Sanbing Shen

Per Prof of Fundamental Stem Cell Biolog B.Sc, M.Sc, Ph.D

Contact Details

Per Prof of Fundamental Stem Cell Biolog
REMEDI
NUI Galway

E: sanbing.shen@nuigalway.ie
 
researcher

Biography

Prof. Shen is currently starting a new research group on fundamental stem cell biology at REMEDI. Previously, he has derived new ES cell lines from C57BL/6JCrl mice, and demonstrated that expression of a mutant RARβ was able to promote stemness in mouse ES cells and alter lineage differentiation (Chatzi et al, 2010). His group also developed a technology to differentiate mouse ES cells into homogenous GABAergic neurons, which are deficient in a wide range of neurological conditions such as Huntington's disease, brain and spinal cord injuries, seizure, stroke, pain, schizophrenia, anxiety and other mood disorders (Chatzi et al, 2009).

His team at Galway is making iPS cells from patients of various neurological conditions including schizophrenia, autism, Parkinson’s diseases, velo-cardio-facial syndrome, amyotrophic lateral sclerosis, glaucoma and cardiomyopathy in collaboration with clinicians from Ireland, Scotland and China. They are also interesting in developing artificial chromosome technology and neuronal differentiation protocols, examining disease phenotype on dish and exploring cell transplantation therapy in animal models.

