Research Interests

Expression of recombinant proteins; Glycoprotein expression and engineering; Nanomedicine; Targeted delivery; Protein immobilisation, sensor development

Research Projects

Project: Expression and glycoengineering of gylcoproteins in Escherichia coli ( .) Role: PI Description: Start/End Dates: 10-JAN-11 /

Project: Development of a targeted therapy for nucleus pulposus ( .) Role: PI Description: Targeted drug delivery for intravertebral disc regeneration Start/End Dates: 01-SEP-08 /

Project: Trigger factor psychrobacter - g wall ( RM8215) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-09 / 31-DEC-09

Project: EI PC 2007 021 GERARD WALL ( REI892) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-07 / 28-FEB-09

Project: BIO ELECTRIC SURFACE CPFP2125332 G WALL ( RE7016) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-08 / 30-SEP-11

Project: IRCSET EMPOWER POSTDOCTORAL FELLOWSHIP GERARD WALL DR MARIA HORTIGUELA ( RCS1076) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-10 / 30-SEP-12

 

Book Chapters

Hu X, O Connor IB, Wall JG (2011) 'Antibody Immobilization on Solid Surfaces: Methods and Applications' In: Syed T (eds). Biological Interactions with Surface Charge Biomaterials. London: Royal Society of Chemistry. [Details]

Wall JG, Cunningham C, Harris WJ (1992) 'European Biotechnology Today Intercept Andover, U.K' In: [Details]

 

Peer Reviewed Journals

Power KA, Grad S, Rutges J, Creemers LB, van Rijen MHP, Ó Gaora P, Wall JG, Alini M, Pandit A, Gallagher WM (2011) 'Identification of Cell Surface Markers to Target Human Nucleus Pulposus Cells: Expression of Carbonic Anhydrase 12 Varies with Age and Degeneration'. Arthritis & Rheumatism , 63 (12):3876-3886. [Details]

Wall JG, Plückthun A (1999) 'The hierarchy of mutations influencing the folding of antibody domains in Escherichia coli'. PROTEIN ENGINEERING, 12 (7):605-611. [Details]

Corcoran D, O'Sullivan M, Wall JG (1999) 'Clinical spectrum and diagnosis of systemic lupus erythematosus in the Republic of Ireland'. MEDICAL SCIENCE RESEARCH, 27 (11):769-771. [Details]

Corcoran D, Wall JG (2000) 'Lupus support and awareness in the Republic of Ireland'. IRISH MEDICAL JOURNAL, 93 (2):54-55. [Details]

Gibert Y, Spada S, Wall JG, Pembroke JT (2001) 'Cloning and characterisation of the hint homologue of the thermophile Thermus thermophilus'. DNA SEQUENCES, 12 (3):179-185. [Details]

Spada S, Gibert Y, Pembroke JT, Wall JG (2001) 'Isolation and characterisation of the ylmE homologue of Thermus thermophilus'. DNA SEQUENCES, 11 (6):507-514. [Details]

Deere J, Magner E, Wall JG, Hodnett BK (2001) 'Adsorption and activity of cytochrome c adsorbed onto mesoporous silicates'. CHEMICAL COMMUNICATIONS, 5 :466-465. [Details]

Spada S, Pembroke JT, Wall JG (2002) 'Isolation of a novel Thermus thermophilus metal efflux protein that improves E. coli growth under stress conditions'. EXTREMOPHILES, 6 (4):301-308. [Details]

Deere J, Magner E, Wall JG, Hodnett BK (2002) 'Mechanistic and structural features of protein adsorption onto mesoporous silicates'. JOURNAL OF PHYSICAL CHEMISTRY B, 106 (29):7340-7347. [Details]

Smyth TP, Wall JG, Nitanai Y (2003) 'A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase'. 11 (6):991-998. [Details]

Deere J, Magner E, Wall JG, Hodnett BK (2003) 'Adsorption and activity of proteins onto mesoporous silica'. CATALYSIS LETTERS, 85 (01-Feb):19-23. [Details]

Deere J, Magner E, Wall JG, Hodnett BK (2003) 'Oxidation of ABTS by silicate immobilized cytochrome c in nonaqueous solutions'. BIOTECHNOLOGY PROGRESS, 19 (4):1238-1243. [Details]

