Research Interests

The control of adipogenesis, influence of steroid hormones and environmental estrogens

 

     

Peer Reviewed Journals

McHale, L & Headon, D.R. (1980) 'Analysis by IEF of the microsomal proteins of skeletal muscle'. J Muscle Res & Cell Motility, 4 :463-446. [Details]

A.P.McHale, L. McHale & W.Blau (1988) 'The effects of hematoporphyrin detivative (HPD)and human erythrocyte encapsulated HPD on a mouse myeloma cell line'. Cancer Biochemistry and Biophysics, 10 :157-164. [Details]

B.Donlon, McHale, L. (1988) 'Modification of human salivary amylase using dextran T-70'. Biotechnology Letters, 5 :559-562. [Details]

McHale & L.McHale (1988) 'Use of a tetrazolium based colorimetric assay in assessing photoradiation therapy in vitro'. Cancer Letters, 41 :315-321. [Details]

A.P.McHale, T.J. Hackett & L. McHale (1989) 'A specific zymogram staining procedure for exocellobiohydrolase components produced by T emersonii'. Enzyme and Microbial Technology, 11 :17-20. [Details]

Bunni, L. McHale & A.P.McHale (1989) 'Production, isolation and partial characterisation of an alpha-amylase produced by T emersonii L'. Enzyme and Microbial Technology, 11 :370-375. [Details]

B.Jones, U.McCarthy, L.Bunni, L.McHale, B.Butler, J. Seary & A.P.McHale (1989) 'Use of piezoelectric shock waves to effect release of amylase from capsules containing the amylase producing rat pancreatic tumour cell line AR42J'. Biotechnology Techniques, 3 :355-360. [Details]

L.Bunni, D.C.Coleman, L.McHale, T.J. Hackett & A.P.McHale (1992) 'cDNA cloning and expression of a T emersonii amylase encoding genetic determinant in E coli'. Biotechnology Letters, 14 :1009-1114. [Details]

D.McCormack, B.J.Jones, J.McElwain, L.McHale & A.P.McHale (1993) 'The tumoricidal potential of extracorporeal shock-wave therapy'. European Journal of Surgical Oncology, 19 :232-234. [Details]

M.Fleming, N.Barron, L.McHale, R.Marchant & A.P.McHale (1993) 'Studies on the growth of a thermotolerant yeast strain, Kluyvermyces marxianus IMB3, on sucrose containng media'. Biotechnology Letters, 15 :1195-1198. [Details]

L.Bunni, T.J.Hackett, L.McHale, & A.P. McHale (1993) 'Molecular cloning and functional expression of a T emersonii derived alpha- Amylase encoding genetic determinant in a human cell line'. Biotechnology Letters, 15 :1095-1100. [Details]

L.Spear, J.Gallagher, L.McHale & A.P.McHale (1993) 'Production of cellulae and beta-glucosidase activities following growth of Streptomyces hygroscopicus on cellulose containing media'. Biotechnology Letters, 15 :1265-1268. [Details]

A.M.Nolan, N.Barron, D.Brady, T.McAree, D.Smith, L.McHale, A.P.McHale (1994) 'Ethanol production at 45oC by an alginate-immobilised thermotolerant strain of Kluyveromyces marxianus following growth on glucose-containing media'. Biotechnology Letters, 16 :849-852. [Details]

G.Flynn, T.J.Hackett, L.McHale & A.P.McHale (1994) 'Magnetically responsive photosensitising reagents for possible use in photo- Radiation therapy'. Cancer Letters, 78 :109-114. [Details]

A,P,McHale & L McHale (Eds: M.Moo-Young, B.R. Glick, Y. Christi, C.R. Barnett, J.S..G.Dooley, A.P.McHale & P.G.McKenna (1994) 'Microbial biosorption of metals: Potential in the treatment of metal pollution'. Biotechnology Advances: Special Issue: Biotechnology and Industry: Present and Future, :647-652. [Details]

D.Brady, R.Marchant, L.McHale & A.P.McHale (1994) 'Production of ethanol by the thermotolerant yeast kluyveromyces marxianus IMB3 during growth on lactose-containing media'. Biotechnology Letters, 16 :737-740. [Details]

G.Flynn, L.McHale & A.P. McHale (1994) 'Methotrexate-loaded, photosensitized erythrocytes: A photo-activatable carrier/ delivery system for use in cancer therapy'. Cancer Letters, 82 :225-229. [Details]

N.Barron, R.Marchant, L.McHale& A.P.McHale (1994) 'Growth of a thermotolerant, ethanol-producing strain of Kluyveromyces Marxianus IMB3 during growth on lactose-containing media'. Biotechnology Letters, 16 :625-630. [Details]

G.Flynn, T.J.Hackett, L.McHale & A.P.McHale (1994) 'Encapsulation of the thrombolytic enzyme, brinase, in photosensitised erythrocytes: a novel thrombolytic system based upon photodynamic therapy'. Journal of Photochemistry and Photobiology, 26 :193-196. [Details]

Barron, R.Marchant, L.McHale & A.P.McHale (1995) 'Partial characterization of -glucosidase activity produced by Kluyveromyces marxianus IMB3 during growth on cellulose-containing media at 45oC N'. Biotechnology Letters, 17 :1047-1050. [Details]

