Afshin Samali

Head of Department B.Sc, Ph.D

 
researcher

Biography

I have been a reviewer for 18 international journals, a member of the Editorial Board of J. Cell. Mol. Med. (JCMM), Cancers, BMC Cell Biol. and Int J of Cell Biol. (IJCB). I was Guest Editor of a Review Series on Apoptosis in JCMM (2007/2008), Cell Stress & Cell death in a Special issue of IJCB (2010), and on Cell Death & Cancer in a Special issue of Cancers (2010). I just completed editing a book on “ER stress in Health and Disease”, with Patrizia Agostinis (KU Leuven) to be published early 2012 by Springer. I have been a grant reviewer for AICR, Royal Soc New Zealand, Cancer Research UK, Wellcome Trust, Agance National de Recherche, FWO, French National Cancer Institute. As well as publications, I have given many invited presentations and lectures. Success in my field of research can be recognized from my publication record, h-index of 36 and approx 6600 citations, 7 patent applications filed and 2 spin off companies.

Research Interests

The main focus of my research is delineating the signaling pathways and understanding molecular control of the cellular responses to endoplasmic reticulum (ER) stress, whether it is an adaptive response or cell death.  The adaptive response to ER stress is called Unfolded Protein Response (UPR), which is aimed at correcting overall protein processing in order to reduce accumulation of malfolded proteins and restore normal cell function. If ER stress is too severe or if the adaptive response fails than cell death occurs. There are three ER transmembrane proteins, PERK, ATF6 and IRE1, involved in the initiation of downstream signaling of the UPR.  ER stress and UPR are involved in neurodegenerative diseases, inflammatory conditions, diabetes and cancer.  The main funded programmes in my group are:

(1)  Mechanism of ER stress induced-cell death and autophagy (funded by SFI)

(2)  Regulation of apoptosis by Hsp27 (HspB1) (funded by SFI and NUIG)

(3)  Targeting IRE1/XBP1 axis for cancer therapy (funded by MannKind Corp, Breast Cancer Campaign, Irish Cancer Society)

 

Research Projects

  Project Start Date End Date
CS/2011/375 FP7 PROPOSAL PREPARATION CO-ORDINATOR SUPPORT ENTERPRISE IRELAND PROF AFSHIN SAMALI 01-FEB-11 30-SEP-11
EU TNF LIGAND RECEPTOR QLK3 2001 00498 SAMALI 01-JAN-02 26-NOV-07
PC20080340 Prof Afshin Samali Evaluation Targets o 01-FEB-09 31-MAR-12
SFI OVERHEADS EQUIPMENT AFSHIN SAMALI 01-JAN-08 31-DEC-08
IRCSET EMBARK 2007, MARIANNE VAN DIJK 01-OCT-07 28-FEB-12
SFI 09 SIRG B1575 AFSHIN SAMALI NOVEL RATIOMETRIC APPROACH TO IDENTIFY DECISIVE MOLECULAR 01-OCT-09 30-SEP-15
REGULATION IRE1 SIGNAL SFI 09/RFP/BIC2371 - A SAMALI 01-OCT-09 19-FEB-15
PRTLI3 BMES 2 2 01-JUL-02 28-JAN-08
989 MF 33 00 M EFFECTS OF HSP 01-JUL-00 29-NOV-04
HAEMATOLOGY RESEARCH FUND A SAMALI 15-MAY-06 14-MAY-13
SFI RFP 05 RFP BIC002 A SAMALI 01-MAY-06 30-APR-09
MF2003 MF 75 03 CARDIAC DISEASE A SAMALI 01-JAN-04 29-NOV-04
APOPTOSIS A SAMALI NCBES T SMITH 15-JAN-04 15-JAN-07
MF2004 MF65 04 DR. AFSHIN SAMALI 01-OCT-04 30-JUL-06
IHF GENE EXPRESSION SAMALI 01-SEP-01 31-DEC-04
TRIDENT EC STREP COORDINATION 01-OCT-06 30-SEP-09
10 YEAR CELEBRATION APOPTOSIS AFSHIN SAMALI 01-JUN-10 31-MAY-11
IRISH CANCER SOCIETY CRF09SZE AFSHIN SAMALI 01-DEC-09 30-JUN-13
MF2002 MF86 02 M MICHAEL O DWYER 01-DEC-02 29-NOV-04
EI CFTD 06 112 TRITAN A SAMALI 01-JUL-06 28-FEB-10
CANCER CARE WEST A SAMALI M O DWYER 01-JUL-06 30-SEP-09
TARGETING THE HSP72-IRE1 INTERACTION TO MODULATE THE UNFOLDED PROTEIN RESPONSE IN BREAST CANCER 2010NOVPR13 01-MAR-11 30-SEP-14
HAEMATOLOGY RESEARCH FUND A. SAMALI ORTHO BIOTECH 15-MAY-06 14-MAY-11
SFI ER STRESS-INDUCED APOPTOSIS AFSHIN SAMALI 31-MAR-06 31-MAR-10
CRI SECLECTIVE REGULATORS TRAIL A SAMALI 01-OCT-05 18-NOV-10
MILL FND MAJOR A SAMALI OX LDL INDUCED APOPTOSIS 01-NOV-01 15-OCT-09
ROLE IN DBP 1 IN BREAST CANCER DEVELOPMENT AND RESISTANCE TO THERAPY IRISH CANCER SOCIETY CRS11CLE AFSHIN SAMALI 01-OCT-11 31-MAR-15
IRISH CANCER SOC CRS10VIN A SAMALI 01-OCT-10 31-MAY-12
ENTERPRISE IRELAND FP7 PROPOSAL PREPARATION CO-ORDINATOR SUPPORT CS/2011/427 AFSHIN SAMALI 22-SEP-11 21-NOV-12
HRB HRA 2009 59 AFSHIN SAMALI 01-OCT-09 30-NOV-12
MF 81 2005 M A SAMALI M KEANE 01-OCT-05 30-APR-07
MF2003 MF99 03 M M O DWYER A SAMALI 01-APR-04 25-DEC-04
TRIDENT EC STREP INNOVATION PROJ AFSHIN SAMALI 01-OCT-06 30-SEP-09
APOPTOSIS SAMALI IND OVERHEADS N VAT 01-FEB-06 31-MAY-23
EI FEASIBILITY EVE IP 2006 413Y SAMALI 01-MAR-07 30-SEP-07
PRTLI3 BMES 2 3 01-JUL-02 12-MAY-08

