Prof Rhodri Ceredig B.Sc., M.B., Ch.B., Ph.D., FRCPath.
Contact Details
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Biography:
| I am a basic cellular and molecular immunologist whose approach to immunology has been heavily influenced by experimental hematology, that is that lymphocytes are the progeny of hematopoietic stem cells and that their development follows many of the general rules of hematology. For my PhD, carried out at the Walter and Eliza Hall Institute, Australia in the group of Prof. Don Metcalf, I characterized the ontogeny of so-called "alloreactive" T cell precursors in the developing mouse thymus. Alloreactive T cells are involved in allogeneic graft rejection. Part of my work at this time (1979) was also to show that non-cytotoxic (CD8-) T cells were responsible for allogeneic mouse skin graft rejection. For my post-doctoral studies at the Ludwig Institute for Cancer Resaerch, Lausanne, Switzerland I was one of the first to combine flow cytometry, monoclonal antibodies and limiting dilution to quantify the alloreactive T cell response. We also identified for the first time, early T cell progenitors in the thymus. In Canberra, Australia I was responsible for establishing a functional flow cytometry facility at the John Curtin School of Medical Research. With Peter Doherty, we dissected the inflammatory infiltrate in mouse lymphocytic choriomeningitis virus infection and showed that this immune response in vivo obeyed the now-accepted rules of MHC restriction. In collaboration with Charmaine Simeonovic, we described immunological aspects of tolerance induction to transplanted xenogeneic (pig) pro-islets. In the LGME institute directed by Pierre Chambon in Strasbourg, France I learnt how molecular biology could impact on my own research interests. There, we generated a transgenic mouse over-expressing the cytokine Interleukin-7 (IL-7), a molecule involved both in lymphocyte development and survival. From these transgenic mice and in order to biologically clone cell lines from lymphomas that arose in these mice, we developed a bone marrow-derived mesenchymal stromal cell (MSC) clone. Since that time (1993), I have focused my research interest on IL-7. The advent of a recent mesenchymal stromal cell-based co-culture system supplemented with IL-7 for growing and influencing the commitment and development of lymphoid progenitors has revolutionized our approach to lymphocyte development. From 2003-2008, I was a guest scientist in the group of Prof. Ton Rolink at the University of Basel. Here, I collaborated with scientists investigating the immunological properties of MSC in vitro, work resulting in two publications. With Prof. Rolink, we were interested in the role of regulatory T cells in preventing auto-immunity that arises following bone marrow transplantation. Recently, with colleagues in Birmingham and Basel, I have become interested in more general aspects of lymphocyte development and hematopoietic lineage commitment. This has resulted in several publications, a book and recently attribution of an FP7 Marie Curie Initial Training Network grant entitled "DECIDE" with which we hope to further develop our modifiied model of hematopoiesis. In addition to science, I'm interested in Irish traditional music. I play the fiddle. I'm also interested in hill walking and fitness. |
Peer Reviewed Journals
| Swee LK, Bosco N, Malissen B, Ceredig R, Rolink A (2009) 'Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment'. Blood, 113 (25):6277-6287. [DOI] [Details] |
| T. Sugrue, J. Brown, N.L. Lowndes and Rh. Ceredig (2012) 'Multiple Facets of the DNA Damage Response Contribute to the Radioresistance of Mouse Mesenchymal Stromal Cell Lines'. Stem Cells, . [Details] |
| Rhodri Ceredig (2012) 'Fates and potentials of thymus-seeding progenitors'. Nature Immunology, 13 . [Details] |
| Schmutz, S,Bosco, N,Chappaz, S,Boyman, O,Acha-Orbea, H,Ceredig, R,Rolink, AG,Finke, D (2009) 'Cutting Edge: IL-7 Regulates the Peripheral Pool of Adult ROR gamma(+) Lymphoid Tissue Inducer Cells'. Journal Of Immunology, 183 :2217-2221. [DOI] [Details] |
| Duffy M (Duffy, Michelle)1, Pindjakova J (Pindjakova, Jana)1, Weidhofer G (Weidhofer, Gudrun)1, Hanley S (Hanley, Shirley)1, Mahon BP (Mahon, Bernard P.)2, Ceredig R (Ceredig, Rhodri)1, Griffin M (Griffin, Matthew)1 (2010) 'Mesenchymal Stromal Cells (MSCs) Potently Inhibit the Primary Induction of T-Helper 17 Cells through Cell-Cell Contact'. AMERICAN JOURNAL OF TRANSPLANTATION, 10 (4):465-465. [Details] |
