Dr Sergey Alexandrov

Ph.D

Contact Details

Post Doctoral Researcher
School of Physics
NUI Galway

E: sergey.alexandrov@nuigalway.ie
 
researcher

Biography

Sergey Alexandrov received his Ph.D. from St. Petersburg State University, St. Petersburg, Russia. Currently he is a Researcher at School of Physics, the National University of Ireland in Galway. Before Ireland he worked as a Research Associate with the University of Pittsburgh, Department of Medicine, PA, USA and as a Research Assistant Professor with Optical Biomedical Engineering Laboratory (OBEL), Department of Electrical, Electronic & Computer Engineering, at the University of Western Australia (UWA). His research interests are optics, biomedical optics, optical imaging, including optical microscopy, super-resolution, optical coherence tomography (OCT), development of novel optical imaging approaches for different applications, including medicine and biology. His main experience is development of new optical methods and tools, such as microscopic imaging and measuring techniques (holographic, interference, polarization, spectral, etc.) for biomedical and other applications. Significant contribution has resulted in the creation of new optical microscopy and optical coherence tomography (OCT) methods and techniques for high resolution (super-resolution) imaging, non-destructive testing, diagnostic and its application to different objects, including biomedical. 

Research Interests

My research interests are optics, biomedical optics, optical imaging, including optical microscopy, super-resolution microscopy, optical coherence tomography (OCT). I am interested and work on development of novel optical imaging approaches for different applications, including medicine and biology.