Peer Reviewed Journals

  Year Publication
(2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'
Séverine Cruet-Hennequart; Tanja Paavilainen; Michael O’Dwyer; Réka Tóth; Michael P Carty; Afshin Samali; Eva Szegezdi (2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'. Journal of Leukemia, 4 [DOI] [Details]
(2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'
Deegan, S,Koryga, I,Glynn, SA,Gupta, S,Gorman, AM,Samali, A (2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'. Biochemical And Biophysical Research Communications, 456 :305-311 [DOI] [Details]
(2015) 'Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells'
Saveljeva, S,Mc Laughlin, SL,Vandenabeele, P,Samali, A,Bertrand, MJM (2015) 'Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells'. Cell Death & Disease, 6 [DOI] [ARAN Link] [Details]
(2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675 [DOI] [Details]
(2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'
Read, DE,Gupta, A,Ladilov, Y,Samali, A,Gupta, S (2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'. Cell And Bioscience, 4 [DOI] [ARAN Link] [Details]
(2014) 'Stressed to death - mechanisms of ER stress-induced cell death'
Sovolyova, N,Healy, S,Samali, A,Logue, SE (2014) 'Stressed to death - mechanisms of ER stress-induced cell death'. Biological Chemistry, 395 (1):1-13 [DOI] [Details]
(2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'
Mnich, K,Carleton, LA,Kavanagh, ET,Doyle, KM,Samali, A,Gorman, AM (2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'. Cell Death & Disease, 5 [DOI] [Details]
(2013) 'New directions in ER stress-induced cell death'
Logue SE, Cleary P, Saveljeva S, Samali A (2013) 'New directions in ER stress-induced cell death'. Apoptosis, 18 (5):537-546 [DOI] [Details]
(2013) 'The eIF2α kinases: their structures and functions'
Donnelly N, Gorman AM, Gupta S, Samali A (2013) 'The eIF2α kinases: their structures and functions'. Cellular And Molecular Life Sciences, 70 (19):3493-3511 [DOI] [Details]
(2013) 'Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma'
Vincenz, L,Jager, R,O'Dwyer, M,Samali, A (2013) 'Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma'. Molecular Cancer Therapeutics, 12 (6):831-843 [DOI] [Details]
(2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'
van Dijk, M,Halpin-McCormick, A,Sessler, T,Samali, A,Szegezdi, E (2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'. Cell Death & Disease, 4 [DOI] [ARAN Link] [Details]
(2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'
Verfaillie T, van Vliet A, Garg AD, Dewaele M, Rubio N, Gupta S, de Witte P, Samali A, Agostinis P (2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'. Biochem, 438 (3):500-506 [DOI] [Details]
(2013) 'Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion'
Cawley, K,Logue, SE,Gorman, AM,Zeng, QP,Patterson, J,Gupta, S,Samali, A (2013) 'Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion'. Plos One, 8 [DOI] [ARAN Link] [Details]
(2013) 'Atypical heat shock response and acquisition of thermotolerance in P388D1 cells'
Oommen, D,Giricz, Z,Srinivas, UK,Samali, A (2013) 'Atypical heat shock response and acquisition of thermotolerance in P388D1 cells'. Biochemical And Biophysical Research Communications, 430 :236-240 [DOI] [Details]
(2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'
Deegan S, Saveljeva S, Gorman AM, Samali A (2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'. Life Sciences, 70 (14):2425-2441 [DOI] [Details]
(2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'
van Dijk M, Halpin-McCormick A, Sessler T, Samali A, Szegezdi E (2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'. Cell, 4 [DOI] [Details]
(2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'
Sessler, T,Healy, S,Samali, A,Szegezdi, E (2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'. Pharmacology & Therapeutics, 140 (2):186-199 [DOI] [Details]
(2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'
Gorman AM, Healy SJ, Jäger R, Samali A (2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'. Pharmacology & therapeutics, 134 (3):306-316 [DOI] [Details]
(2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'
Nürnberger S, Miller I, Duvigneau JC, Kavanagh ET, Gupta S, Hartl RT, Hori O, Gesslbauer B, Samali A, Kungl A, Redl H, Kozlov AV (2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'. American Journal Of Physics, 303 (12):1-83 [DOI] [Details]
(2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'
Gupta S, Giricz Z, Natoni A, Donnelly N, Deegan S, Szegezdi E, Samali A (2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'. Febs Letters, 586 (22):4023-4030 [DOI] [Details]
(2012) 'Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells'
Chris Linehan, Sanjeev Gupta, Afshin Samali, Lynn O’Connor (2012) 'Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells'. Plos One, [ARAN Link] [Details]
(2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'
Nurnberger, S,Miller, I,Duvigneau, JC,Kavanagh, ET,Gupta, S,Hartl, RT,Hori, O,Gesslbauer, B,Samali, A,Kungl, A,Redl, H,Kozlov, AV (2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, 303 :1373-1383 [DOI] [Details]
(2012) 'PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress'
Verfaillie, T,Rubio, N,Garg, AD,Bultynck, G,Rizzuto, R,Decuypere, JP,Piette, J,Linehan, C,Gupta, S,Samali, A,Agostinis, P (2012) 'PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress'. Cell Death And Differentiation, 19 :1880-1891 [DOI] [Details]
(2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'
Szegezdi, E,van der Sloot, AM,Mahalingam, D,O'Leary, L,Cool, RH,Munoz, IG,Montoya, G,Quax, WJ,de Jong, S,Samali, A,Serrano, L (2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'. Molecular & Cellular Proteomics, 11 [DOI] [Details]
(2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'
Jäger R, Bertrand MJ, Gorman AM, Vandenabeele P, Samali A (2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'. Cell, 104 (5):259-270 [DOI] [Details]
(2012) 'The unfolded protein response at the crossroads of cellular life and death during ER stress'
Jäger R, Bertrand MJM, Gorman AM, Vandenabeele P, Samali A (2012) 'The unfolded protein response at the crossroads of cellular life and death during ER stress'. Biology of the Cell, [DOI] [Details]
(2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'
Gupta, S,Read, DE,Deepti, A,Cawley, K,Gupta, A,Oommen, D,Verfaillie, T,Matus, S,Smith, MA,Mott, JL,Agostinis, P,Hetz, C,Samali, A (2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'. Cell Death & Disease, 3 [DOI] [Details]
(2011) 'Assays for detecting the unfolded protein response'
Cawley K, Deegan S, Samali A, Gupta S. (2011) 'Assays for detecting the unfolded protein response'. Methods Enzymol, 490 :31-51 [Details]
(2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic'
Van Dijk M, Murphy E, Morrell R, Knapper S, O'Dwyer M, Samali A and Szegezdi E. (2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic'. Differentiation to TRAIL Mediated Apoptosis Cancers, 3 (1):1329-1350 [DOI] [Details]
(2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'
Doyle, K.M., Kennedy, D., Gorman, A.M., Gupta, S., Healy, S.J.M., Samali, A. (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. Journal of Cellular and Molecular Medicine, 15 (10):2025-2039 [Details]
(2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'
van Dijk M, Murphy E, Morrell M , Knapper S , O'Dwyer M, Samali A, Eva Szegezdi E. (2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'. Cancers, 3 :1329-1350 [ARAN Link] [Details]
(2011) 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'
Natoni, A,Murillo, LS,Kliszczak, AE,Catherwood, MA,Montagnoli, A,Samali, A,O'Dwyer, M,Santocanale, C (2011) 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'. Molecular Cancer Therapeutics, 10 :1624-1634 [DOI] [ARAN Link] [Details]
(2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'
Szegezdi, E,Reis, CR,van der Sloot, AM,Natoni, A,O'Reilly, A,Reeve, J,Cool, RH,O'Dwyer, M,Knapper, S,Serrano, L,Quax, WJ,Samali, A (2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'. Journal Of Cellular And Molecular Medicine, 15 :2216-2231 [DOI] [Details]
(2011) 'An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro'
Foley SA, Szegezdi E, Mulloy B, Samali A, Tuohy MG (2011) 'An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro'. Journal Of Natural Products, 74 (9):1851-1861 [DOI] [Details]
(2010) 'HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1 alpha-XBP1 Signaling through a Physical Interaction'
Gupta, S,Deepti, A,Deegan, S,Lisbona, F,Hetz, C,Samali, A (2010) 'HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1 alpha-XBP1 Signaling through a Physical Interaction'. Plos Biology, 8 [DOI] [Details]
(2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'
Reis, CR,van der Sloot, AM,Natoni, A,Szegezdi, E,Setroikromo, R,Meijer, M,Sjollema, K,Stricher, F,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'. Cell Death & Disease, 1 [DOI] [Details]
(2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'
Mahalingam, D,Natoni, A,Keane, M,Samali, A,Szegezdi, E (2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'. British Journal Of Cancer, 102 :754-764 [DOI] [Details]
(2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'
Vrielink, J,Heins, MS,Setroikromo, R,Szegezdi, E,Mullally, MM,Samali, A,Quax, WJ (2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'. Febs Journal, 277 :1653-1665 [DOI] [Details]
(2010) 'Regulation of NF-kB responses by epigenetic suppression of IkBa expression in HCT116 intestinal epithelial cells'
