Dr Sandra Healy PhD
Contact Details
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Biography:
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My research interests over the past 15 years have been primarily in the field of cancer research. After completing my PhD I moved to the UK where I studied the mechanisms regulating cell division and the response to DNA damage in research institutes (Cancer research UK, Clare Hall laboratories) and universities (Cambridge University) and then continued this work at the University of Milan, Italy. Following my postdoctoral studies I worked as a research scientist in industry where I contributed to the development of novel cancer chemotherapeutic agents (Pharmacia/ Pfizer/ Nerviano Medical Sciences). In Industry I set up and ran a Microarray laboratory where we studied late stage compounds that the company had approved for phase 1 clinical studies. I analysed the effects of these compounds on the gene expression profile of cells to further characterise their mechanism of action and to develop biomarkers that would allow us to follow the activity of these compounds in clinical studies. On returning to Ireland in 2007 I worked for two years as a research manager/scientific reviewer in Prof. Afshin Samali’s group at NUIG and contributed significantly to writing research and review articles, grant proposals and reports. More recently I am working as University Teacher which involves teaching Biochemistry to Medical students and Nursing students. I plan and coordinate the delivery of courses which involves lecturing, running practical laboratories and tutorials and coordinating staff, timetables, exams etc. At the same time I am integrated into research activities of the laboratories of both Prof. Afshin Samali and Prof. Corrado Santocanale (working on apoptosis and DNA replication) where I contribute to writing papers and reviews, participate in lab meetings and student supervision and contribute to writing grant applications. |
Book Chapters
| McCarthy,T.V., Healy,S.J.M., Lehane, M., Heffron,j.j.a., Deufel, T., Lehmann-Horn,F., Farrell,M and Johnson K (1990) 'Molecular genetics of Malignant Hyperthermia' In: Mortier W (eds). Malignant Hyperthermia, Neuromuscular Diseases and Anaesthesia. Stuggart, New York: Georg Thieme Verlag. [Details] |
Peer Reviewed Journals
| McCarthy TV, Healy JM, Heffron JJ, Lehane M, Deufel T, Lehmann-Horn F, Farrall M, Johnson K (1990) 'Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2'. Nature, 343 (6258):562-564. [DOI] [Details] |
| Healy JM, Lehane M, Heffron JJ, Farrell M, Johnson K, McCarthy TV (1990) 'Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-q13.2'. Biochemical Society Transactions, 18 (2). [DOI] [Details] |
| McCarthy TV, Healy JM, Lehane M, Heffron JJ. (1990) 'Recent developments in the molecular genetics of malignant hyperthermia: implications for future diagnosis at the DNA level'. Acta Anaesthesiol Belg, 41 (2):107-112. [DOI] [Details] |
| Quane KA, Healy JM, Keating KE, Manning BM, Couch FJ, Palmucci LM, Doriguzzi C, Fagerlund TH, Berg K, Ording H, et al (1993) 'Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia'. Nature Genetics . (Impact Factor 34.3), 5 (1):51-55. [DOI] [Details] |
| Quane KA, Keating KE, Manning BM, Healy JM, Monsieurs K, Heffron JJ, Lehane M, Heytens L, Krivosic-Horber R, Adnet P, et al. (1994) 'Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies'. Hum Mol Genetics, 3 (3):471-476. [DOI] [Details] |
| Quane KA, Keating KE, Healy JM, Manning BM, Krivosic-Horber R, Krivosic I, Monnier N, Lunardi J, McCarthy TV. (1994) 'Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores'. Genomics, 23 (1):236-239. [DOI] [Details] |
| Quane KA, Keating KE, Healy JM, Heffron JJ, Lehane M, Krivosic-Horber R, Heytens L, McCarthy TV (1995) 'Haplotype analysis of the BYR1 gene in malignant hyperthermia and central core disease'. Biochemical Society Transactions, 23 (2). [DOI] [Details] |
| Healy JM, Quane KA, Keating KE, Lehane M, Heffron JJ, McCarthy TV (1996) 'Diagnosis of malignant hyperthermia: a comparison of the in vitro contracture test with the molecular genetic diagnosis in a large pedigree'. Journal Of Medical Genetics, 33 (1):18-24. [DOI] [Details] |
| Huntley R, Healy S, Freeman D, Lavender P, de Jager S, Greenwood J, Makker J, Walker E, Jackman M, Xie Q, Bannister AJ, Kouzarides T, Gutiérrez C, Doonan JH, Murray JA (1998) 'The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins'. Plant Mol Biol, 37 (1):155-169. [DOI] [Details] |
| Cockcroft CE, den Boer BG, Healy JM, Murray JA (2000) 'Cyclin D control of growth rate in plants'. Nature, 405 (6786):575-579. [DOI] [Details] |
| Riou-Khamlichi C, Menges M, Healy JM, Murray JA (2000) 'Sugar control of the plant cell cycle: differential regulation of Arabidopsis D-type cyclin gene expression'. Mol Cell Biol, 20 (13):4513-4521. [DOI] [Details] |
| Healy JM, Menges M, Doonan JH, Murray JA. (2001) 'The Arabidopsis D-type cyclins CycD2 and CycD3 both interact in vivo with the PSTAIRE cyclin-dependent kinase Cdc2a but are differentially controlled'. J Biol Chem, 276 (10):7041-7047. [DOI] [Details] |
| Sorrell DA, Menges M, Healy JM, Deveaux Y, Amano C, Su Y, Nakagami H, Shinmyo A, Doonan JH, Sekine M, Murray JA (2001) 'Cell cycle regulation of cyclin-dependent kinases in tobacco cultivar Bright Yellow-2 cells'. Plant Physiol, . [DOI] [Details] |
| Dewitte W, Riou-Khamlichi C, Scofield S, Healy JM, Jacqmard A, Kilby NJ, Murray JA (2003) 'Altered cell cycle distribution, hyperplasia, and inhibited differentiation in Arabidopsis caused by the D-type cyclin CYCD3'. Plant Cell, 15 (1):79-92. [DOI] [Details] |
| Bosotti R, Locatelli G, Healy S, Scacheri E, Sartori L, Mercurio C, Calogero R, Isacchi A (2007) 'Cross platform microarray analysis for robust identification of differentially expressed genes'. Bmc Bioinformatics, . [DOI] [Details] |
| Montagnoli A, Valsasina B, Croci V, Menichincheri M, Rainoldi S, Marchesi V, Tibolla M, Tenca P, Brotherton D, Albanese C, Patton V, Alzani R, Ciavolella A, Sola F, Molinari A, Volpi D, Avanzi N, Fiorentini F, Cattoni M, Healy S, Ballinari D, Pesenti E, Isacchi A, Moll J, Bensimon A, Vanotti E and Santocanale C. (2008) 'A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity'. Nature Chemical Biology, 4 (6):357-365. [Details] |
| Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. J Cell Mol Med, . [DOI] [Details] |
| Gorman AM, Healy SJM, Jäger R, Samali A (2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'. Pharmacology And Therapeutics, . [Details] |
| Bosotti R, Carpinelli P, Healy S, Locatelli G, Cappella P, Lanfrancone L, Calogero R, Moll J and Isacchi A (2012) 'Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells'. Gene, 494 (2):202-208. [Details] |