Peer Reviewed Journals

  Year Publication
(2014) 'The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system'
Pei, Z.a and Lang, B.a and Fragoso, Y.D.a b and Shearer, K.D.a and Zhao, L.a and Mccaffery, P.J.A.a and Shen, S.a c and Ding, Y.Q.d and McCaig, C.D.a and Collinson, J.M.a (2014) 'The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system'. Neuroscience, 271 :119-136 [Details]
(2014) 'Over-expression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development'
Zhu X, Wu Y, Huang S, Chen Y, Tao Y, Wang Y, He S, Shen S, Wu J, Guo X, Li B, He L, Ma G (2014) 'Over-expression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development'. Exp Dermatol, [DOI] [Details]
(2014) 'Constitutive Activation of Ectodermal beta-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure'
Zhu, XM,Huang, SX,Zhang, LL,Wu, YM,Chen, YW,Tao, YX,Wang, YS,He, SG,Shen, SB,Wu, J,Li, BJ,Guo, XZ,He, L,Ma, G (2014) 'Constitutive Activation of Ectodermal beta-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure'. Plos One, 9 [DOI] [Details]
(2014) 'Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility'
Lang, B,Pu, J,Hunter, I,Liu, M,Martin-Granados, C,Reilly, TJ,Gao, GD,Guan, ZL,Li, WD,Shi, YY,He, G,He, L,Stefansson, H,St Clair, D,Blackwood, DH,McCaig, CD,Shen, SB (2014) 'Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility'. Journal Of Cell Science, 127 :630-640 [DOI] [Details]
(2014) 'Altered brain network connectivity and glutamate system functioning in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1'
Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Randall A, Shen S, Seymour PA, Hughes ZA, Dunlop J, Brown J, Brandon NJ, Morris BJ, Pratt JA. (2014) 'Altered brain network connectivity and glutamate system functioning in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1'. Translational Psychiatry, [Details]
(2014) 'Upregulation of autophagy by rapamycin induces spontaneous formation of uniform embryoid bodies and accelerates differentiation of human induced pluripotent stem cells'
Sotthibundhu A, McDonagh K, Klawiter A, Thompson K, Dockery P, Devine M, Kunath T, O’Brien T, Barry F, Shen S* (2014) 'Upregulation of autophagy by rapamycin induces spontaneous formation of uniform embryoid bodies and accelerates differentiation of human induced pluripotent stem cells'. Autophagy, [Details]
(2014) 'Expression of a novel serine/threonine kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development'
Dominguez L, Schlosser G; Shen S* (2014) 'Expression of a novel serine/threonine kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development'. Neuroscience, [Details]
(2013) 'PACAP and PAC1 receptor in brain development and behavior'
Shen, SB,Gehlert, DR,Collier, DA (2013) 'PACAP and PAC1 receptor in brain development and behavior'. Neuropeptides, 47 :421-430 [DOI] [Details]
(2012) 'HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells'
Lang B, Alrahbeni TM, Clair DS, Blackwood DH, McCaig CD, Shen S (2012) 'HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells'. Stem Cells and Development, 1 (1):31-41 [Details]
(2012) 'Progress on stem cell research towards the treatment of Parkinson's disease'
Gibson, S.A.a and Gao, G.-D.b and McDonagh, K.c and Shen, S.c (2012) 'Progress on stem cell research towards the treatment of Parkinson's disease'. Stem Cell Research and Therapy, 3 (2) [Details]
(2011) 'A zinc finger protein Zfp521 directs neural differentiation and beyond'
Shen, S. and Pu, J. and Lang, B. and McCaig, C.D. (2011) 'A zinc finger protein Zfp521 directs neural differentiation and beyond'. Stem Cell Research and Therapy, 2 (2) [Details]
(2010) 'Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins'
Houssen, W.E.a b and Lu, Z.b and Edrada-Ebel, R.c and Chatzi, C.a f and Tucker, S.J.a and Sepčić, K.d and Turk, T.d and Zovko, A.d and Shen, S.a and Mancini, I.e and Scott, R.H.a and Jaspars, M.b (2010) 'Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins'. Journal of Chemical Biology, 3 (3):113-125 [Details]
(2010) 'Expression of a mutant retinoic acid receptor β alters lineage differentiation in mouse embryonic stem cells'
Chatzi, C.a and Van Den Brink, C.E.b and Van Der Saag, P.T.b and McCaig, C.D.a and Shen, S.a (2010) 'Expression of a mutant retinoic acid receptor β alters lineage differentiation in mouse embryonic stem cells'. Stem Cells and Development, 19 (7):951-960 [Details]
(2010) 'GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice'
Lang, B.a and Zhao, L.a and Cai, L.b and McKie, L.c and Forrester, J.V.a and McCaig, C.D.a and Jackson, I.J.c and Shen, S.a (2010) 'GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice'. Neuropharmacology, 58 (1):215-225 [Details]
(2009) 'Deregulation of EIF4E: A novel mechanism for autism'
Neves-Pereira, M.a and Müller, B.b and Massie, D.c and Williams, J.H.G.a and O'Brien, P.C.M.d and Hughes, A.a and Shen, S.-B.b and St. Clair, D.a and Miedzybrodzka, Z.a c (2009) 'Deregulation of EIF4E: A novel mechanism for autism'. Journal of Medical Genetics, 46 (11):759-765 [Details]