Plantivaux A, Szegezdi E, Samali A, Egan L. (2010) 'Regulation of NF-kB responses by epigenetic suppression of IkBa expression in HCT116 intestinal epithelial cells'. American Journal Of Physiology: Gastrointestinal And Liver Physiology, 299 (1):96-105 [DOI] [Details]
(2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization.010; PubMed Central PMCID: PMC2821636'
Gupta S, Cuffe L, Szegezdi E, Logue SE, Neary C, Healy S, Samali A. (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization.010; PubMed Central PMCID: PMC2821636'. Int J Cell Biol, [ARAN Link] [Details]
(2010) 'Cellular Stress Responses: cell survival and cell death'
Fulda S, Gorman AM, Hori O, Samali A. (2010) 'Cellular Stress Responses: cell survival and cell death'. Int J Cell Biol, [DOI] [Details]
(2010) 'Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response'
Samali, A., Fitzgerald, U., Deegan, S., & Gupta, S. (2010) 'Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response'. International Journal Of Cell Biology, [ARAN Link] [Details]
(2010) 'Cell stress and cell death'
Samali A, Fulda S, Gorman AM, Hori O, Srinivasula SM. (2010) 'Cell stress and cell death'. Int J Cell Biol, 2010 :245803-2pp [Details]
(2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'
Mahalingam, D,Keane, M,Pirianov, G,Mehmet, H,Samali, A,Szegezdi, E (2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'. British Journal Of Cancer, 100 :1415-1424 [DOI] [Details]
(2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'
Reis, CR,van der Sloot, AM,Szegezdi, E,Natoni, A,Tur, V,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'. Biochemistry, 48 :2180-2191 [DOI] [Details]
(2009) 'Stem cells are resistant to TRAIL receptor-mediated apoptosis'
Szegezdi, E,O'Reilly, A,Davy, Y,Vawda, R,Taylor, DL,Murphy, M,Samali, A,Mehmet, H (2009) 'Stem cells are resistant to TRAIL receptor-mediated apoptosis'. Journal Of Cellular And Molecular Medicine, 13 :4409-4414 [DOI] [Details]
(2009) 'Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model'
Duiker, EW,de Vries, EGE,Mahalingam, D,Meersma, GJ,Ek, WBV,Hollema, H,Hooge, MNLD,van Dam, GM,Cool, RH,Quax, WJ,Samali, A,van der Zee, AGJ,de Jong, S (2009) 'Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model'. Clinical Cancer Research, 15 :2048-2057 [DOI] [Details]
(2009) 'Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?'
Plantivaux A, Szegezdi E, Samali A, Egan L (2009) 'Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?'. Annals of the New York Academy of Sciences, 1171 :38-49 [DOI] [Details]
(2009) 'Bcl-2 family on guard at the ER'
Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A (2009) 'Bcl-2 family on guard at the ER'. American Journal Of Physiology, 296 (5):1-53 [DOI] [Details]
(2009) 'Elevation of cAMP in Mesenchymal Stem Cells Transiently Upregulates Neural Markers Rather than Inducing Neural Differentiation'
Rooney, GE,Howard, L,O'Brien, T,Windebank, AJ,Barry, FP (2009) 'Elevation of cAMP in Mesenchymal Stem Cells Transiently Upregulates Neural Markers Rather than Inducing Neural Differentiation'. Stem Cells And Development, 18 :387-398 [DOI] [Details]
(2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'
Healy SJ, Gorman AM, Mousavi-Shafaei P, Gupta S, Samali A (2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'. European Journal Of Pharmacology, 625 (1-3):234-246 [DOI] [Details]
(2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'
Mahalingam, D.,Szegezdi, E.,Keane, M.,de Jong, S.,Samali, A. (2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'. Cancer Treatment Reviews, 35 (33):280-288 [Details]
(2009) 'Bcl-2 family on guard at the ER'
Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A. (2009) 'Bcl-2 family on guard at the ER'. American Journal Of Physiology: Cell Physiology, [ARAN Link] [Details]
(2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'
Tur, V,van der Sloot, AM,Reis, CR,Szegezdi, E,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'. Journal Of Biological Chemistry, 283 :20560-20568 [DOI] [Details]
(2008) 'Structure based design of a DR4 selective TRAIL variant'
Tur V, van der Sloot AM, Reis CR, Szegezdi E, Cool RH, Serrano L Samali A and Quax W (2008) 'Structure based design of a DR4 selective TRAIL variant'. Journal Of Biological Chemistry, 283 :20560-20568 [Details]
(2008) 'Y Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'
Szegezdi, E,Reed Herbert, K,Kavanagh, ET,Samali, A,Gorman, AM (2008) 'Y Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 :2482-2496 [DOI] [Details]
(2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'
Mylotte, LA,Duffy, AM,Murphy, M,O'Brien, T,Samali, A,Barry, F,Szegezdi, E (2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'. Stem Cells and Development, 26 :1325-1336 [DOI] [Details]
(2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'
Holohan, C,Szegezdi, E,Ritter, T,O'Brien, T,Samali, A (2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'. Journal Of Cellular And Molecular Medicine, 12 :591-606 [DOI] [Details]
(2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'
Szegezdi E, Herbert KR, Kavanagh ET, Samali A, Gorman AM (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 (6A):2482-2496 [DOI] [Details]
(2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'
Mhaille, AN,McQuaid, S,Windebank, A,Cunnea, P,McMahon, J,Samali, A,FitzGerald, U (2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'. Journal Of Neuropathology And Experimental Neurology, 67 :200-211 [Details]
(2007) 'Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase'
Halvey, PJ,Hansen, JM,Johnson, JM,Go, YM,Samali, A,Jones, DP (2007) 'Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase'. Antioxidants & Redox Signaling, 9 :807-816 [DOI] [Details]
(2007) 'A tribute to professor Richard A. Lockshin on his 70th birthday'
Samali A (2007) 'A tribute to professor Richard A. Lockshin on his 70th birthday'. Journal Of Cellular And Molecular Medicine, 11 (6):1210-1211 [DOI] [Details]
(2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'
Samali, A,O'Mahoney, M,Reeve, J,Logue, S,Szegezdi, E,McMahon, J,Fearnhead, HO (2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'. Apoptosis, 12 :465-474 [DOI] [Details]
(2007) 'OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas'
Reeve, JLV,Stenson-Cox, C,O'Doherty, A,Porn-Ares, I,Ares, M,O'Brien, T,Samali, A (2007) 'OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas'. Biochemical And Biophysical Research Communications, 356 :681-686 [DOI] [Details]
(2007) 'Apoptosis: a mapped path to cell death'
Samali A (2007) 'Apoptosis: a mapped path to cell death'. Journal Of Cellular And Molecular Medicine, 11 (6):1212-1213 [DOI] [Details]
(2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'
Reeve, JLV,Szegezdi, E,Logue, SE,Chonghaile, TN,O'Brien, T,Ritter, T,Samali, A (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'. Journal Of Cellular And Molecular Medicine, 11 :509-520 [DOI] [Details]
(2006) 'Cytoprotection of beta cells: rational gene transfer strategies'
McCabe C, Samali A, O'Brien T (2006) 'Cytoprotection of beta cells: rational gene transfer strategies'. Diabetes, 22 (3):241-252 [DOI] [Details]
(2006) 'Mediators of ER stress-induced apoptosis'
Szegezdi E, Logue SE, Gorman AM and Samali A (2006) 'Mediators of ER stress-induced apoptosis'. EMBO Reports, 7 :880-885 [Details]
(2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'
Szegezdi, E,Cahill, S,Meyer, M,O'Dwyer, M,Samali, A (2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'. British Journal Of Cancer, 94 :398-406 [DOI] [Details]
(2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'
Duffy, A,Liew, A,O'Sullivan, J,Avalos, G,Samali, A,O'Brien, T (2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'. Endothelium-Journal Of Endothelial Cell Research, 13 :9-16 [DOI] [Details]
(2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'
Van der Sloot, AM,Tur, V,Szegezdi, E,Mullally, MM,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 103 :8634-8639 [DOI] [Details]
(2006) 'beta cell cytoprotective strategies: Establishing the relative roles for iNOS and ROS'
McCabe, C,Samali, A,O'Brien, T (2006) 'beta cell cytoprotective strategies: Establishing the relative roles for iNOS and ROS'. Biochemical And Biophysical Research Communications, 342 :1240-1248 [DOI] [Details]
(2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'
Szegezdi, E,Duffy, A,O'Mahoney, ME,Logue, SE,Mylotte, LA,O'Brien, T,Samali, A (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochemical And Biophysical Research Communications, 349 :1406-1411 [DOI] [Details]
(2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'
Ni Chonghaile, T,Concannon, CG,Szegezdi, E,Gorman, AM,Samali, A (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'. Apoptosis, 11 :1247-1255 [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi, E.,Logue, S. E.,Gorman, A. M.,Samali, A. (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (99):880-885 [Details]
(2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'
Kavanagh, ET,Loughlin, JP,Herbert, KR,Dockery, P,Samall, A,Doyle, KM,Gorman, AM (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochemical And Biophysical Research Communications, 351 :890-895 [DOI] [Details]
(2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochem. Biophys. Res. Commun, 327 :801-810 [Details]
(2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochemical And Biophysical Research Communications, 327 :801-810 [Details]
(2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilisation'
