Prof Ciaran Morrison

BSc, MSc, Dr.Rer.Nat,,Nat.Cert

Contact Details

Personal Professor
Centre for Chromosome Biology
School of Natural Sciences
Biosciences Building, NUI Galway
Dangan

T: Ext. 2056
E: ciaran.morrison@nuigalway.ie
 
researcher

Biography

Personal Professor, NUIG Biochemistry 2011.
Senior Lecturer, NUIG Biochemistry 2005-2011.
SFI Investigator, NUIG Biochemistry 2002, 2008, 2011.
Postdoctoral fellowship (EMBO), Edinburgh University 1999-2002.
Postdoctoral fellowship (JSPS), Kyoto University 1997-1999.
PhD (Dr. rer. nat.) 1997, University of Vienna (IMP).
MSc 1993, NUIG.
BSc (Hons) 1991, NUIG.

Research Interests

DNA double-strand break repair, cell cycle, genome stability. Centrosomes. Analysis of mitotic effects of DNA damage (microscopy and proteomic approaches). Reverse genetics using tissue culture lines.

Peer Reviewed Journals

  Year Publication
(2015) 'Centrin2 regulates CP110 removal in primary cilium formation'
Prosser SL, Morrison CG (2015) 'Centrin2 regulates CP110 removal in primary cilium formation'. Journal Of Cell Biology, 208 (6):693-701 [DOI] [Details]
(2015) 'Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis'
Prosser, SL,Sahota, NK,Pelletier, L,Morrison, CG,Fry, AM (2015) 'Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis'. Journal Of Cell Biology, 209 :339-348 [DOI] [Details]
(2014) 'Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells'
Flach, J,Bakker, ST,Mohrin, M,Conroy, PC,Pietras, EM,Reynaud, D,Alvarez, S,Diolaiti, ME,Ugarte, F,Forsberg, EC,Le Beau, MM,Stohr, BA,Mendez, J,Morrison, CG,Passegue, E (2014) 'Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells'. Nature, 512 [DOI] [Details]
(2014) 'Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity'
Breslin, L,Prosser, SL,Cuffe, S,Morrison, CG (2014) 'Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity'. Cell Cycle, 13 :2773-2779 [DOI] [Details]
(2013) 'Calcium-Binding Capacity of Centrin2 Is Required for Linear POC5 Assembly but Not for Nucleotide Excision Repair'
Dantas, TJ,Daly, OM,Conroy, PC,Tomas, M,Wang, YF,Lalor, P,Dockery, P,Ferrando-May, E,Morrison, CG (2013) 'Calcium-Binding Capacity of Centrin2 Is Required for Linear POC5 Assembly but Not for Nucleotide Excision Repair'. Plos One, 8 [DOI] [Details]
(2013) 'Loss of centrioles causes chromosomal instability in vertebrate somatic cells'
Sir, JH,Putz, M,Daly, O,Morrison, CG,Dunning, M,Kilmartin, JV,Gergely, F (2013) 'Loss of centrioles causes chromosomal instability in vertebrate somatic cells'. Journal Of Cell Biology, 203 :747-756 [DOI] [Details]
(2013) 'Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells'
Inanc, B,Putz, M,Lalor, P,Dockery, P,Kuriyama, R,Gergely, F,Morrison, CG (2013) 'Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells'. Molecular Biology Of The Cell, 24 :2645-2654 [DOI] [Details]
(2013) 'Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response'
Wang Y, Dantas TJ, Lalor P, Dockery P, Morrison CG (2013) 'Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response'. Cell Cycle, 12 (4):635-646 [DOI] [Details]
(2012) 'Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification'
Prosser, SL,Samant, MD,Baxter, JE,Morrison, CG,Fry, AM (2012) 'Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification'. Journal Of Cell Science, 125 :5353-5368 [DOI] [Details]
(2012) 'Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance'
Dantas TJ, Daly OM, Morrison CG (2012) 'Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance'. Cellular And Molecular Life Sciences, 69 (18):2979-2997 [Details]
(2012) 'C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis'
Conroy, PC,Saladino, C,Dantas, TJ,Lalor, P,Dockery, P,Morrison, CG (2012) 'C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis'. Cell Cycle, 11 :3769-3778 [DOI] [Details]
(2012) 'SUMO ligase activity of vertebrate Mms21/Nse2 is required for efficient DNA repair but not for Smc5/6 complex stability'
Kliszczak M, Stephan AK, Flanagan AM, Morrison CG (2012) 'SUMO ligase activity of vertebrate Mms21/Nse2 is required for efficient DNA repair but not for Smc5/6 complex stability'. Dna Repair, 11 (10):799-810 [DOI] [Details]
(2011) 'Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins'
Dantas TJ, Wang Y, Lalor P, Dockery P, Morrison CG (2011) 'Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins'. Journal Of Cell Biology, 193 (2):307-318 [DOI] [Details]
(2011) 'The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability'
Stephan, AK,Kliszczak, M,Morrison, CG (2011) 'The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability'. Febs Letters, 585 :2907-2913 [DOI] [Details]
(2011) 'Roles of Vertebrate Smc5 in Sister Chromatid Cohesion and Homologous Recombinational Repair'