| Duffy, MM,Pindjakova, J,Hanley, SA,McCarthy, C,Weidhofer, GA,Sweeney, EM,English, K,Shaw, G,Murphy, JM,Barry, FP,Mahon, BP,Belton, O,Ceredig, R,Griffin, MD (2011) 'Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'. Eur J Immunol, 41 :2840-2851. [DOI] [Details] |
Tussiwand, R., Engdahl, C., Gehre, N., Bosco, N., Ceredig, R., Rolink, A.G. (2011) 'The preTCR-dependent DN3 to DP transition requires Notch signaling, is improved by CXCL12 signaling and is inhibited by IL-7 signaling'. European Journal of Immunology, 41 (11):3371-3380.  [Details] |
| Toh, B. H.,Ceredig, R.,Cornell, F. N.,Clarke, F. M. (1977) 'Multiple myeloma and monoclonal IgA with anti-actin reactivity'. Clin Exp Immunol, 30 (33):379-83. [Details] |
| Ceredig, R.,Toh, B. H. (1977) 'Reaction of human smooth muscle autoantibody with gastric parietal cells: a pitfall in the diagnosis of parietal cell autoantibody'. J Clin Pathol, 30 (77):666-70. [Details] |
| Ceredig R, Henderson DC, Nairn RC (1977) 'Experimental model of ulcerative colitis'. Nature, 266 (5597):74-75. [Details] |
| Nairn, R. C.,Nind, A. P.,Pihl, E.,Ceredig, R.,Jablonka, I. M.,Cuthbertson, A. M.,Hughes, E. S.,Rollo, A. J. (1977) 'Sequential antitumour immunoreactivity and carcinoembryonic antigen levels as a guide to prognosis in colorectal carcinoma'. Aust N Z J Surg, 47 (55):637-41. [Details] |
| Ceredig, R.,Toh, B. H. (1978) 'Ontogeny of actin and microsomal antigens in gastric parietal cells'. J Clin Pathol, 31 (66):578-84. [Details] |
| Toh, B. H.,Clarke, F. M.,Ceredig, R. (1978) 'Reaction of human smooth muscle autoantibody with skeletal muscle, cardiac muscle, and thymic myoid cells'. Clin Immunol Immunopathol, 9 (11):28-36. [Details] |
| Ceredig, R. (1979) 'Frequency of alloreactive cytotoxic T cell precursors in the mouse thymus and spleen during ontogeny'. Transplantation, 28 (55):377-81. [Details] |
| Macfarlan, R. I.,Ceredig, R.,White, D. O. (1979) 'Comparison of natural killer cells induced by Kunjin virus and Corynebacterium parvum with those occurring naturally in nude mice'. Infect Immun, 26 (33):832-6. [Details] |
| Handman, E.,Ceredig, R.,Mitchell, G. F. (1979) 'Murine cutaneous leishmaniasis: disease patterns in intact and nude mice of various genotypes and examination of some differences between normal and infected macrophages'. Aust J Exp Biol Med Sci, 57 (11):9-29. [Details] |
| Ceredig, R. (1980) 'Frequencies of alloreactive cytotoxic T-lymphocyte precursors responding to H-2 antigens alone'. Immunology, 40 (22):163-9. [Details] |
| Ceredig, R.,Mandel, T. E. (1981) 'Frequencies of cytotoxic T lymphocyte precursors in thymus-grafted nude mice'. Transplantation, 31 (66):482-4. [Details] |
| Ceredig, R. (1981) 'Spontaneous cytotoxicity'. Aust J Exp Biol Med Sci, 59 (Pt 6Pt 6):681-94. [Details] |
| Stanbridge, E. J.,Ceredig, R. (1981) 'Growth-regulatory control of human cell hybrids in nude mice'. Cancer Res, 41 (22):573-80. [Details] |
| Loveland, B. E.,Hogarth, P. M.,Ceredig, R.,McKenzie, I. F. (1981) 'Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection'. J Exp Med, 153 (55):1044-57. [Details] |
| Loveland, B.,Ceredig, R.,Hogarth, M.,McKenzie, I. (1981) 'The key role of Lyt-1+ cells in skin graft rejection in the mouse'. Transplant Proc, 13 (1 Pt 21 Pt 2):1079-81. [Details] |
| Ceredig, R.,MacDonald, H. R. (1982) 'Phenotypic and functional properties of murine thymocytes. II. Quantitation of host- and donor-derived cytolytic T lymphocyte precursors in regenerating radiation bone marrow chimeras'. J Immunol, 128 (22):614-20. [Details] |
| Ceredig, R.,Glasebrook, A. L.,MacDonald, H. R. (1982) 'Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of mature thymocytes as analyzed by monoclonal antibodies and flow microfluorometry'. J Exp Med, 155 (22):358-79. [Details] |
| Ceredig, R.,Jenkinson, E. J.,MacDonald, H. R.,Owen, J. J. (1982) 'Development of cytolytic T lymphocyte precursors in organ-cultured mouse embryonic thymus rudiments'. J Exp Med, 155 (22):617-22. [Details] |
| Ceredig, R.,MacDonald, H. R. (1982) 'Ontogeny of murine thymus cells: correlation of surface phenotype with the appearance of cytolytic T lymphocyte precursors'. Prog Clin Biol Res, 85 Pt A :443-9. [Details] |
| Sekaly, R. P.,Ceredig, R.,MacDonald, H. R. (1983) 'Generation of thymocyte subpopulations in organ culture: correlated analysis of Lyt-2 phenotype and cell cycle status by flow microfluorometry'. J Immunol, 131 (33):1085-9. [Details] |