Concannon G., Holmberg C., FitzGerald U., Szegezdi E., Sistonen L. and Samali A. (2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilisation'. Cell Stress And Chaperones, 10 (l):59-65 [DOI] [Details]
(2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'
Gorman, AM,Szegezdi, E,Quigney, DJ,Samali, A (2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'. Biochemical And Biophysical Research Communications, 327 :801-810 [DOI] [Details]
(2005) 'Compartmental oxidation of thiol/disulfide redox couples during EGF signaling'
Halvey P.J., Watson W.H., Hansen J.M., Go Y-M., Samali A., Jones D.P. (2005) 'Compartmental oxidation of thiol/disulfide redox couples during EGF signaling'. Biochem. J, 386 :215-219 [DOI] [Details]
(2005) 'Ischemia/reperfusion injury at the intersection with cell death'
Logue SE, Gustafsson AB, Samali A, Gottlieb RA (2005) 'Ischemia/reperfusion injury at the intersection with cell death'. Molecular Cell, 38 (1):21-33 [DOI] [Details]
(2005) 'Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling'
Halvey PJ, Watson WH, Hansen JM, Go YM, Samali A, Jones DP (2005) 'Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling'. Biochemical Journal, 386 (Pt 2):215-219 [DOI] [Details]
(2005) 'Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease'
Reeve JL, Duffy AM, O'Brien T, Samali A (2005) 'Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease'. Journal Of Cellular And Molecular Medicine, 9 (3):609-622 [Details]
(2005) 'Don’t loose Heart: Therapeutic value of anti-apoptotic strategies in the treatment of cardiovascular disease'
Reeve J., Duffy A., O'Brien T., Samali A. (2005) 'Don’t loose Heart: Therapeutic value of anti-apoptotic strategies in the treatment of cardiovascular disease'. J. Cell. Mol. Med, :609-622 [Details]
(2004) 'The switch from survival responses to apoptosis after chromosomal breaks'
Bree R, Neary C, Samali A and Lowndes NF (2004) 'The switch from survival responses to apoptosis after chromosomal breaks'. DNA Repair, 3 :989-995 [Details]
(2003) 'Heat shock inhibits MPP+-induced cell death in PC-12 cells'
Quigney D., Gorman A.M., Samali A. (2003) 'Heat shock inhibits MPP+-induced cell death in PC-12 cells'. Brain Res, 993 :133-139 [Details]
(2003) 'Caspase-12 and ER-stress-mediated apoptosis: the story so far'
Szegezdi E, Fitzgerald U, Samali A (2003) 'Caspase-12 and ER-stress-mediated apoptosis: the story so far'. Annals of the New York Academy of Sciences, 1010 :186-194 [Details]
(2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'
O'Mahoney M, Logue SE, Szegezdi E, FitzGerald U, Samali A (2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'. Apoptosis: From Signaling Pathways To Therapeutic Tools, 1010 :728-732 [Details]
(2003) 'In the cut and thrust of apoptosis, serine proteases come of age'
Stenson-Cox, C.M., FitzGerald, U., Samali, A. (2003) 'In the cut and thrust of apoptosis, serine proteases come of age'. Biochem Biopharm, 66 :1469-1474 [Details]
(2003) 'Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis'
Cahill S, Szegezdi E, Samali A, O'Dwyer M (2003) 'Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis'. Blood, 102 :861A-861A [Details]
(2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'
O'Mahoney ME, Logue S, Szegezdi E, Stenson-Cox C, Fitzgerald U, Samali A (2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'. Annals of the New York Academy of Sciences, 1010 :728-732 [Details]
(2003) 'Heat shock protects PC12 cells against MPP+ toxicity'
Quigney, DJ,Gorman, AM,Samali, A (2003) 'Heat shock protects PC12 cells against MPP+ toxicity'. Brain Research, 993 :133-139 [DOI] [Details]
(2003) 'On the role of Hsp27 in regulating apoptosis'
Concannon CG, Gorman AM, Samali A (2003) 'On the role of Hsp27 in regulating apoptosis'. Apoptosis, 8 :61-70 [Details]
(2002) 'Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?'
Gill C, Mestril R, Samali A (2002) 'Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?'. Faseb Journal, 16 (2):135-146 [DOI] [Details]
(2001) 'Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c'
Concannon, CG,Orrenius, S,Samali, A (2001) 'Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c'. Gene Expression, 9 :195-201 [Details]
(2001) 'Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli'
Samali, A,Robertson, JD,Peterson, E,Manero, F,van Zeijl, L,Paul, C,Cotgreave, IA,Arrigo, AP,Orrenius, S (2001) 'Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli'. Cell Stress & Chaperones, 6 :49-58 [Details]
(2001) 'Determination of apoptosis and necrosis'
Zhivotovsky B, Samali A, Orrenius S (2001) 'Determination of apoptosis and necrosis'. Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.], Chapter 2 [DOI] [Details]
(2001) 'Interleukin-1, interleukin-8, tumor necrosis factor alpha and inteferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines'
Zachrisson C., Neopikhanov V., Samali A., Uribe A. (2001) 'Interleukin-1, interleukin-8, tumor necrosis factor alpha and inteferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines'. Eur. J. Gastro. Hepatol, 13 :551-559 [Details]
(2001) 'Current concepts in cell toxicity'
Samali A, Zhivotovsky B, Orrenius S (2001) 'Current concepts in cell toxicity'. Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.], Chapter 2 [DOI] [Details]
(2000) 'Soluble proteins of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'
Neopikhanov V., Samali A., Wreiber K., Engstrand L., Uribe A. (2000) 'Soluble proteins of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'. Digestion, 61 :22-29 [Details]
(2000) 'Triggering and modulation of apoptosis by oxidative stress'
Chandra J, Samali A, Orrenius S (2000) 'Triggering and modulation of apoptosis by oxidative stress'. Free radical biology & medicine, 29 (3-4):323-333 [Details]
(2000) '40- to 100-kD protein(s) of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'
Neopikhanov V, Samali A, Wreiber K, Engstrand L, Uribe A (2000) '40- to 100-kD protein(s) of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'. Digestion, 61 (1):22-29 [DOI] [Details]
(1999) 'Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins'
Samali, A,Holmberg, CI,Sistonen, L,Orrenius, S (1999) 'Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins'. Febs Letters, 461 :306-310 [Details]
(1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'
Gorman, AM,Heavey, B,Creagh, E,Cotter, TG,Samali, A (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. Febs Letters, 445 :98-102 [Details]
(1999) 'A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis'
Samali A, Nordgren H, Zhivotovsky B, Peterson E, Orrenius S (1999) 'A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis'. Biochem, 255 (1):6-11 [DOI] [Details]
(1999) 'Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells'
Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S (1999) 'Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells'. Embo Journal, 18 (8):2040-2048 [DOI] [Details]
(1999) 'Apoptosis: cell death defined by caspase activation'
Samali A, Zhivotovsky B, Jones D, Nagata S, Orrenius S (1999) 'Apoptosis: cell death defined by caspase activation'. Cell Death And Differentiation, 6 (6):495-496 [DOI] [Details]
(1999) 'Caspases: their intracellular localization and translocation during apoptosis'
Zhivotovsky B, Samali A, Gahm A, Orrenius S (1999) 'Caspases: their intracellular localization and translocation during apoptosis'. Cell Death And Differentiation, 6 (7):644-651 [DOI] [Details]
(1999) 'Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression'
Fadeel B, Gleiss B, Högstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A (1999) 'Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression'. Biochem, 266 (2):504-511 [DOI] [Details]
(1998) 'Detection of pro-caspase-3 in cytosol and mitochondria of various tissues'
Samali A, Zhivotovsky B, Jones DP, Orrenius S (1998) 'Detection of pro-caspase-3 in cytosol and mitochondria of various tissues'. Febs Letters, 431 (2):167-169 [Details]
(1998) 'Cleavage of the calpain inhibitor, calpastatin, during apoptosis'
Pörn-Ares MI, Samali A, Orrenius S (1998) 'Cleavage of the calpain inhibitor, calpastatin, during apoptosis'. Cell Death And Differentiation, 5 (12):1028-1033 [DOI] [Details]
(1998) 'Heat shock proteins: regulators of stress response and apoptosis'
Samali A, Orrenius S (1998) 'Heat shock proteins: regulators of stress response and apoptosis'. Cell Stress & Chaperones, 3 (4):228-236 [Details]
(1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'
Gorman, AM,Samali, A,McGowan, AJ,Cotter, TG (1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'. Cytometry, 29 :97-105 [Details]
(1997) 'Role of Bcr-abl in resistance to apoptosis'
Samali A, Gorman A, Cotter TG (1997) 'Role of Bcr-abl in resistance to apoptosis'. Adv. Pharmacol, 41 :533-552 [Details]
(1997) 'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'
Samali A, Gilje B, Døskeland SO, Cotter TG, Houge G (1997) 'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'. Cell Death And Differentiation, 4 (4):289-293 [DOI] [Details]
(1996) 'Anti-oxidants and apoptosis'
McGowan AJ, Fernandes RS, Samali A, Cotter TG (1996) 'Anti-oxidants and apoptosis'. Biochemical Society Transactions, 24 (1):229-233 [Details]
(1996) 'Heat shock proteins increase resistance to apoptosis'
Samali, A,Cotter, TG (1996) 'Heat shock proteins increase resistance to apoptosis'. Experimental Cell Research, 223 :163-170 [Details]
(1996) 'Apoptosis -- the story so far'
Samali A, Gorman AM, Cotter TG (1996) 'Apoptosis -- the story so far'. Experientia, 52 (10-11):933-941 [Details]

