR J LAFFEY ANAESTHESIA ( RIB266) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-03 / 31-JUL-09 |
|
Project: HRB JOHN LAFFEY ¿178,700 RP2004/9 ( RHR879) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-04 / 25-AUG-08 |
|
Project: HRB CRT 2005 33 JOHN LAFFEY ( RHR884) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-05 / 30-JUN-07 |
|
Project: HRB EUR30000 EQUIPMENT GRANT LAFFEY ( RHR461) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-DEC-04 / 31-AUG-07 |
|
Project: MF2004 MF50 04 DR. JOHN LAFFEY ( RM4050) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 30-SEP-04 / 20-JUL-07 |
|
Project: YAMANOUCHI EUROPEAN FOUNDATION FSHIP ( RNR201) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUN-02 / 28-FEB-07 |
|
Project: MF MINOR 2005 HYPERTONIC SALINE & ETHYL PYRUVATE L ( RM5070) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-05 / 31-OCT-06 |
Book Chapters
| Laffey JG, O'Croinin D, McLoughlin P, Kavanagh BP. (2006) 'Permissive Hypercapnia: Role in Protective Lung ventilatory strategies' In: MR Pinsky, L Brochard, J Mancebo (eds). Applied Physiology in Intensive Care. Berlin, Germany: Springer Verlag. [Details] |
| Farragher R, Laffey JG. (2006) 'Analgesia following Caesarean Section' In: G. Shorten, M. Puig, J. Browne, D. Harmon (eds). Postoperative Pain Management: An Evidence-Based Guide to Practice. Amsterdam, The Netherlands: Elsevier Press Inc. [Details] |
| Laffey JG, Kavanagh BP (2006) 'Modulation of Lung Injury by Hypercapnia' In: D. Dreyfuss, R Hubmayr, G. Saumon (eds). Ventilator-Induced Lung injury (Series on Lung Biology in Health and Disease). New York, US: Marcel Dekker Inc. [Details] |
| Laffey JG, Kavanagh BP. (2006) 'Permissive Hypercapnia' In: M. Tobin (eds). Principles & Practice of Mechanical Ventilation. New York, US: McGraw-Hill Companies Inc. [Details] |
| Contreras M, Hassett P, Laffey JG (2008) 'Hypercapnia - Permissive, Therapeutic or not at all?' In: JL Vincent (eds). 2008 Yearbook of Intensive Care and Emergency Medicine. Belgium: Springer-Verlag. [Details] |
| Contreras M, Hassett P, Laffey JG. (2009) 'Is Permissive Hypercapnia helpful or harmful?' In: Deutschman & Neligan (Editors) (eds). Evidence-Based Practice of Critical Care. United States: Elselvier. [Details] |
| Hassett P, Laffey JG (2009) 'Permissive Hypercapnia' In: E Romano (eds). Il Malato Critico. (The Critically Ill Patient.). Torino, Italy: UTET Scienze Mediche. [Details] |
| Curley G, Hayes M, Laffey JG (2011) 'Can ‘permissive’ hypercapnia modulate sepsis induced ALI/ARDS?' In: J. L. Vincent (eds). 2011 Yearbook of Intensive Care and Emergency Medicine. Belgium: Springer-Verlag. [Details] |
| Walshe C, Kevin L, Laffey JG, Kavanagh BP (2011) 'Acute Respiratory Distress Syndrome' In: Sladen RN (eds). Postoperative Cardiac Care. A Society of Cardiovascular Anesthesiologists Monograph. Baltimore, US: Lippincott Williams & Wilkins. [Details] |
| Laffey J.G, Kavanagh, B.P. (2012) 'Permissive Hypercapnia' In: Martin tobin (eds). Principles & Practice of Mechanical Ventilation. US: McGraw-Hill Companies Inc. [Details] |
Peer Reviewed Journals
| Laffey J, Murphy D, Regan J, O'Keeffe D (1998) 'Cost-benefit analysis of spinal cord stimulation for intractable angina pectoris: a win-win scenario?'. Hospital Medicine, 59 (10):820-821. [Details] |
| Fagan C, Frizelle HP, Laffey J, Hannon V, Carey M (2000) 'The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia'. Anesthesia And Analgesia, 91 (1):201-205. [Details] |
| Murphy, PM,Stack, D,Kinirons, B,Laffey, JG (2003) 'Optimizing the dose of intrathecal morphine in older patients undergoing hip arthroplasty'. Anesthesia And Analgesia, 97 :1709-1715. [DOI] [Details] |
| Lane, A,Westbrook, A,Grady, D,O'Connor, R,Counihan, TJ,Marsh, B,Laffey, JG (2004) 'Maternal brain death: medical, ethical and legal issues'. Intensive Care Medicine, 30 :1484-1486. [DOI] [Details] |
