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Welcome to the Regenerative Medicine Institute (REMEDI®)

Dr. Nicolas Madigan

Postdoctoral Researcher
Phone: 
+353 91 524411
nicolas.madigan@nuigalway.ie

Spinal Cord Injury repair through implantable polymer scaffolds, using a combined approach of MSC neurotrophic support and glial scar inhibition.

Researcher in

Research Project Area: 

A strong international collaboration has been developed here that builds on respective expertise in polymer scaffold bioengineering, mesenchymal stem cell (MSC) and retroviral gene therapy technologies for spinal cord repair. Our approach investigates the growth of different spinal cord neuron populations, supported by selective neurotrophins. We have developed a retrovirus library for transduction of rat MSCs and Schwann cells, engineered to secrete neurotrophic factors. These cell types are seeded into poly (lactic-co-glycolic) acid (PLGA) scaffolds and implanted into transected rat spinal cords. This approach is combined with a siRNA silencing strategies to reduce proteoglycan signals in the glial scar that are inhibitory to axonal growth.

Positions Held: 

 2006-present
Postdoctoral Researcher
National University of Ireland Galway, REMEDI &
Mayo Clinic, Rochester MN USA
Spinal Cord Injury repair through implantable polymer scaffolds, using a combined approach of MSC neurotrophic support and glial scar inhibition.

2004-present
Physician
Department of Medicine, University College Hospital Galway
General Internal Medicine,
Neurology Registrar

2003 - 2005
Research Assistant
National University of Ireland Galway, REMEDI
Drug Inducible Retroviral Systems

2002-2003
Research Assistant
National University of Ireland, Galway - Medical Laboratory
Adeno-Associated Virus gene therapy for Lipid Oxidation in Atherosclerosis

1999-2004
Medical Student
National University of Ireland Galway

Awards & Honours: 

5/2004
MB BCH BAO with Honours

2003
HRB Summer Scholarship Grant, finalist for Watts Medal Competition (top 8 national projects).
 

Selected Publications: 

Glial-Derived Neurotrophic Factor_Expressing Mesenchymal Stem Cells
Survive Transplantation Into the Contused Spinal Cord Without
Differentiating Into Neural Cells
Journal of Neurotrauma, under review.

Search PubMed for Papers by Dr. Nicolas Madigan >>