Book Chapters

  Year Publication
(2012) 'ER stress signaling pathways in cell survival and death'
Verfaillie, T; Jäger, R; Samali, A; Agostinis, P (2012) 'ER stress signaling pathways in cell survival and death' In: ER stress in health and disease. New York: Springer. [Details]
(2012) 'Biology of the Endoplasmic Reticulum'
Sandra JM Healy, Tom Verfaillie, Richard Jager, Patrizia Agostinis and Afshin Samali (2012) 'Biology of the Endoplasmic Reticulum' In: ER Stress in Health and Disease. Dordrecht, Netherlands: Springer Science+Business Media. [Details]
(2011) 'Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus'
Vincenz L, Szegezdi E, Jaeger R, Holohan C, O'Brien T, Samali A. (2011) 'Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus' In: Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments. Rijeka, Croatia: InTech publishers. [DOI] [Details]
(2006) 'The role of heat shock proteins in neuronal differentiation and development'
Reed Herbert K, Samali A, Gorman AM. (2006) 'The role of heat shock proteins in neuronal differentiation and development' In: Heat Shock Proteins in Neural Cells. TX, USA: Landes Bioscience. [Details]
(2006) 'Heat shock proteins and the regulation of apoptosis'
Fitzgerald, U, Gorman AM, Samali A. (2006) 'Heat shock proteins and the regulation of apoptosis' In: Heat Shock Proteins in Neural Cells. TX, USA: Landes Bioscience. [Details]
(2005) 'Heat shock proteins in regulation of neural apoptosis'
FitzGerald U., Gorman A.M., Samali A. (2005) 'Heat shock proteins in regulation of neural apoptosis' In: Heat Shock Proteins in Neural Cells. TX, USA: Landes Bioscience. [Details]
(2005) 'The role of heat shock proteins in neuronal differentiation and development'
Herbert-Reed K., Samali A., Gorman A.M. (2005) 'The role of heat shock proteins in neuronal differentiation and development' In: Heat Shock Proteins in Neural Cells. Landes Bioscience, TX, USA. [Details]
(2005) 'Molecular basis of inhibition of apoptosis by Heat shock proteins'
Gill C., Meyer M., Samali A. (2005) 'Molecular basis of inhibition of apoptosis by Heat shock proteins' In: Stress response: a molecular Biology approach. Research Signpost, India. [Details]
(1999) 'Measurement of cells in culture'
Samali A., Cotter T.G. (1999) 'Measurement of cells in culture' In: Animal Cell Biotechnology: Methods and protocols (Methods in Biotechnology series). Germany: Springer. [DOI] [Details]
(1999) 'Current Concepts in Cell Toxicity'
Samali A., Zhivotovsky B., Orrenius S. (1999) 'Current Concepts in Cell Toxicity' In: Current Protocols in Toxicology. New York: John Wiley and Sons, Inc. [DOI] [Details]
(1999) 'Methods for the detection of apoptosis and necrosis'
Zhivotovsky B., Samali A., Orrenius S. (1999) 'Methods for the detection of apoptosis and necrosis' In: Current Protocols in Toxicology. NJ, USA: John Wiley and Sons, Inc. [DOI] [Details]

