Cynthia investigates the application of adult human bone marrow derived mesenchymal stem cells to treat osteoarthritis. The aim of her ongoing research is to assess the combination of mesenchymal stem cells (MSCs) and growth/differentiation factor 5 (GDF-5) as a potential therapeutic for arthritis, specifically focusing on the deposition of extracellular matrix proteins.
Caroline is looking into developing methods for the therapeutic delivery of stem cells to the joint defects in an effort to enhance tissue repair in diseases such as osteoarthritis.