| O'Croinin, DF,Hopkins, NO,Moore, MM,Boylan, JF,McLoughlin, P,Laffey, JG (2005) 'Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury'. Critical Care Medicine, 33 :2606-2612. [DOI] [Details] |
| Maharaj, CH,Higgins, BD,Harte, BH,Laffey, JG (2006) 'Evaluation of intubation using the Airtraq (R) or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy - a manikin study'. Anaesthesia, 61 :469-477. [DOI] [Details] |
| Maharaj, CH,O'Croinin, D,Curley, G,Harte, BH,Laffey, JG (2006) 'A comparison of tracheal intubation using the Airtraq (R) or the Macintosh laryngoscope in routine airway management: a randomised, controlled clinical trial'. Anaesthesia, 61 :1093-1099. [DOI] [Details] |
| Maharaj, CH,Costello, JF,Higgins, BD,Harte, BH,Laffey, JG (2006) 'Learning and performance of tracheal intubation by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscope'. Anaesthesia, 61 :671-677. [DOI] [Details] |
| Maharaj, CH,Chonghaile, MN,Higgins, BD,Harte, BH,Laffey, JG (2006) 'Tracheal intubation by inexperienced medical residents using the Airtraq and Macintosh laryngoscopes - a manikin study'. American Journal Of Emergency Medicine, 24 :769-774. [DOI] [Details] |
| Mahajan, VA,Ni Chonghaile, M,Bokhari, SA,Harte, BH,Flynn, NM,Laffey, JG (2007) 'Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane'. European Journal Of Anaesthesiology, 24 :505-510. [DOI] [Details] |
| Maharaj, CH,Costello, J,Higgins, BD,Harte, BH,Laffey, JG (2007) 'Retention of tracheal intubation skills by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscopes'. Anaesthesia, 62 :272-278. [DOI] [Details] |
| Maharaj, CH,Costello, JF,McDonnell, JG,Harte, BH,Laffey, JG (2007) 'The Airtraq (R) as a rescue airway device following failed direct laryngoscopy: a case series'. Anaesthesia, 62 :598-601. [DOI] [Details] |
| Maharaj, CH,Buckley, E,Harte, BH,Laffey, JG (2007) 'Endotracheal intubation in patients with cervical spine immobilization - A comparison of Macintosh and Airtraq laryngoscopes'. Anesthesiology, 107 :53-59. [Details] |
| McDonnell, JG,O'Donnell, BD,Farrell, T,Gough, N,Tuite, D,Power, C,Laffey, JG (2007) 'Transversus abdominis plane block: A cadaveric and radiological evaluation'. Regional Anesthesia And Pain Medicine, 32 :399-404. [DOI] [Details] |
| Maharaj, CH,McDonnell, JG,Harte, BH,Laffey, JG (2007) 'A comparison of direct and indirect laryngoscopes and the ILMA in novice users: a manikin study'. Anaesthesia, 62 :1161-1166. [DOI] [Details] |
| McDonnell, JG,Curley, G,Carney, J,Benton, A,Costello, J,Maharaj, CH,Laffey, JG (2008) 'The analgesic efficacy of transversus abdominis plane block after cesarean delivery: A randomized controlled trial'. Anesthesia And Analgesia, 106 :186-191. [DOI] [Details] |
| Malik, MA,Maharaj, CH,Harte, BH,Laffey, JG (2008) 'Comparison of Macintosh, Truview EVO2 (R), Glidescope (R), and Airwayscope (R) laryngoscope use in patients with cervical spine immobilization'. British Journal Of Anaesthesia, 101 :723-730. [DOI] [Details] |
| Chonghaile, MN,Higgins, BD,Costello, JF,Laffey, JG (2008) 'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism'. Critical Care Medicine, 36 :3135-3144. [DOI] [Details] |
| O'Croinin, DF,Nichol, AD,Hopkins, N,Boylan, J,O'Brien, S,O'Connor, C,Laffey, JG,McLoughlin, P (2008) 'Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury'. Critical Care Medicine, 36 :2128-2135. [DOI] [Details] |
| Farragher, R,Maharaj, CH,Higgins, BD,Crowe, S,Burke, P,Laffey, CD,Flynn, NM,Laffey, JG (2008) 'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids'. Anesthesia And Analgesia, 107 :171-177. [DOI] [Details] |
| Higgins, BD,Costello, J,Contreras, M,Hassett, P,O'Toole, D,Laffey, JG (2009) 'Differential Effects of Buffered Hypercapnia versus Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis'. Anesthesiology, 111 :1317-1326. [Details] |
