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Grace O'Malley

PhD Student g.omalley2@nuigalway.ie

Tumour-stromal interactions in colon cancer

Researcher in

Research Project Area: 

I’m looking into the effects of tumour cell NF-κB on tumour-stromal interactions in colon cancer, with a particular focus on mesenchymal stem cells and cancer-associated fibroblasts. I’m also interested in looking at the effect of exosomes secreted by the different tumour and stromal cell populations on signalling in the tumour microenvironment.

Positions Held: 

Undergraduate – Department of Pharmacology and Therapeutics, NUI Galway

Awards & Honours: 
  • Poster prize – Irish Association for Cancer Research national conference 2015
  • Irish Research Council postgraduate scholarship 2013
  • Charles River project of the year (Dept. of Pharmacology and Therapeutics) 2013
  • Wellcome Trust Biomedical Vacation Scholarship 2012

 

Selected Publications: 

Targeting colon cancer cell NF-κB promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis.
Ryan AE, Colleran A, O'Gorman A, O'Flynn L, Pindjacova J, Lohan P, O’Malley G, Nosov M, Mureau C, Egan LJ. Oncogene. 2014 Apr;0.  PubMed ID: 24704833

Evaluation of cartilage repair by mesenchymal stem calls seeded on a PEOT/PBT scaffold in an osteochondral defect.
Barron V, Merghani G, Shaw G, Coleman CM, Hayes JS, Ansboro S, Manian A, O’Malley G, Connolly E, Nandakumar A et al. Annals of Biomedical Engineering. 2015 PubMed ID 25589372

Research Funding: 

Irish Research Council GOIPG/2013/998

Professional and Personal Interests: 

IMMUNOLOGY, CANCER RESEARCH