| Ceredig, R.,Cummings, D. E. (1983) 'Phenotypic and functional properties of murine thymocytes. III. Kinetic analysis of the recovery of intrathymic cytolytic T lymphocyte precursors after in vivo administration of hydrocortisone acetate'. J Immunol, 130 (11):33-7. [Details] |
| Ceredig, R.,Dialynas, D. P.,Fitch, F. W.,MacDonald, H. R. (1983) 'Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5'. J Exp Med, 158 (55):1654-71. [Details] |
| Ceredig, R.,Sekaly, R. P.,MacDonald, H. R. (1983) 'Differentiation in vitro of Lyt 2+ thymocytes from embryonic Lyt 2- precursors'. Nature, 303 (59145914):248-50. [Details] |
| Ceredig, R.,MacDonald, H. R.,Jenkinson, E. J. (1983) 'Flow microfluorometric analysis of mouse thymus development in vivo and in vitro'. Eur J Immunol, 13 (33):185-90. [Details] |
| Czitrom, A. A.,Sunshine, G. H.,Reme, T.,Ceredig, R.,Glasebrook, A. L.,Kelso, A.,MacDonald, H. R. (1983) 'Stimulator cell requirements for allospecific T cell subsets: specialized accessory cells are required to activate helper but not cytolytic T lymphocyte precursors'. J Immunol, 130 (22):546-50. [Details] |
| Ceredig, R.,Lopez-Botet, M.,Moretta, L. (1984) 'Phenotypic and functional properties of mouse and human thymocytes'. Semin Hematol, 21 (44):244-56. [Details] |
| Bamat, J.,Sordat, B.,Lees, R. K.,Zaech, P.,Ceredig, R.,MacDonald, H. R. (1984) 'Development and localization of 'T-like' cells in the nude mouse'. Exp Cell Biol, 52 (1-21-2):25-9. [Details] |
| Ceredig, R.,Schreyer, M. (1984) 'Immunohistochemical localization of host and donor-derived cells in the regenerating thymus of radiation bone marrow chimeras'. Thymus, 6 (1-21-2):15-26. [Details] |
| Ceredig, R.,MacDonald, H. R. (1985) 'Intrathymic differentiation: some unanswered questions'. Surv Immunol Res, 4 (22):87-95. [Details] |
| Davignon, J. L.,Budd, R. C.,Ceredig, R.,Piguet, P. F.,MacDonald, H. R.,Cerottini, J. C.,Vassalli, P.,Izui, S. (1985) 'Functional analysis of T cell subsets from mice bearing the lpr gene'. J Immunol, 135 (44):2423-8. [Details] |
| Ceredig, R.,Lowenthal, J. W.,Nabholz, M.,MacDonald, H. R. (1985) 'Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells'. Nature, 314 (60066006):98-100. [Details] |
| Romani, N.,Tschachler, E.,Schuler, G.,Aberer, W.,Ceredig, R.,Elbe, A.,Wolff, K.,Fritsch, P. O.,Stingl, G. (1985) 'Morphological and phenotypical characterization of bone marrow-derived dendritic Thy-1-positive epidermal cells of the mouse'. J Invest Dermatol, 85 (1 Suppl1 Suppl). [Details] |
| Titus, R. G.,Ceredig, R.,Cerottini, J. C.,Louis, J. A. (1985) 'Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice'. J Immunol, 135 (33):2108-14. [Details] |
| McKinnon, D.,Ceredig, R. (1986) 'Changes in the expression of potassium channels during mouse T cell development'. J Exp Med, 164 (66):1846-61. [Details] |
| Ceredig, R.,Corradin, G. (1986) 'High antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones'. Eur J Immunol, 16 (11):30-4. [Details] |
| Chaudhri, G.,Clark, I. A.,Hunt, N. H.,Cowden, W. B.,Ceredig, R. (1986) 'Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation'. J Immunol, 137 (88):2646-52. [Details] |
| Ceredig, R. (1986) 'Major histocompatibility-restricted cytolytic T-lymphocyte precursors from the thymus of in vivo primed mice: increased frequency and resistance to anti-Lyt-2 antibody inhibition'. Curr Top Microbiol Immunol, 126 :27-33. [Details] |
| Lowenthal, J. W.,Howe, R. C.,Ceredig, R.,MacDonald, H. R. (1986) 'Functional status of interleukin 2 receptors expressed by immature (Lyt-2-/L3T4-) thymocytes'. J Immunol, 137 (88):2579-84. [Details] |
| Ceredig, R. (1986) 'Proliferation in vitro and interleukin production by 14 day fetal and adult Lyt-2-/L3T4- mouse thymocytes'. J Immunol, 137 (77):2260-7. [Details] |
| Ceredig, R.,Lynch, F.,Newman, P. (1987) 'Phenotypic properties, interleukin 2 production, and developmental origin of a mature subpopulation of Lyt-2- L3T4- mouse thymocytes'. Proc Natl Acad Sci U S A, 84 (2323):8578-82. [Details] |
| Ceredig, R.,Allan, J. E.,Tabi, Z.,Lynch, F.,Doherty, P. C. (1987) 'Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis'. J Exp Med, 165 (66):1539-51. [Details] |
| Lynch, F.,Chaudhri, G.,Allan, J. E.,Doherty, P. C.,Ceredig, R. (1987) 'Expression of Pgp-1 (or Ly24) by subpopulations of mouse thymocytes and activated peripheral T lymphocytes'. Eur J Immunol, 17 (11):137-40. [Details] |
| Chaudhri, G.,Hunt, N. H.,Clark, I. A.,Ceredig, R. (1988) 'Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin'. Cell Immunol, 115 (11):204-13. [Details] |
| Ceredig, R. (1988) 'Differentiation potential of 14-day fetal mouse thymocytes in organ culture. Analysis of CD4/CD8-defined single-positive and double-negative cells'. J Immunol, 141 (22):355-62. [Details] |