(2009) 'Derivation of homogeneous GABAergic neurons from mouse embryonic stem cells'
Chatzi, C. and Scott, R.H. and Pu, J. and Lang, B. and Nakamoto, C. and McCaig, C.D. and Shen, S. (2009) 'Derivation of homogeneous GABAergic neurons from mouse embryonic stem cells'. Experimental Neurology, 217 (2):407-416 [Details]
(2008) 'Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1'
Shen, S.a and Lang, B.a and Nakamoto, C.a and Zhang, F.a and Pu, J.a and Kuan, S.-L.a and Chatzi, C.a and He, S.b and Mackie, I.c and Brandon, N.J.d and Marquis, K.L.d and Day, M.e and Hurko, O.e f and McCaig, C.D.a and Riedel, G.a and St Clair, D.a (2008) 'Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1'. Journal of Neuroscience, 28 (43):10893-10904 [Details]
(2006) 'Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission'
Jennings, K.A.a and Loder, M.K.b and Sheward, W.J.b and Pei, Q.a and Deacon, R.M.J.c and Benson, M.A.a and Olverman, H.J.b and Hastie, N.D.d and Harmar, A.J.b and Shen, S.b f and Sharp, T.a e (2006) 'Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission'. Journal of Neuroscience, 26 (35):8955-8964 [Details]
(2006) 'Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice'
Lang, B.a and Song, B.a and Davidson, W.a and MacKenzie, A.a and Smith, N.b and McCaig, C.D.a and Harmar, A.J.c and Shen, S.a d (2006) 'Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice'. Journal of Clinical Investigation, 116 (7):1924-1934 [Details]
(2006) 'Modification and amplification of yeast artificial chromosomes'
Shen, S. and Harmar, A. and Hastie, N. (2006) 'Modification and amplification of yeast artificial chromosomes'. Methods in molecular biology (Clifton, N.J.), 349 :67-74 [Details]
(2004) 'Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites'
Kalló, I.a b and Kalamatianos, T.a and Wiltshire, N.a and Shen, S.c and Sheward, W.J.c and Harmar, A.J.c and Coen, C.W.a (2004) 'Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites'. European Journal of Neuroscience, 19 (8):2201-2211 [Details]
(2004) 'Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia'
Kerr, L.E.a and McGregor, A.L.a and Amet, L.E.A.a and Asada, T.a e and Spratt, C.a and Allsopp, T.E.a c and Harmar, A.J.b and Shen, S.b d and Carlson, G.a and Logan, N.a and Kelly, J.S.a and Sharkey, J.a (2004) 'Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia'. Cell Death and Differentiation, 11 (10):1102-1111 [Details]
(2004) 'Overexpression of the 5-Hydroxytryptamine Transporter Gene: Effect on Pulmonary Hemodynamics and Hypoxia-Induced Pulmonary Hypertension'
MacLean, M.R.a d and Deuchar, G.A.b and Hicks, M.N.b and Morecroft, I.a and Shen, S.c and Sheward, J.c and Colston, J.a and Loughlin, L.a and Nilsen, M.a and Dempsie, Y.a and Harmar, A.c (2004) 'Overexpression of the 5-Hydroxytryptamine Transporter Gene: Effect on Pulmonary Hemodynamics and Hypoxia-Induced Pulmonary Hypertension'. Circulation, 109 (17):2150-2155 [Details]
(2003) 'The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro'
Cutler, D.J.a and Haraura, M.a and Reed, H.E.a and Shen, S.b and Sheward, W.J.b and Morrison, C.F.b and Marston, H.M.b c and Harmar, A.J.b and Piggins, H.D.a (2003) 'The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro'. European Journal of Neuroscience, 17 (2):197-204 [Details]
(2003) 'A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus'
King, V.M.a and Chahad-Ehlers, S.a and Shen, S.b and Harmar, A.J.b and Maywood, E.S.a c and Hastings, M.H.a c (2003) 'A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus'. European Journal of Neuroscience, 17 (4):822-832 [Details]
(2003) 'Erratum: A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus (European Journal of Neuroscience (2003) 17 (822-832))'
King, V.M. and Chahad-Ehlers, S. and Shen, S. and Harmar, A.J. and Maywood, E.S. and Hastings, M.H. (2003) 'Erratum: A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus (European Journal of Neuroscience (2003) 17 (822-832))'. European Journal of Neuroscience, 17 (11) [Details]
(2002) 'The VPAC2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei'
Harmar, A.J.a and Marston, H.M.a b and Shen, S.a and Spratt, C.a b and West, K.M.a c and Sheward, W.Johna and Morrison, C.F.a and Dorin, J.R.c and Piggins, H.D.d and Reubi, J.-C.e and Kelly, J.S.a b and Maywood, E.S.f and Hastings, M.H.f (2002) 'The VPAC2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei'. Cell, 109 (4):497-508 [Details]
(2001) 'Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide'
Goetzl, E.J.a c and Voice, J.K.a and Shen, S.b and Dorsam, G.a and Kong, Y.a and West, K.M.b and Morrison, C.F.b and Harmar, A.J.b (2001) 'Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide'. Proceedings of the National Academy of Sciences of the United States of America, 98 (24):13854-13859 [Details]
