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Dr Michelle Roche BSc., MSc., PhD.
|Dr Roche graduated in 1999 with a B.Sc. (Hons.) degree in Physiology at NUI Galway following which she undertook an M.Sc. in Neuropharmacology (1999-2001). Her interest in stress-related disorders began during her time as a research assistant in Prof Rita Valentino laboratory in Philadelphia (2001) where she examined the neural circuitry underlying stress-induced changes in the serotonergic system. She subsequently pursued a Ph.D. (2002-2005) characterizing behavioural and physiological responses in models of depression at the Department of Pharmacology, NUI Galway. Following a year as a contract lecturer, Dr Roche undertook a post-doctoral research (2005-2008) position with Dr David Finn focused on the role of the endocannabinoid system on conditioned stress-induced changes in pain responding and inflammation. In September 2008, Dr Roche was appointed Lecturer in Physiology at NUI Galway.
Dr Roches' research interests include:
|Roche M (2011) 'The Olfactory Bulbectomised Mouse' In: Ed T Gould (eds). In Mood and Anxiety Related Phenotypes in Mice. USA: Humana Press. [Details]|
Peer Reviewed Journals
|Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., & Hughes, B. M. (2015) 'Salivary cortisol levels and challenging behaviour in children with autism spectrum disorder'. Research In Autism Spectrum Disorders, . [Details]|
|Rea, K,Olango, WM,Okine, BN,Madasu, MK,McGuire, IC,Coyle, K,Harhen, B,Roche, M,Finn, DP (2014) 'Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli'. Pain, 155 :69-79. [DOI] [Details]|
|Olango, WM,Geranton, SM,Roche, M,Hunt, SP,Finn, DP (2014) 'Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats'. European Journal Of Pain, 18 :182-191. [DOI] [Details]|
|Henry, RJ,Kerr, DM,Finn, DP,Roche, M (2014) 'FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus'. Journal Of Neuroimmunology, 276 :126-134. [DOI] [Details]|
|Burke NN, Finn DP, Roche M (2014) 'Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype'. Behavioural Brain Research, . [DOI] [Details]|
|Rea K, Ford GK, Olango WM, Harhen B, Roche M, Finn DP (2014) 'Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state'. European Journal Of Neuroscience, 39 (3):435-443. [Details]|
|Burke NN, Kerr DM, Moriarty O, Finn DP, Roche M (2014) 'Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression'. Brain Behavior And Immunity, . [DOI] [Details]|
|Jennings EM, Okine BN, Roche M, Finn DP (2014) 'Stress-induced hyperalgesia'. Progress in neurobiology, 121C :1-18. [DOI] [Details]|
|Okine BN, Rea K, Olango WM, Price J, Roche M, Finn DP (2014) 'A role for PPAR-α in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats'. British J Pharmacology, . [Details]|
|Rea, K,Olango, WM,Harhen, B,Kerr, DM,Galligan, R,Fitzgerald, S,Moore, M,Roche, M,Finn, DP (2013) 'Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats'. Pain, 154 :576-585. [DOI] [Details]|
|Burke NN, Geoghegan E, Kerr DM, Moriarty O, Finn DP, Roche M. (2013) 'Altered Neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala'. Genes Brain And Behavior, 0 (0):0-0. [DOI] [Details]|
|Burke NN, Llorente R, Marco EM, Tong K, Finn DP, Viveros M-P, Roche M (2013) 'Maternal deprivation is associated with sex dependant alterations in nociceptive behavioura nd neuriinflammatory mediators in the rat following peripheral nerve injury'. Journal Of Pain, 14 (10):1173-1184. [DOI] [Details]|
|Kerr DM, Downey L, Conboy M, Finn DP, Roche M (2013) 'Alterations in the endocannabinoid system in the rat valproic acid model of autism'. Behavioural Brain Research, 249 (0):124-132. [DOI] [Details]|
|Kerr DM, Harhen B, Egan LJ, Finn DP, Roche M (2013) 'Pharmacological inhibition of monoacylglycerol lipase attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action'. British Journal Of Pharmacology, 169 (4):808-819. [DOI] [ARAN Link] [Details]|
|Kerr DM, Burke NN, Ford GK, Connor TJ, Harhen B, Egan LP, Finn DP, Roche M (2012) 'Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the rat hypothalamus following an immunological stressor'. Neuroscience, 204 :53-63. [ARAN Link] [Details]|
|Butler RK, Ford GK, Hogan M, Roche M, Doyle KM, Kelly JP, Kendall DA, Chapman V, Finn DP. (2012) 'Fear-induced suppression of nociceptive behaviour and activation of signal transduction molecules in the rat periaqueductal grey: role of fatty acid amide hydrolase'. Journal Of Psychopharmacology, . [ARAN Link] [Details]|