| Chaudhri, G.,Clark, I. A.,Ceredig, R. (1988) 'Proliferation in vitro of Lyt2-,L3T4- thymocytes shows responsiveness to interleukin 1'. Clin Exp Immunol, 73 (11):51-6. [Details] |
| Lynch, F.,Ceredig, R. (1988) 'Ly-24 (Pgp-1) expression by thymocytes and peripheral T cells'. Immunol Today, 9 (11):7-10. [Details] |
| Doherty, P. C.,Allan, J. E.,Ceredig, R. (1988) 'Contributions of host and donor T cells to the inflammatory process in murine lymphocytic choriomeningitis'. Cell Immunol, 116 (22):475-81. [Details] |
| McCrae, C.,Maxwell, L.,Ceredig, R. (1988) 'Intracellular pathway of interleukin-2 receptors studied using immunogold electron microscopy'. Immunol Cell Biol, 66 ( Pt 3) :185-91. [Details] |
| Ceredig, R.,Robins, T.,Campbell, H. D.,Young, I. G.,Hapel, A. J. (1988) 'Correlation of interleukin-2 receptor expression with tissue-specific growth of an interleukin-3-dependent autocrine leukemia'. J Natl Cancer Inst, 80 (33):165-70. [Details] |
| Ceredig, R.,Lynch, F.,Medveczky, J. (1988) 'Phenotypic analysis of mouse thymus development'. Immunol Res, 7 (44):265-78. [Details] |
| Tabi, Z.,Lynch, F.,Ceredig, R.,Allan, J. E.,Doherty, P. C. (1988) 'Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium ionophore'. Cell Immunol, 113 (22):268-77. [Details] |
| Tabi, Z.,Allan, J. E.,Ceredig, R.,Doherty, P. C. (1988) 'Lethal vaccinia infection in cyclophosphamide-suppressed mice is associated with decreased expression of Thy-1, Lyt-2 and L3T4 and diminished IL-2 production in surviving T cells'. Immunology, 63 (33):423-9. [Details] |
| Doherty, P. C.,Ceredig, R.,Allan, J. E. (1988) 'Immunogenetic analysis of cellular interactions governing the recruitment of T lymphocytes and monocytes in lymphocytic choriomeningitis virus-induced immunopathology'. Clin Immunol Immunopathol, 47 (11):19-26. [Details] |
| Ceredig, R.,Medveczky, J.,Skulimowski, A. (1989) 'Mouse fetal thymus lobes cultured in IL-2 generate CD3+, TCR-gamma delta-expressing CD4-/CD8+ and CD4-/CD8- cells'. J Immunol, 142 (1010):3353-60. [Details] |
| Wilson, J. D.,Simeonovic, C. J.,Ting, J. H.,Ceredig, R. (1989) 'Role of CD4+ T-lymphocytes in rejection by mice of fetal pig proislet xenografts'. Diabetes, 38 Suppl 1 :217-9. [Details] |
| Simeonovic, C. J.,Ceredig, R.,Wilson, J. D. (1989) 'Reversal of diabetes in CD4+ T cell-depleted mice by xenotransplantation of pig proislets'. Transplant Proc, 21 (55):3811-2. [Details] |
| Simeonovic, C. J.,Ceredig, R.,Wilson, J. D. (1989) 'Mechanism of rejection of fetal pig proislet xenografts in mice'. Transplant Proc, 21 (1 Pt 31 Pt 3):2728-9. [Details] |
| Lynch, F.,Doherty, P. C.,Ceredig, R. (1989) 'Phenotypic and functional analysis of the cellular response in regional lymphoid tissue during an acute virus infection'. J Immunol, 142 (1010):3592-8. [Details] |
| Lynch, F.,Ceredig, R. (1989) 'Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation'. Eur J Immunol, 19 (22):223-9. [Details] |
| Lynch, F.,Ceredig, R.,Hartley, D.,Doherty, P. C. (1989) 'Persistence of the irradiated host component in thymocyte populations from bone marrow radiation chimeras infected with lymphocytic choriomeningitis virus'. Cell Immunol, 118 (22):482-90. [Details] |
| Simeonovic, C. J.,Wilson, J. D.,Ceredig, R. (1990) 'Antibody-induced rejection of pig proislet xenografts in CD4+ T cell-depleted diabetic mice'. Transplantation, 50 (44):657-62. [Details] |
| Simeonovic, C. J.,Ceredig, R.,Wilson, J. D. (1990) 'Antibody-induced rejection of long-term, functioning pig proislet xenografts in CD4+ T-cell-depleted diabetic mice'. Transplant Proc, 22 (55):2091-2. [Details] |
| Simeonovic, C. J.,Ceredig, R.,Wilson, J. D. (1990) 'Effect of GK1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD4+ T cell-depleted mice'. Transplantation, 49 (55):849-56. [Details] |
| Ceredig, R. (1990) 'Intrathymic proliferation of perinatal mouse alpha beta and gamma delta T cell receptor-expressing mature T cells'. Int Immunol, 2 (99):859-67. [Details] |
| Ceredig, R.,Waltzinger, C. (1990) 'Neonatal mouse CD4+ mature thymocytes show responsiveness to interleukin 2 and interleukin 7: growth in vitro of negatively selected V beta 6- and V beta 11-expressing CD4+ cells from (C57BL/6 x DBA/2)F1 mice'. Int Immunol, 2 (99):869-77. [Details] |
| Doherty, P. C.,Allan, J. E.,Lynch, F.,Ceredig, R. (1990) 'Dissection of an inflammatory process induced by CD8+ T cells'. Immunol Today, 11 (22):55-9. [Details] |