N.Barron, R.Marchant, L.McHale & A.P.McHale (1995) 'Studies on the use of a thermotolerant strain of Kluyveromyces marxianus in simultaneous saccharification and fermentation of cellulose to ethanol'. Applied Microbiologyand Biotechnology, 43 :518-520. [Details]

D.Brady, R.Marchant, L.McHale & A.P.McHale (1995) 'Partial characterization of -galactosidase activity produced by a thermotolerant strain of Kluyveromyces marxianus IMB3 during growth on lactose-containing media'. Enzyme and Microbial Technolology, 17 :696-699. [Details]

U.Nilsson, N.Barron, L.McHale & A.P.McHale (1995) 'The effects of phosphoric acid pretreatment on conversion of cellulose to ethanol at 45oC using the thermotolerant yeast Kluyveromyces marxianus IMB3'. Biotechnology Letters, 17 :985-988. [Details]

L.Bergstrom, B.Jogansson, L.McHale, R.Marchant & A.P.McHale (1995) 'Studies on the biosorption of uranium by Talaromyces emersonii CBS 814 70'. Applied Microbiology and Biotechnology, 42 :807-811. [Details]

J.Simpson, D.Brady, A.Rollan, N.Barron, L.McHale &A.P.McHale (1995) 'Increased ethanol production during growth of electric-field stimulated Kluyveromyces marxianus IMB3 during growth on lactose-containing media'. Biotechnology Letters, 17 :757-760. [Details]

Donnellan, A.Rollan, L.McHale & A.P.McHale (1995) 'The effect of electric field stimulation on the biosorption of uranium by non- living biomass derived from Kluyveromyces marxianus IMB3 N'. Biotechnology Letters, 17 :439-442. [Details]

A.McCabe, N.Barron, L.McHale & A.P.McHale (1995) 'Increased efficiency of substrate utilization by exposure of the thermotolerant yeast strain, Kluyveromyces marxianus IMB3 to electric field stimulation'. Biotechnology Techniques, 9 :133-136. [Details]

D.Brady, R.Marchant, L.McHale & A.P.McHale (1995) 'The effects of Mn2 on ethanol production by Kluyveromyces marxianus IMB3 during growth on lactose containing media at 45C'. Biotechnology Letters, 17 :233-236. [Details]

C.Ward, A.M.Nolan, K.O'Hanlon, T.McAree, N.Barron, L.McHale & A.P.McHale. (1995) 'Production of ethanol at 45oC on starch-containing media by mixed cultures of the thermotolerant, ethanol-producing yeast Kluyveromyces marxianus IMB3 and the thermophilicfilamentous fungus Talaromyces emersonii CBS 814 70'. Applied Microbiology and Biotechnology, 43 :408-411. [Details]

M.Bustard, N.Donnellan, A.Rollan, L.McHale & A.P.McHale (1996) 'The effect of pulse field strength on electric field stimulated biosorptin of uranium by Kluyveromyces marxianus IMB3'. Biotechnology Letters, 18 :479-482. [Details]

N.Barron, R.Marchant, L.McHale & A.P.McHale (1996) 'Ethanol production from cellulose at 45oC using a batch-fed system containing alginate- immobilized Kluyveromyces marxianus IMB3'. World Journal of Microbiology and Biotechnology, 12 :103-104. [Details]

A.Rollan, T.Ward, G.Flynn, G.McKerr, L.McHale & A.P.McHale (1996) 'Use of real-time confocal laser scanning microscopy to study immediate effects of photodynamic activation on photosensitized erythrocytes'. Cancer Letters, 101 :165-169. [Details]

J.Gallagher, A.Winters, N.Barron, L.McHale & A.P.McHale (1996) 'Production of cellulase and -glucosidase activity during growth of the actinomycete Micromonospora chalcae on cellulose-containing media'. Bi Biotechnology Letters, 18 :537-540. [Details]

C.Riordan, D.Brady, N.Barron, M.Fleming, R.Marchant, L.McHale & A.P.McHale (1996) 'Production of ethanol from sucrose at 45oC by alginate-immobilized preparations of the thermotolerant yeast strain Kluyveromyces marxianus IMB3'. Bioresource Technology, 55 :171-173. [Details]

D. Brady, L. McHale & A.P. McHale (1996) 'Magnetically responsive alginate-based biocatalysts: Applications in Space Biotechnology'. Life Sciences Research in Space: European Space Agency Publication SP 390, :339-344. [Details]

D. Brady, P. Nigam, L. McHale & A.P. McHale (1996) 'Ethanol production at 45oC by Kluyveromyces marxianus IMB3 immobilized in magnetically responsive alginate matrices'. Biotechnology Letters, 18 :1213-1216. [Details]

T. Ward, A. Rollan, N. Barron, L. McHale & A.P. McHale (1996) 'The effects of electric fields on photosensitized erythrocytes: Possible enhancement of photodynamic activation'. Cancer Letters, 106 :69-74. [Details]

A.Rollan, D.McCormack, H.McCormack, L.McHale & A.P.McHale (1996) 'A rapid in situ colorimetric assay for the determinatino of mammalian cell variability in alginate-immobilized and encapsulated systems'. Bioprocess Engineering, 15 :47-49. [Details]

N.Barron, D.Brady, G.Love, R.Marchant, L.McHale & A.P.McHale (1996) 'Alginate-immobilized thermotolerant yeast for conversion of cellulose to ethanol'. Progress in Biotechnology 11 Immobilized Cells: Basics and Applications, 11 . [Details]