Conference Publications

  Year Publication
(2013) Perk-dependent repression of miR-106b-25 cluster is required for ER stress induced apoptosis
Read, DE,Agostinis, P,Hetz, C,Mott, JL,Samali, A,Gupta, S (2013) Perk-dependent repression of miR-106b-25 cluster is required for ER stress induced apoptosis , pp.117-120 [Details]
(2011) Improved Tumor Cell Killing by Trail Requires Selective and High Affinity Receptor Activation
Szegezdi, E.,van der Sloot, A. M.,Alessandro, N.,Mahalingam, D.,Cool, R. H.,Munoz, I. G.,Montoya, G.,Quax, W. J.,Serrano, S. D. L.,Samali, A. (2011) Improved Tumor Cell Killing by Trail Requires Selective and High Affinity Receptor Activation , pp.808-808 [Details]
(2011) Advances in Tnf Family Research
Quax, W. J.,Reis, C. R.,van der Sloot, A. M.,Tur, V.,Szegezdi, E.,Natoni, A.,Cool, R. H.,Samali, A.,Serrano, L. (2011) Designed Receptor Specific Rhtrail Variants Enhance Induction of Apoptosis in Cancer Cells Advances in Tnf Family Research , pp.726-727 [Details]
(2011) Advances in Tnf Family Research
Reis, C. R.,van der Sloot, A. M.,Szegezdi, E.,Natoni, A.,Tur, V.,Cool, R. H.,Samali, A.,Serrano, L.,Quax, W. J. (2011) Enhancement of Antitumor Properties of Rhtrail by Affinity Increase toward Its Death Receptors Advances in Tnf Family Research , pp.807-808 [Details]
(2011) Advances in Tnf Family Research
van der Sloot, A. M.,Szegezdi, E.,Reis, C. R.,Tur, V.,Quax, W. J.,Samali, A.,Serrano, L. (2011) Computational Design of Receptor Selective Trail Variants Advances in Tnf Family Research , pp.809-809 [Details]
(2010) RAMI Conference
van Dijk, M.,Samali, A.,Szegezdi, E. (2010) Mechanism of Trail Resistance in Non-Transformed Cells RAMI Conference [Details]
(2010) AS
Gupta, S; Gerlach, J; Miura, Y; Yamazaki, T; Nakahara, T; Asada, H; Samali, A; Joshi, L. (2010) High Throughput Glycanmap (R) Analysis of Glycosylation during ER Stress and Apoptosis in a Colon Cancer Model AS [Details]
(2010) American Society of Hematology Meeting Abstract
Morrell, R. C.,Szegezdi, E.,Halpin-McCormick, A.,Cawley, K.,Samali, A.,O'Dwyer, M. (2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia American Society of Hematology Meeting Abstract , pp.768-768 [Details]
(2009) Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?
Plantivaux, A,Szegezdi, E,Samali, A,Egan, L (2009) NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance? , pp.38-49 [DOI] [Details]
(2009) PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL
Natoni, A,Hayat, A,Montagnoli, A,Callagy, G,Samali, A,Santocanale, C,O'Dwyer, MC (2009) BLOOD PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL , pp.934-934 [Details]
(2008) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
Plantivaux A, Szegezdi E, Samali A, Egan LJ. (2008) TRAIL resistance in colon cancer cells: is NF-?B involved? APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS [Details]
(2007) Proceedings Of The American Association For Cancer Research. Annual Meeting
Szegezdi E, Mahalingam D, Van der Sloot A, Quax W, Keane M, Samali A (2007) Decoy-insensitive TRAIL variants kill tumour cells more efficiently without damaging non-transformed cells Proceedings Of The American Association For Cancer Research. Annual Meeting [Details]
(2003) In the cut and thrust of apoptosis, serine proteases come of age
Stenson-Cox, C,FitzGerald, U,Samali, A (2003) BIOCHEMICAL PHARMACOLOGY In the cut and thrust of apoptosis, serine proteases come of age , pp.1469-1474 [DOI] [Details]
(2003) Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes
O'Mahoney, ME,Logue, S,Szegezdi, E,Stenson-Cox, C,Fitzgerald, U,Samali, A (2003) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes , pp.728-732 [DOI] [Details]
(2003) American Society of Hematology. Meeting Abstract
Cahill, S.,Szegezdi, E.,Samali, A.,O'Dwyer, M. (2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis American Society of Hematology. Meeting Abstract [Details]
(1996) Anti-oxidants and apoptosis
McGowan, AJ,Fernandes, RS,Samali, A,Cotter, TG (1996) BIOCHEMICAL SOCIETY TRANSACTIONS Anti-oxidants and apoptosis , pp.229-233 [Details]

Edited Books

  Year Publication
(2012)
Patrizia Agostinis and Afshin Samali (Ed.). (2012) ER stress in health and disease. Amsterdam: Springer. [Details]

Conference Contributions

  Year Publication
(2010) Annual Conference of the Society for Glycobiology,
Sanjeev Gupt1, Jared Gerlach, Yoshiaki Miura, Toshiaki Yamazaki3, Taku Nakahara, Hidehisa Asada, Afshin Samali and Lokesh Joshi (2010) High throughput GlycanMap® analysis of glycosylation during ER stress and apoptosis in a colon cancer model. [Poster Presentation], Annual Conference of the Society for Glycobiology, Florida, USA , 07-NOV-10 - 10-NOV-10. [Details]
(2010) Apoptosis Symposium,
Gorman A, Szegezdi E, Samali A. (2010) A one day international meeting of researchers in Galway, 2010. [Conference Organising Committee Member], Apoptosis Symposium, Galway , 20-AUG-10 - 20-AUG-10. [Details]