(2000) 'Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes'
Shen, S.a d and Battersby, S.a and Weaver, M.b and Clark, E.a and Stephens, K.b c and Harmar, A.J.a (2000) 'Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes'. European Journal of Human Genetics, 8 (1):75-78 [Details]
(2000) 'Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice'
Shen, S.a and Spratt, C.a b and Sheward, W.J.a and Kallo, I.c and West, K.a and Morrison, C.F.a and Coen, C.W.c and Marston, H.M.a b and Harmar, A.J.a (2000) 'Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice'. Proceedings of the National Academy of Sciences of the United States of America, 97 (21):11575-11580 [Details]
(1999) 'Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2'
Lutz, E.M.a and Shen, S.b and Mackay, M.b and West, K.b and Harmar, A.J.b (1999) 'Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2'. FEBS Letters, 458 (2):197-203 [Details]
(1999) 'Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene'
Battersby, S.a e and Ogilvie, A.D.a and Blackwood, D.H.R.b and Shen, S.a and Muqit, M.M.K.a and Muir, W.J.b and Teague, P.c and Goodwin, G.M.d and Harmar, A.J.a (1999) 'Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene'. Journal of Neurochemistry, 72 (4):1384-1388 [Details]
(1995) 'Regulation of Oct-4 Gene expression during differentiation of EC cells'
Schoorlemmer J, Jonk L, Shen S, Vanpuijenbroek A, Feijen A and Kruijer W. (1995) 'Regulation of Oct-4 Gene expression during differentiation of EC cells'. Molecular biology reports, 21 :129-40 [Details]
(1994) 'Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures'
Charité, J.a and De Graaff, W.a and Shen, S.a b and Deschamps, J.a (1994) 'Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures'. Cell, 78 (4):589-601 [Details]
(1993) 'Dominant negative retinoic acid receptor β'
Shen, S. and Van Der Saag, P.T. and Kruijer, W. (1993) 'Dominant negative retinoic acid receptor β'. Mechanisms of Development, 40 (3):177-189 [Details]
(1992) 'Embryonic stem cells stably transfected with mRARβ2-lacZ exhibit specific expression in chimeric embryos'
Shen, S. and Van Den Brink, C.E. and Kruijer, W. and Van Der Saag, P.T. (1992) 'Embryonic stem cells stably transfected with mRARβ2-lacZ exhibit specific expression in chimeric embryos'. International Journal of Developmental Biology, 36 (4):465-476 [Details]
(1992) 'A preliminary report on pluripotent embryonic stem cells in pig embryos and generation of two chimeric pigs by blastocyst injection. 猪的胚胎嵌合试验中若干技术环节的研究(初报)'
林大光,经荣斌,孙长美,成勇,崔恒宓,李碧春,龚允成,杜淼,邹贤刚,沈三兵 (S Shen),陆德裕 (1992) 'A preliminary report on pluripotent embryonic stem cells in pig embryos and generation of two chimeric pigs by blastocyst injection. 猪的胚胎嵌合试验中若干技术环节的研究(初报)'. 江苏农学院学报, [Details]
(1991) 'Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness'
Shen, S. and Kruyt, F.A. and den Hertog, J. and van der Saag, P.T. and Kruijer, W. (1991) 'Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness'. DNA sequence : the journal of DNA sequencing and mapping, 2 (2):111-119 [Details]
(1990) 'Characteristics of embryonic stem cell differentiation: A comparison with two embryonal carcinoma cell lines'
Mummery, C.L. and Feyen, A. and Freund, E. and Shen, S. (1990) 'Characteristics of embryonic stem cell differentiation: A comparison with two embryonal carcinoma cell lines'. Cell Differentiation and Development, 30 (3):195-206 [Details]
(1990) 'Developmental potency of mouse primitive ectoderm cells, embryonic ectoderm cells and primordial germ cells after blastocyst injection'
Shen S* (1990) 'Developmental potency of mouse primitive ectoderm cells, embryonic ectoderm cells and primordial germ cells after blastocyst injection'. Cell Research, 1 :53-65 [Details]
(1990) 'The study of the developmental potential of early embryonic cells of rabbit'
Du M, Lu DY, Shen S, Huang GP, Zhou XG (1990) 'The study of the developmental potential of early embryonic cells of rabbit'. Shi Yan Sheng Wu Xue Bao, 23 :477-85 [Details]
(1989) 'Study on the developmental potential of rabbit embryonic cells through construction of chimera'
Lu DY, Tu M, Shen S, Zhou X, Huang G (1989) 'Study on the developmental potential of rabbit embryonic cells through construction of chimera'. Cell Differentiation and Development, 27 [Details]
(1988) 'Developmental potential of mouse primitive ectoderm cells following blastocyst injection'
Shen SB*, Tu M and Lu DY (1988) 'Developmental potential of mouse primitive ectoderm cells following blastocyst injection'. Shi Yan Sheng Wu Xue Bao, 21 (2):189-99 [Details]
(1988) 'Construction of chimeric rabbits by blastocyst injection of ICM cells from different developmental stages'
Lu, DY, Du M and Shen S* (1988) 'Construction of chimeric rabbits by blastocyst injection of ICM cells from different developmental stages'. Acta Zoologica Sinica, 34 :382-3 [Details]