| Malik, MA,Hassett, P,Carney, J,Higgins, BD,Harte, BH,Laffey, JG (2009) 'A comparison of the Glidescope (R), Pentax AWS (R), and Macintosh laryngoscopes when used by novice personnel: a manikin study'. Canadian Journal Of Anaesthesia-Journal Canadien D Anesthesie, 56 :802-811. [DOI] [Details] |
| Malik, MA,O'Donoghue, C,Carney, J,Maharaj, CH,Harte, BH,Laffey, JG (2009) 'Comparison of the Glidescope (R), the Pentax AWS (R), and the Truview EVO2 (R) with the Macintosh laryngoscope in experienced anaesthetists: a manikin study'. British Journal Of Anaesthesia, 102 :128-134. [DOI] [Details] |
| Maharaj, CH,O'Toole, D,Lynch, T,Carney, J,Jarman, J,Higgins, BD,Morrison, JJ,Laffey, JG (2009) 'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries'. Reproductive Biology And Endocrinology, 7 . [DOI] [Details] |
| O'Toole, D,Hassett, P,Contreras, M,Higgins, BD,McKeown, STW,McAuley, DF,O'Brien, T,Laffey, JG (2009) 'Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism'. Thorax, 64 :976-982. [DOI] [Details] |
| Malik, MA,Subramaniam, R,Maharaj, CH,Harte, BH,Laffey, JG (2009) 'Randomized controlled trial of the Pentax AWS (R), Glidescope (R), and Macintosh laryngoscopes in predicted difficult intubation'. British Journal Of Anaesthesia, 103 :761-768. [DOI] [Details] |
| Farrell, HP,Garvey, M,Cormican, M,Laffey, JG,Rowan, NJ (2010) 'Investigation of critical inter-related factors affecting the efficacy of pulsed light for inactivating clinically relevant bacterial pathogens'. Journal Of Applied Microbiology, 108 :1494-1508. [DOI] [Details] |
| McElwain, J,Malik, MA,Harte, BH,Flynn, NM,Laffey, JG (2010) 'Comparison of the C-MAC (R) videolaryngoscope with the Macintosh, Glidescope (R), and Airtraq (R) laryngoscopes in easy and difficult laryngoscopy scenarios in manikins'. Anaesthesia, 65 :483-489. [DOI] [Details] |
| Carney, J,Finnerty, O,Rauf, J,Curley, G,McDonnell, JG,Laffey, JG (2010) 'Ipsilateral Transversus Abdominis Plane Block Provides Effective Analgesia After Appendectomy in Children: A Randomized Controlled Trial'. Anesthesia And Analgesia, 111 :998-1003. [DOI] [Details] |
| McElwain, J,Malik, MA,Harte, BH,Flynn, NH,Laffey, JG (2010) 'Determination of the optimal stylet strategy for the C-MAC (R) videolaryngoscope'. Anaesthesia, 65 :369-378. [DOI] [Details] |
| Hayes, M,Curley, GF,Laffey, JG (2011) 'Lung stem cells - from an evolving understanding to a paradigm shift?'. Stem Cell Research & Therapy, 2 . [DOI] [Details] |
| Carney, J,Finnerty, O,Rauf, J,Bergin, D,Laffey, JG,Mc Donnell, JG (2011) 'Studies on the spread of local anaesthetic solution in transversus abdominis plane blocks'. Anaesthesia, 66 :1023-1030. [DOI] [Details] |
| Laffey J (2011) 'Placebo blocks in local anaesthesia studies: the need for balance'. Anaesthesia, 66 (5):390-31. [DOI] [Details] |
| Curley, GF,Contreras, M,Higgins, B,O'Kane, C,McAuley, DF,O'Toole, D,Laffey, JG (2011) 'Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat'. Anesthesiology, 115 :1022-1032. [DOI] [Details] |
| McDonnell, JG,Finnerty, O,Laffey, JG (2011) 'Stellate ganglion blockade for analgesia following upper limb surgery'. Anaesthesia, 66 :611-614. [DOI] [Details] |
| McElwain, J,Laffey, JG (2011) 'Comparison of the C-MAC (R), Airtraq (R), and Macintosh laryngoscopes in patients undergoing tracheal intubation with cervical spine immobilization'. British Journal Of Anaesthesia, 107 :258-264. [DOI] [Details] |
| Murphy, C,Rooney, SJ,Maharaj, CH,Laffey, JG,Harte, BH (2011) 'Comparison of three cuffed emergency percutaneous cricothyroidotomy devices to conventional surgical cricothyroidotomy in a porcine model'. British Journal Of Anaesthesia, 106 :57-64. [DOI] [Details] |
| Hayes M, Curley G, Laffey JG (2012) 'Mesenchymal stem cells - a promising therapy for Acute Respiratory Distress Syndrome'. 1, 4 . [DOI] [Details] |