Stephan, AK,Kliszczak, M,Dodson, H,Cooley, C,Morrison, CG (2011) 'Roles of Vertebrate Smc5 in Sister Chromatid Cohesion and Homologous Recombinational Repair'. Molecular And Cellular Biology, 31 :1369-1381 [DOI] [Details]
(2011) 'Centrosome Amplification in CHO and DT40 Cells by Inactivation of Cyclin-Dependent Kinases'
Steere, N,Wagner, M,Beishir, S,Smith, E,Breslin, L,Morrison, CG,Hochegger, H,Kuriyama, R (2011) 'Centrosome Amplification in CHO and DT40 Cells by Inactivation of Cyclin-Dependent Kinases'. Cytoskeleton, 68 :446-458 [DOI] [Details]
(2010) 'MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification'
Brown, JAL,Bourke, E,Liptrot, C,Dockery, P,Morrison, CG (2010) 'MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification'. Oncogene, 29 :5537-5544 [DOI] [Details]
(2010) 'Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis'
Mohrin, M,Bourke, E,Alexander, D,Warr, MR,Barry-Holson, K,Le Beau, MM,Morrison, CG,Passegue, E (2010) 'Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis'. Cell Stem Cell, 7 :174-185 [DOI] [Details]
(2010) 'DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2'
Bourke, E.,Brown, J. A.,Takeda, S.,Hochegger, H.,Morrison, C. G. (2010) 'DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2'. Oncogene, 29 (44):616-24 [Details]
(2010) 'A Centrosome-autonomous Signal That Involves Centriole Disengagement Permits Centrosome Duplication in G2 Phase after DNA Damage'
Inanc, B,Dodson, H,Morrison, CG (2010) 'A Centrosome-autonomous Signal That Involves Centriole Disengagement Permits Centrosome Duplication in G2 Phase after DNA Damage'. Molecular Biology Of The Cell, 21 :3866-3877 [DOI] [Details]
(2009) 'Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells'
Cooley C, Baird KM, Faure V, Wenner T, Stewart JL, Modino S, Slijepcevic P, Farr CJ, Morrison CG (2009) 'Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells'. Molecular Biology Of The Cell, 20 (10):2563-2571 [DOI] [Details]
(2009) 'Centriole separation in DNA damage-induced centrosome amplification'
Saladino C, Bourke E, Conroy PC, Morrison CG (2009) 'Centriole separation in DNA damage-induced centrosome amplification'. Environmental And Molecular Mutagenesis, 50 (8):725-732 [DOI] [Details]
(2009) 'Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells'
Dodson, H,Morrison, CG (2009) 'Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells'. Nucleic Acids Research, 37 :6054-6063 [DOI] [Details]
(2008) 'Deconstructing survivin: comprehensive genetic analysis of survivin function by conditional knockout in a vertebrate cell line'
Yue, Z., Carvalho, A., Xu, Z., Yuan, X., Cardinale, S., Ribeiro, S., Lai, F., Gudmundsdottir, E., Gassmann, R., Morrison, C.G., Ruchaud, S. and Earnshaw, W.C. (2008) 'Deconstructing survivin: comprehensive genetic analysis of survivin function by conditional knockout in a vertebrate cell line'. J. Cell Biol, 183 :279-296 [Details]
(2008) 'Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line'
Faure, V,Wenner, T,Cooley, C,Bourke, E,Farr, CJ,Takeda, S,Morrison, CG (2008) 'Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line'. Dna Repair, 7 :713-724 [DOI] [Details]
(2008) 'Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization'
Jeffers, LJ,Coull, BJ,Stack, SJ,Morrison, CG (2008) 'Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization'. Oncogene, 27 :139-144 [DOI] [Details]
(2007) 'DNA damage induces Chk1-dependent centrosome amplification'
Bourke, E,Dodson, H,Merdes, A,Cuffe, L,Zachos, G,Walker, M,Gillespie, D,Morrison, CG (2007) 'DNA damage induces Chk1-dependent centrosome amplification'. Embo Reports, 8 :603-609 [DOI] [Details]
(2007) 'Involvement of centrosome amplification in radiation-induced mitotic catastrophe'
Dodson, H,Wheatley, SP,Morrison, CG (2007) 'Involvement of centrosome amplification in radiation-induced mitotic catastrophe'. Cell Cycle, 6 :364-370 [Details]
(2006) 'Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells'
Hochegger, H,Dejsuphong, D,Fukushima, T,Morrison, C,Sonoda, E,Schreiber, V,Zhao, GY,Saberi, A,Masutani, M,Adachi, N,Koyama, H,de Murcia, G,Takeda, S (2006) 'Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells'. Embo Journal, 25 :1305-1314 [DOI] [Details]
(2004) 'Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores'
Vagnarelli, P,Morrison, C,Dodson, H,Sonoda, E,Takeda, S,Earnshaw, WC (2004) 'Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores'. Embo Reports, 5 :167-171 [DOI] [Details]
(2004) 'Chromosome damage and progression into and through mitosis in vertebrates'
Morrison, C,Rieder, CL (2004) 'Chromosome damage and progression into and through mitosis in vertebrates'. Dna Repair, 3 :1133-1139 [DOI] [Details]
(2004) 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'