Book Chapters

  Year Publication
(2014) 'Molecular Pathways in Autistic Spectrum Disorders'
Gallagher L, Shen S, Anney R (2014) 'Molecular Pathways in Autistic Spectrum Disorders' In: -. -: -. [Details]
(2006) 'Modification and amplification of yeast artificial chromosomes'
Shen S*, Harmar AJ, Hastie N. (2006) 'Modification and amplification of yeast artificial chromosomes' In: YAC Protocols. US: Humana Press. [Details]
(1987) 'Micromanipulation'
Shen S*, Yan SY (1987) 'Micromanipulation' In: Encyclopedia of China. 显微操作,《中国大百科全书》 第一版. 外文名称. China: Chinese: 中国大百科全书出版社. [Details]

Abstract

  Year Publication
(2014) Unc-51-like kinase 4 heterozygous (Ulk4+/-) mice display an anxiogenic-like behavioural phenotype and alterations in the GABAergic system within the amygdale. ECNP conference, Berlin.
Fitzgibbon M, Liu M, Bannon J, Shen S, Roche M (2014) Unc-51-like kinase 4 heterozygous (Ulk4+/-) mice display an anxiogenic-like behavioural phenotype and alterations in the GABAergic system within the amygdale. ECNP conference, Berlin. Abstract [Details]
(2014) Behavioral characterization of unc-51-like kinase 4 heterozygous (ULK4+/-) mice. International Behavioural Neuroscience Society (IBNS) conference, June 2014, Las Vegas.
Fitzgibbon M, Liu M, Shen S, Roche M (2014) Behavioral characterization of unc-51-like kinase 4 heterozygous (ULK4+/-) mice. International Behavioural Neuroscience Society (IBNS) conference, June 2014, Las Vegas. Abstract [Details]
(2013) Establishing in Vitro Models of Autism Spectrum Disorders Using Induced Pluripotent Stem Cells. ISSCR Conference 2013, Boston.
McDonagh K, Sotthibundhu A, Thompson K, McDermott E, Dockery P., Schwartz PH, Brick DJ, O’Brien T, Barry F, Shen S* (2013) Establishing in Vitro Models of Autism Spectrum Disorders Using Induced Pluripotent Stem Cells. ISSCR Conference 2013, Boston. Abstract [Details]
(2013) Autophagy mechanism in reprogramming and induced pluripotent stem cells. ISSCR Conference 2013, Boston.
Sotthibundhu A, McDonagh K, Klawiter A, Thompson K, Dockery P., Devine M, Kunath T, O’Brien T, Barry F, Shen S* (2013) Autophagy mechanism in reprogramming and induced pluripotent stem cells. ISSCR Conference 2013, Boston. Abstract [Details]
(2013) Assessing The Therapeutic Potential Of Induced Pluripotent Stem Cells In In Vitro Models Of Acute Lung Injury. American Thoracic Society International Conference. 2013, Philadelphia.
O'Toole D, Horie S, McDonagh K, Masterson CH, Shen S, Laffey JG. (2013) Assessing The Therapeutic Potential Of Induced Pluripotent Stem Cells In In Vitro Models Of Acute Lung Injury. American Thoracic Society International Conference. 2013, Philadelphia. Abstract [Details]
(2012) Stem cells and neural development. 2012. 7th Annual Neuroscience Ireland meeting, RCSI, Dublin.
Shen S* (2012) Stem cells and neural development. 2012. 7th Annual Neuroscience Ireland meeting, RCSI, Dublin. Abstract [Details]
(2012) “A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. 2012, Shanghai.
Shen S* (2012) “A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. 2012, Shanghai. Abstract [Details]
(2011) Creating Mouse Models of Behavioural and Psychiatric Disorders, Sheffield Institute for Translational Neuroscience, Sheffield University.