| Ansari B, Laffey JG (2012) 'Ischemia-reperfusion-induced lung injury: Could hypercapnia have a therapeutic role?*'. Critical Care Medicine, 40 (2):688-690. [DOI] [Details] |
| Mehigan D, Boylan, Laffey JG (2000) 'Postoperative neurological deficit despite normal cerebral oximetry during carotid endarterectomy'. Journal of Clinical Anaesthesia, :573-574. [Details] |
| Fagan C, Frizelle HP, Laffey JG, Hannon V, Carey M (2000) 'Effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena following general anaesthesia'. Anaesthesia and Analgesia, :201-205. [Details] |
| Engelberts D, Kavanagh BP, Laffey JG (2000) 'Injurious effects of Hypocapnic Alkalosis in the Lung'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDIC, :399-405. [Details] |
| Coleman M, Boylan JF, Laffey JG (2000) 'Patients’ knowledge of perioperative care'. IRISH JOURNAL OF MEDICAL SCIENCE, :113-118. [Details] |
| Boylan JF, Cheng, DCH, Laffey JG (2002) 'The systemic inflammatory response to Cardiac Surgery - implications for the Anesthesiologist'. Anesthesiology, :215-252. [Details] |
| Sakamoto H, Corcoran TB, Laffey JG, Shorten GD (2002) 'Isoprostanes - Markers of Ischaemia Reperfusion Injury'. European Journal of Anaesthesiology, :550-559. [Details] |
| Kavanagh BP, Laffey JG (2002) 'Mechanisms of Disease: Hypocapnia'. NEW ENGLISH JOURNAL OF MEDICINE, :43-53. [Details] |
| Curran E, O' Gorman D. Phelan D, Laffey JG (2002) 'An audit of activity patterns in a HDU and its impact on ICU utilization'. Clinical Intensive Care, :13-20. [Details] |
| Boylan JF, Laffey JG (2002) 'Droperidol and Cyclizine have comparable antiemetic efficacy and side effects during patient controlled analgesia'. IRISH JOURNAL OF MEDICAL SCIENCE, :141-144. [Details] |
| Loughrey J, Laffey JG, Moore B, Lynch F, McLoughlin P, Boylan J (2003) 'Interleukin-1ß Rapidly inhibits Aortic Endothelium-Dependent relaxation by a DNA Transcription-Dependent mechanism'. Critical Care Medicine, :910-915. [Details] |
| Tobin E, Boylan J, McShane AJ, Laffey JG (2003) 'A simple artificial neural network can help predict residual neuromuscular blockade'. British Journal of Anaesthesia, :48-52. [Details] |
| BP Kavanagh, Laffey JG (2003) 'Perioperative control of CO2'. Canadian Journal of Anesthesia (Supplement), . [Details] |
| Jankov R, Engelberts D, Tanswell AK, Post M, Lindsay T, Mullen JB, Romaschin A, Stephens D, McKerlie C, Kavanagh BP, Laffey JG (2003) 'Effects of Therapeutic Hypercapnia on Mesenteric Ischemia - Reperfusion Injury'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDIC, . [Details] |
| S Rai, Engelberts D, Laffey JG, Frevert C, Kajikawa O, Martin TR, Post M, Kavanagh BP (2004) 'Therapeutic Hypercapnia Improves Oxygenation but does not Protect Against Stretch-Induced Injury in the in vivo Saline-Lavaged Rabbit'. Pediatric Research, . [Details] |
| Croinin D, McLoughlin P, Kavanagh BP, Laffey JG (2004) 'Permissive Hypercapnia - Role in Protective Lung Ventilatory Strategies'. Intensive Care Medicine, . [Details] |
| Maharaj C, Laffey JG (2004) 'Strategies that attenuate the Inflammatory response to Cardiac Surgery. Current Opinion in Anaesthesiology'. Current Opinion in Anaesthesiology, . [Details] |
| Farragher R, Marsh B, Laffey JG (2005) 'Maternal Brain Death - an Irish Perspective'. IRISH JOURNAL OF MEDICAL SCIENCE, . [Details] |
| Farragher R, Laffey JG (2005) 'Maternal Brain Death. Neurocrit Care'. . [Details] |
| Maharaj CM, Kallam SR, Malik A, Hassett P, Grady D, Laffey JG (2005) 'Preoperative intravenous fluid therapy decreases postoperative nausea and vomiting in high risk patients'. . [Details] |
| Hopkins, N,Gunning, Y,O'Croinin, DF,Laffey, J,McLoughlin, P (2006) 'Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection'. Journal Of Pathology, 209 :198-205. [DOI] [Details] |
| Kavanagh BP, Laffey JG (2006) 'Hypercapnia: permissive and therapeutic. Minerva Anestesiol'. . [Details] |
