Intra-articular cartilage regeneration using stem cells loaded composite scaffolds.
Researcher in
Cartilage has a limited ability to repair after injury and this lack may ultimately lead to the development of osteoarthritis in affected joints. However, successful intervention after traumatic injury to joint cartilage may prevent or slow the onset of osteoarthritis. To date tissue engineering of cartilage has met with little success because of limited mechanical integrity and abnormal expression of cartilage collagens in the repair tissue. This project will test the hypothesis that articular hyaline cartilage can be restored using scaffolds seeded with 1) stem cells specifically mesenchymal stem cells (MSC) or 2) gene vectors or stem cells transduced to express genes that either promote hyaline cartilage formation or prevent formation of inappropriate collagens. We will work with traditional scaffolds or novel nano-scaffold materials to treat chondral or osteochondral defects which will be created in a rabbit joint as a model of human disease. The aim of the project will be to reverse the articular damage and create the potential to change the way we treat all articular diseases in humans.
November 2010 - Present M.D Researcher, REMEDI, NUI, Galway for M.D. Degree & Tutor in Orthopaedics, School of Medicine, NUI Galway
October 2008 - Present M.Sc in Orthopaedic Engineering, School of Engineering, University of Cardiff
July 2009 – June 2010 Registrar Orthopaedics, Galway University Hospital
July 2008 – June 2009 Registrar Orthopaedics, Tullamore General Hospital
January 2008 – June 2008 SHO General Surgery BST, Tullamore General Hospital
January 2007 – December 2007 SHO General Surgery BST, Mullingar General Hospital
January 2007 – July 2007 SHO General Surgery BST, Our Lady's Hospital For Sick Children, Crumlin, Dublin
January 2006 – December 2006 SHO Othopaedics BST, Tullamore General Hospital
May 2005 – October 2005 SHO Orthopaedics, Princess Alexandria Hospital, UK
February – December 2004 SHO Cardiac Surgery, National Centre for Cardiac Surgery, Ahmed Gasim, Sudan
2003 – 2004 SHO in General Surgery, Ribat University Teaching Hospital, Sudan
2001 – 2003 Medical Intern – Orthopaedics/General Surgery/General Medicine/Paediatrics, Ribat University Teaching
Hospital, Sudan/Omdurman University Teaching Hospital, Sudan/Sudanese Chinese Friendship Hospital, Sudan
Professional Memberships
Founding Member & Head of Research, Society of Endemic Diseases, University of Khartoum, Sudan
Sudanese Surgeons Association
Member of Royal College of Surgeons of Ireland (RCSI)
Member of Société Internationale de Chirurgie Orthopédique et de Traumatologie (SICOT)
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