Siobhan McMahon

Lecturer Above The Bar B.Sc., Ph.D.

Contact Details

Lecturer Above The Bar
Department of Anatomy
NUI
Galway

T: Ext. 2838
E: siobhan.mcmahon@nuigalway.ie
 
researcher

Biography

Dr Siobhan McMahon was awarded her B.Sc.(Hons) in Biology from NUI Maynooth in 1994. She was awarded her Ph.D. in 2000 from University College Cork where she investigated the differentiation of radial glial in the developing spinal cord. She continued her research in University College Cork as a postdoctoral research fellow investigating the lineage potential of glial cells in the developing spinal cord. In 2005 she joined REMEDI as a HRB funded postdoctoral fellow. Her research then focused on the use of lentiviral vectors to treat injury in the central nervous system. In November 2006 she took up as position as a lecturer in Anatomy at NUI Galway. Her research currently involves use of stem cells, viral vectors and polymer scaffolds to promote regeneration following spinal cord injury.

Research Interests

spinal cord repair, glial scarring, neurotrophic factors, developmental neurobiology, stem cell biology, gene therapy, scaffolds for spinal cord tissue engineering, rnerve regeneration.

Peer Reviewed Journals

  Year Publication
(2001) 'Proliferation and migration of glial precursor cells in the developing rat spinal cord'
McMahon SS, McDermott KW. (2001) 'Proliferation and migration of glial precursor cells in the developing rat spinal cord'. Journal Of Neurocytology, 30 (9-10):821-828 [Details]
(2002) 'Morphology and Differentiation of Radial Glia in the Developing Rat Spinal Cord'
McMahon, S.S. & McDermott, K.W. (2002) 'Morphology and Differentiation of Radial Glia in the Developing Rat Spinal Cord'. JOURNAL OF COMPARATIVE NEUROLOGY, THE, 454 (3):263-271 [Details]
(2005) 'Role of radial glia in cytogenesis, patterning and boundary formation in the developing rat spinal cord'
McDermott K.W., Barry D.S. & McMahon S.S. (2005) 'Role of radial glia in cytogenesis, patterning and boundary formation in the developing rat spinal cord'. JOURNAL OF ANATOMY, 207 :241-250 [Details]
(2006) 'A comparison of cell transplantation and retroviral gene transfection as tools to study lineage and differentiation in the rat spinal cord'
McMahon, SS,McDermott, KW (2006) 'A comparison of cell transplantation and retroviral gene transfection as tools to study lineage and differentiation in the rat spinal cord'. Journal Of Neuroscience Methods, 152 :243-249 [DOI] [Details]
(2007) 'Developmental potential of radial glia investigated by transplantation into the developing rat ventricular system in utero'
McMahon, SS,McDermott, KW (2007) 'Developmental potential of radial glia investigated by transplantation into the developing rat ventricular system in utero'. Experimental Neurology, 203 :128-136 [DOI] [Details]
(2009) 'Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds'
Madigan NN, McMahon S, O'Brien T, Yaszemski MJ, Windebank AJ. (2009) 'Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds'. Respiratory Medicine, 169 (2):183-199 [Details]
(2010) 'Spinal cord injury in vitro: modelling axon growth inhibition. '
Abu-Rub M, McMahon S, Zeugolis DI, Windebank A, Pandit A.  (2010) 'Spinal cord injury in vitro: modelling axon growth inhibition. '. Drug Discov Today, 15 (11-12):436-443 [Details]

Abstract

  Year Publication
(2007) Analysis of cellular environment of the injured rat spinal cord following treatment with cyclosporin A.
McMahon, S,Brennan, S,Kelly, J,O'Brien, L,Ryan, E,Dockery, P,Rooney, G,Moran, C,Windebank, A,Barry, F (2007) Analysis of cellular environment of the injured rat spinal cord following treatment with cyclosporin A. Abstract [Details]
(2008) An ultrastructural study of the effect of silencing NG2 inhibitory factor.
McMahon, S,Dockery, P,Donnelly, E,Fraher, J,Strappe, P,O'Brien, T (2008) An ultrastructural study of the effect of silencing NG2 inhibitory factor. Abstract [Details]
(2009) AN ASTROCYTE-DORSAL ROOT GANGLION CO-CULTURE MODEL TO ASSESS NEURITE OUTGROWTH FROM LENTIVIRAL VECTOR EXPRESSED NEUROTROPHIN-3.
McMahon, S,Rooney, G,Donnelly, E,O'Brien, T,Fraher, J,Windebank, A,Dockery, P,Hampton, D,Strappe, P (2009) AN ASTROCYTE-DORSAL ROOT GANGLION CO-CULTURE MODEL TO ASSESS NEURITE OUTGROWTH FROM LENTIVIRAL VECTOR EXPRESSED NEUROTROPHIN-3. Abstract [Details]

