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Natural Sciences

Dr Stephen Rea

B.Sc., Ph.D.

Contact Details

Lecturer
Centre for Chromosome Biology (CCB)
Room G69
School of Natural Sciences
Biosciences Building
NUI Galway

T: +353 91 495750 ext.5750
E: stephen.rea@nuigalway.ie
W: http://www.chromosome.ie/ccb/rea/index.html
http://www.nuigalway.ie/biochemistry/staff/rea/index.html
">http://www.chromosome.ie/ccb/rea/index.html
http://www.nuigalway.ie/biochemistry/staff/rea/index.html
 
researcher

Biography

Research Interests

Research Projects

  Project Start Date End Date
HMOF AS A DETERMINANT OF BREAST CANCER INVASIVE AND PROLIFERATIVE POTENTIAL BREAST CANCER CAMPAIGN 2011NOVPHD03 STEPHEN REA 01-AUG-12 31-DEC-16

Peer Reviewed Journals

  Year Publication
(2013) 'Msl2 Is a Novel Component of the Vertebrate DNA Damage Response'
Lai, Z,Moravcova, S,Canitrot, Y,Andrzejewski, LP,Walshe, DM,Rea, S (2013) 'Msl2 Is a Novel Component of the Vertebrate DNA Damage Response'. Plos One, 8 [DOI] [Details]
(2000) 'Regulation of chromatin structure by site-specific histone H3 methyltransferases'
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z. W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., and Jenuwein, T. (2000) 'Regulation of chromatin structure by site-specific histone H3 methyltransferases'. Nature, 406 :593-599 [Details]
(2000) 'Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression'
O'Carroll, D., Scherthan, H., Peters, A. H., Opravil, S., Haynes, A. R., Laible, G., Rea, S., Schmid, M., Lebersorger, A., Jerratsch, M., Sattler, L., Mattei, M. G., Denny, P., Brown, S. D., Schweizer, D., and Jenuwein, T. (2000) 'Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression'. Mol Cell Biol, [Details]
(2001) 'Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins'
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001) 'Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins'. Nature, 410 :116-120 [Details]
(2002) 'Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing'
Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J., Rea, S., Jenuwein, T., Dorn, R., and Reuter, G. (2002) 'Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing'. Embo J, [Details]
(2005) 'hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells'
Taipale, M., Rea, S., Richter, K., Vilar, A., Lichter, P., Imhof, A., and Akhtar, A. (2005) 'hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells'. Mol Cell Biol, 25 :6798-6810 [Details]
(2007) 'Reversal of H3K9Me2 by a small molecule inhibitor for the G9a histone methyltransferase'
Kubicek, S, O'Sullivan, RJ, August, EM, Hickey, ER, Zhang, Q, Teodoro, ML, Rea, S, Mechtler, K, Kowalski, JA, Homon, CA, Kelly, TA and Jenuwein, T. (2007) 'Reversal of H3K9Me2 by a small molecule inhibitor for the G9a histone methyltransferase'. Mol. Cell, 25 (3):473-481 [Details]
(2008) 'The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma'
Pfister, S., Rea, S., Taipale M., Mendrzyk, F., Straub, B., Ittrich, C., Thuerigen, O., Sinn, H.P., Lichter, P. and Akhtar, A. (2008) 'The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma'. Int J Can, 122 (6):1207-1213 [Details]

Reviews

  Year Publication
(2006) MSL proteins and the regulation of gene expression. Curr Top Microbiol Immunol.
Rea, S., Akhtar, A., (2006) MSL proteins and the regulation of gene expression. Curr Top Microbiol Immunol. Reviews [Details]
(2007) Males absent on the first MOF: from flies to humans. Oncogene.
Rea, S., Xouri, G., Akhtar, A., (2007) Males absent on the first MOF: from flies to humans. Oncogene. Reviews [Details]
(2010) Core and linker histone modifications involved in the DNA amage response.
Chubb JE, Rea S. Subcell Biochem. (2010) Core and linker histone modifications involved in the DNA amage response. Reviews [Details]