Research Interests

Developmental biology, gene expression in the early zebrafish embryo, role of IGF signalling in zebrafish, molecular and cellular basis of cardiovascular disease in zebrafish.

Research Projects

Project: GSO HARDIMAN SCHOLARSHIP FUND LUCY BYRNES ( RNR1140) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 16-AUG-12 / 16-AUG-22

Project: THOMAS CRAWFORD HAYES OLD SCHEME P MORGAN ( RCH813) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-12 / 31-DEC-20

Project: THOMAS CRAWFORD HAYES NEW SCHEME CALL 1-7 P MORGAN ( RCH816) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-MAY-09 / 31-DEC-12

Project: MF2002 MF85 02 M LUCY BYRNES ( RM2085) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-NOV-02 / 29-NOV-04

Project: 930 ST 98 529 TEPPS BYRNE TUOHY ( REI828) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 15-MAR-99 / 01-OCT-01

Project: SFI OVERHEADS EQUIPMENT LUCY BYRNES ( RSF1050) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-08 / 30-JUN-08

Project: THOMAS CRAWFORD HAYES NEW SCHEME CALL 8-11 L BYRNES ( RCH818) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-NOV-12 / 31-OCT-14

Project: NANOR, A NOVEL VERTEBRATE WITH A ROLE IN CARDIOVAS ( RSF525) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-SEP-07 / 28-FEB-11

Project: SFI IGF SIGNALS IN VERTEBRATE EMBRYO L BYRNES ( RSF444) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-AUG-05 / 31-JAN-09

Project: MF2003 MF76 03 M LUCY BYRNES ( RM3076) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-DEC-03 / 29-JAN-09

Project: IRCSET EMBARK SCHOLARSHIP 2007-2010 MELISSA WALSH ( RCS722) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-07 / 30-SEP-12

Project: MF2004 MF60 04 LUCY BYRNES ( RM4060) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-04 / 20-JUL-07

Project: 978 HEA BIOMED CENTRE P05 1 SMITH ( RH9125) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-99 / 31-MAR-09

Project: AQUACHARR DEV A C L BYRNE ( RNR082) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-94 / 31-DEC-12

Project: EI SC 2002 448 IGF 1 RECEPTOR L BYRNES ( REI505) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-02 / 30-JUL-06

Project: 989 MF 12 01 M TRANS FACTORS BYRNES ( RM1612) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-SEP-01 / 29-NOV-04

Project: EU AQUACHARR L BYRNE ( RE4442) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-DEC-96 / 30-JUN-09

Project: SIGNALS IN EMBRYONIC SHIELD OF ZEBRATISH EMBRYOS ( RCS229) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-06 / 21-APR-09

Project: 989 MF 8 00 L BYRNES BIO ( RM0508) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-MAY-00 / 29-NOV-04

Project: PRTLI3 BMES 2 1B BYRNES ( RH3226) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-02 / 28-JAN-08

Project: SC 2003 461 APR IN RAINBOW TROUT L BYRNES ( REI664) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 30-SEP-03 / 30-DEC-06

 

Book Chapters

Byrnes, L., Enenkel, B., Gannon F., and Smith, T.J. (1995) 'Preparation of DNA probes' In: Eds. Higgins, S. and Hames, D (eds). Gene Probes: A Practical Approach. [Details]

Byrnes L, Enenkel B, Gannon F and Smith T (1995) 'Preparation of DNA for use as probes' In: Hames, B.D.; Higgins, S.J (eds). Gene Probes 1: A Practical Approach. IRL Press. [Details]

Wagner A Deryckere F Hardiman G Byrnes L Gannon F (1993) 'The isolation and structure of liver and globin genes from Atlantic salmon' In: Aquaculture: Fundamental and Applied Research. Washington: American Biophysical Union. [Details]

 

Peer Reviewed Journals

Cunningham S, Brennan-Fournet ME, Ledwith D, Byrnes L and L Joshi (2013) 'Effect of nanoparticle stabilisation and physicochemical properties on exposure outcome: Acute toxicity of silver nanoparticle preparations in zebrafish (Danio rerio)'. Environmental Science & Technology, . [Details]

Moriarty, MA, Ryan, R, Lalor, P, Dockery, P, Byrnes, L, Grealy, M (2012) 'Loss of plakophilin 2 disrupts heart development in zebrafish'. The International Journal Of Developmental Biology, . [Details]

Hartnett L, Glynn C, Nolan CM, Grealy M and L Byrnes (2010) 'Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos'. International Journal Of Developmental Biology, 54 :573-583. [Details]