Peer Reviewed Journals

  Year Publication
(2015) 'Novel approach for label free super-resolution imaging in far field'
S. Alexandrov, J. McGrath, H. Subhash, F. Boccafoschi, C. Giannini and Martin Leahy (2015) 'Novel approach for label free super-resolution imaging in far field'. Scientific Reports, 5 (srep13274) [DOI] [Details]
(2014) 'Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures'
Alexandrov, S,Subhash, H,Leahy, M (2014) 'Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures'. Quantum Electronics, 44 :657-663 [DOI] [Details]
(2014) 'In vivo imaging of human microcirculation with linear-array based photoacoustic tomography: a feasibility study for clinical application'
H. Subhash, S. Alexandrov, H. Zafar, J. Jose, M.J. Leahy (2014) 'In vivo imaging of human microcirculation with linear-array based photoacoustic tomography: a feasibility study for clinical application'. Spie Proceedings, 8943 [Details]
(2014) 'Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer'
Liu, Y,Uttam, S,Alexandrov, S,Bista, RK (2014) 'Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer'. Bmc Biophysics, 7 [DOI] [Details]
(2014) 'Nano-sensitive optical coherence tomography'
S. Alexandrov, H. M. Subhash, A. Zam and M. Leahy (2014) 'Nano-sensitive optical coherence tomography'. Nanoscale, 6 :3545-3549 [Details]
(2014) 'Nano-sensitive optical coherence tomography (nsOCT) for depth resolved characterization of 3D submicron structure'
S. Alexandrov, H. Subhash, A. Zam, and M. Leahy (2014) 'Nano-sensitive optical coherence tomography (nsOCT) for depth resolved characterization of 3D submicron structure'. Spie Proceedings, 8934 [Details]
(2013) 'Tomographic imaging via spectral encoding of spatial frequency'
S. Uttam, S. Alexandrov, R. K. Bista, and Y. Liu (2013) 'Tomographic imaging via spectral encoding of spatial frequency'. Optics Express, [Details]
(2013) 'Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation'
Uttam, S,Bista, RK,Staton, K,Alexandrov, S,Choi, S,Bakkenist, CJ,Hartman, DJ,Brand, RE,Liu, Y (2013) 'Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation'. Biomedical Optics Express, 4 :596-613 [Details]
(2012) 'Spectral encoding of spatial frequency approach for characterization of nanoscale structures'
S. Alexandrov, S. Uttam, R.K. Bista, K. Staton and Y. Liu (2012) 'Spectral encoding of spatial frequency approach for characterization of nanoscale structures'. Applied Physics Letters, 101 [Details]
(2012) 'Real-time quantitative visualization of 3D structural information'
S. Alexandrov, S. Uttam, R. K. Bista, Chengquan Zhao and Y. Liu (2012) 'Real-time quantitative visualization of 3D structural information'. Optics Express, 20 (8):9203-9214 [Details]
(2011) 'Spectral contrast imaging microscopy'
S. Alexandrov, S. Uttam, R. K. Bista, and Y. Liu (2011) 'Spectral contrast imaging microscopy'. Optics Letters, 36 (17):3323-3325 [Details]
(2010) 'Coherent aperture-synthesis wide-field high-resolution holographic microscopy of biological tissue'
T. Gutzler, T.R. Hillman, S. Alexandrov, D.D. Sampson (2010) 'Coherent aperture-synthesis wide-field high-resolution holographic microscopy of biological tissue'. Optics Letters, 35 (8) [Details]
(2010) 'Three-dimensional depth-resolved and extended-resolution micro-particle characterization by holographic light scattering spectroscopy'
T. Gutzler, T.R. Hillman, S. Alexandrov, D.D. Sampson (2010) 'Three-dimensional depth-resolved and extended-resolution micro-particle characterization by holographic light scattering spectroscopy'. Optics Express, 18 (24) [Details]
(2009) 'Audio frequency optical coherence elastography'
S.G. Adie, B.F. Kennedy, S. Alexandrov, J.J. Armstrong, D.D. Sampson (2009) 'Audio frequency optical coherence elastography'. Phys Med Biol, 54 [Details]
(2009) 'High-resolution, wide-field object reconstruction with synthetic aperture Fourier holographic optical microscopy'
11. T.R. Hillman, T. Gutzler, S. Alexandrov, and D.D. Sampson (2009) 'High-resolution, wide-field object reconstruction with synthetic aperture Fourier holographic optical microscopy'. Optics Express, 17 (10) [Details]
(2008) 'Spatial information transmission beyond a system’s diffraction limit using optical spectral encoding of spatial frequency'
