Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Principal Investigators

Prof. Frank Barry

Scientific Director of REMEDI

The therapeutic application of adult stem cells, especially mesenchymal stem cells (MSCs) from bone marrow.

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Prof. Noel Caplice

Director, Centre for Research into Vasculer Biology (CRVB), University College Cork

Vascular stem cell biology, atherosclerosis and vascular remodelling with emphasis on translation of ideas to the clinical cardiology arena in areas of novel diagnostics and therapeutics in the field of stem cells, gene delivery and tissue engineering.

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Prof. Rhodri Ceredig

I am a basic cellular and molecular immunologist whose approach to immunology has been heavily influenced by experimental hematology, that is that lymphocytes are the progeny of hematopoietic stem cells and that their development follows many of the general rules of hematology. For my PhD (1980), carried out at the Walter and Eliza Hall Institute, Australia in the group of Prof. Don Metcalf, I characterized the development of functional T lymphocytes in the thymus. For my post-doctoral studies (1980-85) at the Ludwig Institute for Cancer Research, Lausanne, Switzerland I was one of the first to combine flow cytometry, monoclonal antibodies and limiting dilution to quantify a T cell response in vitro. We also identified for the first time, early T cell progenitors in the thymus. In Canberra, Australia (1985-1989) I was responsible for establishing a functional flow cytometry facility at the John Curtin School of Medical Research. With Peter Doherty (Nobel Laureate), we dissected the inflammatory infiltrate in mouse lymphocytic choriomeningitis virus infection and showed that this immune response in vivo obeyed the now-accepted rules of MHC restriction. Whilst Professor of Immunology at the European School of Biotechnology, Université Louis Pasteur, Strasbourg, France (1989-1994) in an institute directed by Prof. Pierre Chambon, I learnt how molecular biology could impact on my own research interests. There, we generated a transgenic mouse over-expressing the cytokine Interleukin-7 (IL-7), a molecule involved both in lymphocyte development and survival. Since that time (1993), I have focused most of my research interest on IL-7. From 2003-2008, I was a guest scientist in the group of Prof. Ton Rolink at the University of Basel, Switzerland. Here, I collaborated with scientists in Basel investigating the immunological properties of mesenchymal stem cells (MSC), the cells that constitute the research focus of REMEDI. Recently, with colleagues in Birmingham and Basel, I have become interested in more general aspects of lymphocyte development and hematopoietic lineage commitment.

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Dr. Alan Colman

Adult stem cells, Differentiation, Drug discovery, Customized stem cells

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Dr. Uri Frank

Senior Lecturer in Zoology

Developmental Biology, Stem Cells in animals and marine organisms, the manipulation of key stem cells and their derivatives

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Prof. Matthew Griffin

Professor of Transplant Biology

Immunological Properties of Dendritic Cells in Acute Kidney Injury.
Interactions Between Dendritic Cells and T-cells in Acute Renal Obstruction.

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Dr. Bernard Mahon

Mucosal Immunology Laboratory, NUI Maynooth

Examination of the neonatal immune response. We explore how adult derived stem cells can be transplanted even when mismatched (allogeneic transplantation).

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Dr. Mary Murphy

Lecturer in Regenerative Medicine & Director of Toxicology, REMEDI

The Biology, Mechanism of action and Use of adult stem cells for tissue regeneration in osteoarthritis.

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Prof. Timothy O'Brien

Director of REMEDI

Development of gene and cell therapy approaches to vascular disease with a special focus on the augmentation of nitric oxide bioavailability.

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Dr. Thomas Ritter

Senior Lecturer in Medicine (Gene Therapy)

Cellular Immunology, Cornea Transplantation, Gene Therapy.

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Dr. Faisal Sharif

Senior Lecturer in Regenerative Medicine

His key area of interest is translational medicine focusing on cardiovascular clinical trials for medical devices and basic science outputs.

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Prof. Sanbing Shen

Stem cells, neuronal differentiation, CNS diseases and underlying mechanisms

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