Martin ED, Moriarty MA, Byrnes L and M Grealy (2009) 'Plakoglobin has both structural and signalling roles in zebrafish development'. Developmental Biology, . [Details]

Tsalavouta M, Astudillo O, Byrnes L and Nolan CM (2009) 'Regulation of expression of zebrafish (Danio rerio) insulin-like growth factor 2 receptor: implications for evolution at the IGF2R locus'. Evol Dev, 11 :547-559. [DOI] [Details]

Moriarty MA, Martin ED, Byrnes L and M Grealy (2008) 'Molecular cloning and developmental expression of plakophilin 2 in zebrafish'. Biochimica Et Biophysica Acta, 367 :124-129. [Details]

Geoghehan E Byrnes L (2008) 'Mouse induced pluripotent stem cells'. International Journal Of Developmental Biology, 52 :1015-1022. [Details]

O'Boyle, S,Bree, RT,McLoughlin, S,Grealy, M,Byrnes, L (2007) 'Identification of zygotic genes expressed at the midblastula transition in zebrafish'. Biochemical And Biophysical Research Communications, 358 :462-468. [DOI] [Details]

Collins, CM,Murray, PG,Denman, S,Morrissey, JP,Byrnes, L,Teeri, TT,Tuohy, MG (2007) 'Molecular cloning and expression analysis of two distinct beta-glucosidase genes, bg1 and aven1, with very different biological roles from the thermophilic, saprophytic fungus Talaromyces emersonii'. Mycological Research, 111 :840-849. [DOI] [Details]

Nolan, CM,McCarthy, K,Eivers, E,Jirtle, RL,Byrnes, L (2006) 'Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish'. Development Genes And Evolution, 216 :144-151. [DOI] [Details]

Bree, RT,McLoughlin, S,Jin, SW,McMeel, OM,Stainier, DYR,Grealy, M,Byrnes, L (2005) 'nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish'. Biochemical And Biophysical Research Communications, 333 :722-728. [DOI] [Details]

Eivers, E,McCarthy, K,Glynn, C,Nolan, CM,Byrnes, L (2004) 'Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo'. International Journal Of Developmental Biology, 48 :1131-1140. [DOI] [Details]

Grassick, A.,Murray, P.G.,Thompson,R.,Collins, C.M.,Byrnes, L.,Birrane, G.,Higgins, T.M.,Tuohy, M.G. (2004) 'Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii'. European Journal of Biochemistry, 271 (22). [Details]

Bree RT Stenson C Grealy M Byrnes L Gorman AM Samali A (2002) 'Cellular longevity: role of apoptosis and replicative senescence'. Biogerontology, 3 :195-206. [Details]

Brabazon, E. D., Bree, R. T., Carton, M. W., Colleran, S., Grealy, M., & Byrnes, L. (2002) 'Cyclin dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development'. Biochemica et Biophysica Acta, 1576 :202-208. [Details]

Ayaso, E,Nolan, CM,Byrnes, L (2002) 'Zebrafish insulin-like growth factor-I receptor: molecular cloning and developmental expression'. Molecular And Cellular Endocrinology, 191 :137-148. [DOI] [Details]

Carton, MW,Schmitz, M,Cutts, CJ,Kelly, AK,Hill, JA,Brabazon, ED,Adams, CE,Byrnes, L (2002) 'Expressed sequence tags in larval Arctic charr (Salvelinus alpinus)'. Fish Physiology And Biochemistry, 26 :231-238. [Details]

Stenson, C., McNair, A., Byrnes, L., Murphy, M., Smith, T., and Gannon, F. (2000) 'Atlantic Salmon HNF-3/forkhead: cDNA sequence, evolution, expression, and functional analysis'. DNA AND CELL BIOLOGY, 19 :59-68. [Details]

Fluoriot G, ducouret B, Byrnes L and Valotaire Y (1998) 'Transcriptional regulation of expression of the rainbow trout albumin gene by estrogen'. J Mol Endocrinol, 20 :355-362. [Details]

Dercykere F, Byrnes L, Wagner A, McMorrow T and Gannon, F (1995) 'Salmon HNF1:cDNA sequene, evolution, tissue specificity and binding to the salmon serum albumin promoter'. J Mol Biol, 2247 :1-10. [Details]

Hardiman G, Byrnes L and Gannon F (1994) 'An analysis of highly expressed salmon liver genes during smoltification in the Atlantic salmon (Salmo salar L)'. Molecular Marine Biol Biotech, 3 :51-56. [Details]

Byrnes L Gannon F (1992) 'Sequence analysis of a second cDNA for salmon serum albumin'. Gene, 120 :319-320. [Details]