S. Alexandrov, D. D. Sampson (2008) 'Spatial information transmission beyond a system’s diffraction limit using optical spectral encoding of spatial frequency'. Journal Of Optics A-Pure And Applied Optics, 10 (2) [Details]
(2008) 'A first demonstration of audio-frequency optical coherence elastography of tissue'
Adie, S.G., S. Alexandrov, Armstrong, J.J., Kennedy, B.F., Sampson, D.D. (2008) 'A first demonstration of audio-frequency optical coherence elastography of tissue'. Spie Proceedings, 7139 [Details]
(2006) 'Microscopic particle discrimination using spatially-resolved Fourier-holographic light scattering angular spectroscopy'
T.R. Hillman, S. Alexandrov, T. Gutzler, and D.D. Sampson (2006) 'Microscopic particle discrimination using spatially-resolved Fourier-holographic light scattering angular spectroscopy'. Optics Express, 14 (23) [Details]
(2006) 'Synthetic aperture Fourier holographic optical microscopy'
S. Alexandrov, T.R. Hillman, T. Gutzler, and D.D. Sampson (2006) 'Synthetic aperture Fourier holographic optical microscopy'. Physical Review Letters, 97 [Details]
(2006) 'Particle sizing with spatially resolved Fourier-holographic light scattering angular spectroscopy'
S. Alexandrov, T.R. Hillman, T. Gutzler, M.B. Same, and D.D. Sampson (2006) 'Particle sizing with spatially resolved Fourier-holographic light scattering angular spectroscopy'. Spie Proceedings, 6081 [Details]
(2005) 'Spatially resolved Fourier holographic light scattering angular spectroscopy'
S. Alexandrov, T.R. Hillman and D.D. Sampson (2005) 'Spatially resolved Fourier holographic light scattering angular spectroscopy'. Optics Letters, 30 (24) [Details]
(2004) 'Refractive index tomography of turbid media by bifocal optical coherence refractometry'
A.V. Zvyagin, S. Alexandrov, K. K. M. B. D. Silva, T. R. Hillman, J. J. Armstrong, T. Tsuzuki, D. D. Sampson (2004) 'Refractive index tomography of turbid media by bifocal optical coherence refractometry'. Spie Proceedings, 5316 [Details]
(2003) 'Bifocal optical coherence refractometry of turbid media'
S. Alexandrov, A.V. Zvyagin, K.K.M.B.D.Silva, D.D.Sampson (2003) 'Bifocal optical coherence refractometry of turbid media'. Optics Letters, 28 (2) [Details]
(2003) 'In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography'
J.J. Armstrong, M.S. Leigh, I.D. Walton, A.V. Zvyagin, S. Alexandrov, S. Schwer, D.R. Hillman, P.R. Eastwood and D.D. Sampson (2003) 'In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography'. Optics Express, 11 (15) [Details]
(2003) 'Refractive index tomography of turbid media by bifocal optical coherence refractometry'
A.V. Zvyagin, K.K.M.B.D. Silva, S. Alexandrov, T.R. Hillman, J.J. Armstrong, T. Tsuzuki and D.D. Sampson (2003) 'Refractive index tomography of turbid media by bifocal optical coherence refractometry'. Optics Express, 11 (25) [Details]
(2000) 'Interference method for determination of the refractive index and thickness'
S. Alexandrov, I.V. Chernyh (2000) 'Interference method for determination of the refractive index and thickness'. Optical Engineering, 39 (9) [Details]
(1998) 'Incoherent method of hologram formation'
24. S. Alexandrov (1998) 'Incoherent method of hologram formation'. Optics And Spectroscopy, 85 (6) [Details]
(1997) 'Laser interferometer for determination of refractive index and thickness'
S. Alexandrov, I.V. Chernyh, P.T. Lischenko (1997) 'Laser interferometer for determination of refractive index and thickness'. Spie Proceedings, 3134 [Details]
(1996) 'Interference refractometer and thicknessmeter'
S. Alexandrov, I.V. Chernyh, V.N. Korban (1996) 'Interference refractometer and thicknessmeter'. Spie Proceedings, 2769 [Details]
(1996) 'Laser specklometer for determining the biomechanical parameters of skeletal muscles and the microhaemodynamics of human skin'
L.V. Tanin, S.C. Dick, S.A. Alexandrov, M.M. Loiko, A.A. Kumeisha, I.V. Markhvida, L.A. Vasilevskaya (1996) 'Laser specklometer for determining the biomechanical parameters of skeletal muscles and the microhaemodynamics of human skin'. Spie Proceedings, 2769 [Details]
(1996) 'Holographic polarization interferometry'
S. Alexandrov (1996) 'Holographic polarization interferometry'. Journal Of Optics A-Pure And Applied Optics, 5 :767-776 [Details]