| Simeonovic, C. J.,Wilson, J. D.,Ceredig, R. (1991) 'Requirements for tolerance induction to pig proislet xenografts in mice'. Transplant Proc, 23 (1 Pt 11 Pt 1):731-2. [Details] |
| Haegel, H.,Ceredig, R. (1991) 'Transcripts encoding mouse CD44 (Pgp-1, Ly-24) antigen: strain variation and induction by mitogen'. Eur J Immunol, 21 (66):1549-53. [Details] |
| Schleussner, C.,Fisher, A.,Ceredig, R. (1991) 'Culture conditions dictate whether mouse fetal thymus lobes generate predominantly gamma/delta or alpha/beta T cells'. Curr Top Microbiol Immunol, 173 :25-8. [Details] |
| Fisher, A. G.,Ceredig, R. (1991) 'Gamma delta T cells expressing CD8 or CD4low appear early in murine foetal thymus development'. Int Immunol, 3 (1212):1323-8. [Details] |
| Fisher, A. G.,Waltzinger, C.,Ceredig, R. (1992) 'Selection of murine T cell receptor alpha beta and gamma delta cells in organ cultures established from 14-day embryos'. Eur J Immunol, 22 (77):1765-71. [Details] |
| Schleussner, C.,Kuzio, S.,Schultze, N.,Burdet, C.,Fisher, A. G.,Ceredig, R. (1992) 'T cell receptor repertoire of gamma delta cells generated from the 14-day embryonic mouse thymus'. Thymus, 20 (44):195-216. [Details] |
| Ivanov, V.,Ceredig, R. (1992) 'Transcription factors in mouse fetal thymus development'. Int Immunol, 4 (77):729-37. [Details] |
| Fisher, A. G.,Burdet, C.,LeMeur, M.,Haasner, D.,Gerber, P.,Ceredig, R. (1993) 'Lymphoproliferative disorders in an IL-7 transgenic mouse line'. Leukemia, 7 Suppl 2 . [Details] |
| Schleussner C, Ceredig R (1993) 'Analysis of intraepithelial lymphocytes from major histocompatibility complex (MHC)-deficient mice: no evidence for a role of MHC class II antigens in the positive selection of V delta 4+ gamma delta T cells'. Journal Of Immunology, 23 (7):1615-1622. [DOI] [Details] |
| Haegel H, Tölg C, Hofmann M, Ceredig R (1993) 'Activated mouse astrocytes and T cells express similar CD44 variants. Role of CD44 in astrocyte/T cell binding'. Journal Of Cell Biology, 122 (5):1067-1077. [Details] |
| Ivanov V, Merkenschlager M, Ceredig R (1993) 'Antioxidant treatment of thymic organ cultures decreases NF-kappa B and TCF1(alpha) transcription factor activities and inhibits alpha beta T cell development'. Journal Of Immunology, 151 (9):4694-4704. [Details] |
| Haegel H, Dierich A, Ceredig R (1994) 'CD44 in differentiated embryonic stem cells: surface expression and transcripts encoding multiple variants'. Developmental immunology, 3 (4):239-246. [Details] |
| Ezine, S.,Ceredig, R. (1994) 'Haemopoiesis and early T-cell differentiation'. Immunol Today, 15 (44):151-4. [Details] |
| Mertsching E, Burdet C, Ceredig R (1995) 'IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro'. International immunology, 7 (3):401-414. [Details] |
| Fisher AG, Burdet C, Bunce C, Merkenschlager M, Ceredig R (1995) 'Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential'. International immunology, 7 (3):415-423. [Details] |
| Barrat, F.,Haegel, H.,Louise, A.,Vincent-Naulleau, S.,Boulouis, H. J.,Neway, T.,Ceredig, R.,Pilet, C. (1995) 'Quantitative and qualitative changes in CD44 and MEL-14 expression by T cells in C57BL/6 mice during aging'. Res Immunol, 146 (11):23-34. [Details] |
| Lombard-Platet, S.,Fisher, A. G.,Meyer, V.,Ceredig, R. (1995) 'Expression of functional MHC class II molecules by a mouse pro-B cell clone'. Dev Immunol, 4 (22):85-92. [Details] |
| Valenzona HO, Pointer R, Ceredig R, Osmond DG (1996) 'Prelymphomatous B cell hyperplasia in the bone marrow of interleukin-7 transgenic mice: precursor B cell dynamics, microenvironmental organization and osteolysis'. Experimental Hematology, 24 (13):1521-1529. [Details] |
| Lalli, E.,Sassone-Corsi, P.,Ceredig, R. (1996) 'Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway'. EMBO J, 15 (33):528-37. [Details] |
| Mertsching, E.,Ceredig, R. (1996) 'T cell receptor-gamma, delta-expressing fetal mouse thymocytes are generated without T cell receptor V beta selection'. Eur J Immunol, 26 (44):804-10. [Details] |
| Mertsching E, Grawunder U, Meyer V, Rolink T, Ceredig R (1996) 'Phenotypic and functional analysis of B lymphopoiesis in interleukin-7-transgenic mice: expansion of pro/pre-B cell number and persistence of B lymphocyte development in lymph nodes and spleen'. Journal Of Immunology, 26 (1):28-33. [DOI] [Details] |
| Mertsching, E.,Wilson, A.,MacDonald, H. R.,Ceredig, R. (1997) 'T cell receptor alpha gene rearrangement and transcription in adult thymic gamma delta cells'. Eur J Immunol, 27 (22):389-96. [Details] |