POWELL, R,HIGGINS, DG,WOLFF, J,BYRNES, L,STACK, M,SHARP, PM,GANNON, F (1991) 'THE SALMON GENE ENCODING APOLIPOPROTEIN-A-I - CDNA SEQUENCE, TISSUE EXPRESSION AND EVOLUTION'. Gene, 104 :155-161. [Details]

Powell R, Byrnes L and Gannon, F (1991) 'Sequence of a cDNA clone encoding an Atlantic salmon ribodomal protein'. Gene, 101 :303-304. [Details]

Powell R Byrnes L Gannon F (1990) 'Transgenic fish'. The Genetic Engineer And Biotechnologist, 10 :7-9. [Details]

Powell, R, Byrnes L, Barry T and Gannon, F (1990) 'A rapid procedure to isolate major abundance mRNA transcripts and study the transcription profile of a tissue'. Technique, 2 :213-215. [Details]

BYRNES, L,GANNON, F (1990) 'ATLANTIC SALMON (SALMO-SALAR) SERUM-ALBUMIN - CDNA SEQUENCE, EVOLUTION, AND TISSUE EXPRESSION'. Dna And Cell Biology, 9 :647-655. [Details]

Byrnes L, Luo CC, Li WH, Yang CY and Chan L (1987) 'Chicken apolipoprotein A-I; cDNA sequence, tissue expression and evolution'. Biochem Biophys Res Comm, 148 :485-492. [Details]

 

Conference Publications

McCarthy K Glynn C Hartnett L Grealy M Nolan C Byrnes L (2005) The role of insulin-like growth factor-2 (IGF-2) in zebrafish embryonic development Developmental Biology 283 620-621 [Details]

McLoughlin S Bree RT O'Boyle S Grealy M Byrnes L (2004) Gene expression at the midblastula transition in zebrafish Biochem Soc Trans 32 135A [Details]

O'Connor D Byrnes L (2001) ONECUT domain transcription factors in the zebrafish Biochem Soc Trans 29 135A [Details]

Kelly A Schmitz M Hill J Cutts C Adams C Byrnes L (1999) Molecular basis for variation in metabolic rate in juvenile charr J Fish Biol 55A 244-245 [Details]

Ayaso E Nolan C Byrnes L (1999) Zebrafish IGF-1 receptor expression during development Growth hormone and IGF Research 9 347 [Details]

O'Connor D Byrnes L (1999) CCAAT/enhancer binding protein in zebrafish J Fish Biol 55A 247 [Details]

Stenson C McNair A Byrnes L Gannon F (1996) Cloning of an Atlantic salmon transcription factor Biochem Soc Trans 24 1 106S [Details]

Stenson, C,McNair, A,Byrnes, L,Gannon, F (1996) BIOCHEMICAL SOCIETY TRANSACTIONS Cloning of an Atlantic salmon transcription factor , pp.106-106 [Details]

Powell R Byrnes L Gannon F (1990) Liver gene expression: cloning of abundant messenger RNA transcripts from the liver of Atlantic salmon (Salmo salar). Identification of salmon apolipoprotein A-1 gene Proc. 5th European Congress on Biotechnology 5 453-456 [Details]

Abdul-Ahad W Byrnes L Gosling JP (1987) The use of Fab'-beta-lactamase conjugate in an enzyme-linked immunosorbent assay for bovine luteinizing hormone Biochem Soc Trans 15 277-278 [Details]

 

Abstract

O'Connor, D. and L. Byrnes (2001) ONECUT domain transcription factors in the zebrafish. BIOCHEMICAL SOCIETY TRANSACTIONS. Abstract [Details]

                   

Conference Paper

Bree, R.T., McMeel, O., Brabazon, E.D., Cairns, M., Smith, T., Grealy, M. & Byrnes, L. (2001) Characterisation of the molecular events occurring at the mid-blastula transition during zebrafish embryo development. 2nd European conference on zebrafish genetics and development. London: Conference Paper [Details]

Conference Poster

Tsalavouta M, Astudillo O, Byrnes L and Nolan C (2006) Complex regulation of expression of an evolutionarily important gene: the zebrafish CI-MPR/IGF2R. 7th International meeting: Zebrafish Development and Genetics. Madison, Wisconsin, USA: Conference Poster [Details]

Collins C, Murray P, Morrissey J, Byrnes L and M Tuohy (2006) Evidence of a phytopathogenic gene in the thermophoilic, saprophytic fungus Talaromyces emersonii. 8th European Fungal Genetics meeting. Austria: Conference Poster [Details]

Hartnett L, McCarthy K, Glynn C, Grealy M and Byrnes L (2006) Targeted knockdown of IGF-2 disrupts cardiovascular development in zebrafish embryos. BSDB Autumn Meeting. Dundee, Scotland: Conference Poster [Details]

