The immunologic profile of allogenic differentiated MSCs for therapeutic applications, Immunology & Cancer cell biology, Immunology & Mechanisms of colon cancer metastasis
Researcher in
The focus of Aideen’s research is in the Immunologic profiling of differentiated MSCs in-vitro and in-vivo
2010 - Present Postdoctoral Researcher, Immunology Research Group, REMEDI, NUI, Galway
2006 - 2010 Postdoctoral Researcher, Department of Pharamcology & Therapeutics , NUIG
2005 - 2006 Postdoctoral Researcher, Department of Medicine, UCC & Cork University Hospital
October 2001 - June 2005 Ph.D postgraduate student, Department of Medicine, University College Cork & Cork University Hospital
May 2001-October 2001 Medical Laboratory Assistant, Portiuncula Hospital, Ballinasloe, Galway
Awards
2010 Poster of Distinction Award, American Gastroenterological Association (AGA) at the Digestive Disease Week 2010, New Orleans, USA “Colon cancer cell NF-кB regulates tumor-associated macrophage polarization and promotes peritoneal metastasis”
2006 Awarded Best Poster, Irish Association of Cancer Research Annual Meeting, Galway “Addressing the “Fas counterattack” controversy: blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo”
2004 Irish Cancer Society Oncology Scholars Travel award to attend a Keystone Symposium on ‘Immune Evasion’, Taos, New Mexico (€2000)
2004 Award to attend the British Council/Health Research Board Scientific Writing Workshop
2001 Awarded an independent Enterprise Ireland Research Scholarship (€8000)
2000 Awarded Higher Education Authority (HEA) Postgraduate Scholarship
1999 Award for Highest grades achieved in Microbiology, NUI Galway
Honours
2009 Invited reviewer for the international journal ‘Gut’
2009 Invited Oral Presentation at the Irish Epithelial Physiology Group (IEPG), Kilkenny. “The role of NF-κB in colon cancer and inflammation”
Ryan AE, Colleran A, O’Gorman A, Mureau C and Egan LJ. 2011 Colon cancer cell NF-кB regulates tumor-associated macrophage polarization and promotes peritoneal metastasis (Submitted to Cancer Research)
Colleran A, Ryan AE, O’Gorman A, Dockery P, Egan LJ. 2010 Autophagosomal IκB-α degradation plays a role in the long term control of tumor necrosis factor- α induced NF-κB activity (Re- Submitted to Journal Biological Chemistry MS ID#: JBC/2010/199950 with approved corrections)
O’Gorman A, Colleran A, Ryan AE, Mann J, Egan LJ. 2010 Regulation of NF-κB responses by epigenetic suppression of IκB-α expression in HCT116 intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. Jul; 299 (1): G96-G105. PMID 20378831
Houston AM, Michael-Robinson JM, Walsh MD, Cummings MC, Ryan AE, Lincoln D, Pandeya N, Jass JR, Radford-Smith GL, O’Connell J. 2008. The ‘Fas counterattack’ is not an active mode of tumor immune evasion in colorectal cancer with high level microsatellite instability. Hum Pathol. Feb; 39 (2) :243-50. PMID 17961631
Ryan AE, Lane S, Shanahan F, O’Connell J, Houston AM. 2006. Fas Ligand expression in human and mouse cancer cell lines; a caveat on over-reliance on mRNA data. J Carcinog. Feb 2; 5:5. PMID 16457714
Ambrose M, Ryan AE, O’Sullivan GC, Dunne C, Barry OP. 2006. Induction of apoptosis in renal cell carcinoma by reactive oxygen species : involvement of extracellular signal-regulated kinase 1/2, p38 δ/γ, cyclooxygenase-2 down regulation, and translocation of apoptosis-inducing factor. Mol Pharmacol. Jun; 69 (6): 1879-90. PMID 16543392
Ryan AE, Shanahan F, O’Connell J, Houston AM. 2006. Fas ligand promotes tumor immune evasion of colon cancer in vivo. Cell Cycle. Feb; 5(3): 246-9. PMID 16418579
Ryan AE, Shanahan F, O’Connell J, Houston AM. 2005. Addressing the’ Fas counterattack ‘controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo. Cancer Research. Nov 1; 65 (21): 9817-23. PMID 16267003
O’Connell J, Houston AM, Kelly R, O’Brien D, Ryan AE, Bennett MW, Nally K. 2002. Rapid development of a qualitative –competitive (qc) RT-PCR assay using a composite primer approach. Methods Mol Biol. 193:93-102. PMID 12325528.
Published Abstracts
Raja Affendi Raja Ali, Zulquernain SA, Ryan AE, Colleran A, Hartnett L, O’Gorman A, Lee JM, Egan LJ. 2010. Gastroenterology (In Press) M1808
Colleran A, Ryan AE, O’Gorman A, Liptrot CH, Dockery P, Egan LJ. 2010. Gastroenterology Presentation 557
Ryan AE, Colleran A, O'Gorman A, Mureau C, Egan LJ. 2010. Gastroenterology (In press) W186
Ryan AE, Colleran A, O’Gorman A, Foran E, Egan LJ. 2009. Gastroenterology 136, 5; 147-339
Ryan AE, Shanahan F, O’Connell J, Houston AM. 2005. Gastroenterology 128: 4: T1450 –A-481
Ryan AE, Shanahan F, O’Connell J, Houston AM. 2005. Endoscopy 12 (37) A-18
Presentations
2009 Poster Presentation for American Gastroenterological Association (AGA) at the Digestive Disease Week, Chicago, USA. “Colon cancer cell NF-кB promotes peritoneal metastasis”
2008 Poster Presentation at Keystone Symposium, ‘Inflammation & Cancer’, Colorado, USA. “Colon cancer cell NF-кB promotes peritoneal metastasis"
2008 Poster Presentation at Irish Association of Cancer Research, Newcastle, Co. Down
2005 Oral presentation at the Irish Society of Gastroenterology (ISG), Limerick
2002 Presented research poster at the Annual Medical Research Day, UCC