Dodson, H,Bourke, E,Jeffers, LJ,Vagnarelli, P,Sonoda, E,Takeda, S,Earnshaw, WC,Merdes, A,Morrison, C (2004) 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'. Embo Journal, 23 :3864-3873 [DOI] [Details]
(2002) 'Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate'
Morrison, C,Henzing, AJ,Jensen, ON,Osheroff, N,Dodson, H,Kandels-Lewis, SE,Adams, RR,Earnshaw, WC (2002) 'Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate'. Nucleic Acids Research, 30 :5318-5327 [Details]
(2001) 'Scc1/ Rad21/ Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells'
Sonoda, E., Matsusaka, T., Morrison, C., Vagnarelli, P., Hoshi, O.,Ushiki, T., Nojima, K., Fukugawa, T., Waizenegger, I.C., Peters, J.-M., Earnshaw, W.C. and Takeda, S. (2001) 'Scc1/ Rad21/ Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells'. Dev. Cell, 1 :759-770 [Details]
(2001) 'Ku impedes homologous DNA recombination: competition between the major DNA double-strand break repair pathways'
Fukushima, T., Takata, M., Morrison, C., Araki, R., Fujimori A., Abe, M., Tatsumi, K., Jasin, M., Dhar, P.K., Sonoda, E., Chiba, T. and Takeda, S (2001) 'Ku impedes homologous DNA recombination: competition between the major DNA double-strand break repair pathways'. J. biol. Chem, 276 :44413-44418 [Details]
(2000) 'The Rad51 paralog Rad51B promotes homologous recombinational repair'
Takata, M., Sasaki, M.S., Sonoda, E., Fukushima, T., Morrison, C., Albala, J., Swagemakers, S.M.A., Kanaar, R., Thompson, L.H. and Takeda, S. (2000) 'The Rad51 paralog Rad51B promotes homologous recombinational repair'. Mol. Cell. Biol, 20 :6476-6482 [Details]
(2000) 'The controlling role of ATM in homologous recombinational repair of DNA damage'
Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K. and Takeda, S. (2000) 'The controlling role of ATM in homologous recombinational repair of DNA damage'. EMBO J, 19 :463-471 [Details]
(1999) 'Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells'
Yamaguchi-Iwai, Y., Sonoda, E., Sasaki, M.S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y.M., Takata, M., Price, C., Kakazu, N. and Takeda, S. (1999) 'Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells'. EMBO J, 18 :6619-6629 [Details]
(1999) 'Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation'
Takao, N., Kato, H., Mori, R., Morrison, C., Sonoda, E., Sun, X., Shimizu, H., Yoshioka, K., Takeda, S. and Yamamoto, K. (1999) 'Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation'. Oncogene, 18 :7002-7009 [Details]
(1999) 'The essential functions of human Rad51 do not require ATP hydrolysis'
Morrison, C., Shinohara, A., Sonoda, E., Yamaguchi-Iwai, Y., Takata, M., Weichselbaum, R.R. and Takeda, S. (1999) 'The essential functions of human Rad51 do not require ATP hydrolysis'. Mol. Cell. Biol, 19 :6891-6897 [Details]
(1999) 'Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells'
Sonoda, E., Sasaki, M.S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M. and Takeda, S. (1999) 'Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells'. Mol. Cell. Biol, 19 :5166-5169 [Details]
(1998) 'Homologous recombination and nonhomologous end-joining pathways of double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells'
Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A. and Takeda, S (1998) 'Homologous recombination and nonhomologous end-joining pathways of double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells'. EMBO J, 17 :5497-5508 [Details]
(1998) 'Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52'
Yamaguchi-Iwai, Y., Sonoda, E., Buerstedde, J.-M., Bezzubova, O., Morrison, C., Takata, M., Shinohara, A. and Takeda, S. (1998) 'Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52'. Mol. Cell. Biol, 18 :6430-6435 [Details]
(1997) 'PARP is important for genomic stability but dispensable in apoptosis'
Wang, Z.Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K. and Wagner, E.F. (1997) 'PARP is important for genomic stability but dispensable in apoptosis'. Genes Dev, 11 :2347-2358 [Details]
(1997) 'Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis'
Morrison, C., Smith G.C.M., Stingl, L., Jackson, S.P., Wagner, E.F. and Wang, Z.Q. (1997) 'Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis'. Nat. Genet, 17 :479-482 [Details]
(1996) 'Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems'
Morrison, C. and Wagner, E. (1996) 'Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems'. Nucleic Acids Res, 24 :2053-2058 [Details]
(1994) 'THE IMPACT OF THE PCR PLATEAU-PHASE ON QUANTITATIVE PCR'
MORRISON, C,GANNON, F (1994) 'THE IMPACT OF THE PCR PLATEAU-PHASE ON QUANTITATIVE PCR'. Biochimica Et Biophysica Acta-Gene Structure And Expression, 1219 :493-498 [Details]