Conference Poster

  Year Publication
(2007) Effect of lentiviral vector expressing neurotrophin-3 on neurite outgrowth following spinal cord injury. Irish Society for Gene and Cell Therapy Meeting Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway.
McMahon S.S., Donnelly E., Fraher J.P., Dockery P., O'Brien T., Strappe P. (2007) Effect of lentiviral vector expressing neurotrophin-3 on neurite outgrowth following spinal cord injury. Irish Society for Gene and Cell Therapy Meeting Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway. Conference Poster [Details]
(2007) Analysis of the Effect of Cyclosporin A on the Cellular Environment of the Injured Rat Spinal Cord. Irish Society for Gene and Cell Therapy Meeting Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway.
Siobhan McMahon, Siobhan Brennan, Johanne Kelly, Laura O'Brien, Éanna Ryan, Peter Dockery, Gemma Rooney, Cathal Moran, Anthony Windebank, Frank Barry. (2007) Analysis of the Effect of Cyclosporin A on the Cellular Environment of the Injured Rat Spinal Cord. Irish Society for Gene and Cell Therapy Meeting Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway. Conference Poster [Details]
(2008) Effect of lentiviral vector expressing Neurotrophin-3 and shRNA for NG2 on cellular environment of injured spinal cord. ESGCT meeting Brugge.
Eleanor Donnelly, Siobhan McMahon, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Lisa McGinley, Timothy O'Brien. (2008) Effect of lentiviral vector expressing Neurotrophin-3 and shRNA for NG2 on cellular environment of injured spinal cord. ESGCT meeting Brugge. Belgium: Conference Poster [Details]
(2008) Thermosensitive Hydrogel For Prolonged Lentivirus Delivery. Neuroscience Ireland Meeting.
S.McMahon, N Nikolskaya, S. Ní Choileán, N. Hennessy, Y. Rochev. (2008) Thermosensitive Hydrogel For Prolonged Lentivirus Delivery. Neuroscience Ireland Meeting. NUI Galway: Conference Poster [Details]
(2008) Regeneration Of Injured Spinal Cord Neurons Through Implantable Polymer Bridges Using A Combined Approach Of Neurotrophic Support And Glial Scar Inhibition.. Neuroscience Ireland Meeting NUI.
N. Madigan, G. Rooney, T. Ritter, F. Barry, A. Windebank, T. O'Brien, S. McMahon. (2008) Regeneration Of Injured Spinal Cord Neurons Through Implantable Polymer Bridges Using A Combined Approach Of Neurotrophic Support And Glial Scar Inhibition.. Neuroscience Ireland Meeting NUI. Galway: Conference Poster [Details]
(2008) Neural stem cells reduce apoptosis following transplantation into injured rat spinal cord.. Neuroscience Ireland Meeting NUI Galway.
Jacqueline Hynes, Elaine Bourke, Eoin McCarthy Deering, Graham Doherty, Andrea Murray, Peter Dockery, Karen Doyle, Adrienne Gorman, Timothy Allsopp, Frank P. Barry, Siobhan S. McMahon. (2008) Neural stem cells reduce apoptosis following transplantation into injured rat spinal cord.. Neuroscience Ireland Meeting NUI Galway. Conference Poster [Details]
(2008) Analysis of Neural Stem Cells Following Transplantation into Injured Rat Spinal Cord. Irish Society for Gene and Cell Therapy Meeting University College Cork.
Siobhan S. McMahon, Silke Albermann , Gemma E. Rooney, Timothy O'Brien, Yolanda Garcia, Peter Dockery, Anthony J. Windebank, Timothy E. Allsopp, Frank P. Barry. (2008) Analysis of Neural Stem Cells Following Transplantation into Injured Rat Spinal Cord. Irish Society for Gene and Cell Therapy Meeting University College Cork. Conference Poster [Details]
(2008) Silencing Ng2 Inhibitory Factor And Its Effect On Dorsal Root Ganglia Neurite Outgrowth. Neuroscience Ireland Meeting NUI.
Eleanor Donnelly, Lisa Mcginley, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Nicolas Madigan, Gemma Rooney, Timothy O'Brien, Siobhan McMahon. (2008) Silencing Ng2 Inhibitory Factor And Its Effect On Dorsal Root Ganglia Neurite Outgrowth. Neuroscience Ireland Meeting NUI. Galway: Conference Poster [Details]
(2008) Analysis Of Neuron Cell Surface Glycosylation Differentials In A Chondroitin Sulphate Proteoglycan Inhibitory Environment. Neuroscience Ireland Meeting NUI Galway.
Claire O'Leary, Michelle Kilcoyne, Lokesh Joshi, Peter Dockery, Siobhan McMahon. (2008) Analysis Of Neuron Cell Surface Glycosylation Differentials In A Chondroitin Sulphate Proteoglycan Inhibitory Environment. Neuroscience Ireland Meeting NUI Galway. Conference Poster [Details]