| Lombard-Platet, S.,Meyer, V.,Ceredig, R. (1997) 'Both IFN-gamma and IL-4 induce MHC class II expression at the surface of mouse pro-B cells'. Dev Immunol, 5 (22):115-20. [Details] |
| Mertsching, E.,Meyer, V.,Linares, J.,Lombard-Platet, S.,Ceredig, R. (1998) 'Interleukin-7, a non-redundant potent cytokine whose over-expression massively perturbs B-lymphopoiesis'. Int Rev Immunol, 16 (3-43-4):285-308. [Details] |
| Ceredig R, ten Boekel E, Rolink A, Melchers F, Andersson J (1998) 'Fetal liver organ cultures allow the proliferative expansion of pre-B receptor-expressing pre-B-II cells and the differentiation of immature and mature B cells in vitro'. International immunology, 10 (1):49-59. [Details] |
| Rolink AG, ten Boekel E, Yamagami T, Ceredig R, Andersson J, Melchers F (1999) 'B cell development in the mouse from early progenitors to mature B cells'. Immunology Letters, 68 (1):89-93. [Details] |
| Ceredig R, Rolink AG, Melchers F, Andersson J (1999) 'Fetal liver organ cultures as a tool to study selection processes during B cell development'. Current topics in microbiology and immunology, 246 :11-1. [Details] |
| Fehling HJ, Gilfillan S, Ceredig R (1999) 'Alpha beta/gamma delta lineage commitment in the thymus of normal and genetically manipulated mice'. Advances in immunology, 71 :1-76. [Details] |
| Ceredig, R.,Andersson, J.,Melchers, F.,Rolink, A. (1999) 'Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors'. Eur J Immunol, 29 (99):2797-807. [Details] |
| Ceredig, R.,Rolink, A. G.,Melchers, F.,Andersson, J. (2000) 'The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation'. Eur J Immunol, 30 (33):759-67. [Details] |
| Martensson, I. L.,Ceredig, R. (2000) 'Review article: role of the surrogate light chain and the pre-B-cell receptor in mouse B-cell development'. Immunology, 101 (44):435-41. [Details] |
| Matsuda, J. L.,Gapin, L.,Sidobre, S.,Kieper, W. C.,Tan, J. T.,Ceredig, R.,Surh, C. D.,Kronenberg, M. (2002) 'Homeostasis of V alpha 14i NKT cells'. Nat Immunol, 3 (1010):966-74. [Details] |
| Pasqual, N.,Gallagher, M.,Aude-Garcia, C.,Loiodice, M.,Thuderoz, F.,Demongeot, J.,Ceredig, R.,Marche, P. N.,Jouvin-Marche, E. (2002) 'Quantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoire'. J Exp Med, 196 (99):1163-73. [Details] |
| Kieper, W. C.,Tan, J. T.,Bondi-Boyd, B.,Gapin, L.,Sprent, J.,Ceredig, R.,Surh, C. D. (2002) 'Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells'. J Exp Med, 195 (1212):1533-9. [Details] |
| Ceredig, Rh., Rolink, A., Melchers, F. and Andersson, J (2002) 'Over-expression of IL-7 leads to IL-15-independent generation of memory-phenotype CD8+ T cells'. J. Exp. Med, 195 (153):1533-1539. [Details] |
| J. L. Matsuda, L. Gapin, S. Sidobre, W. C. Kieper, J. T. Tan, Rh Ceredig, C. D. Surh and M Kronenberg (2002) 'The ontogeny of B cells in the thymus of normal, CD3 KO, RAG-2 KO and IL-7 transgenic mice'. International Immunology, 14 (36):81-93. [Details] |
| Ceredig, R. (2002) 'What can Venter teach students about ethics?'. Nature, 417 (68886888). [Details] |
| Ceredig, R. (2002) 'The ontogeny of B cells in the thymus of normal, CD3 epsilon knockout (KO), RAG-2 KO and IL-7 transgenic mice'. Int Immunol, 14 (11):87-99. [Details] |
| Ceredig R (2002) 'The ontogeny of B cells in the thymus of normal, CD3 epsilon knockout (KO), RAG-2 KO and IL-7 transgenic mice'. International immunology, 14 (1):87-99. [Details] |
| N. Pasqual, M. Gallagher, C. Aude-Garcia, M. Loiodice, F. Thuderoz, J. Demongeot, Rh Ceredig, P. N. Marche and E. Jouvin-Marche. (2002) 'A pT -Negative Subpopulation of CD25+ TN Thymocytes Revealed by a Transgenic Marker'. Scandinavian Journal of Immunology, 55 (17):119-128. [Details] |
| Ceredig, R.,Rolink, T. (2002) 'A positive look at double-negative thymocytes'. Nat Rev Immunol, 2 (1111):888-97. [Details] |
| W. C. Kieper, J. T. Tan, B. Bondi-Boyd, L. Gapin, J. Sprent, Rh Ceredig & C. D. Surh (2003) 'In Interleukin-7 transgenic mice, increasing B lymphopoiesis increases follicular but not marginal zone B cell numbers'. European Journal of Immunology, 33 (5):2567-2576. [Details] |
| K. Petersson, A. Mårtensson, E. Mertsching, T. Winkler, R. Ceredig, I.-L. Mårtensson & F. Ivars (2004) 'New insights into the proliferation and differentiation of early mouse thymocytes'. International Immunology, 14 (36):1069-1080. [Details] |
| Balciunaite G, Ceredig R, Massa S, Rolink AG (2005) 'A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential'. Journal Of Immunology, 35 (7):2019-2030. [DOI] [Details] |