Abstract

  Year Publication
(2010) Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells.
Santocanale, A,Natoni, A,Murillo, L,Catherwood, M,Montagnoli, A,Samali, A,O'Dwyer, M (2010) Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells. Abstract [Details]
(2009) WHAT IS ENDOPLASMIC RETICULUM STRESS DOING DURING MULTIPLE SCLEROSIS PROGRESSION?.
Mcmahon, J,Mhaille, AN,Mcquaid, S,Farrell, M,Cunnea, P,Dolphin, C,Samali, A,Fitzgerald, U (2009) WHAT IS ENDOPLASMIC RETICULUM STRESS DOING DURING MULTIPLE SCLEROSIS PROGRESSION?. Abstract [Details]
(2007) Selective reduction of protein disulfide isomerase (PDI) redox state by TNF-alpha in a cystic fibrosis cell model.
Halvey, PJ,Samali, A,Jones, DP,Stecenko, AA,Hansen, JM (2007) Selective reduction of protein disulfide isomerase (PDI) redox state by TNF-alpha in a cystic fibrosis cell model. Abstract [Details]
(2007) Endoplasmic reticulum stress in multiple sclerosis. Neuron Glia Biology.
Mhaille AN, McQuaid S, Windebank A, Cunnea P, McMahon J, Samali A, FitzGerald U. (2007) Endoplasmic reticulum stress in multiple sclerosis. Neuron Glia Biology. Abstract [Details]
(2007) Endoplasmic reticulum stress in multiple sclerosis.
Mhaille, AN,McQuaid, S,Windebank, A,Cunnea, P,McMahon, J,Samali, A,FitzGerald, U (2007) Endoplasmic reticulum stress in multiple sclerosis. Abstract [Details]
(2006) Selective nuclear oxidative stress oxidizes glutathione and inhibits NF-kappa B reporter activity without thioredoxin 1 oxidation.
Halvey, PJ,Hansen, JM,Johnson, JM,Go, YM,Samali, A,Jones, DP (2006) Selective nuclear oxidative stress oxidizes glutathione and inhibits NF-kappa B reporter activity without thioredoxin 1 oxidation. Abstract [Details]
(2005) Adenoviral-mediated antioxidant overexpression: possible protective role against hyperglycemic conditions in HAEC. American Society for Gene Therapy.
Duffy A, Liew A, Samali A, O' Brien T (2005) Adenoviral-mediated antioxidant overexpression: possible protective role against hyperglycemic conditions in HAEC. American Society for Gene Therapy. Abstract [Details]
(2005) Cytoprotection of RIN cells from Cytokine-Mediated toxicity by gene transfer of anti-apoptotic proteins. Irish Endocrine Society.
Bell M, Conroy S, Ritter T, Houlihan C, Samali A, O' Brien T (2005) Cytoprotection of RIN cells from Cytokine-Mediated toxicity by gene transfer of anti-apoptotic proteins. Irish Endocrine Society. Limerick: Abstract [Details]
(2005) Distinct Effects of High Glucose Conditions on endothelial cells of macrovascular and microvascular origin. Irish Angiology Society, Fifth Annual Meeting, March 2005 and Irish Endocrinology Society.
Duffy A, Liew A, O' Sullivan J, Samali A, Avalos G, O' Brien T (2005) Distinct Effects of High Glucose Conditions on endothelial cells of macrovascular and microvascular origin. Irish Angiology Society, Fifth Annual Meeting, March 2005 and Irish Endocrinology Society. Abstract [Details]
(2005) Transcriptosome profiling of human Coronary Artery Smooth Muscle Cells in response to oxidized Low Density Lipoprotein. Royal Academy of Medicine Ireland, Section of Biomedical Sciences Summer Meeting.
Reeve J, Stenson-Cox C, Porn-Ares I, Ares M, O'Brien T, Samali A (2005) Transcriptosome profiling of human Coronary Artery Smooth Muscle Cells in response to oxidized Low Density Lipoprotein. Royal Academy of Medicine Ireland, Section of Biomedical Sciences Summer Meeting. Abstract [Details]
(2005) Staurosporine-induced cell death requires caspase and non-caspase dependant proteolytic mechanisms in a cell specific manner.
Stenson-Cox, CM,Holohan, C,Fitzgerald, U,Samali, A (2005) Staurosporine-induced cell death requires caspase and non-caspase dependant proteolytic mechanisms in a cell specific manner. Abstract [Details]
(2004) Compartmental oxidation of thiol/disulfide redox couples during EGF signaling.
Halvey, PJ,Watson, WH,Hansen, JM,Go, YM,Samali, A,Jones, DP (2004) Compartmental oxidation of thiol/disulfide redox couples during EGF signaling. Abstract [Details]
(2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis.
Cahill, S,Szegezdi, E,Samali, A,O'Dwyer, M (2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis. Abstract [Details]

Editorial

  Year Publication
(2010) Cell Stress and Cell Death. International Journal of Cell Biology.
Afshin Samali, Simone Fulda, Adrienne M. Gorman, Osamu Hori, and Srinivasa M. Srinivasula (2010) Cell Stress and Cell Death. International Journal of Cell Biology. Editorial [DOI] [Details]
(2007) Apoptosis: a mapped path to cell death.
Samali, A (2007) Apoptosis: a mapped path to cell death. Editorial [DOI] [Details]

Meeting

  Year Publication
(2011) ENHANCEMENT OF ANTITUMOR PROPERTIES OF RHTRAIL BY AFFINITY INCREASE TOWARD ITS DEATH RECEPTORS.
Reis, CR,van der Sloot, AM,Szegezdi, E,Natoni, A,Tur, V,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2011) ENHANCEMENT OF ANTITUMOR PROPERTIES OF RHTRAIL BY AFFINITY INCREASE TOWARD ITS DEATH RECEPTORS. Meeting [Details]
(2011) DESIGNED RECEPTOR SPECIFIC RHTRAIL VARIANTS ENHANCE INDUCTION OF APOPTOSIS IN CANCER CELLS.
Quax, WJ,Reis, CR,van der Sloot, AM,Tur, V,Szegezdi, E,Natoni, A,Cool, RH,Samali, A,Serrano, L (2011) DESIGNED RECEPTOR SPECIFIC RHTRAIL VARIANTS ENHANCE INDUCTION OF APOPTOSIS IN CANCER CELLS. Meeting [Details]
(2011) IMPROVED TUMOR CELL KILLING BY TRAIL REQUIRES SELECTIVE AND HIGH AFFINITY RECEPTOR ACTIVATION.
Szegezdi, E,van der Sloot, AM,Alessandro, N,Mahalingam, D,Cool, RH,Munoz, IG,Montoya, G,Quax, WJ,Serrano, SDL,Samali, A (2011) IMPROVED TUMOR CELL KILLING BY TRAIL REQUIRES SELECTIVE AND HIGH AFFINITY RECEPTOR ACTIVATION. Meeting [Details]
(2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia.
Morrell, RC,Szegezdi, E,Halpin-McCormick, A,Cawley, K,Samali, A,O'Dwyer, M (2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia. Meeting [Details]
(2010) MECHANISM OF TRAIL RESISTANCE IN NON-TRANSFORMED CELLS.
van Dijk, M,Samali, A,Szegezdi, E (2010) MECHANISM OF TRAIL RESISTANCE IN NON-TRANSFORMED CELLS. Meeting [Details]
(2010) ULTRASTRUCTURAL CHANGES AND UNDERLYING MOLECULAR MECHANISMS IN RAT LIVERS INDUCED BY ENDOTOXIC SHOCK.
Nuernberger, S,Gupta, S,Kavanagh, ET,Duvigneau, JC,Miller, I,Hori, O,Samali, A,Redl, H,Kozlov, AV (2010) ULTRASTRUCTURAL CHANGES AND UNDERLYING MOLECULAR MECHANISMS IN RAT LIVERS INDUCED BY ENDOTOXIC SHOCK. Meeting [Details]
(1995) PROGRAMMED CELL-DEATH - MAKING FRIENDS WITH DEATH GENES.
COTTER, TG,FERNANDES, R,SAMALI, A,MCGAHON, A (1995) PROGRAMMED CELL-DEATH - MAKING FRIENDS WITH DEATH GENES. Meeting [Details]