| Maharaj CH, O' Croinin D, Curley G, Harte BH, Laffey JG (2006) 'Evaluation of ease of intubation with the Airtraq® or Macintosh laryngoscope in routine airway management: a randomized, controlled clinical trial'. . [Details] |
| McDonnell JG, O'Donnell B, Curley G, Heffernan A, Power C, Laffey JG (2007) 'The analgesic efficacy of transversus abdominis plane block after abdominal surgery: a prospective randomized controlled trial'. . [Details] |
| Lynch T, Kinirons B, Laffey JG (2007) 'Meralgia Paraesthetica [Letter] (in press)'. IRISH MEDICAL JOURNAL, . [Details] |
| Malik MA, Maharaj CH, Harte BH, Laffey JG. (2008) 'Hypercapnic acidosis attenuates the severity of severe pulmonary sepsis by a neutrophil independent mechanism'. Critical Care Medicine, 36 (12):3135-3144. [DOI] [Details] |
| Higgins BD, Costello J, Contreras M, Hassett P, O' Toole D, Laffey JG. (2008) 'Determination of the efficacy and side-effect profile of lower doses of Intrathecal Morphine in Patients undergoing Total Knee Replacement'. BMC Anesthesiology, 8 (5). [Details] |
| Higgins BD, Costello J, Contreras M, Hassett P, O' Toole D, Laffey JG. (2008) 'A Comparison of Macintosh, Truview EV02â, Glidescope® and Airwayscope® Laryngoscopes in Patients with Cervical Spine Immobilization'. Br J Anaesth, 101 (5):723-730. [DOI] [Details] |
| Murphy C, Rooney SJ, Maharaj CH, Laffey JG, Harte BH. (2009) 'Tracheal intubation in patients with cervical spine immobilization: A comparison of the Airwayscope, LMA CTrach, and the Macintosh laryngoscopes. '. Br J Anaesth, 102 (5):654-661. [DOI] [Details] |
| Carney J, Finnerty O, Rauf J, Curley G, McDonnell JG, Laffey JG. (2009) 'A comparison of the Glidescope ®, the Pentax AWS ® and the Truview ® EVO2 to the Macintosh laryngoscope in experienced Anaesthetists - A manikin study'. Br J Anaes, 102 :128-134. [DOI] [Details] |
Laffey, J. G. (2009) 'Lung Injury and is Impact in ACS'. Acta Clinica Belgica, 64 (33):248-248.  [Details] |
| McElwain, J., Malik, M.A.,Harte, B.H., Flynn, N.M.,Laffey, J.G. (2010) 'Comparison of the C-MAC Videolaryngoscope with the Glidescope, Airtraq and Macintosh laryngoscope in easy and difficult laryngoscopy scenarios in manikins'. Anaesthesia, . [DOI] [Details] |
| Curley G, Kavanagh BP, Laffey JG. (2010) 'Hypocapnia in Acute Brain Injury: More harm than Benefit'. Critical Care Medicine, 38 (5):1348-1359. [DOI] [Details] |
| McElwain J, Malik MA, Laffey JG. (2010) 'Letter regarding IDS score'. Br J Anaes 2010 (in press), . [Details] |
| Curley G, Laffey JG, Kavanagh BP. (2010) 'Bench to Bedside Review: Carbon Dioxide'. Critical Care, 14 (220). [Details] |
| McElwain J, Malik MA, Harte BH, Flynn NH, Laffey JG, (2010) 'Determination of the optimal stylet strategy for use with the C-MAC laryngoscope - A manikin study'. Anaesthesia, 65 (4):369-378. [DOI] [Details] |
| Neligan P, Laffey JG (2011) 'Special Populations - Critical illness and pregnancy'. Critical Care, 15 . [DOI] [Details] |
| Laffey, JG (2011) 'Strengthening the evidence base for airway equipment: time to become more ‘ADEPT’?'. Anaesthesia, 66 (8):656-658. [Details] |
| White MB, Laffey JG, Kevin LG (2011) 'Casual bystander or active participant? New clues about adiponectin and traumatic injury'. Critical Care Medicine, 39 (8):2007-2008. [Details] |
| Curley G, Laffey, JG. (2011) 'Hypocapnia induced cerebral ischaemia during therapeutic hypothermia - potential for harm?'. Resuscitation, 82 (9):1122-1123. [Details] |
| Devaney J, Contreras M, Laffey JG. (2011) 'Gene based therapies for ALI/ARDS: where are we now?'. Critical Care, 15 (3). [Details] |
| Murphy, C, Rooney, SJ, Maharaj CH, Laffey JG, Harte BH. (2011) 'A comparison of three novel cuffed emergency percutaneous cricothyroidotomy devices to conventional surgical cricothyroidotomy in experienced Anaesthetists'. British Journal Of Anaesthesia, 106 (1):57-64. [Details] |
