Dr Sanjeev Gupta

B.Sc.,M.Sc.,Ph.D

 
researcher
 

Biography

Education

1997- 2002                  Ph.D
                                   Centre for Cellular and Molecular Biology.
                                   Jawaharlal Nehru University, New Delhi, India
                                    Award date: 20 May, 2002

1994- 1996                  Master of Science (M. Sc.) Biochemistry
                                    First class, Hamdard University, New Delhi, India

1991- 1994                  Bachelor of Science (B. Sc.)
                                    First class, Delhi University, Delhi, India

Employment

Post-doctoral fellow                       Kimmel Cancer Center, Thomas Jefferson University
                                                        Philadelphia, USA. 2003 to 2006.

Assistant Professor                         Indian Institute of Technology-Madras (IIT-Madras),
(fixed term)                                     Department of Biotechnology, Chennai, India. 2006-2007.

Senior Researcher                           School of Natural Sciences & NCBES, National University of Ireland,
                                                        Galway, September 2007-2010.                                   

Lecturer                                          School of Medicine, Discipline of Pathology National University of Ireland,                                                        Galway, October 2010-present.

Peer Reviewed Journals

  Year Publication
(2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'
Cawley, K;Deegan, S;Samali, A;Gupta, S (2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'. Methods In Enzymology: Unfolded Protein Response And Cellular Stress, Vol 490, Pt B, 490 :31-51 [DOI] [Details]
(2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Gupta, A;Caffrey, E;Callagy, G;Gupta, S (2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. Biochemical Society Transactions, 40 :752-758 [DOI] [Details]
(2013) 'Prognostic Significance of Deregulated Dicer Expression in Breast Cancer'
Caffrey, E;Ingoldsby, H;Wall, D;Webber, M;Dinneen, K;Murillo, LS;Inderhaug, C;Newell, J;Gupta, S;Callagy, G (2013) 'Prognostic Significance of Deregulated Dicer Expression in Breast Cancer'. Plos One, 8 [DOI] [Details]
(2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'
Gupta, A;Read, DE;Gupta, S (2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'. Methods in Molecular Biology, 1292 :19-38 [DOI] [Details]
(2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'
Kennedy, D,Mnich, K,Oommen, D,Chakravarthy, R,Almeida-Souza, L,Krols, M,Saveljeva, S,Doyle, K,Gupta, S,Timmerman, V,Janssens, S,Gorman, AM,Samali, A (2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'. Cell Death & Disease, 8 [DOI] [Details]
(2018) 'Investigation of Anemia and Pie Dielectric Properties of Human Blood at Microwave Frequencies'
Santorelli, A;Abbasi, B;Lyons, M;Hayat, A;Gupta, S;O'Halloran, M;Gupta, A (2018) 'Investigation of Anemia and Pie Dielectric Properties of Human Blood at Microwave Frequencies'. Ieee Access, 6 :56885-56892 [DOI] [Details]
(2012) 'Estrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Ananya Gupta, Emer Caffrey, Grace Callagy, Sanjeev Gupta. (2012) 'Estrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. Biochemical Society Transactions, [Details]
(2006) 'cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas'
Hu S, Du M-Q, Park S-M, Alcivar A, Qu L, Gupta S, Tang J, Baens M, Ye H, Lee TH, Marynen P, Riley JL, Yang X (2006) 'cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas'. Journal Of Clinical Investigation, [Details]
(2005) 'Role of p73 in regulating human caspase-1 gene transcription induced by interferon-gamma and cisplatin'
Jain N, Gupta S, Sudhakar Ch, Radha V, Swarup G. (2005) 'Role of p73 in regulating human caspase-1 gene transcription induced by interferon-gamma and cisplatin'. Journal Of Biological Chemistry, [Details]
(2005) 'Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis'
Sadasivam S, Gupta S, Radha V, Batta K, Kundu TK, Swarup G (2005) 'Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis'. Oncogene, [Details]
(2004) 'The carboxy terminal tail of Presenilin regulates Omi/HtrA2 protease activity'
Gupta S, Singh R, Datta P, Zhang Z, Orr C, Lu Z, DuBois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2004) 'The carboxy terminal tail of Presenilin regulates Omi/HtrA2 protease activity'. Journal Of Biological Chemistry, [Details]
(2004) 'Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death'
Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, Gupta S, Bonventre JV, Alnemri ES, Zervos AS (2004) 'Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death'. Journal Of Biological Chemistry, [Details]
(2003) 'Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2'
Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES (2003) 'Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2'. Journal Of Biological Chemistry, [Details]
(2003) 'Loss of Omi/HtrA2 protease activity causes neuromuscular disorder in mnd2 mutant mice'
Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, Alnemri ES. (2003) 'Loss of Omi/HtrA2 protease activity causes neuromuscular disorder in mnd2 mutant mice'. Nature, [Details]
(2002) 'A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis'
Gupta S, Radha V, Sudhakar Ch, Swarup G. (2002) 'A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis'. Febs Letters, [Details]
(2001) 'Direct transcriptional activation of human caspase-1 by tumor suppressor p53'
Gupta S, Radha V, Furukawa Y, Swarup G. (2001) 'Direct transcriptional activation of human caspase-1 by tumor suppressor p53'. Journal Of Biological Chemistry, [Details]
(2001) 'A Nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-myc protein level'
Ganapati U, Gupta S, Radha V, Manogaran PS, Swarup G (2001) 'A Nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-myc protein level'. Experimental Cell Research, [Details]