Other Item

  Year Publication
(2007) Apoptosis: a mapped path to cell death. J Cell Mol Med.
Samali, A. (2007) Apoptosis: a mapped path to cell death. J Cell Mol Med. Other Item [Details]
(2007) A tribute to Professor Richard A. Lockshin on his 70th birthday. J Cell Mol Med.
Samali, A. (2007) A tribute to Professor Richard A. Lockshin on his 70th birthday. J Cell Mol Med. Other Item [Details]

Reviews

  Year Publication
(2013) The eIF2 alpha kinases: their structures and functions.
Donnelly, N,Gorman, AM,Gupta, S,Samali, A (2013) The eIF2 alpha kinases: their structures and functions. Reviews [DOI] [Details]
(2012) Stress management at the ER: Regulators of ER stress-induced apoptosis.
Gorman, AM,Healy, SJM,Jager, R,Samali, A (2012) Stress management at the ER: Regulators of ER stress-induced apoptosis. Reviews [DOI] [Details]
(2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.
Jager, R,Bertrand, MJM,Gorman, AM,Vandenabeele, P,Samali, A (2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. Reviews [DOI] [Details]
(2012) The unfolded protein response at the crossroads of cellular life and death during ER stress.
Jäger, R; Bertrand, MJ; Gorman, AM; Vandenabeele, P; Samali, A (2012) The unfolded protein response at the crossroads of cellular life and death during ER stress. Reviews [Details]
(2011) ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE.
Cawley, K,Deegan, S,Samali, A,Gupta, S (2011) ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE. Reviews [DOI] [Details]
(2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders.
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A. (2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders. Reviews [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SJM,Gorman, AM,Mousavi-Shafaei, P,Gupta, S,Samali, A (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Reviews [DOI] [Details]
(2009) Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?. Ann N Y Acad Sci.
Plantivaux A, Szegezdi E, Samali A, Egan L. (2009) Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?. Ann N Y Acad Sci. Reviews [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SZ, Gorman, AM, Mousavi-Shafaei, P, Gupta, S, Samali, A. (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Reviews [Details]
(2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL?.
Mahalingam, D,Szegezdi, E,Keane, M,de Jong, S,Samali, A (2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL?. Reviews [DOI] [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis.
Szegezdi, E,Logue, SE,Gorman, AM,Samali, A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. Reviews [DOI] [Details]
(2006) Cytoprotection of beta cells: rational gene transfer strategies. Diabetes Metab Res Rev.
McCabe C, Samali A, O'Brien T (2006) Cytoprotection of beta cells: rational gene transfer strategies. Diabetes Metab Res Rev. Reviews [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep.
Szegezdi E., Logue S.E., Gorman A.M., Samali A. (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. Reviews [Details]
(2006) Cytoprotection of beta cells: rational gene transfer strategies.
McCabe, C,Samali, A,O'Brien, T (2006) Cytoprotection of beta cells: rational gene transfer strategies. Reviews [DOI] [Details]
(2005) Ischemia/Reperfusion injury at the intersection with cell death. Mol. Cell. Cardiol.
Logue S.E., Gustafsson Å.B., Samali A., Gottlieb R.A. (2005) Ischemia/Reperfusion injury at the intersection with cell death. Mol. Cell. Cardiol. Reviews [Details]
(2005) Don’t Lose Heart - Therapeutic Value of Apoptosis Prevention in the Treatment of Cardiovascular Disease. Journal of Cellular and Molecular Medicine.
O'Brien, T Samali, A, Duffy, AM, Reeve, JL (2005) Don’t Lose Heart - Therapeutic Value of Apoptosis Prevention in the Treatment of Cardiovascular Disease. Journal of Cellular and Molecular Medicine. Reviews [Details]
(2005) Ischemia/reperfusion injury at the intersection with cell death.
Logue, SE,Gustafsson, AB,Samali, A,Gottlieb, RA (2005) Ischemia/reperfusion injury at the intersection with cell death. Reviews [DOI] [Details]
(2005) Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease.
Reeve, JLV,Duffy, AM,O'Brien, T,Samali, A (2005) Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease. Reviews [Details]
(2004) The switch from survival responses to apoptosis after chromosomal breaks.
Bree, RT,Neary, C,Samali, A,Lowndes, NF (2004) The switch from survival responses to apoptosis after chromosomal breaks. Reviews [DOI] [Details]
(2004) The switch from DNA repair to apoptosis after chromosomal breaks. DNA Repair.
Bree R.T., Neary C., Samali A., Lowndes N.F. (2004) The switch from DNA repair to apoptosis after chromosomal breaks. DNA Repair. Reviews [Details]
(2003) On the role of Hsp27 in regulating apoptosis. Apoptosis.
Concannon C.G., Gorman A.M., Samali A. (2003) On the role of Hsp27 in regulating apoptosis. Apoptosis. Reviews [Details]
(2003) Caspase-12 and ER-stress-mediated apoptosis: The story so far. Ann. NY Acad. Sci.
Szegezdi E., FitzGerald U., Samali A. (2003) Caspase-12 and ER-stress-mediated apoptosis: The story so far. Ann. NY Acad. Sci. Reviews [Details]
(2003) In the cut and thrust of apoptosis, serine proteases come of age. Biochem. Pharmacol.
Stenson-Cox C., FitzGerald U., Samali A. (2003) In the cut and thrust of apoptosis, serine proteases come of age. Biochem. Pharmacol. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology.
Bree RT, Stenson C, Grealy M, Byrnes L, Gorman AM and Samali A (2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescence.
Bree, RT,Stenson-Cox, C,Grealy, M,Byrnes, L,Gorman, AM,Samali, A (2002) Cellular longevity: role of apoptosis and replicative senescence. Reviews [Details]
(2002) Losing heart: the role of apoptosis in heart disease - a novel therapeutic target?.
Gill, C,Mestril, R,Samali, A (2002) Losing heart: the role of apoptosis in heart disease - a novel therapeutic target?. Reviews [Details]
(1996) Apoptosis - The story so far .
Samali, A,Gorman, AM,Cotter, TG (1996) Apoptosis - The story so far . Reviews [Details]

Employment

  Employer Position From / To
National University of Ireland, Galway Senior Lecturer 01-JAN-04 /
National University of Ireland, Galway Lecturer 01-JAN-00 / 30-AUG-04