Dr Róisín Dwyer BSc, MSc, PhD
| Róisín Dwyer is a Lecturer in Translational Science in the Discipline of Surgery at NUI Galway. Following graduation from UCD with a degree in Science, Róisín went on to complete an MSc in Biological Sciences at DCU, and then was awarded her PhD in Medicine and Therapeutics from UCD. Róisín's research background in breast cancer led to a 3 year postdoctoral research position at the Mayo Clinic, Rochester, Minnesota. Upon her return to Ireland, she was awarded a National University of Ireland (NUI) Postdoctoral Fellowship in the Sciences, and joined the research team of Professor Michael Kerin in the National Breast Cancer Research Institute (NBCRI) at NUI Galway. She received Health Research Board funding in 2007, and a subsequent Project Grant awarded by the Irish Cancer Society in 2008. She was named Irish Cancer Society "Researcher of the Year" in 2012. Róisín's current research, in collaboration with both national and international research groups, focuses on novel approaches to breast cancer therapy. Her work investigates the potential of adult stem cells as vehicles for targeted delivery of therapeutic agents to breast tumours, with a specific interest in imaging modalities to track their migration in vivo. Other areas of interest include cellular interactions in the breast tumour microenvironment mediated by cytokines and microRNAs.
Peer Reviewed Journals
|Havelin RJ, Miller BW, Barrett HH, Furenlid LR, Murphy JM, Dwyer RM, Foley MJ (2013) 'Design and performance of a small-animal imaging system using synthetic collimation'. Physics In Medicine And Biology, 58 (10):3397-3412. [DOI] [ARAN Link] [Details]|
|Hogan NM, Joyce MR, Murphy JM, Barry FP, O'Brien T, Kerin MJ, Dwyer RM (2013) 'Impact of Mesenchymal Stem Cell Secreted PAI-1 on Colon Cancer Cell Migration and Proliferation'. Biochem Biophy Res Commun, . [DOI] [Details]|
|Glynn C, Khan S, Kerin MJ and Dwyer RM. (2012) 'Isolation of secreted microRNAs (miRNAs) from cell-conditioned media'. MicroRNA, . [ARAN Link] [Details]|
|Waters, PS,McDermott, AM,Wall, D,Heneghan, HM,Miller, N,Newell, J,Kerin, MJ,Dwyer, RM (2012) 'Relationship between Circulating and Tissue microRNAs in a Murine Model of Breast Cancer'. Plos One, 7 . [DOI] [Details]|
|Potter, SM,Dwyer, RM,Hartmann, MC,Khan, S,Boyle, MP,Curran, CE,Kerin, MJ (2012) 'Influence of stromal-epithelial interactions on breast cancer in vitro and in vivo'. Breast Cancer Research And Treatment, 131 :401-411. [DOI] [Details]|
|Hogan, NM,Dwyer, RM,Joyce, MR,Kerin, MJ (2012) 'Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications'. International Journal Of Cancer, 131 (1):1-7. [DOI] [Details]|
|Ryan J, Curran CE, Hennessy E, Newell J, Morris JC, Kerin MJ, Dwyer RM. (2011) ''The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue''. Plos One, 6 (1). [Details]|
|Hartmann MC, Dwyer RM, Costello M, Potter SM, Curran C, Hennessy E, Newell J, Griffin DG, Kerin MJ (2011) 'Relationship between CCL5 and transforming growth factor-Î²1 (TGFÎ²1) in breast cancer'. European Journal Of Cancer, 47 (11):1669-1675. [DOI] [Details]|
|Dwyer, RM,Ryan, J,Havelin, RJ,Morris, JC,Miller, BW,Liu, ZL,Flavin, R,O'Flatharta, C,Foley, MJ,Barrett, HH,Murphy, JM,Barry, FP,O'Brien, T,Kerin, MJ (2011) 'Mesenchymal Stem Cell-Mediated Delivery of the Sodium Iodide Symporter Supports Radionuclide Imaging and Treatment of Breast Cancer'. Stem Cells, 29 (7):1149-1157. [DOI] [Details]|
|Dwyer RM, Khan S, Barry FP, O'Brien T and Kerin MJ (2010) ''Advances in mesenchymal stem cell-mediated gene therapy for cancer''. Stem Cell Research And Therapy, 1 (3). [Details]|
|Lowery, AJ, Miller, N, Dwyer, RM, Kerin, MJ (2010) 'Dysregulated miR-183 inhibits migration in breast cancer cells'. BMC Cancer, 10 . [DOI] [Details]|
