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Natural Sciences

Dr Stephen Rea

B.Sc., Ph.D.

Contact Details

Lecturer
Centre for Chromosome Biology (CCB)
Room G69
School of Natural Sciences
Biomedical Sciences Building
NUI Galway

T: +353 (0)91 495750
E: stephen.rea@nuigalway.ie
W: http://www.chromosome.ie/ccb/rea/index.html http://www.nuigalway.ie/biochemistry/staff/rea/index.html
 
researcher

Biography

  • Director of BSc in Biotechnology programme, NUI Galway 2015-present
  • Lecturer in Biochemistry, NUI Galway 2008-present
  • President of Ireland Young Researcher 2007-2012
  • Postdoc, EMBL, Heidelberg, Germany 2003-07, with Dr Asifa Akhtar
  • PhD, IMP Vienna, Austria, 1998-2002, with Prof Thomas Jenuwein
  • BSc (Biotech), NUI Galway, 1994-98

Research Interests

  • Histone modifications
  • Epigenetics
  • Breast Cancer

Research Projects

  Project Start Date End Date
HMOF AS A DETERMINANT OF BREAST CANCER INVASIVE AND PROLIFERATIVE POTENTIAL BREAST CANCER CAMPAIGN 2011NOVPHD03 STEPHEN REA 01-AUG-12 30-NOV-18

Peer Reviewed Journals

  Year Publication
(2018) 'Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment'
Whitton, L;Apostolova, G;Rieder, D;Dechant, G;Rea, S;Donohoe, G;Morris, DW (2018) 'Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment'. Plos Genetics, 14 [DOI] [Details]
(2016) 'Cognitive Analysis of Schizophrenia Risk Genes That Function as Epigenetic Regulators of Gene Expression'
Whitton, L;Cosgrove, D;Clarkson, C;Harold, D;Kendall, K;Richards, A;Mantripragada, K;Owen, MJ;O'Donovan, MC;Walters, J;Hartmann, A;Konte, B;Rujescu, D;Gill, M;Corvin, A;Rea, S;Donohoe, G;Morris, DW (2016) 'Cognitive Analysis of Schizophrenia Risk Genes That Function as Epigenetic Regulators of Gene Expression'. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics, 171 :1170-1179 [DOI] [Details]
(2013) 'Msl2 Is a Novel Component of the Vertebrate DNA Damage Response'
Lai, Z,Moravcova, S,Canitrot, Y,Andrzejewski, LP,Walshe, DM,Rea, S (2013) 'Msl2 Is a Novel Component of the Vertebrate DNA Damage Response'. Plos One, 8 [DOI] [Details]
(2010) 'Core and Linker Histone Modifications Involved in the DNA Damage Response'
Chubb, JE,Rea, S,Nasheuer, HP (2010) 'Core and Linker Histone Modifications Involved in the DNA Damage Response'. Genome Stability And Human Diseases, 50 :17-42 [DOI] [Details]
(2008) 'The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma'
Pfister, S., Rea, S., Taipale M., Mendrzyk, F., Straub, B., Ittrich, C., Thuerigen, O., Sinn, H.P., Lichter, P. and Akhtar, A. (2008) 'The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma'. Int J Can, 122 (6):1207-1213 [Details]
(2007) 'Reversal of H3K9Me2 by a small molecule inhibitor for the G9a histone methyltransferase'
Kubicek, S, O'Sullivan, RJ, August, EM, Hickey, ER, Zhang, Q, Teodoro, ML, Rea, S, Mechtler, K, Kowalski, JA, Homon, CA, Kelly, TA and Jenuwein, T. (2007) 'Reversal of H3K9Me2 by a small molecule inhibitor for the G9a histone methyltransferase'. Mol. Cell, 25 (3):473-481 [Details]
(2005) 'hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells'
Taipale, M., Rea, S., Richter, K., Vilar, A., Lichter, P., Imhof, A., and Akhtar, A. (2005) 'hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells'. Mol Cell Biol, 25 :6798-6810 [Details]
(2002) 'Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing'
Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J., Rea, S., Jenuwein, T., Dorn, R., and Reuter, G. (2002) 'Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing'. Embo J, [Details]
(2001) 'Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins'
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001) 'Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins'. Nature, 410 :116-120 [Details]
(2000) 'Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression'
O'Carroll, D., Scherthan, H., Peters, A. H., Opravil, S., Haynes, A. R., Laible, G., Rea, S., Schmid, M., Lebersorger, A., Jerratsch, M., Sattler, L., Mattei, M. G., Denny, P., Brown, S. D., Schweizer, D., and Jenuwein, T. (2000) 'Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression'. Mol Cell Biol, [Details]
(2000) 'Regulation of chromatin structure by site-specific histone H3 methyltransferases'
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z. W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., and Jenuwein, T. (2000) 'Regulation of chromatin structure by site-specific histone H3 methyltransferases'. Nature, 406 :593-599 [Details]

Reviews

  Year Publication
(2010) Core and linker histone modifications involved in the DNA amage response.
Chubb JE, Rea S. Subcell Biochem. (2010) Core and linker histone modifications involved in the DNA amage response. Reviews [Details]
(2007) Males absent on the first MOF: from flies to humans. Oncogene.
Rea, S., Xouri, G., Akhtar, A., (2007) Males absent on the first MOF: from flies to humans. Oncogene. Reviews [Details]
(2006) MSL proteins and the regulation of gene expression. Curr Top Microbiol Immunol.
Rea, S., Akhtar, A., (2006) MSL proteins and the regulation of gene expression. Curr Top Microbiol Immunol. Reviews [Details]