Book Chapters

  Year Publication
(2007) 'DNA Repair in vertebrates'
Morrison, C. (2007) 'DNA Repair in vertebrates' In: Cell Biology. Saunders Philadelphia. [Details]

Conference Contributions

  Year Publication
(2016) Irish Association for Cancer Research annual meeting,
Ciaran Morrison (2016) Plenary talk. [Plenary Lecture], Irish Association for Cancer Research annual meeting, Cork, Ireland , 25-FEB-16 - 26-FEB-16. [Details]
(2015) Gordon Research Conference on ‘Cell Growth and Proliferation’,
Ciaran Morrison (2015) Selected abstract. [Oral Presentation], Gordon Research Conference on ‘Cell Growth and Proliferation’, Mount Snow, VT, USA , 12-JUL-15 - 16-JUL-15. [Details]
(2014) EMBO Conference on ‘Centrosomes and Spindle Pole Bodies’,
Ciaran Morrison (2014) Selected abstract. [Oral Presentation], EMBO Conference on ‘Centrosomes and Spindle Pole Bodies’, Lisbon, Portugal , 30-SEP-14 - 03-OCT-14. [Details]
(2013) Keystone Symposium ‘Genome Instability and Repair’,
Ciaran Morrison (2013) Selected abstract. [Conference Organising Committee Chairperson], Keystone Symposium ‘Genome Instability and Repair’, Banff, AB, Canada , 02-MAR-13 - 06-MAR-13. [Details]
(2012) International Seminar on 'Genetic Discrimination - Transatlantic Perspectives on the Case for a European Level Legal Response',
Ciaran Morrison (2012) Invited speaker. [Invited Oral Presentation], International Seminar on 'Genetic Discrimination - Transatlantic Perspectives on the Case for a European Level Legal Response', European Parliament, Brussels, Belgium , 06-MAR-12 - 06-MAR-12. [Details]
(2012) 28th Radiation Biology Centre- National Institute of Radiological Sciences International Symposium,
Ciaran Morrison (2012) Invited speaker. [Invited Oral Presentation], 28th Radiation Biology Centre- National Institute of Radiological Sciences International Symposium, Kyoto, Japan , 26-NOV-12 - 29-NOV-12. [Details]

Editorial

  Year Publication
(2011) Getting permission How DNA damage causes centrosome amplification.
Inanc, B,Morrison, CG (2011) Getting permission How DNA damage causes centrosome amplification. Editorial [DOI] [Details]