|Kerin MJ (2010) 'Mesenchymal Stem Cells (MSCs) and Cancer: tumour specific delivery vehicles or therapeutic targets?'. Human Gene Therapy, 21 (11):1506-1512. [Details]|
|Martin FT, Dwyer RM, Kelly J, Khan S, Murphy JM, Curran C, Miller N, Hennessy E, Dockery P, Barry FP, O'Brien T, Kerin MJ (2010) ''Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)''. Breast Cancer Res Treat, 124 (2):317-326. [Details]|
|Dwyer R et al. (2009) 'Sodium iodide symporter (NIS) mediated tracking of mesenchymal stem cell (MSC) migration to breast tumours in vivo'. Human Gene Therapy, 20 (11). [Details]|
|Molloy, AP,Martin, FT,Dwyer, RM,Griffin, TP,Murphy, M,Barry, FP,O'Brien, T,Kerin, MJ (2009) 'Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells'. International Journal Of Cancer, 124 :326-332. [DOI] [Details]|
|Potter, SM,Dwyer, RM,Curran, CE,Hennessy, E,Harrington, KA,Griffin, DG,Kerin, MJ (2009) 'Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones'. Breast Cancer Research And Treatment, 115 :279-287. [DOI] [Details]|
|Hartmann, M. C.,Dwyer, R. M.,Boyle, M. P.,Potter, S. M.,Kerin, M. J. (2009) 'EFFECT OF MONOCYTE CHEMOTACTIC PROTEIN-1(MCP-1) ON BREAST CANCER CELL PROLIFERATION AND GENE EXPRESSION'. Annals of Oncology, 20 :28-28. [Details]|
|Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O'Brien T, Kerin MJ (2007) 'Monocyte Chemotactic Protein-1 (MCP-1) secreted by primary breast tumors stimulates migration of Mesenchymal Stem Cells (MSCs)'. Clinical Cancer Research, 13 (17):5020-5027. [Details]|
|Bergert ER, Gendler SJ, O'Connor MK and Morris JC (2006) 'Sodium Iodide Symporter (NIS)-mediated Radioiodide Imaging and Therapy of Ovarian Tumor Xenografts in Mice'. Gene Therapy, 13 (1):60-66. [Details]|
|Bergert ER, Gendler SJ, O'Connor MK and Morris JC (2006) 'Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors'. Human Gene Therapy, 17 (6):661-668. [Details]|
|Bergert ER, Gendler SJ, O'Connor MK and Morris JC (2005) 'In Vivo Radioiodide Imaging and Treatment of Breast Cancer Xenografts Following MUC1-driven Expression of the Sodium Iodide Symporter (NIS)'. Cinical Cancer Research, 11 (4):1483-1489. [Details]|
|Schatz SM, Bergert ER, Myers RM, Harvey ME, Classic KL, Marler RJ, O'Connor MK and Morris JC (2005) 'A Preclinical Large Animal Model of Adenovirus-Mediated Expression of the Sodium-Iodide Symporter for Radioiodide Imaging and Therapy of Locally Recurrent Prostate Cancer'. Molecular Therapy, 12 (5):835-841. [Details]|
|Smyth PPA (2002) 'The Sodium Iodide Symporter and Thyroid Disease'. Clinical Endocrinology, 56 (4):427-429. [Details]|
|Kilbane MT, Ajjan RA, Weetman AP, Dwyer R, McDermott EWM, O'Higgins N J and Smyth PPA (2000) 'Tissue Iodine Content and Serum Mediated 125I Uptake Blocking Activity in Breast Cancer'. Journal of Clinical Endocrinology and Metabolism, 85 :1245-1250. [Details]|
|Smyth, PPA,Dwyer, RM (2002) The sodium iodide symporter and thyroid disease. Editorial [Details]|
Honours and Awards
| Year: 2013.
Title: BREAST-PREDICT Collaborative Cancer Research Centre
| Year: 2012.
Title: Irish Cancer Society Researcher of the Year Award
| Year: 2008.
Title: Research Project Grant
| Year: 2007.
Title: Research Project Grant
| Year: 2005.
Title: National University of Ireland Postdoctroal Fellowship in the Sciences
| Active collaborations within NUIG with:
Professor Timothy O'Brien, Professor Frank Barry, Dr Mary Murphy and Dr Linda Howard: Regenerative Medicine Institute
Professor Martin Leahy, Dr Mark Foley : School of Physics
Dr Gerhard Schlosser, Dr Dagmar Stengel : School of Natural Sciences
Dr Margaret Rae : Marine Institute
| Active International Collaborations with:
Professor John Morris, Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
Dr Harrisson Barrett, Center for Gamma-Ray Imaging, University of Arizona, Tucson, Arizona, USA