| Finnerty O, McDonnell JG, Laffey JG (2011) 'Stellate Ganglion blockade may provide analgesia following major upper limb surgery: a case series'. Anaesthesia, 66 (7):611-614. [Details] |
| Hayes M, Curley G, Laffey JG (2011) 'Lung derived Stem Cells - from an evolving understanding to a paradigm shift?'. Stem Cell Research & Therapy, 2 (5). [Details] |
| Curley G, Hayes M, Laffey JG. (2011) 'Can ‘permissive’ hypercapnia modulate sepsis induced ALI/ARDS'. Critical Care, 15 (2). [Details] |
| O'Sullivan E, Laffey J, Pandit JJ. (2011) 'A rude awakening after our fourth ‘NAP’: lessons for Airway Management'. Anaesthesia, 66 (5):390-392. [DOI] [Details] |
| McElwain J, Laffey JG (2011) 'A Comparison of the C-MAC®, Airtraq®, and Macintosh Laryngoscopes in Patients undergoing tracheal intubation with Cervical Spine Immobilisation'. British Journal Of Anaesthesia, 107 (2):258-264. [Details] |
| Quigley, E.M., Laffey, J.G. (2011) 'Selective Gut Decontamination: The authors reply'. Critical Care Medicine, 39 (12). [Details] |
| Farrell, H,Hayes, J,Laffey, J,Rowan, N (2011) 'Studies on the relationship between pulsed UV light irradiation and the simultaneous occurrence of molecular and cellular damage in clinically-relevant Candida albicans'. Journal Of Microbiological Methods, 84 :317-326. [DOI] [Details] |
| Hassett P, Curley GF, Contreras M, Masterson C, Higgins BD, O'Brien T, Devaney J, O'Toole D, Laffey JG. (2011) 'Overexpression of pulmonary extracellular uperoxide dismutase attenuates endotoxin induced acute lung injury'. Intensive Care Medicine, 37 (10):1680-1687. [Details] |
Other Journals
| Laffey JG (2003) 'Attenuation of the Stress response to Cardiac Surgery is Beneficial' Society of Cardiovascular Anaesthesia Newsletter . [Details] |
| Laffey JG (2003) 'Perioperative ACE Inhibitors and Outcome' Proceedings of the College of Anaesthetists RCSI Annual Scientific Meeting :30-33. [Details] |
| Laffey JG (2003) 'Permissive Hypercapnia - with or without Acidosis?' Journal fur Anasthesie und Intensivbehandlung :157-158. [Details] |
| Laffey JG (2003) 'The role of permissive hypercapnia in a concept of protective lung ventilation' Journal fur Anasthesie und Intensivbehandlung :100-102. [Details] |
| Laffey JG (2004) 'The inflammatory response to Surgery' Proceedings of the 2004 Annual Winter Anaesthesia Symposium . [Details] |
Conference Publications
| Heraty, K.B., Laffey, J.G., Quinlan, N.J. (2008) Fluid dynamics of gas exchange in high frequency oscillatory ventilation . In: Reilly, G.; Fitzpatrick, D eds. Proceedings of the 14th Annual Conference of the Section of Bioengineering of Royal Academy of Medicine in Ireland Sligo, Ireland, , 25-JAN-08 - 26-JAN-08 [Details] |
| Laffey JG (2008) Hypercapnia: Permissive and Therapeutic Society of Pediatric Anesthesia 2008 Winter Symposium [Details] |
Abstract
| MacLoughlin R, Higgins B, Laffey J, O'Brien T (2007) A systematic approach to maximising aerosol delivery of adeno-associated viral (AAV) vector to the lungs. British Association for Lung Research (BALR), 'Gene and Stem Cell Therapies for Lung Diseases', National University of Ireland, Maynooth, Ireland. Abstract [Details] |
| MacLoughlin R, Higgins B, Laffey J, O' Brien T (2007) Optimization of aerosol delivery to the lungs of Sprague-Dawley rat, an in vitro study of aerosol performance. International Society for Aerosols in Medicine (ISAM), 16th Congress, Vinci Congress Center. Tours, France: Abstract [Details] |
| MacLoughlin R, Higgins B, Laffey J, O'Brien T (2008) Aerosol delivery of rAAV pseudotypes 2, 2/5 and 2/6. ISGCT Annual Conference. UCC: Abstract [Details] |
| Laffey, JG (2009) Lung Injury and is Impact in ACS. Abstract [Details] |
| Hassett, P,Curley, G,O'Toole, D,O'Higgins, B,Laffey, J (2009) INTRAPULMONARY DELIVERY OF EXTRACELLULAR SUPEROXIDE DISMUTASE AMELIORATES LIPO-POLYSACCHARIDE INDUCED LUNG INJURY IN RATS. Abstract [Details] |
