Udo's research interests are in Antibody Phage Display, Liposome-mediated Gene Delivery, and Biomaterials.
Researcher in
Science Foundation Ireland Research Cluster, Network for Excellence in Biomaterials (NFB)
Next generation of genetically modified (lipofected) stem/ progenitor cells for regenerative medicine/ cardiovascular applications. Antibody-mediated targeting of MSC to osteoarthritic cartilage Liposomal coatings for devices to be used in osteointegration.
Enterprise Ireland Development of Antibody Phage Display Libraries
Science Foundation Ireland Fibrin-mediated Gene Transfer of Engineered Conjugates Encapsulating a therapeutic Gene for Wound Healing Applications
Health Research Board Developing a Degradable Nanoshell for Targeted Gene Delivery of Type VII Collagen
2004 - present
Senior Researcher & Research Fellow
NCBES/REMEDI, NUI, Galway, Ireland.
Gene Therapy (Lipoplexes/ Cardiovascular Research) and Stem Cell Research (Antibody-mediated targeting of osteoarthritic cartilage and liposomal coatings for devices to be used in osteointegration)
P.I. Prof. Timothy O’Brien, M.D.
2001 - 2003
Research Scientist
Hermes Biosciences Inc., South San Francisco, CA, USA. Cancer Treatments (Antibody-targeted liposomes)
1998 - 2001
Postdoctoral fellow
UCSF Cancer Center, San Francisco, CA, USA.
“Targeting immunoliposomes to vascular endothelial receptors“
P.I. John Park, MD.
1997 - 1998
Postdoctoral fellow
California Pacific Medical Center, San Francisco, CA, USA.
“A novel non-viral delivery system for gene therapy“
P.I. Dr. Demetrios Papahadjopoulos.
1993 - 1997 Ph.D Student Max-Planck-Group/ Friedrich-Schiller-University Jena/ Germany
1987 - 1993 B.Sc in Chemistry/Biochemistry Ruhr-University Bochum, NRW, Germany
Research Grants Awarded
2010 - 2012 Science Foundation Ireland Research Cluster, Network for Excellence in Biomaterials (NFB II) one of 15 co PI's
2007 - 2010 Science Foundation Ireland: Research Cluster, Network for Excellence in Biomaterials (NFB I); one of 15 co-PI’s
2008 - 2012
Research Cluster, Network for Excellence in Biomaterials, co-PI
2006 - 2008
Technology Development Award, Development of Antibody Phage Display Libraries, Principal Investigator
2006 - 2009
Research Frontiers Program, Fibrin-mediated Gene Transfer of Engineered Conjugates Encapsulating a therapeutic Gene for Wound Healing Applications. co-PI, grant obtained by Professor Abhay Pandit
2006 - 2009
Research Grant, Developing a Degradable Nanoshell for Targeted Gene Delivery of Type VII Collagen co-PI, grant obtained by Professor Abhay Pandit
PubMed Link: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=Greiser%20U
Most Significant Referred Journal Publications
Kulkarni MM, Greiser U, O'Brien T, Pandit A. A Temporal Gene Delivery System Based on Fibrin Microspheres. Mol Pharm. 2011 Jan 12. [Epub ahead of print]
Hoare, M.٭, Greiser, U.٭, Schu, S., Mashayekhi, K., Eydogan, E., Murphy, M., Barry, F., Ritter, T., and O’Brien, T. ‘Enhanced Lipoplex-Mediated Gene Expression in Mesenchymal Stem Cells Using Reiterated Nuclear Localization Sequence Peptides’. Journal of Gene Medicine 2010: 12: 207-218 PMID:21171649 ٭These authors contributed equally to the publication
Greiser, U., O’Brien, T. and Pandit, A. ‘Liposomal Delivery Mediated by Tissue Engineered Scaffolds’. Trends in Biotechnology 2010: 28: 28- 36
Kulkarni, M., Breen, A., Greiser, U., O’Brien, T. and Pandit, A. ‘Fibrin-lipoplex system for controlled topical delivery of multiple genes‘. Biomacromolecules 2009: 10: 1650-1654.