Nolan CM, Astudillo O, Callanan S, McCann A, Jirtle RL, Byrnes L and O'Sullivan F (2005) Evolution of an imprinted gene: the mannose 6-phosphate/IGF2 receptor. Environmental Epigenomics, Imprinting and Disease susceptibility. Durham, North Carolina, USA: Conference Poster [Details]

O'Boyle S, Bree RT, McLoughlin S, Schindler S, Muller F, Grealy M and Byrnes L (2005) A study of gene expression at the midblastula transition in zebrafish. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details]

Astudillo A, McCarthy K, Byrnes L and Nolan C (2005) Evolution of an imprinted gene: the zebrafish mannose 6-phosphate/IGF2 receptor. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details]

Reynolds T and Byrnes L (2005) Embryonic development in Atlantic salmon (Salmo salar). British Societies for Cell and Developmental Biology Joint Spring Meeting. University of Warwick, U.K: Conference Poster [Details]

Ferg M, Lovas A, Bree R, O'Boyle S, Byrnes L and Muller F (2005) Regulation of differential gene expression during zebrafish development by alternative transcription initiation complexes. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details]

Hartnett L, McCarthy K, Glynn C, Grealy M, Nolan C and Byrnes L (2005) Insulin-like growth factors are involved in heart and somite development in zebrafish. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details]

McCarthy K, Eivers E, Nolan C and Byrnes L (2004) Molecular characterisation and expression analysis of the cation independent mannose 6-phosphate receptor (CI-M6PR) in zebrafish. Joint meeting of Genetics Society and British Society for Developmental Biology. University of Warwick, UK: Conference Poster [Details]

Eivers E, McCarthy K, Glynn C, Nolan CM and Byrnes L (2004) IGF signalling and neural development in the zebrafish embryo. Zebrafish Development & Genetics. University of Wisconsin-Madison, USA: Conference Poster [Details]

McLoughlin S, Bree RT, O'Boyle S, Grealy M, and Byrnes, L (2004) Gene expression at the midblastula transition in zebrafish. BioScience 2004 from molecules to organisms. Glasgow, UK: Conference Poster [Details]

Nolan C, McCarthy K, Byrnes L and Jirtle R (2004) Evolution of the mannose 6-phosphate/IGF2 receptor: a novel regulatory element?. 69th Cold Spring Harbor Symposium on Quantitative Biology: Epigenetics. Cold Spring Harbor, New York, USA: Conference Poster [Details]

Nolan C, McCarthy K, Byrnes L and Jirtle R (2004) Evolution of the cation-independent mannose 6-phosphate receptor: the zebrafish receptor. Gordon Conference on Lysosomes and Endocytosis. New Hampshire, USA: Conference Poster [Details]

Bree RT, McMeel O, Brabazon ED, Cairns M, Smith T, Grealy M and L Byrnes (2001) Characterisation of the molecular events occurring at the mid-blastula transition during zebrafish embryo development. 2nd European conference on Zebrafish Genetics and Development. University College London, UK: Conference Poster [Details]

Brabazon ED, Byrnes L and Grealy M (2001) Cadherin and catenin expression and localisation during early zebrafish morphogenesis. Cell and Tissue Morphogenesis, British Societies for Cell and Developmental Biology Joint Spring Meeting. University of Sussex, Brighton, UK: Conference Poster [Details]

Brabazon ED, Byrnes L and M Grealy (2001) Cadherin and catenin expression and localization during early zebrafish embryo morphogenesis. Cell and Tissue Morphogenesis, British Societies for Cell and Developmental Biology Joint Spring Meeting. University of Sussex, Brighton, UK: Conference Poster [Details]

Collins C, Murray PG, Byrnes L and Tuohy M (2001) Molecular genetics of cellulase production in the filamentous fungus Talaromyces emersonii. 4th Carbohydrate Bioengineering Meeting. Stockholm, Sweden: Conference Poster [Details]

E D Brabazon, R T Bree, M Grealy and L Byrnes (2001) Characterisation of Zebrafish Cyclin Dependent Kinase 8: cDNA Sequencing and Expression Studies. 2nd European conference on Zebrafish Genetics and Development. University College London, UK: Conference Poster [Details]

D O'Connor and L Byrnes (2001) Isolation and expression of a ONECUT domain transcription factor from the zebrafish. 2nd European conference on Zebrafish Genetics and Development. University College London, UK: Conference Poster [Details]

Brabazon ED, Byrnes L and M Grealy (2000) Expression and localization of cadherins and catenins during zebrafish embryo development. Zebrafish Development & Genetics. Cold Spring Harbor, New York: Conference Poster [Details]