| Agenes, F.,Bosco, N.,Mascarell, L.,Fritah, S.,Ceredig, R. (2005) 'Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naive and regulatory T cells'. Immunology, 115 (22):179-88. [Details] |
| Bosco, N.,Agenes, F.,Ceredig, R. (2005) 'Effects of increasing IL-7 availability on lymphocytes during and after lymphopenia-induced proliferation'. J Immunol, 175 (11):162-70. [Details] |
| Harfst, E.,Andersson, J.,Grawunder, U.,Ceredig, R.,Rolink, A. G. (2005) 'Homeostatic and functional analysis of mature B cells in lambda5-deficient mice'. Immunol Lett, 101 (22):173-84. [Details] |
| J. Laurent, N. Bosco, P. N. Marche and Rh. Ceredig. (2005) 'B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential'. European Journal of Immunology, 35 (5):2019-2030. [Details] |
| G. Balcuinaite, Rh. Ceredig, S. Massa and Antonius G. Rolink A (2005) 'The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage and natural killer, but no B lymphocyte potential'. Blood, 105 :1930-1936. [Details] |
| Rh. Ceredig, N. Bosco, P. N. Marche, J. Andersson and A. Rolink. (2005) 'Effects of increasing IL-7 availability on lymphocytes during and following lymphopenia-induced proliferation'. J. Immunol, 175 (65):162-170. [Details] |
| M. N. Bosco, F. Agenès and Rh. Ceredig (2005) 'The role of Notch and IL-7 signalling in early thymocyte proliferation and differentiation'. European Journal of Immunology, 35 (5):1292-1230. [Details] |
| Bocelli-Tyndall, A. Barbero, C. Candrian, Rh. Ceredig, A. Tyndall and I. Martin. (2006) 'Human articular chondrocytes immunosuppress in vitro anti-CD3 activated peripheral blood mononuclear cells'. JOURNAL OF CELLULAR PHYSIOLOGY, 209 :732-734. [Details] |
| Rolink, A. G.,Massa, S.,Balciunaite, G.,Ceredig, R. (2006) 'Early lymphocyte development in bone marrow and thymus'. Swiss Med Wkly, 136 (43-4443-44):679-83. [Details] |
| Rolink, A. G.,Balciunaite, G.,Demoliere, C.,Ceredig, R. (2006) 'The potential involvement of Notch signaling in NK cell development'. Immunol Lett, 107 (11):50-7. [Details] |
| Massa, S.,Balciunaite, G.,Ceredig, R.,Rolink, A. G. (2006) 'Critical role for c-kit (CD117) in T cell lineage commitment and early thymocyte development in vitro'. European Journal Of Immunology, 36 (33):526-32. [Details] |
| Maerki, S.,Ceredig, R.,Rolink, A. (2006) 'Induction of chemokine receptor expression during early stages of T cell development'. Immunol Lett, 104 (1-21-2):110-7. [Details] |
| Bosco, N.,Hung, H. C.,Pasqual, N.,Jouvin-Marche, E.,Marche, P. N.,Gascoigne, N. R.,Ceredig, R. (2006) 'Role of the T cell receptor alpha chain in the development and phenotype of naturally arising CD4+CD25+ T cells'. Mol Immunol, 43 (33):246-54. [Details] |
| Bosco, N.,Agenes, F.,Rolink, A. G.,Ceredig, R. (2006) 'Peripheral T cell lymphopenia and concomitant enrichment in naturally arising regulatory T cells: the case of the pre-Talpha gene-deleted mouse'. J Immunol, 177 (88):5014-23. [Details] |
| Bocelli-Tyndall, C.,Barbero, A.,Candrian, C.,Ceredig, R.,Tyndall, A.,Martin, I. (2006) 'Human articular chondrocytes suppress in vitro proliferation of anti-CD3 activated peripheral blood mononuclear cells'. J Cell Physiol, 209 (33):732-4. [Details] |
| Benard, A.,Ceredig, R.,Rolink, A. G. (2006) 'Regulatory T cells control autoimmunity following syngeneic bone marrow transplantation'. Eur J Immunol, 36 (99):2324-35. [Details] |
| Meier, D.,Bornmann, C.,Chappaz, S.,Schmutz, S.,Otten, L. A.,Ceredig, R.,Acha-Orbea, H.,Finke, D. (2007) 'Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells'. Immunity, 26 (55):643-54. [Details] |
| Ceredig R, Bosco N, Rolink AG (2007) 'The B lineage potential of thymus settling progenitors is critically dependent on mouse age'. Journal Of Immunology, 37 (3):830-837. [DOI] [Details] |
| Rolink, A. G.,Massa, S.,Balciunaite, G.,Ceredig, R. (2007) 'Early lymphocyte development in bone marrow and thymus'. Swiss Med Wkly, 137 Suppl 155 . [Details] |
| Brown G, Hughes PJ, Michell RH, Rolink AG, Ceredig R (2007) 'The sequential determination model of hematopoiesis'. Trends in immunology, 28 (10):442-448. [DOI] [Details] |
| Ceredig, R.,Bosco, N.,Rolink, A. G. (2007) 'The B lineage potential of thymus settling progenitors is critically dependent on mouse age'. Eur J Immunol, 37 (33):830-7. [Details] |
| Rh. Ceredig, N. Bosco and A.G.Rolink. (2007) 'The B lineage potential of Thymus Settling Progenitors is critically dependent on mouse age'. EUROPEAN JOURNAL OF IMMUNOLOGY, 37 (5):830-7. [Details] |
| Bocelli-Tyndall, C.,Bracci, L.,Spagnoli, G.,Braccini, A.,Bouchenaki, M.,Ceredig, R.,Pistoia, V.,Martin, I.,Tyndall, A. (2007) 'Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro'. Rheumatology (Oxford), 46 (33):403-8. [Details] |