Conference Publications

  Year Publication
(2016) EACR 24
1. Sanjeev Gupta, Ananya Gupta, Muhammad Mosaraf Hossain, Grace Callagy, Michael Kerin (2016) XBP1 modulates luminal breast cancer by transcriptional regulation of SRC-3 during estrogen signaling EACR 24 [Details]

Other Journals

  Year Publication
(2015) 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis'
A Gupta, D Read, D Oommen, A Samali, S Gupta (2015) 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis' BioRxiv, . [Details]
(2016) 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer'
S Mullarkey, V Arabkari, MM Hossain, S Gupta, A Gupta (2016) 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer' BioRxiv, . [Details]

Conference Contributions

  Year Publication
(2013) BELPSO Meeting,
Logue SE, Deegan S, Saveljeva S, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. (2013) Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. [Oral Presentation], BELPSO Meeting, Ghent , 04-APR-13 - 06-APR-13. [Details]

Editorial

  Year Publication
(2018) miR-17-92 cluster, an oncogenic microRNA cluster acts as a context dependent tumour suppressor in breast cancer.
Hossain, MM,Arabkari, V,Barua, D,Gupta, A,Islam, MN,Gupta, S (2018) miR-17-92 cluster, an oncogenic microRNA cluster acts as a context dependent tumour suppressor in breast cancer. Editorial [Details]

Reviews

  Year Publication
(2009) Bcl-2 family on guard at the ER.
Szegezdi, E;MacDonald, DC;Chonghaile, TN;Gupta, S;Samali, A (2009) Bcl-2 family on guard at the ER. BETHESDA: Reviews [DOI] [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SJM;Gorman, AM;Mousavi-Shafaei, P;Gupta, S;Samali, A (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. AMSTERDAM: Reviews [DOI] [Details]
(2009) The mitochondrial death pathway: a promising therapeutic target in diseases.
Gupta, S;Kass, GEN;Szegezdi, E;Joseph, B (2009) The mitochondrial death pathway: a promising therapeutic target in diseases. HOBOKEN: Reviews [DOI] [Details]
(2013) The eIF2 alpha kinases: their structures and functions.
Donnelly, N;Gorman, AM;Gupta, S;Samali, A (2013) The eIF2 alpha kinases: their structures and functions. BASEL: Reviews [DOI] [Details]