Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Immunology

Dr. Bairbre McNicholas

Bairbre's research is focusing on diabetic kidney disease (diabetic nephrology), in particular looking at approaches used in vivo animal and human studies.

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Prof. Rhodri Ceredig

I am a basic cellular and molecular immunologist whose approach to immunology has been heavily influenced by experimental hematology, that is that lymphocytes are the progeny of hematopoietic stem cells and that their development follows many of the general rules of hematology. For my PhD (1980), carried out at the Walter and Eliza Hall Institute, Australia in the group of Prof. Don Metcalf, I characterized the development of functional T lymphocytes in the thymus. For my post-doctoral studies (1980-85) at the Ludwig Institute for Cancer Research, Lausanne, Switzerland I was one of the first to combine flow cytometry, monoclonal antibodies and limiting dilution to quantify a T cell response in vitro. We also identified for the first time, early T cell progenitors in the thymus. In Canberra, Australia (1985-1989) I was responsible for establishing a functional flow cytometry facility at the John Curtin School of Medical Research. With Peter Doherty (Nobel Laureate), we dissected the inflammatory infiltrate in mouse lymphocytic choriomeningitis virus infection and showed that this immune response in vivo obeyed the now-accepted rules of MHC restriction. Whilst Professor of Immunology at the European School of Biotechnology, Université Louis Pasteur, Strasbourg, France (1989-1994) in an institute directed by Prof. Pierre Chambon, I learnt how molecular biology could impact on my own research interests. There, we generated a transgenic mouse over-expressing the cytokine Interleukin-7 (IL-7), a molecule involved both in lymphocyte development and survival. Since that time (1993), I have focused most of my research interest on IL-7. From 2003-2008, I was a guest scientist in the group of Prof. Ton Rolink at the University of Basel, Switzerland. Here, I collaborated with scientists in Basel investigating the immunological properties of mesenchymal stem cells (MSC), the cells that constitute the research focus of REMEDI. Recently, with colleagues in Birmingham and Basel, I have become interested in more general aspects of lymphocyte development and hematopoietic lineage commitment.

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Joana Cabral

Immunology and Regenerative Medicine/Glycosylation

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Eanna Connaughton

Phenotypic, functional and molecular analysis of novel human monocyte subpopulations.

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Tara Sugrue

Tara's research focuses on stem cell biology and immunology in the context of radio-resistance.

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Prof. Matthew Griffin

Professor of Transplant Biology

Immunological Properties of Dendritic Cells in Acute Kidney Injury.
Interactions Between Dendritic Cells and T-cells in Acute Renal Obstruction.

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Lisa O' Flynn

Lisa's project is focusing on the generation of tolerogenic bone marrow derived dendritic cells by gene therapy and chemical modification, for the application in allogeneic transplantation.

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Dr. Bernard Mahon

Mucosal Immunology Laboratory, NUI Maynooth

Examination of the neonatal immune response. We explore how adult derived stem cells can be transplanted even when mismatched (allogeneic transplantation).

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Andreia Ribeiro

Personalised Stem Cell Therapy for Inflammatory Diseases: A Feasibility Study of Whole Blood Testing for Optimising Patient-Specific Stem Cell Potency and Efficacy

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Claas Baustian

The main goal of Claas's project is to determine the relationship between differentiation potential and immune modulatory function in clonally-selected MSCs of mouse and human.

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Stephanie Slevin

Biomarker discovery in monocytes of patients with inflammatory bowel disease

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Dr. Aideen Ryan

The immunologic profile of allogenic differentiated MSCs for therapeutic applications, Immunology & Cancer cell biology, Immunology & Mechanisms of colon cancer metastasis

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Dr. Thomas Ritter

Senior Lecturer in Medicine (Gene Therapy)

Cellular Immunology, Cornea Transplantation, Gene Therapy.

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Nahidul Islam

The main goals of Nahidul's project are to investigate the characteristics of post-traumatic immune-suppression (PTI) following major surgery and to determine the effect of autologous salvaged blood transfusion in modulating PTI.

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Senthilkumar Alagesan

Senthil's research aims to understand how immuno-suppressive drugs and cells can interact with mesenchymal stem cells (MSCs).

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