|Olango, WM,Roche, M,Ford, GK,Harhen, B,Finn, DP (2012) 'The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone'. British Journal Of Pharmacology, 165 :2549-2560. [DOI] [Details]|
|Roche, M., Kerr, D.M., Hunt, S.P. and Kelly, J.P. (2012) 'Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression'. Behavioural Brain Research, 228 (0):91-98. [DOI] [Details]|
|Moriarty, O,Roche, M,McGuire, BE,Finn, DP (2012) 'Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain'. Journal Of Neuroscience Methods, 204 :1-8. [DOI] [Details]|
|Rea, K,Roche, M,Finn, DP (2011) 'Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala'. Journal Of Pain, 12 :712-721. [DOI] [ARAN Link] [Details]|
|Burke, NN,Hayes, E,Calpin, P,Kerr, DM,Moriarty, O,Finn, DP,Roche, M (2010) 'Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions'. Neuroscience, 171 (0):1300-1313. [DOI] [ARAN Link] [Details]|
|Roche M, Finn DP (2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'. Pharmaceuticals (Invited Review), 3 (0):2517-2553. [DOI] [ARAN Link] [Details]|
|Roche, M,Johnston, P,Mhuircheartaigh, ON,Olango, WM,Mackie, K,Finn, DP (2010) 'Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear'. European Journal Of Pain, 14 :487-495. [DOI] [Details]|
|Roche M, Finn DP (2009) '6-iodonordihydrocapsaicin'. Xpharm, 0 (0):0-0. [DOI] [ARAN Link] [Details]|
|Smith, KL,Roche, M,Jessop, DS,Finn, DP (2009) 'The effects of synthetic and endogenous imidazoline binding site ligands on neuronal activity in discrete brain regions of naive and restraint-stressed rats'. European Neuropsychopharmacology, 19 :371-380. [DOI] [Details]|
|Roche M, Shanahan E, Harkin A, Kelly JP (2008) 'Trans-species assessment of antidepressant activity in a rodent model of depression'. Pharmacological Reports, 60 (0):404-408. [DOI] [Details]|
|Roche M, Kelly JP, O'Driscoll M, Finn DP (2008) 'Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats'. Immunology, 125 (2):263-271. [DOI] [Details]|
|Roche, M., Harkin, A., Kelly, J. P. (2007) 'Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat'. Neuropsychopharmacology, 32 (6):1312-1320. [ARAN Link] [Details]|
|Rea K, Roche M, Finn DP (2007) 'Supraspinal sites and mechanisms mediating the effects of cannabinoids on pain: the role of GABA and glutamate'. British Journal Of Pharmacology, 152 (2):267-286. [DOI] [Details]|
|Roche M, O’Connor E, Diskin C, Finn DP. (2007) 'The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats'. European Journal Of Neuroscience, 26 (9):2643-2653. [DOI] [Details]|
|Roche M, Diamond M, Kelly JP, Finn DP (2006) 'In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids'. Journal Of Neuroimmunology, 181 (1-2):57-67. [DOI] [Details]|
|Zueger, A,Urani, A,Chourbaji, S,Zacher, C,Roche, M,Harkin, A,Gass, P (2005) 'Olfactory bulbectomy in mice induces alterations in exploratory behavior'. Neuroscience Letters, 374 :142-146. [DOI] [Details]|
|Roche, M., Commons, K. G., Peoples, A. & Valentino, R. J. (2003) 'Circuitry underlying regulation of the serotonergic system by swim stress'. Journal of Neuroscience, 23 (3):990-997. [Details]|
| Coordinator for 3rd year Physiology (B.Sc. and B.Sc. Biomedical Science).
Deliver lecturers, seminars and projects in the areas of Neurophysiology, Endocrinology, Advanced Research Methods
PhD students: 2009-present: Nikita Burke
2009-present: Nikita Burke
Post Doctoral Researchers (co-PI)
2011-present: Dr Kieran Rea
|2008-present Understanding of the physiological actions of hormones: Endocrinology|
|2008-present Pathophysiology underlying neurological, psychiatric and neurodegenerative disorders: Advanced Neurophysiology|
|2008-present Understanding the physiologial action of neurons, glia and the physiological processes underlying movement, sensation, hearing, vision, emotion, speech and language: Neurophysiology|
|2009-present : Advanced Research Methods|
| Dr David Finn
Dr John Kelly
Prof Sanbing Shen
Prof Abhay Pandit
Prof Laurence Egan
| Dr Andrew Harkin, Trinity College Dublin, Ireland
Prof Stephen Hunt, University College, London, UK
Dr Marie-Christine Pardon, University of Nottingham, UK
Prof Maria-Paz Viveros, University of Madrid Spain
Dr Eva Marco, University of Madrid, Spain
Dr Daniel Broom, Covidien, USA
Dr Massimiliano Bianchi, MAPERG, Paris, France
Dr Daniel Deaver, Alkermes Inc, USA