Conference Paper
| J.G. Laffey (2001) Managing Care - Is there a role for step-down units?' . Geneva, Switzerland: Conference Paper [Details] |
| J.G. Laffey (2003) Scientific Programme Chair, 2003 West of Ireland Symposium in Anaesthesia . Galway, Ireland: Conference Paper [Details] |
| J.G. Laffey (2003) 'The role of permissive hypercapnia in Protective Lung Ventilation strategies'. HAI 2003 Congress. Berlin, Germany: Conference Paper [Details] |
| J.G. Laffey (2003) Permissive Hypercapnia - with or without Acidosis?'. Bremen, Germany: Conference Paper [Details] |
| J.G. Laffey (2003) Chairman, Ventilation Session, Autumn Scientific Meeting, Intensive Care Society of Ireland . Galway, Ireland: Conference Paper [Details] |
| J.G. Laffey (2004) Symposium Co-Chairman, Session ‘Mechanical Ventilation: New Experimental Insights’, Annual Scientific Meeting, American Thoracic Society. Conference Paper [Details] |
| J.G. Laffey (2005) Succeeding in Basic Science Research. Intensive Care society Winter Meeting . Belfast, Northern Ireland: Conference Paper [Details] |
| J.G. Laffey (2006) Session chair - ESICM Conference. Conference Paper [Details] |
Editorial
| Costello, JF,Laffey, JG (2007) Implementing scientific advances into clinical practice in critical care - New challenges and new insights. Editorial [DOI] [Details] |
| Hassett, P,Laffey, JG (2007) Permissive hypercapnia: Balancing risks and benefits in the peripheral micro circulation. Editorial [DOI] [Details] |
| Kevin, LG,Laffey, JG (2008) Carbon monoxide - From poison to therapy for cardiopulmonary bypass-induced lung injury?. Editorial [Details] |
| Curley, GF,Kevin, LG,Laffey, JG (2009) Mechanical Ventilation Taking Its Toll on the Lung. Editorial [Details] |
| Laffey, JG (2011) Strengthening the evidence base for airway equipment: time to be more 'ADEPT'?. Editorial [DOI] [Details] |
| White, M,Laffey, JG,Kevin, LG (2011) Casual bystander or active participant? New clues about adiponectin and traumatic injury. Editorial [DOI] [Details] |
| Curley, G,Laffey, JG (2011) Hypocapnia induced cerebral ischaemia during therapeutic hypothermia-Potential for harm?. Editorial [DOI] [Details] |
| Ansari, B,Laffey, JG (2012) Ischemia-reperfusion-induced lung injury: Could hypercapnia have a therapeutic role?. Editorial [DOI] [Details] |
| O'Sullivan, E,Laffey, J,Pandit, JJ (2011) A rude awakening after our fourth 'NAP': lessons for airway management. Editorial [DOI] [Details] |
Invited papers
| J.G. Laffey (1998) The Post Anaesthesia Care Unit - the anaesthetists’ perspective, National symposium on Post-Anaesthesia Care, Mater Hospital Dublin, Ireland. Invited papers [Details] |
| J.G. Laffey (2000) Carbon Dioxide and the critically ill - too little of a good thing. Critical Care Grand Rounds, University of Toronto, Hospital for Sick Children. Invited papers [Details] |
| J.G. Laffey (2001) Carbon dioxide and Acute Organ Injury. Respiratory Research Rounds. St. Vincent?s University Hospital Dublin, Ireland: Invited papers [Details] |
| J.G. Laffey (2001) Therapeutic Hypercapnia - current insights, future prospects.Research Grand Rounds. University College Hospital Galway, Ireland: Invited papers [Details] |
| J.G. Laffey (2001) Hypercapnia - from ‘Permissive’ to Therapeutic’. Anaesthesia Grand Rounds. Adelaide Meath and National Children?s Hospital: Invited papers [Details] |
| J.G. Laffey (2003) Maternal Brain Death in Ireland - Medical, Legal and Ethical issues. Submission to Roundtable Discussion Forum, Winter Scientific Meeting. Intensive Care Society of Ireland Dublin, Ireland: Invited papers [Details] |
| J.G. Laffey (2003) Perioperative ACE Inhibitors and Patient Outcome . Dublin, Ireland: Invited papers [Details] |
| J.G. Laffey (2003) Buffering that Acidosis - treating the patient or the physician?. Galway, Ireland: Invited papers [Details] |
