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Dr. Elizabeth Clayton

Research Fellow SBI ElizabethClayton@hotmail.co.uk

Mesenchymal stem cells (MSCs) can be directed to differentiate into various cell types that produce different tissues including fat, bone and cartilage. Elizabeth is studying transcriptional networks in MSCs as part of the Systems Biology Ireland group.

Researcher in

Research Project Area: 

Mesenchymal stem cells (MSCs) can be directed to differentiate into various cell types that produce different tissues including fat, bone and cartilage. The ability to differentiate along the cartilage forming lineage, chondrogenesis, provides great potential for improving cell-based therapies for joint disease and injury. This research project will define in high resolution the changes in gene expression that orchestrate the commitment of MSC’s specifically to the chondrogenic lineage. The association of enzymes that control gene expression, transcription factors, with particular groups of regulated genes will be determined using computational and bioinformatic methods, and tested using molecular and biochemical methods. Gene regulatory networks associated with chondrogenesis will be assembled that define the nuclear and cellular mechanisms that promote cartilage growth and maintenance. This will inform us on the most effective conditioning or treatment of MSCs for enhanced chondrogenesis which may then translate to optimal cartilage repair strategies.

Positions Held: 

2011-Present Research Fellow in Transcriptional Networks, SBI

2007-2011 The University of Edinburgh, MRC Centre for Regenerative Medicine, Postdoctoral Research Fellow

2003-2006 The Hutchison/MRC Research Centre, Cambridge, Cancer Cell Unit, MRC Career Development Fellow

2000-2003 The University of Cambridge/Babraham Institute, PhD, MRC funded Studentship

1998-1999 The University of Cambridge/Babraham Institute, Research Assistant

1995-1997 The National Institute for Medical Research, London, Scientific Officer

Awards & Honours: 

PhD, B-cell signalling and function , Cambridge University
MSc, Medical Molecular Biology, University of Westminster

Selected Publications: 

Clayton E, Doupe D, Klein A, Winton DJ, Simons B, Jones PH. A single type of progenitor cell maintains normal epidermis. Nature. 2007 Mar 8;446(7132):185-9.

Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M. A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med. 2002 Sep 16;196(6):753-63.

Doody GM, Bell SE, Vigorito E, Clayton E, McAdam S, Tooze R, Fernandez C, Lee IJ, Turner M. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol. 2001 Jun;2(6):542-7.

Lorenzini S, Bird TG, Boulter L, Bellamy C, Samuel K, Aucott R, Clayton E, Andreone P, Bernardi M, Golding M, Alison MR, Iredale JP, Forbes SJ. Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut. 2010 May;59(5):645-54.

Clayton E, Forbes SJ. The isolation and in vitro expansion of hepatic Sca-1 progenitor cells. Biochem Biophys Res Commun. 2009 Apr 17;381(4):549-53.

Clayton E, McAdam S, Coadwell J, Chantry D, Turner M. Structural organization of the mouse phosphatidylinositol 3-kinase p110d gene. Biochem Biophys Res Commun. 2001 Feb 9;280(5):1328-32.

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