Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Dr. Khalid Merghani Salih Mohamed

M.D Researcher
+353 91 495039

Intra-articular cartilage regeneration using stem cells loaded composite scaffolds.

Researcher in

Research Project Area: 

Cartilage has a limited ability to repair after injury and this lack may ultimately lead to the development of osteoarthritis in affected joints. However, successful intervention after traumatic injury to joint cartilage may prevent or slow the onset of osteoarthritis. To date tissue engineering of cartilage has met with little success because of limited mechanical integrity and abnormal expression of cartilage collagens in the repair tissue. This project will test the hypothesis that articular hyaline cartilage can be restored using scaffolds seeded with 1) stem cells specifically mesenchymal stem cells (MSC) or 2) gene vectors or stem cells transduced to express genes that either promote hyaline cartilage formation or prevent formation of inappropriate collagens. We will work with traditional scaffolds or novel nano-scaffold materials to treat chondral or osteochondral defects which will be created in a rabbit joint as a model of human disease. The aim of the project will be to reverse the articular damage and create the potential to change the way we treat all articular diseases in humans.

Positions Held: 

November 2010 - Present   M.D Researcher, REMEDI, NUI, Galway for M.D. Degree & Tutor in Orthopaedics, School of Medicine, NUI Galway

October 2008 - Present   M.Sc in Orthopaedic Engineering, School of Engineering, University of Cardiff

July 2009  – June 2010  Registrar Orthopaedics, Galway University Hospital

July 2008  – June 2009  Registrar Orthopaedics, Tullamore General Hospital

January 2008 – June 2008  SHO General Surgery BST, Tullamore General Hospital

January 2007 – December 2007  SHO General Surgery BST, Mullingar General Hospital

January 2007 – July 2007  SHO General Surgery BST, Our Lady's Hospital For Sick Children, Crumlin, Dublin

January 2006 – December 2006  SHO Othopaedics BST, Tullamore General Hospital

May 2005  – October 2005  SHO Orthopaedics, Princess Alexandria Hospital, UK

February – December 2004  SHO Cardiac Surgery, National Centre for Cardiac Surgery, Ahmed Gasim, Sudan

2003 – 2004  SHO in General Surgery, Ribat University Teaching Hospital, Sudan

2001 – 2003  Medical Intern – Orthopaedics/General Surgery/General Medicine/Paediatrics, Ribat University Teaching
Hospital, Sudan/Omdurman University Teaching Hospital, Sudan/Sudanese Chinese Friendship Hospital, Sudan

Professional and Personal Interests: 

Professional Memberships

Founding Member & Head of Research, Society of Endemic Diseases, University of Khartoum, Sudan

Sudanese Surgeons Association

Member of Royal College of Surgeons of Ireland (RCSI)

Member of Société Internationale de Chirurgie Orthopédique et de Traumatologie (SICOT)                                                                                                                                                               

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