Dr. Elaine Dunleavy

PhD

Contact Details

Senior Lecturer
------------------------
Room 126
Biochemistry
School of Natural Sciences
Bioresearch Building
NUI Galway

T: Ext. 4046
E: ELAINE.DUNLEAVY@nuigalway.ie
W: https://www.chromosome.ie/researchers/dunleavy/
 
researcher

Biography

Dr. Elaine Dunleavy is a cell and molecular biologist interested in the regulation of centromeres, key chromosomal loci that oversee proper chromosome segregation during cell division. Dr. Dunleavy graduated from the National University of Ireland, Galway with a BSc in Biotechnology in 2002. She received a Wellcome Trust Four Year Studentship to complete her PhD in Life Sciences at the University of Edinburgh in 2007, under the supervision of Prof. Robin Allshire. During her PhD, using fission yeast as a model system, Dr. Dunleavy began to develop her now long-standing interest in centromere biology. She carried out her postdoctoral research at the Curie Institute in Paris in the laboratory of Dr. Genevieve Almouzni, where she identified the key human centromere assembly factor HJURP, a major finding in the field. In 2010, Dr. Dunleavy received a postdoctoral fellowship from the Human Frontier Science Program to investigate centromere assembly mechanisms in the fruit fly Drosophila melanogaster in the laboratory of Dr.  Gary Karpen at the Lawrence Berkeley National Laboratory and University of California, Berkeley.  Since June 2013, Dr. Dunleavy is a Wellcome Trust Research Career Development Fellow in Basic Biomedical Science, at the Centre for Chromosome Biology (CCB) at the National University of Ireland, Galway. This Fellowship is made in partnership with Science Foundation Ireland (SFI) and the Health Research Board (HRB) of Ireland. At the CCB, Dr. Dunleavy continues to use the fruit fly as an experimental system to explore chromosome segregation mechanisms during meiosis, the special type of cell division that gives rise to gametes (eggs and sperm).

Peer Reviewed Journals

  Year Publication
(2013) 'Solo or Doppio: How many CENP-As make a centromeric nucleosome?'
Dunleavy EM, Zhang W, Karpen, GH (2013) 'Solo or Doppio: How many CENP-As make a centromeric nucleosome?'. Nature Structural & Molecular Biology, [Details]
(2012) 'The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C'
Dunleavy EM, Beier NL, Gorgescu W, Tang J, Costes SV, Karpen GH (2012) 'The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C'. Plos Biology, [Details]
(2009) 'HJURP is a cell cycle dependent maintenance and deposition factor of CENP-A at centromeres'
Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti, G (2009) 'HJURP is a cell cycle dependent maintenance and deposition factor of CENP-A at centromeres'. Cell, [Details]
(2009) 'Epigenetic inheritance during the cell cycle'
Probst AV*, Dunleavy EM*, Almouzni G (2009) 'Epigenetic inheritance during the cell cycle'. Nature Reviews Genetics, [Details]
(2008) 'A DNA polymerase α accessory protein, Mcl1, is required for propagation of centromeric structures in fission yeast'
Natsume T, Tsutsui Y, Sutani T, Dunleavy EM, Pidoux AL, Iwasaki H, Shirahige K, Allshire RC, Yamao F (2008) 'A DNA polymerase α accessory protein, Mcl1, is required for propagation of centromeric structures in fission yeast'. Plos One, [Details]
(2007) 'A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres'
Dunleavy EM, Pidoux AL, Monet M, Bonilla C, Richardson W, Hamilton GL, Ekwall K, McLaughlin PJ, Allshire RC (2007) 'A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres'. Molecular Cell, [Details]
(2005) 'Centromeric chromatin makes its mark'
Dunleavy EM, Pidoux AL, Allshire RC (2005) 'Centromeric chromatin makes its mark'. Trends In Cell Biology, [Details]