Holladay, C., Keeney, M., Greiser, U., Murphy, M., O’Brien, T. and Pandit, A. ‘A matrix reservoir for improved control of non-viral gene delivery’. J Control Release. 2009: 136: 220-225
Kealy, B., Liew, A., McMahon, J., Ritter, T., O’Doherty, A., Hoare, M., Greiser, U., Vaughan, E.E., Maenz, M., O’Shea, C., Barry, F. and O’Brien, T. ‘Comparison of viral and nonviral vectors for gene transfer to human endothelial progenitor cells’. Tissue Eng Part C Methods. 2009: 15: 223-231.
Mooney, E; Dockery, P; Greiser, U; Murphy, M; and Barron, V., (in press 2008) ‘Carbon Nanotubules and Mesenchymal Stem cells: Biocompatibility, Proliferation and Differentiation’. Nano Letters.
McMahon, J.M., Conroy, S., Lyons, M., Greiser, U., O’Shea, C., Strappe, P., Howard, L., Murphy, M., Barry, F., and O’Brien, T. (2006) ‘Gene Transfer into Rat Mesenchymal Stem Cells: A Comparative Study of Viral and Non-viral Vectors’. Stem Cells and Development. 2006: 15: 87-96.
Mamot, C., Drummond, D.C., Greiser, U., Hong, K., Kirpotin, D.B., Marks, J.D., and Park, J.W. ‘EGFR-targeted Immunoliposomes Mediate Specific and Efficient Drug Delivery to EGFR- and EGFRvIII-overexpressing Tumor Cells’. Cancer Research. 2003: 63: 3154-3161.
Suarez-Pestana, E., Greiser, U., Sanchez, B., Fernandez, L.E., Lage, A., Perez, R., and Boehmer, F. ‘Growth Inhibition of Human Lung Adenocarcinoma Cells by Antibodies against Epidermal Growth Factor Receptor and by Ganglioside GM3’. British Journal of Cancer.1996: 75: 213-220.
Tomic, S., Greiser, U., Lammers, R., Kharitonenkov, A., Imyanitov, E., Ullrich, A., and Boehmer, F. ‘Association of SH2 Domain Protein Tyrosine Phosphatase with the Epidermal Growth Factor Receptor in Human Tumor Cells- Phosphatidic Acid Activates Receptor Dephosphorylation by PTP 1C’. Journal of Biological Chemistry. 1995: 270: 21277-21284.
Selected invited conference & poster presentations
“Towards antibody targeted, liposome mediated gene delivery to enriched stem cell preparations” invited conference presentation by Udo Greiser, Inaugural Meeting of the Irish Society for Gene and Cellular Therapy, May 2007
Mamot, C., Drummond, D.C., Greiser, U., Hong, K., Kirpotin, D.B., Marks, J.D., Benz, C.C. and Park, J.W., ‘EGFR-targeted Drug Delivery via Immunoliposomes’. Proceedings of the American Association for Cancer Research. 2002: 43: 413.
Greiser, U., Drummond, D.C., Mamot, C., Nielsen, U.B., Zhu, Z., Kirpotin, D.B., Marks, J.D., Hong, K., Benz, C.C., and Park, J.W. ‘Targeting Immunoliposomes to Endothelial Receptors’. Proceedings of the American Association for Cancer Research. 2002
Park, J.W., Kirpotin, D.B., Hong, K., Drummond, D.C., Greiser, U., Mamot, C., Marks J.D. and Benz, C.C. ‘Development of Immunoliposome Technology as a Targeted Drug Delivery System’. NCI, 9th Spore Investigator’s Workshop, Washington. 2001: 9: 49.
Park, J.W., Kirpotin, D.B., Hong, K., Drummond, D.C., Greiser, U., Mamot, C., Marks J.D., and Benz, C.C. ‘Applications of Immunoliposome Technology for Targeted Drug Delivery’. Proceedings of the AACR-NCI-EORTC Meeting, Clin. Cancer Res. 2001: 7: 11.