| C. C. Bocelli-Tyndall, L. Bracci, G. Spagnoli , A. Braccini, M. Bouchenaki, Rh. Ceredig , V. Pistoia, I. Martin and A. Tyndall. (2008) 'Bone marrow-derived mesenchymal stem cells (BM-MSCs) from healthy and autoimmune disease patients reduce in vitro the proliferation of anti-CD3ƒÕ-stimulated autologous and allogeneic lymphocytes'. RHEUMATOLOGY, 46 (4):403-8. [Details] |
| Kirberg, J.,Bosco, N.,Deloulme, J. C.,Ceredig, R.,Agenes, F. (2008) 'Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection'. J Immunol, 181 (22):1207-14. [Details] |
| Rh Ceredig, N. Bosco and A.G. Rolink. (2008) 'Problems defining DN2 thymocytes. Commentary article'. IMMUNOLOGY AND CELL BIOLOGY, 86 :545-547. [Details] |
| Mueller, P.,Massner, J.,Jayachandran, R.,Combaluzier, B.,Albrecht, I.,Gatfield, J.,Blum, C.,Ceredig, R.,Rodewald, H. R.,Rolink, A. G.,Pieters, J. (2008) 'Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering'. Nat Immunol, 9 (44):424-31. [Details] |
| Bosco, N.,Engdahl, C.,Benard, A.,Rolink, J.,Ceredig, R.,Rolink, A. G. (2008) 'TCR-beta chains derived from peripheral gammadelta T cells can take part in alphabeta T-cell development'. Eur J Immunol, 38 (1212):3520-9. [Details] |
| Bosco, N.,Ceredig, R.,Rolink, A. (2008) 'Transient decrease in interleukin-7 availability arrests B lymphopoiesis during pregnancy'. Eur J Immunol, 38 (22):381-90. [Details] |
| N. Bosco1, C. Engdahl1, A. Bénard, J. Rolink, Rh. Ceredig and A. G. Rolink. (2008) 'TCRƒÒ chains derived from peripheral ƒ×ƒÔ T cells can take part in ƒÑƒÒ T ƒncellƒn development'. EUROPEAN JOURNAL OF IMMUNOLOGY, 38 :3520-3529. [Details] |
| Bosco, N.,Kirberg, J.,Ceredig, R.,Agenes, F. (2009) 'Peripheral T cells in the thymus: have they just lost their way or do they do something?'. Immunol Cell Biol, 87 (11):50-7. [Details] |
| Brown, G.,Ceredig, R. (2009) 'Lineage determination in haematopoiesis: quo vadis?'. Trends Immunol, 30 (1010):465-6. [Details] |
| Ceredig, R. (2009) 'The impact of cell re-entry into the primary lymphoid organs on lymphocyte repertoire and functionality'. Immunol Cell Biol, 87 (11):13-5. [Details] |
| Ceredig, R.,Rolink, A. G.,Brown, G. (2009) 'Models of haematopoiesis: seeing the wood for the trees'. Nat Rev Immunol, 9 (44):293-300. [Details] |
| Tussiwand, R.,Bosco, N.,Ceredig, R.,Rolink, A. G. (2009) 'Tolerance checkpoints in B-cell development: Johnny B good'. Eur J Immunol, 39 (99):2317-24. [Details] |
| G. Balciunaite, Rh. Ceredig and A. Rolink (2009) 'Interleukin 7 regulates the peripheral pool of adult ROR?+ lymphoid tissue inducer cells'. Cutting Edge article Journal of Immunology, 183 :2217-2221. [Details] |
| Ceredig R (2009) 'The impact of cell re-entry into the primary lymphoid organs on lymphocyte repertoire and functionality'. Immunology And Cell Biology, 87 (1):13-15. [DOI] [Details] |
| Rh. Ceredig, A. G. Rolink and G. Brown. (2010) 'The versatility of hematopoietic stem cells: implications for leukemia'. Critical reviews in Clinical laboratory Sciences, 47 :171-180. [Details] |
| Bosco N, Swee LK, Bénard A, Ceredig R, Rolink A (2010) 'Auto-reconstitution of the T-cell compartment by radioresistant hematopoietic cells following lethal irradiation and bone marrow transplantation'. Experimental Hematology, 38 (3):222-23200. [DOI] [Details] |
| Duffy MM, Ritter T, Ceredig R, Griffin MD (2011) 'Mesenchymal stem cell effects on T-cell effector pathways'. Stem Cell Research & Therapy, 2 (4). [DOI] [Details] |
| Ceredig R (2011) 'Graft-versus-host disease: who's responsible?'. Immunology And Cell Biology, . [DOI] [Details] |
| Brown G, Hughes PJ, Ceredig R, Michell RH (2012) 'Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemia'. Leukemia research, 36 (1):14-22. [DOI] [Details] |
| Ceredig R (2012) 'When one cell is enough'. Stem Cell Research & Therapy, 3 (1). [DOI] [Details] |
| Pindjakova J, Hanley SA, Duffy MM, Sutton CE, Weidhofer GA, Miller MN, Nath KA, Mills KH, Ceredig R, Griffin MD (2012) 'Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction'. Kidney International, 81 (4):379-390. [DOI] [Details] |
Editorial
| Ceredig, R (2009) The impact of cell re-entry into the primary lymphoid organs on lymphocyte repertoire and functionality. Editorial [DOI] [Details] |
| Ceredig, R (2012) When one cell is enough. Editorial [DOI] [Details] |
Reviews
| Duffy, M. M., Ritter, T., Ceredig, R. and Griffin, M.D. (2011) Mesenchymal Stem Cell Effects on T-cell Effector Pathways. Stem Cell Research & Therapy. Reviews [Details] |