Conference Publications

  Year Publication
(2013) Modelling Cerebral Blood Oxygenation using Monte Carlo XYZ-PA
Zam, A,Jacques, SL,Alexandrov, S,Li, YZ,Leahy, MJ (2013) DYNAMICS AND FLUCTUATIONS IN BIOMEDICAL PHOTONICS IX Modelling Cerebral Blood Oxygenation using Monte Carlo XYZ-PA [DOI] [Details]

Conference Contributions

  Year Publication
(2014) BiOS at SPIE Photonics West symposium,
S. Alexandrov, H. Subhash, A. Zam, and M. Leahy (2014) Oral presentation: Nano-sensitive optical coherence tomography (nsOCT) for depth resolved characterization of 3D submicron structure. [Oral Presentation], BiOS at SPIE Photonics West symposium, San Francisco, California, USA , 01-FEB-14 - 06-FEB-14. [Details]
(2014) OSA Topical Meeting and Exhibit Biomedical Optics (BIOMED),
Sergey Alexandrov, Hrebesh Subhash, and Martin Leahy (2014) Oral presentation: Adaptation of the spectral encoding of spatial frequency approach to optical coherence tomography (OCT). [Oral Presentation], OSA Topical Meeting and Exhibit Biomedical Optics (BIOMED), Miami, Florida, USA Miami Hilton Downtown , 26-APR-14 - 30-APR-14. [Details]
(2014) SFM’14, International Symposium Optics and Biophotonics-II,
S. Alexandrov, J. McGrath, H. Subhash and M. Leahy (2014) Gave Invited internet presentation: Depth resolved visualization of submicron structure with nano-sensitive optical coherence tomography (nsOCT). [Invited Lecture], SFM’14, International Symposium Optics and Biophotonics-II, Saratov, Russia , 23-SEP-14 - 26-SEP-14. [Details]
(2014) Scottish Microscopy Group and the Microscopy Society of Ireland First Joint Meeting,
Sergey Alexandrov, James McGrath, Hrebesh Subhash and Martin Leahy (2014) gave oral presentation: Depth resolved visualization of nano-scale alterations of sub-micron structure. [Oral Presentation], Scottish Microscopy Group and the Microscopy Society of Ireland First Joint Meeting, Glasgow Science Centre, Scotland , 27-NOV-14 - 28-NOV-14. [Details]
(2014) OSA International Meeting on Biomedical Optics, BIOMED 2014,
Sergey Alexandrov (2014) Served as a Presider for the Session: BM2B Optical Quantification of Nanoarchitecture and Microstructure of Cells and Tissues. [Chaired Session], OSA International Meeting on Biomedical Optics, BIOMED 2014, Miami, Florida, USA , 26-APR-14 - 30-APR-14. [Details]
(2014) International Meeting on Biomedical Optics, BIOMED 2014,
Sergey Alexandrov (2014) Invited in Program Committee at BIO 7: Optical Spectoscopy with Applications. [Program Committee], International Meeting on Biomedical Optics, BIOMED 2014, Miami, Florida, USA , 26-APR-14 - 30-APR-14. [Details]
(2013) BiOS at SPIE Photonics West 2013,
Sergey Alexandrov, Shikhar Uttam, Rajan K. Bista, and Yang Liu (2013) Oral presentation: Spectral encoding of spatial frequency approach for characterization of 3D structures. [Oral Presentation], BiOS at SPIE Photonics West 2013, San Francisco, California, USA , 02-FEB-13 - 07-FEB-13. [Details]
(2013) Photonics Ireland 2013,
Sergey Alexandrov, Azhar Zam, Hrebesh Subhash and Martin Leahy (2013) Gave oral presentation: PROBING OF SUBMICRON STRUCTURE OF LABEL FREE OBJECTS WITH NANOSCALE SENSITIVITY. [Oral Presentation], Photonics Ireland 2013, Belfast, Ireland , 04-SEP-13 - 06-SEP-13. [Details]
(2013) Microscopy Society of Ireland 37th Annual Symposium,
S Alexandrov (2013) Invited lecture: Spectral encoding of spatial frequency approach to probe 3D structures. [Invited Lecture], Microscopy Society of Ireland 37th Annual Symposium, Galway, Ireland , 21-AUG-13 - 23-AUG-13. [Details]
(2013) BioPhotonics & Imaging Conference BioPIC 2013,
Sergey Alexandrov, Shikhar Uttam, Rajan K. Bista, Kevin Staton, and Yang Liu (2013) Poster presentation: SPECTRAL ENCODING OF SPATIAL FREQUENCY APPROACH FOR VISUALIZATION AND CHARACTERIZATION OF 3D STRUCTURES. [Poster Presentation], BioPhotonics & Imaging Conference BioPIC 2013, Dublin, Ireland , 25-MAR-13 - 27-MAR-13. [Details]
(2013) BIOS 2013, part of SPIE Photonics West 2013 Congress,
Sergey Alexandrov (2013) Was invited to be a Panel member to discuss Harnessing Biophotonics to study Tissue Biomechanics. [Other], BIOS 2013, part of SPIE Photonics West 2013 Congress, San Francisco, USA , 02-FEB-13 - 07-JAN-13. [Details]

Correction

  Year Publication
(2013) Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation: erratum (vol 4, pg 596, 2013).
Uttam, S,Bista, RK,Staton, K,Alexandrov, S,Choi, S,Bakkenist, CJ,Hartman, DJ,Brand, RE,Liu, Y (2013) Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation: erratum (vol 4, pg 596, 2013). Correction [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2013 Most Technologically Innovative Poster award at Biophotonics and Imaging Conference BioPIC 2013, Dublin, Ireland. Biophotonics and Imaging Conference BioPIC 2013 panel
2014 Microscopy Society of Ireland (MSI) Conference Travel Award Microscopy Society of Ireland