Ayaso E, Nolan CM and L Byrnes (2000) Cloning and developmental expression of the zebrafish IGF-I receptor. Zebrafish Development & Genetics. Cold Spring Harbor, New York: Conference Poster [Details]

                                                     

Other Item

Wagner, A., Deryckere, F., Hardiman, G., Byrnes, L. and F. Gannon (1993) The isolation and structure of liver and globin genes from Atlantic salmon. American Biophysical Union, Washington DC. Other Item [Details]

                     

Reviews

Geoghegan, E,Byrnes, L (2008) Mouse induced pluripotent stem cells. Reviews [DOI] [Details]

Bree, RT,Stenson-Cox, C,Grealy, M,Byrnes, L,Gorman, AM,Samali, A (2002) Cellular longevity: role of apoptosis and replicative senescence. Reviews [Details]

                                   

Meeting

Moriarty, MA,Byrnes, L,Grealy, M (2009) Effects of plakophilin 2 knockdown on zebrafish embryonic development. Meeting [DOI] [Details]

McCarthy, K,Glynn, C,Hartnett, L,Nolan, C,Byrnes, L (2005) The role of insulin-like growth factor-2 (IGF-2) in zebrafish embryonic development. Meeting [Details]

 

Note

DERYCKERE, F,BYRNES, L,WAGNER, A,MCMORROW, T,GANNON, F (1995) SALMON HNF1 - CDNA SEQUENCE, EVOLUTION, TISSUE-SPECIFICITY AND BINDING TO THE SALMON SERUM-ALBUMIN PROMOTER. Note [Details]

BYRNES, L,GANNON, F (1992) SEQUENCE-ANALYSIS OF A 2ND CDNA-ENCODING ATLANTIC SALMON (SALMO-SALAR) SERUM-ALBUMIN. Note [Details]

POWELL, R,BYRNES, L,GANNON, F (1991) SEQUENCE OF A CDNA CLONE ENCODING AN ATLANTIC SALMON RIBOSOMAL-PROTEIN. Note [Details]

   

 

Associations

Association: Irish Network of Developmental Biologists, Function/Role: Convener

Association: The Biochemical Society, Function/Role: Member

Association: British Society for Developmental Biology, Function/Role: Member

       

Committees

Committee : IUA Deans of Graduate Studies Group (2013)

Committee : Academic Council (2010-

Committee : Academic Council Standing Committee (2010-

Committee : Graduate Studies Board (2010-

Committee : Research Committee (2012-

Committee : Council of Deans (2012)

Committee : Sabbatical Leave Committee (2012-2013)

Committee : Senior Lecturer Promotion Board (2011-

Committee : Udaras na hOllscoile (2013-

Committee : Academic Planning & Resource Committee (2013-

Committee : Priorities subcommittee (2013-

Committee : Standing & Strategic Planning committee (2013-

Committee : Academic Management Team (2013-

 

Education

Year 1991 Institution: UCG Qualification: Phd Subject: Molecular biology

Year 1986 Institution: UCG Qualification: BSc Subject: Biochemistry

   

Community Engagement

Judge, Young Scientists Exhibition, 2004-2011

   

 

Recent Postgraduates

Rebecca Ryan (co-supervised with Maura Grealy) PhD (2008-2013) Miriam Moriarty (co-supervised with Maura Grealy), PhD (2006-2010) Lori Hartnett (co-supervised with Maura Grealy and Catherine Nolan, UCD), PhD (2004-2009) Shaun O'Boyle (co-supervised with Maura Grealy), PhD (2003-2008) Karena McCarthy (co-supervised with Catherine Nolan, UCD), PhD (2002-2007) Sarah McLoughlin (co-supervised with Maura Grealy), MSc (2002-2005) Ed Eivers (co-supervised with Catherine Nolan, UCD), PhD (1999-2004) Ronan Bree (co-supervised with Maura Grealy), PhD (1999-2003) Catherine Collins (co-supervised with Maria Tuohy), PhD (1999-2003) Audrey Kelly, PhD (1997-2002) Catherine Glynn (co-supervised with Afshin Samali and Adrienne Gorman), MSc (2001-2002) Deirdre O'Connor, PhD (1997-2002) Elena Ayaso (co-supervised with Catherine Nolan, UCD), PhD (1996-2001) Kathy Gately, PhD (1996-2001)

   

Internal Collaborators

Dr. Maura Grealy, Pharmacology & Therapeutics

External Collaborators

Dr. Catherine Nolan, UCD Prof. Didier Stainier, UCSF