Shen S*. (2011) Creating Mouse Models of Behavioural and Psychiatric Disorders, Sheffield Institute for Translational Neuroscience, Sheffield University. Abstract [Details]
(2011) Role of PACAP signaling in the adult neurogenesis Winter Neuropeptide Conference, 2011, Liverpool.
Shen S* (2011) Role of PACAP signaling in the adult neurogenesis Winter Neuropeptide Conference, 2011, Liverpool. Abstract [Details]
(2010) Expression of Truncated DISC1 Associates with Schizophrenia‐Related Neural and Behavioral Phenotypes in Mice. DISC1 2010, Edinburgh.
Shen S* (2010) Expression of Truncated DISC1 Associates with Schizophrenia‐Related Neural and Behavioral Phenotypes in Mice. DISC1 2010, Edinburgh. Abstract [Details]
(2009) Roles of PACAP signalling in mouse neurogenesis 19th Neuropharmacology Conference - NEUROPEPTIDES. Chicago.
Shen S* (2009) Roles of PACAP signalling in mouse neurogenesis 19th Neuropharmacology Conference - NEUROPEPTIDES. Chicago. Abstract [Details]
(2009) PAC1 & mouse neurogenesis. The 9th International Symposium on VIP, PACAP, and Related Peptides. Kagoshima.
Shen S* (2009) PAC1 & mouse neurogenesis. The 9th International Symposium on VIP, PACAP, and Related Peptides. Kagoshima. Abstract [Details]
(2009) PAC1 & neurogenesis, 30th Winter Neuropeptide Conference, Colorado.
Shen S* (2009) PAC1 & neurogenesis, 30th Winter Neuropeptide Conference, Colorado. Abstract [Details]
(1999) Expression of the human PACAP (PAC1) receptor and a reporter gene from a modified P1 artificial chromosome in transgenic mice. Society for Neuroscience Abstracts 25: 1970.
Shen S*, Sheward WJ and Harmar AJ. (1999) Expression of the human PACAP (PAC1) receptor and a reporter gene from a modified P1 artificial chromosome in transgenic mice. Society for Neuroscience Abstracts 25: 1970. Abstract [Details]
(1999) Expression of the rat and human VPAC2 receptor in the suprachiasmatic nucleus: rostro-caudal distribution and co-localization with vasopressin and VIP mRNA. Society for Neuroscience Abstracts 25: 1370.
Kalló I, Kalamatianos T, Shen S, Sheward WJ, Okamura H, Powell JF, Campbell IC, Piggins HD, Harmar AJ and Coen CW. (1999) Expression of the rat and human VPAC2 receptor in the suprachiasmatic nucleus: rostro-caudal distribution and co-localization with vasopressin and VIP mRNA. Society for Neuroscience Abstracts 25: 1370. Abstract [Details]
(1999) ransgenic approaches to the understanding of VIP and PACAP receptor function. Regulatory Peptides 83: 58.
Shen S*, Sheward WJ, Kallo I, Coen CW and Harmar AJ. (1999) ransgenic approaches to the understanding of VIP and PACAP receptor function. Regulatory Peptides 83: 58. Abstract [Details]
(1992) Regulation and function of RARb in embryonic stem cells and mouse development. Mouse Genetics Conference, Cold Spring Harbor.
Shen S*, Kruijer W, van der Saag PT (1992) Regulation and function of RARb in embryonic stem cells and mouse development. Mouse Genetics Conference, Cold Spring Harbor. Abstract [Details]
(1988) Generation of mice lacking a receptor for VIP and PACAP (the VPAC2 receptor). Society for Neuroscience Abstracts 24: 2049.
West KM, Shen S, Sheward WJ, Mackay MEH, Kilanowski FM, Lutz EM, Dorin JR and Harmar AJ. (1988) Generation of mice lacking a receptor for VIP and PACAP (the VPAC2 receptor). Society for Neuroscience Abstracts 24: 2049. Abstract [Details]

