Mikhail's research is looking into novel therapeutic approaches for the induction of tolerance in cornea transplantation.
Researcher in
The development of novel therapeutic approaches for the induction of tolerance in cornea transplantation. This project consists from use of ex-vivo genetically modified viruses which express immunomodulatory molecules as delivery vehicle into the allotransplant and ex-vivo generated tolerogenic dendritic cells or modified mesenchymal stem cells for the induction of tolerance or for the creation of an anti-inflammatory environment in cornea transplantation.
2008-present
Post Doctoral Researcher
REMEDI, NCBES, NUI, Galway
Induction of tolerance on cornea transplantation
2003-2008
Post doctoral Researcher, Department of Neuroimmunology, Max Planck Institute for Neurobiology, Martinsried, Germany
Role of effector T cells in EAE
1998-2003
Researcher, Institute of Experimental Medicine, St.Petersburg, Russia NeuroImmunomodulation
1997-2001 Ph.D Postgraduate Student, Russian Academy of Medical Science, Institute of Experimental Medicine, RAMS, St.Petersburg, Russia
Biophysics
M. Nosov, D. Lodygin, E. Korneva. Significance of animal models of the experimental autoimmune encephalomyelitis in multiple sclerosis research. Journal of Neuroimmunology, 2010. V 8. № 3-4. P. 4-14. (in Russian).
М. Nosov, M. Anton, W. Weber, S. Barabanova, H. Wekerle, H.. Korneva & A. Fluegel. The toxic effect of radioactive substrate of HSV1-TK on antigen specific T cells during noninvasive imaging. Medical Academician Journal. V 10. № 1. P. 24–30. 2010. (in Russian).
T. Ritter, M. Nosov, M. Griffin. Gene Therapy in Transplantation: Towards Clinical Trials. Opinion in Molecular Therapeutics. Curr Opin Mol Ther. 2009 Oct;11(5):504-12.
Flügel, F. Odoardi, M. Nosov, N. Kawakami. (2007) Autoaggressive effector T cells in the course of Experimental Autoimmune Encephalomyelitis visualized in the light of two-photon microscopy. J Neuroimmunol. 2007 Oct 30.
Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, Klinkert WE, Ellwart JW, Bauer J, Lassmann H, Wekerle H, Flugel A Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):920-5. Epub 2007 Jan 9.
Nosov M., Wekerle H., Flügel A. Titration of autoaggressive T cells by HSV-TK suicide system reveals their important role during clinical EAE. Immunobiology, Volume 210, 6-8, 15.09.2005
Nosov MA, Barabanova SV, Glushikhina MS, Kazakova TB, Korneva EA. Antigen-induced activation of hypothalamic cells (assessed by expression of the c-fos gene). Neurosci Behav Physiol. 2002 Sep-Oct;32(5):523-8.