| J.G. Laffey (2003) Low Tidal volume Ventilation - with or without permissive hypercapnia? . Berlin, Germany: Invited papers [Details] |
| J.G. Laffey (2004) The inflammatory response to Cardiac Surgery, Annual Winter Anaesthesia Symposium. University of Leuven, Belgium: Invited papers [Details] |
| J.G. Laffey (2005) Mechanical Ventilation - From Bench to Bedside' at the Dingle 2005 Annual Symposium . Dingle, Ireland: Invited papers [Details] |
| J.G. Laffey (2006) ‘Meningococcemia’ delivered to Critical Care Nursing Conference . Galway, Ireland: Invited papers [Details] |
| J.G. Laffey (2006) ‘The inflammatory response to Surgery’ delivered at Western anaesthesia Symposium. Invited papers [Details] |
| J.G. Laffey (2006) The critically ill child with Meningococcemia. Critical Care Nursing Conference . Galway, Ireland: Invited papers [Details] |
| J.G. Laffey (2006) ‘Ethylene Glycol Intoxication' delivered at European Society of Intensive Care Medicine Annual conference. Barcelona, Spain: Invited papers [Details] |
| J.G. Laffey (2006) Low Tidal volume Ventilation - with or without permissive hypercapnia?. 'Role of hypercapnia in protective lung ventilatory strategies' at ICSI/SICS Meeting Dunblane, Scotland. Invited papers [Details] |
| J.G. Laffey (2006) Caring for the Critically ill Mother. 'Obstetric Critical Care' Dingle 2006 Conference Dingle, Ireland. Invited papers [Details] |
| J.G. Laffey (2006) ‘Advances in Mechanical Ventilation’, delivered at Association of Critical Care Nurses Annual Meeting, May 27th 2006. Galway, Ireland: Invited papers [Details] |
| J.G. Laffey (2006) Ethylene Glycol Intoxication. ‘The critically ill Obstetric Patient’ delivered at European Society of Intensive Care Medicine Annual conference Barcelona, Spain. Invited papers [Details] |
| J.G. Laffey (2006) ‘Buffering Hypercapnic Acidosis’ delivered at European Society of Intensive Care Medicine Annual conference Barcelona, Spain. Invited papers [Details] |
| J.G. Laffey Permissive Hypercapnia at the Intensive Care Society UK, Annual State of the Art Conference London, UK. Invited papers [Details] |
Honours and Awards
| Year: 2008. Title: Keynote speaker, Drager Medal Lecture |
| Year: 2000. Title: Young Investigator Award |
| Year: 1999. Title: Hynek Rothbart Research Prize |
Associations
| Association: European Society of Intensive Care Medicine, Function/Role: Deputy Chairman, Acute Respiratory Failure Section |
| Association: Irish Critical Care Trials Group, Function/Role: Deputy Chair |
Committees
| Committee : Final Fellowship Examination in Anaesthesia, College of Anaesthetists |
| Committee : Academic Anaesthesia Committee, College of Anaesthetists |
| Committee : Intensive Care Society of Ireland |
| Committee : Anaesthesiology and Pain Medicine Expert Review Panel, F1000 Medicine |
| Committee : Society for Education in Anesthesia |
| Committee : Cochrane Anaesthesia Research Group |
| Committee : Association of Anaesthetists of Great Britain and Ireland |
| Committee : International Anaesthesia Research Society |
| Committee : European Society of Intensive Care Medicine |
| Committee : American Thoracic Society |
| Committee : Intensive Care Society of Ireland |
Education
| Year 1989 Institution: NUI Galway Qualification: BSc Subject: Biochemistry |
| Year 1992 Institution: NUI Galway Qualification: Bachelor of Medicine Subject: Medicine |
| Year 2001 Institution: Institute Of Public Administration, Dublin Qualification: Masters of Arts Subject: Healthcare Management |
| Year 2001 Institution: NUI Galway Qualification: Doctor of Medicine Subject: Medicine |
Teaching Interests
Recent Postgraduates
| 1. Dr John Carney, MB
2. Dr Patrick Hassett, MB
3. Dr
4. Dr Martina Ni Chonghaile, MB
5. Dr
6. Dr
7. Dr Alistair Nichol, MB [Co-supervised with Prof P. McLoughlin, UCD]
8. Dr Donall O’
|