Invited papers

  Year Publication
(2011) Animal and cellular modeling of neurodevelopmental disorders. 2011 Galway Neuroscience Research Day, Galway.
Shen S* (2011) Animal and cellular modeling of neurodevelopmental disorders. 2011 Galway Neuroscience Research Day, Galway. Invited papers [Details]

Invited Seminars

  Year Publication
(2008) “Neuropeptide Signalling, Stem Cells & Neurodevelopmental Disorders”. School of Biomedical Sciences, University of Liverpool, UK.
Shen, S. (2008) “Neuropeptide Signalling, Stem Cells & Neurodevelopmental Disorders”. School of Biomedical Sciences, University of Liverpool, UK. Invited Seminars [Details]
(2009) “Genetic modelling of neurodevelopmental disorders”. Molecular Medicine Centre, University of Edinburgh, UK.
Shen, S. (2009) “Genetic modelling of neurodevelopmental disorders”. Molecular Medicine Centre, University of Edinburgh, UK. Invited Seminars [Details]
(2009) “PAC1 & mouse neurogenesis”, 9th International Symposium on VIP, PACAP & Related Peptides, Kagoshima, Japan.
Shen, S. (2009) “PAC1 & mouse neurogenesis”, 9th International Symposium on VIP, PACAP & Related Peptides, Kagoshima, Japan. Invited Seminars [Details]
(2009) “PAC1 & neurogenesis” 30th Winter Neuropeptide Conference, Colorado, USA.
Shen, S. (2009) “PAC1 & neurogenesis” 30th Winter Neuropeptide Conference, Colorado, USA. Invited Seminars [Details]
(2010) “Stem Cells and Brain Development”, Strathclyde University, Glasgow.
Shen, S. (2010) “Stem Cells and Brain Development”, Strathclyde University, Glasgow. Invited Seminars [Details]
(2010) “Genetic Modeling of Neurodevelopmental disorders”. FMMU, Tang Du Hospital, Xi’an.
Shen, S. (2010) “Genetic Modeling of Neurodevelopmental disorders”. FMMU, Tang Du Hospital, Xi’an. Invited Seminars [Details]
(2010) “Genetic Modeling of Neurodevelopmental disorders”. FMMU, Institute of Neuroscience, Xi’an.
Shen, S. (2010) “Genetic Modeling of Neurodevelopmental disorders”. FMMU, Institute of Neuroscience, Xi’an. Invited Seminars [Details]
(2010) “PAC1 & mouse neurogenesis”, 19th Neuropharmacology Conference - Neuropeptides, Chicago, USA.
Shen, S. (2010) “PAC1 & mouse neurogenesis”, 19th Neuropharmacology Conference - Neuropeptides, Chicago, USA. Invited Seminars [Details]
(2011) “Neurological Diseases & Regenerative Medicine”, Hebei Normal University, China.
Shen, S. (2011) “Neurological Diseases & Regenerative Medicine”, Hebei Normal University, China. Invited Seminars [Details]
(2011) “Neurological disorders & Regenerative Medicine”. Tangdu Hospital, China. Attended as VIP at Neurosurgery Hospital opening ceremony.
Shen, S. (2011) “Neurological disorders & Regenerative Medicine”. Tangdu Hospital, China. Attended as VIP at Neurosurgery Hospital opening ceremony. Invited Seminars [Details]
(2011) “Neurological Diseases & Regenerative Medicine”, Life Science College, Zhejiang University.
Shen, S. (2011) “Neurological Diseases & Regenerative Medicine”, Life Science College, Zhejiang University. Invited Seminars [Details]
(2011) “Stem Cell Therapies: State of the Art”, Science Foundation Ireland, Dublin.
Shen, S. (2011) “Stem Cell Therapies: State of the Art”, Science Foundation Ireland, Dublin. Invited Seminars [Details]
(2011) “Creating Mouse Models of Behavioural and Psychiatric Disorders”, Sheffield Institute for Translational Neuroscience, Sheffield University, UK.
Shen, S. (2011) “Creating Mouse Models of Behavioural and Psychiatric Disorders”, Sheffield Institute for Translational Neuroscience, Sheffield University, UK. Invited Seminars [Details]
(2011) “Stem cells and genetic modelling of neurological disorders”, CLSS-UK, Edinburgh.
Shen, S. (2011) “Stem cells and genetic modelling of neurological disorders”, CLSS-UK, Edinburgh. Invited Seminars [Details]
(2011) “Plans for the Development of a Basic Research Programme in Stem Cell Biology at REMEDI”, REMEDI/NCBES, NUI Galway.
Shen, S (2011) “Plans for the Development of a Basic Research Programme in Stem Cell Biology at REMEDI”, REMEDI/NCBES, NUI Galway. Invited Seminars [Details]
(2011) “Role of PACAP signaling in adult neurogenesis” Winter Neuropeptide Conference, Liverpool.
Shen, S. (2011) “Role of PACAP signaling in adult neurogenesis” Winter Neuropeptide Conference, Liverpool. Invited Seminars [Details]
(2011) “Animal and cellular modeling of neurodevelopmental disorders”. Galway Neuroscience Research Day.
