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Dr. Siobhan Gaughan

091 495272

Laboratory Manager

Positions Held: 

Laboratory Manager
This position involves managing the key resources- functions, people and activities within a busy biomedical research laboratory.

Laboratory Manager and PhD Candidate
The Royal College of Surgeons
This position involved Lab Management and the completion of a PhD Thesis entitled: Epithelial Responses to Inflammation in Cystic Fibrosis.

1998 – 2000
Research Technician
Royal College of Surgeons
Managed Tissue Culture Suites, instructed MD candidates and graduate students in laboratory based techniques.

1997 – 1998
Research technician
Dept of Neuropathology, Beaumont Hospital, Dublin.
Managed Tissue Culture Suites, mentored and instructed MD candidates and graduate students in laboratory based techniques.

1996 -1997
Microbiology Laboratory Technician
Biological Laboratories Ballina, Co. Mayo
Performed Microbiological tests to GMP and GLP standards on pharmaceutical products.

1994 – 1996
Laboratory Technician
Rowett Research Institute, Aberdeen, Scotland
Molecular Biology techniques.


Selected Publications: 

Cell Microbiology
Effect of Pro-inflammatory Stimuli on Mucin Expression and inhibition by Secretory Leuco Protease Inhibitor. Mar; 9 (3) 2007

Journal of Immunology
TLR induced inflammation in cystic fibrosis and non CF airway epithelial cells. July 174 2005

European Respiratory Journal
Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. June 23 (6) 2004

FEBS Letters
Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells. July 546 (2-3) 2003

Increased expression of interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis. June 113 2003

Respiratory Medicine
Release of inflammatory mediators from eosinophils following a hyperosmolar stimulus. August 97 2003

Professional and Personal Interests: 

I enjoy reading, walking and swimming.

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