(2008) Silencing NG2 inhibitory factor and its effect on dorsal root ganglia neurite outgrowth. Irish Society for Gene and Cell Therapy Meeting University College Cork.
Eleanor Donnelly, Siobhan McMahon, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Lisa Mcginley, Timothy O'Brien. (2008) Silencing NG2 inhibitory factor and its effect on dorsal root ganglia neurite outgrowth. Irish Society for Gene and Cell Therapy Meeting University College Cork. Conference Poster [Details]
(2008) Analysis of Neural Stem Cells Following Transplantation into Injured Rat Spinal Cord. Neuroscience Ireland Meeting.
Siobhan S. McMahon, Silke Albermann, Gemma E. Rooney, Timothy O'Brien, Yolanda Garcia, Peter Dockery, Anthony J. Windebank, Timothy E. Allsopp, Frank P. Barry. (2008) Analysis of Neural Stem Cells Following Transplantation into Injured Rat Spinal Cord. Neuroscience Ireland Meeting. NUI Galway: Conference Poster [Details]
(2008) Analysis of Cellular Environment of Spinal Cord Lesion Following Transplantation of Neural Stem Cells into Injured Rat Spinal Cord. Meeting of the Anatomical Society of Great Britain and Ireland Nottingham.
Jacqueline Hynes, Elaine Bourke, Eoin McCarthy Deering, Graham Doherty, Andrea Murray, Peter Dockery, Karen Doyle, Adrienne Gorman, Frank P. Barry, Siobhan S. McMahon. (2008) Analysis of Cellular Environment of Spinal Cord Lesion Following Transplantation of Neural Stem Cells into Injured Rat Spinal Cord. Meeting of the Anatomical Society of Great Britain and Ireland Nottingham. Conference Poster [Details]
(2007) Efficiency of lentiviral vector transduction in injured rat spinal cord. A stereological analysis. Meeting of the Anatomical Society of Great Britain and Ireland.
Toal F., Donnelly E., O'Brien T., Kelly J.P., Fraher J.P., Strappe P., Dockery P., McMahon S.S. (2007) Efficiency of lentiviral vector transduction in injured rat spinal cord. A stereological analysis. Meeting of the Anatomical Society of Great Britain and Ireland. Durham: Conference Poster [Details]
(2007) Analysis of Cellular Environment of the Injured Rat Spinal Cord following Treatment with Cyclosporin. 8th European meeting on glial cell function in health and disease London.
A. Siobhan McMahon, Siobhan Brennan, Johanne Kelly, Laura O'Brien, Éanna Ryan, Peter Dockery, Gemma Rooney, Cathal Moran, Anthony Windebank, Frank Barry. (2007) Analysis of Cellular Environment of the Injured Rat Spinal Cord following Treatment with Cyclosporin. 8th European meeting on glial cell function in health and disease London. Conference Poster [Details]
(2007) Effect of Lentiviral Vector Expressing Neurotrophin-3 on Dorsal Root Ganglia Neurite Outgrowth. 8th European meeting on glial cell function in health and disease London.
Donnelly E., McMahon S.S., Strappe P, Rooney G., Fraher J.P., Dockery P., O'Brien T. (2007) Effect of Lentiviral Vector Expressing Neurotrophin-3 on Dorsal Root Ganglia Neurite Outgrowth. 8th European meeting on glial cell function in health and disease London. Conference Poster [Details]
(2008) Glial-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells. SFN Meeting.
Gemma E. Rooney, Siobhan S. McMahon, Thomas Ritter, Yolanda Garcia, Nicolas Madigan, Alexander Flügel, Kim K. Nickander, Peter Dockery, Timothy O'Brien, Linda Howard, Anthony J. Windebank and Frank P. Barry. (2008) Glial-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells. SFN Meeting. San Diego: Conference Poster [Details]

Invited papers

  Year Publication
(2007) Gene and stem cell therapy approaches to treatment of spinal cord injury. Invited speaker. Irish Network for Neural Stem Cell Investigators Trinity College, Dublin.
McMahon, S. (2007) Gene and stem cell therapy approaches to treatment of spinal cord injury. Invited speaker. Irish Network for Neural Stem Cell Investigators Trinity College, Dublin. Invited papers [Details]

Workshops

  Year Publication
(2008) Effect of Neural Stem Cells on Spinal Cord Contusion injury. 12th Annual Hilton Head Workshop entitled, Regenerative Medicine: Advancing to Next Generation Therapies Hilton Head, South Carolina, U.S.A.
McMahon, S. (2008) Effect of Neural Stem Cells on Spinal Cord Contusion injury. 12th Annual Hilton Head Workshop entitled, Regenerative Medicine: Advancing to Next Generation Therapies Hilton Head, South Carolina, U.S.A. Workshops [Details]