Shen, S. (2011) “Animal and cellular modeling of neurodevelopmental disorders”. Galway Neuroscience Research Day. Invited Seminars [Details]
(2012) Attending International Autism Conference at NUI Galway organised by Geraldine Leader.
Shen, S. (2012) Attending International Autism Conference at NUI Galway organised by Geraldine Leader. Invited Seminars [Details]
(2012) “Stem cells and neural development”. 7th Annual Neuroscience Ireland meeting, Royal College of Surgeons in Ireland, Dublin, Ireland.
Shen, S. (2012) “Stem cells and neural development”. 7th Annual Neuroscience Ireland meeting, Royal College of Surgeons in Ireland, Dublin, Ireland. Invited Seminars [Details]
(2012) “Neurological Diseases & Regenerative Medicine”. Life Science College, Zhejiang University.
Shen, S. (2012) “Neurological Diseases & Regenerative Medicine”. Life Science College, Zhejiang University. Invited Seminars [Details]
(2012) “A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. Shanghai.
Shen, S. (2012) “A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. Shanghai. Invited Seminars [Details]
(2012) “iPS cell modeling of neurological diseases”. FMMU, Xi’an, China.
Shen, S. (2012) “iPS cell modeling of neurological diseases”. FMMU, Xi’an, China. Invited Seminars [Details]
(2012) “iPS cell modeling of neurological diseases”. Xinhua Hospital, Shanghai Jiao Tong University.
Shen, S. (2012) “iPS cell modeling of neurological diseases”. Xinhua Hospital, Shanghai Jiao Tong University. Invited Seminars [Details]
(2012) “iPS cell modeling of neurological diseases”. Bio-X Institute, Shanghai Jiao Tong University.
Shen, S. (2012) “iPS cell modeling of neurological diseases”. Bio-X Institute, Shanghai Jiao Tong University. Invited Seminars [Details]
(2013) “Induced Pluripotent Stem cell models for autism and Fragile X syndrome”, Anti-aging and Regenerative Medicine, Shenzhen.
Shen, S. (2013) “Induced Pluripotent Stem cell models for autism and Fragile X syndrome”, Anti-aging and Regenerative Medicine, Shenzhen. Invited Seminars [Details]
(2013) “Animal and cellular modeling of neurodevelopmental disorders”, Brussels Meeting for H2020.
Shen, S. (2013) “Animal and cellular modeling of neurodevelopmental disorders”, Brussels Meeting for H2020. Invited Seminars [Details]
(2013) “Involvement Of A Novel Kinase ULK4 In Neurodevelopmental Disorders In Mice And Humans”, The 1st Annual Molecular Psychiatry Meeting in San Francisco.
Shen, S. (2013) “Involvement Of A Novel Kinase ULK4 In Neurodevelopmental Disorders In Mice And Humans”, The 1st Annual Molecular Psychiatry Meeting in San Francisco. Invited Seminars [Details]
(2013) 09/13 “Animal /Stem Cell Modeling and Regenerative Medicine”, Healthy Workshop at Shenzhen University, SFI ISCA programme.
Shen, S. (2013) 09/13 “Animal /Stem Cell Modeling and Regenerative Medicine”, Healthy Workshop at Shenzhen University, SFI ISCA programme. Invited Seminars [Details]
(2013) 6 Invited Lectures at Shanghai Jiaotong University in a Summer course of “Brain Facts.
Shen, S. (2013) 6 Invited Lectures at Shanghai Jiaotong University in a Summer course of “Brain Facts. Invited Seminars [Details]
(2013) “Induced Pluripotent Stem (iPS) Cell Research for Autism at NUIG”, 2nd International Conference on Autism Spectrum Disorders, NUI Galway.
Shen, S. (2013) “Induced Pluripotent Stem (iPS) Cell Research for Autism at NUIG”, 2nd International Conference on Autism Spectrum Disorders, NUI Galway. Invited Seminars [Details]
(2013) “Modeling Neurodevelopmental Disorders in Transgenic Mice and Human Induced Pluripotent Stem Cells”, CLASS seminar, UCD.
Shen, S. (2013) “Modeling Neurodevelopmental Disorders in Transgenic Mice and Human Induced Pluripotent Stem Cells”, CLASS seminar, UCD. Invited Seminars [Details]
(2014) “Modeling Neurodevelopmental Disorders in Mice and In Human Induced Pluripotent Stem Cells”, Glasgow Caledonian University.
Shen, S (2014) “Modeling Neurodevelopmental Disorders in Mice and In Human Induced Pluripotent Stem Cells”, Glasgow Caledonian University. Invited Seminars [Details]

Reviews

  Year Publication
(2012) Progress on stem cell research towards the treatment of Parkinson's disease.
Gibson, SAJ,Gao, GD,McDonagh, K,Shen, SB (2012) Progress on stem cell research towards the treatment of Parkinson's disease. Reviews [DOI] [Details]