Moriarty T, O'Sullivan M, Tam A, Gonçalves RM, Wall JG (2003) 'Systemic lupus erythematosus in Portugal: Diagnosis and disease awareness from 1970-2001'. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 18 (10):995-999. [Details]

Guida A, Towler MR, Wall JG, Hill RG, Eramo S (2003) 'Preliminary work on the antibacterial behaviour of strontium-containing glass ionomer cements'. 22 (20):1401-1403. [Details]

Deere J, Serantoni M, Edler K, Hodnett BK, Wall JG, Magner E (2004) 'Measurement of the adsorption of cytochrome c onto the external surface of a thin film mesoporous silicate by ellipsometry'. LANGMUIR, 20 (2):532-536. [Details]

Hu X, O'Dwyer R, Wall JG (2005) 'Cloning, expression and characterisation of a single-chain Fv antibody fragment against domoic acid in Escherichia coli'. JOURNAL OF BIOTECHNOLOGY, 120 (1):38-45. [Details]

Hu X, White S, Spada S, Hudson S, Magner E, Wall JG (2006) 'Adsorption and activity of a domoic acid-binding antibody fragment on mesoporous silicates'. JOURNAL OF PHYSICAL CHEMISTRY B, 110 (37):18703-18709. [Details]

Boyd D, Li H, Tanner DA, Chowdhury SA, Towler M, Wall JG (2006) 'The antibacterial effects of zinc ion migration from zinc based glass polyalkenoate cements'. JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, 17 (6):489-494. [Details]

Höfer N, Kolaj O, Li H, Cherezov V, Gilliam R, Wall JG, Caffrey M (2007) 'Crystallization and preliminary X-ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus'. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE, 63 (8):673-677. [Details]

Hu X, O'Hara L, White S, Magner E, Kane M, Wall JG (2007) 'Optimisation of production of a domoic acid-binding scFv antibody fragment in E. coli using molecular chaperones and functional immobilisation on a mesoporous silicate support'. PROTEIN EXPRESSION AND PURIFICATION, 52 (1):194-201. [DOI] [Details]

V. Cherezov, N. Höfer, D.M.E. Szebenyi, O. Kolaj, J.G. Wall, R. Gillilan, V. Srinivasan, C.P. Jaroniec and M. Caffrey (2008) 'Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus'. 16 (9):1378-1388. [Details]

Kolaj O, Spada S, Robin S, Wall JG (2009) 'Use of folding modulators to improve heterologous protein production in Escherichia coli'. Microb. Cell Fact, 8 . [Details]

Robin S, Togashi DM, Ryder AG, Wall JG. (2009) 'Trigger factor from the psychrophilic bacterium P. frigidicola is a monomeric chaperone'. J. Bacteriol, 191 :1162-1168. [ARAN Link] [Details]

O'Dwyer R, Razzaque R, Hu X, Hollingshead SK, Wall JG. (2009) 'Engineering of cysteine residues leads to improved production of a human dipeptidase enzyme in E. Coli'. Appl. Biochem. Biotechnol, 159 :178-190. [DOI] [Details]

Hu X, O'Connell S, Robin S, Walsh G, Wall JG. (2010) 'Engineering of a fungal ß-galactosidase to remove product inhibition by galactose'. Appl. Microbiol. Biotechnol, 87 :1773-1782. [Details]

                                           

   

Patents

Patent 20060216783 : Polypeptide factor from a thermophilic eubacterial

     

Committees

Committee : Biochemical Society

             

Teaching Interests

<< BSc Microbiology: 1st year Biology, Medical Microbiology; 2nd year Microbiology, Virology; 3rd year Microbiology, Viral Oncogenesis and Immunology; 3rd year Genetics: Recombinant DNA Technologies; 4th year Microbiology, Recombinant Protein Production Technologies. MSc Biotechnology: Protein Technologies>>

Recent Postgraduates

Current Postgraduate Students

Malgorzata Wronska, Doctorate - Ph.D.(Science)   -   Supervisor

Claire Cunningham, Doctorate - Ph.D.(Science)   -   Supervisor