Research Interests

DNA double-strand break repair, telomeres and genome stability. Smc proteins. Centrosomes. Analysis of mitotic effects of DNA damage (microscopy and proteomic approaches). Reverse genetics using tissue culture lines.

 

 

Book Chapters

Morrison, C. (2007) 'Cell Biology' In: Pollard, T.; Earnshaw W.C.; Lippincott-Schwartz, J (eds). Saunders Philadelphia. [Details]

Morrison, C. (2007) 'DNA Repair in vertebrates' In: Pollard, T.; Earnshaw W.C.; Lippincott-Schwartz, J (eds). Cell Biology. Saunders Philadelphia. [Details]

 

Peer Reviewed Journals

MORRISON, C,GANNON, F (1994) 'THE IMPACT OF THE PCR PLATEAU-PHASE ON QUANTITATIVE PCR'. Biochimica Et Biophysica Acta-Gene Structure And Expression, 1219 :493-498. [Details]

Morrison, C. and Wagner, E. (1996) 'Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems'. Nucleic Acids Res, 24 :2053-2058. [Details]

Morrison, C., Smith G.C.M., Stingl, L., Jackson, S.P., Wagner, E.F. and Wang, Z.Q. (1997) 'Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis'. Nat. Genet, 17 :479-482. [Details]

Wang, Z.Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K. and Wagner, E.F. (1997) 'PARP is important for genomic stability but dispensable in apoptosis'. Genes Dev, 11 :2347-2358. [Details]

Yamaguchi-Iwai, Y., Sonoda, E., Buerstedde, J.-M., Bezzubova, O., Morrison, C., Takata, M., Shinohara, A. and Takeda, S. (1998) 'Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52'. Mol. Cell. Biol, 18 :6430-6435. [Details]

Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A. and Takeda, S (1998) 'Homologous recombination and nonhomologous end-joining pathways of double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells'. EMBO J, 17 :5497-5508. [Details]

Takao, N., Kato, H., Mori, R., Morrison, C., Sonoda, E., Sun, X., Shimizu, H., Yoshioka, K., Takeda, S. and Yamamoto, K. (1999) 'Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation'. Oncogene, 18 :7002-7009. [Details]

Morrison, C., Shinohara, A., Sonoda, E., Yamaguchi-Iwai, Y., Takata, M., Weichselbaum, R.R. and Takeda, S. (1999) 'The essential functions of human Rad51 do not require ATP hydrolysis'. Mol. Cell. Biol, 19 :6891-6897. [Details]

Yamaguchi-Iwai, Y., Sonoda, E., Sasaki, M.S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y.M., Takata, M., Price, C., Kakazu, N. and Takeda, S. (1999) 'Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells'. EMBO J, 18 :6619-6629. [Details]

Sonoda, E., Sasaki, M.S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M. and Takeda, S. (1999) 'Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells'. Mol. Cell. Biol, 19 :5166-5169. [Details]

Takata, M., Sasaki, M.S., Sonoda, E., Fukushima, T., Morrison, C., Albala, J., Swagemakers, S.M.A., Kanaar, R., Thompson, L.H. and Takeda, S. (2000) 'The Rad51 paralog Rad51B promotes homologous recombinational repair'. Mol. Cell. Biol, 20 :6476-6482. [Details]

Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K. and Takeda, S. (2000) 'The controlling role of ATM in homologous recombinational repair of DNA damage'. EMBO J, 19 :463-471. [Details]

Fukushima, T., Takata, M., Morrison, C., Araki, R., Fujimori A., Abe, M., Tatsumi, K., Jasin, M., Dhar, P.K., Sonoda, E., Chiba, T. and Takeda, S (2001) 'Ku impedes homologous DNA recombination: competition between the major DNA double-strand break repair pathways'. J. biol. Chem, 276 :44413-44418. [Details]

Sonoda, E., Matsusaka, T., Morrison, C., Vagnarelli, P., Hoshi, O.,Ushiki, T., Nojima, K., Fukugawa, T., Waizenegger, I.C., Peters, J.-M., Earnshaw, W.C. and Takeda, S. (2001) 'Scc1/ Rad21/ Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells'. Dev. Cell, 1 :759-770. [Details]

Dodson, H,Wheatley, SP,Morrison, CG (2007) 'Involvement of centrosome amplification in radiation-induced mitotic catastrophe'. Cell Cycle, 6 :364-370. [Details]

Bourke, E,Dodson, H,Merdes, A,Cuffe, L,Zachos, G,Walker, M,Gillespie, D,Morrison, CG (2007) 'DNA damage induces Chk1-dependent centrosome amplification'. Embo Reports, 8 :603-609. [DOI] [Details]

Yue, Z., Carvalho, A., Xu, Z., Yuan, X., Cardinale, S., Ribeiro, S., Lai, F., Gudmundsdottir, E., Gassmann, R., Morrison, C.G., Ruchaud, S. and Earnshaw, W.C. (2008) 'Deconstructing survivin: comprehensive genetic analysis of survivin function by conditional knockout in a vertebrate cell line'. J. Cell Biol, 183 :279-296. [Details]

Jeffers, LJ,Coull, BJ,Stack, SJ,Morrison, CG (2008) 'Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization'. Oncogene, 27 :139-144. [DOI] [Details]

Stephan, A.K., Kliszczak, M and Morrison, C.G. (2011) 'The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability'. Febs Lett, 585 :2907-2913. [Details]

 

Conference Publications

MORRISON, C et al. (2003) Sister chromatid cohesion and genome stability in vertebrate cells BIOCHEMICAL SOCIETY TRANSACTIONS , pp.263-265 [Details]

                       

Conference Paper

(2006) Telomeres and Genome Stability. Villars-sur-Ollon, Switzerland: Conference Paper [Details]

(2007) Keystone Symposium : Genome Instability and Repair. Breckenridge, Co., USA: Conference Paper [Details]

                                                                                                 

Workshops

(2007) UCSF Developmental and Stem Cell Biology Program . San Francisco, Ca, USA: Workshops [Details]

39052 Mayo Clinic, Rochester, Mn., USA. Workshops [Details]