Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Dr. Aideen Ryan

Postdoctoral Researcher
Phone: 
+353 91 493849
aideen.ryan@nuigalway.ie

The immunologic profile of allogenic differentiated MSCs for therapeutic applications, Immunology & Cancer cell biology, Immunology & Mechanisms of colon cancer metastasis

Researcher in

Research Project Area: 

The focus of Aideen’s research is in the Immunologic profiling of differentiated MSCs in-vitro and in-vivo

Positions Held: 

2010 - Present   Postdoctoral Researcher, Immunology Research Group, REMEDI, NUI, Galway

2006 - 2010   Postdoctoral Researcher, Department of Pharamcology & Therapeutics , NUIG

2005 - 2006   Postdoctoral Researcher, Department of Medicine, UCC & Cork University Hospital

October 2001 - June 2005   Ph.D postgraduate student, Department of Medicine, University College Cork  & Cork University Hospital

May 2001-October 2001   Medical Laboratory Assistant, Portiuncula Hospital, Ballinasloe, Galway

Awards & Honours: 

 

Awards

2010   Poster of Distinction Award, American Gastroenterological Association (AGA) at the Digestive Disease Week 2010, New Orleans, USA “Colon cancer cell NF-кB regulates tumor-associated macrophage polarization and promotes peritoneal metastasis”

2006   Awarded Best Poster, Irish Association of Cancer Research Annual Meeting, Galway “Addressing the “Fas counterattack” controversy: blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo”
 

2004   Irish Cancer Society Oncology Scholars Travel award to attend a Keystone Symposium on ‘Immune Evasion’, Taos, New Mexico (€2000)

2004   Award to attend the British Council/Health Research Board Scientific Writing Workshop

2001   Awarded an independent Enterprise Ireland Research Scholarship (€8000)

2000   Awarded Higher Education Authority (HEA) Postgraduate Scholarship

1999  Award for Highest grades achieved in Microbiology, NUI Galway

 

Honours

2009   Invited reviewer for the international journal ‘Gut’

2009   Invited Oral Presentation at the Irish Epithelial Physiology Group (IEPG), Kilkenny. “The role of NF-κB in colon cancer and inflammation”
 

Selected Publications: 

Ryan AE, Colleran A, O’Gorman A, Mureau C and Egan LJ. 2011 Colon cancer cell NF-кB regulates tumor-associated macrophage polarization and promotes peritoneal metastasis (Submitted to Cancer Research)

Colleran A, Ryan AE, O’Gorman A, Dockery P, Egan LJ. 2010 Autophagosomal IκB-α degradation plays a role in the long term control of tumor necrosis factor- α induced NF-κB activity (Re- Submitted to Journal Biological Chemistry MS ID#: JBC/2010/199950 with approved corrections)

O’Gorman A, Colleran A, Ryan AE, Mann J, Egan LJ. 2010 Regulation of NF-κB responses by epigenetic suppression of IκB-α expression in HCT116 intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. Jul; 299 (1): G96-G105. PMID 20378831

Houston AM, Michael-Robinson JM, Walsh MD, Cummings MC, Ryan AE, Lincoln D, Pandeya N, Jass JR, Radford-Smith GL, O’Connell J. 2008. The ‘Fas counterattack’ is not an active mode of tumor immune evasion in colorectal cancer with high level microsatellite instability. Hum Pathol. Feb; 39 (2) :243-50. PMID 17961631

Ryan AE, Lane S, Shanahan F, O’Connell J, Houston AM. 2006. Fas Ligand expression in human and mouse cancer cell lines; a caveat on over-reliance on mRNA data. J Carcinog. Feb 2; 5:5. PMID 16457714

Ambrose M, Ryan AE, O’Sullivan GC, Dunne C, Barry OP. 2006. Induction of apoptosis in renal cell carcinoma by reactive oxygen species : involvement of extracellular signal-regulated kinase 1/2, p38 δ/γ, cyclooxygenase-2 down regulation, and translocation of apoptosis-inducing factor. Mol Pharmacol. Jun; 69 (6): 1879-90. PMID 16543392

Ryan AE, Shanahan F, O’Connell J, Houston AM. 2006. Fas ligand promotes tumor immune evasion of colon cancer in vivo. Cell Cycle. Feb; 5(3): 246-9. PMID 16418579

Ryan AE, Shanahan F, O’Connell J, Houston AM. 2005. Addressing the’ Fas counterattack ‘controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo. Cancer Research. Nov 1; 65 (21): 9817-23. PMID 16267003

O’Connell J, Houston AM, Kelly R, O’Brien D, Ryan AE, Bennett MW, Nally K. 2002. Rapid development of a qualitative –competitive (qc) RT-PCR assay using a composite primer approach. Methods Mol Biol. 193:93-102. PMID 12325528.

 

Published Abstracts

Raja Affendi Raja Ali, Zulquernain SA, Ryan AE, Colleran A, Hartnett L, O’Gorman A, Lee JM, Egan LJ. 2010. Gastroenterology (In Press) M1808

Colleran A, Ryan AE, O’Gorman A, Liptrot CH, Dockery P, Egan LJ. 2010. Gastroenterology Presentation 557

Ryan AE, Colleran A, O'Gorman A, Mureau C, Egan LJ. 2010. Gastroenterology (In press) W186

Ryan AE, Colleran A, O’Gorman A, Foran E, Egan LJ. 2009. Gastroenterology 136, 5; 147-339

Ryan AE, Shanahan F, O’Connell J, Houston AM. 2005. Gastroenterology 128: 4: T1450 –A-481

Ryan AE, Shanahan F, O’Connell J, Houston AM. 2005. Endoscopy 12 (37) A-18

 

Presentations 

2009   Poster Presentation for American Gastroenterological Association (AGA) at the Digestive Disease Week, Chicago, USA. “Colon cancer cell NF-кB promotes peritoneal metastasis”

2008   Poster Presentation at Keystone Symposium, ‘Inflammation & Cancer’, Colorado, USA. “Colon cancer cell NF-кB promotes peritoneal metastasis"

2008   Poster Presentation at Irish Association of Cancer Research, Newcastle, Co. Down

2005   Oral presentation at the Irish Society of Gastroenterology (ISG), Limerick

2002   Presented research poster at the Annual Medical Research Day, UCC

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