Research Interests

Adult stem cells, Regulation of Stem Cell Differentiation, micro RNA regulation of cell proliferation and differentiation

 

     

Peer Reviewed Journals

Howard L, Glynn P. (1995) 'Membrane-associated metalloproteinase recognized by characteristic cleavage of myelin basic protein: assay and isolation'. Methods in Emzymology, 248 :388-395. [Details]

Howard L, Lu X, Mitchell S, Griffiths S, Glynn P. (1996) 'Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types'. Biochem J, 317 (1):45-50. [Details]

Piñeiro-Sánchez ML, Goldstein LA, Dodt J, Howard L, Yeh Y, Tran H, Argraves WS, Chen WT. (1997) 'Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease'. J. BIOL. CHEM, 272 (12):7595-7601. [Details]

Nakahara H, Howard L, Thompson EW, Sato H, Seiki M, Yeh Y, Chen WT. (1997) 'Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 94 (15):7959-7964. [Details]

Howard L, Nelson KK, Maciewicz RA, Blobel CP. (1999) 'Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1'. J. BIOL. CHEM, 274 (44):31693-31699. [Details]

Mueller SC, Ghersi G, Akiyama SK, Sang QX, Howard L, Pineiro-Sanchez M, Nakahara H, Yeh Y, Chen WT. (1999) 'A novel protease-docking function of integrin at invadopodia'. J. BIOL. CHEM, 274 (35):24947-24953. [Details]

Howard L, Maciewicz RA, Blobel CP. (2000) 'Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28'. Biochem J, 348 (1):21-27. [Details]

Howard L, Zheng Y, Horrocks M, Maciewicz RA, Blobel C. (2001) 'Catalytic activity of ADAM28'. FEBS LETTERS, 498 (1):82-86. [Details]

Neuhuber B, Gallo G, Howard L, Kostura L, Mackay A, Fischer I. (2004) 'Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype'. JOURNAL OF NEUROSCIENCE RESEARCH, 77 (2):192-204. [Details]

McMahon JM, Conroy S, Lyons M, Greiser U, O'shea C, Strappe P, Howard L, Murphy M, Barry F, O'Brien T. (2006) 'Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors'. Stem Cells and Development, 15 (1):87-96. [Details]

Cooney R, Hynes SO, Sharif F, Howard L, O'Brien T. (2007) 'Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury'. Gene Therapy, 14 (5):396-404. [Details]

Neuhuber B, Swanger SA, Howard L, Mackay A, Fischer I. (2008) 'Effects of plating density and culture time on bone marrow stromal cell characteristics'. Exp Hematol, 36 (9):1176-1185. [Details]

Sen S, Conroy S, Hynes SO, McMahon J, O'Doherty A, Bartlett JS, Akhtar Y, Adegbola T, Connolly CE, Sultan S, Barry F, Katusic ZS, O'Brien T. (2008) 'Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model'. J Cell Mol Med, 12 (6B):2628-2643. [DOI] [Details]

Sharif F, Hynes SO, Cooney R, Howard L, McMahon J, Daly K, Crowley J, Barry F, O'Brien T. (2008) 'Gene-eluting stents: adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis'. Molecular Therapy, 16 (10):1674-1680. [Details]

Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP. (2008) '6: Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'. TISSUE ENGINEERING. PART A. TISSUE ENGINEERING, 14 (5):681-690. [Details]

Rooney GE, Howard L, O'Brien T, Windebank AJ, Barry FP. (2009) 'Elevation of cAMP in mesenchymal stem cells transiently upregulates neural markers rather than inducing neural differentiation'. Stem Cells and Development, 18 (3):387-398. [Details]

Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Madigan NN, Fluegel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry F. (2009) 'Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells'. TISSUE ENGINEERING. PART A. TISSUE ENGINEERING, . [Details]

Moloney TC, Rooney GE, Barry FP, Howard L, Dowd E. (2010) 'Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain'. Brain Research, 1359 :33-43. [Details]

Moloney TC, Dockery P, Windebank AJ, Barry FP, Howard L, Dowd E. (2010) 'Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain'. Neurorehabil Neural Repair, 24 (7):645-656. [Details]