Conference Contributions

  Year Publication
(2014) Structure, Function and Regulation of Centromeres and Kinetochores,
Elaine Dunleavy (2014) EMBO workshop. [Invited Oral Presentation], Structure, Function and Regulation of Centromeres and Kinetochores, Barcelona, Spain , 12-OCT-14 - 19-OCT-12. [Details]
(2013) Drosophila Cell Division Cycle,
Elaine Dunleavy (2013) EMBO workshop. [Invited Oral Presentation], Drosophila Cell Division Cycle, Exeter, UK , 12-SEP-13 - 16-SEP-13. [Details]
(2013) Dynamic Kinetochore Workshop,
Elaine Dunleavy (2013) workshop of junior researchers. [Invited Oral Presentation], Dynamic Kinetochore Workshop, Porto, Portugal , 14-MAY-13 - 19-JAN-14. [Details]
(2012) Bay Area Meiosis Meeting,
Elaine Dunleavy (2012) Specialised meeting on meiosis. [Invited Oral Presentation], Bay Area Meiosis Meeting, University of California Berkeley USA , 28-OCT-12 - 28-OCT-12. [Details]
(2012) Human Frontier Science Program Annual Awardees Meeting,
Elaine Dunleavy (2012) Part of annual postodctoral fellowship report. [Poster Presentation], Human Frontier Science Program Annual Awardees Meeting, South Korea , 01-JUL-12 - 07-JUL-12. [Details]
(2011) Drosophila Research Conference,
Elaine Dunleavy (2011) Annual meeting organised by the Genetics Society of America. [Poster Presentation], Drosophila Research Conference, California, USA , 20-MAR-11 - 25-MAR-11. [Details]
(2011) Research seminar,
Elaine Dunleavy (2011) invited to present my postdoctoral research by Prof. Noel Lowndes and meet with scientists at my Alma Mater. [Invited Lecture], Research seminar, Centre for Chromosome Biology, National University of Ireland, Galway , 23-SEP-11 - 23-SEP-11. [Details]
(2011) Invited seminar,
Elaine Dunleavy (2011) While I was a visiting scientist at the Stowers Institute for Medical Research, I was invited by Prof. Scott Hawley to give a seminar. [Oral Presentation], Invited seminar, Stowers Institute for Medical Research , 11-MAY-11 - 11-MAY-11. [Details]
(2011) Nuclear Structure and Dynamics,
Elaine Dunleavy (2011) EMBO workshop. [Invited Oral Presentation], Nuclear Structure and Dynamics, France , 04-SEP-11 - 10-SEP-11. [Details]
(2009) American Society of Biochemistry and Molecular Biology (ASBMB) Annual Meeting,
Elaine Dunleavy (2009) I represented my postdoctoral mentor Dr. Almouzni at her request and gave a research seminar. [Invited Oral Presentation], American Society of Biochemistry and Molecular Biology (ASBMB) Annual Meeting, New Orleans, USA , 06-APR-09 - 06-APR-09. [Details]
(2008) Dynamic Organisation of Nuclear Function’ Meeting,
Elaine Dunleavy (2008) Selected to present my postdoctoral research at this prestigious and competitive international meeting. [Invited Oral Presentation], Dynamic Organisation of Nuclear Function’ Meeting, Cold Spring Harbour Laboratory (New York, USA , 03-SEP-08 - 09-JAN-08. [Details]
(2008) Epigenome Network of Excellence Annual Meeting,
Elaine Dunleavy (2008) Selected to present my postdoctoral research to a broad audience of European scientists. [Invited Oral Presentation], Epigenome Network of Excellence Annual Meeting, Madrid, Spain , 11-JUN-08 - 15-JUN-08. [Details]

Editorial

  Year Publication
(2013) Solo or doppio: how many CENP-As make a centromeric nucleosome?.
Dunleavy, EM,Zhang, WG,Karpen, GH (2013) Solo or doppio: how many CENP-As make a centromeric nucleosome?. Editorial [DOI] [Details]