Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Joshua Chao

PhD Student j.chao1@nuigalway.ie

Scaffold-Mediated Stem Cell Delivery as an Effective Therapeutic for Critical Limb Ischemia

Researcher in

Research Project Area: 

The central research question of this project is to assess the therapeutic potential of stem cell delivery in re-vascularizing ischemic tissue in patients who present with critical limb ischemia (CLI). CLI is a severe manifestation of peripheral vascular disease typically involving rest pain and tissue loss, and while the optimal treatment of CLI is to re-vascularize using stents/bypass, 40% of patients are not suitable and the only therapeutic option is amputation. The development of new therapies for these “no-option” patients is the principal goal of this project. In collaboration with Galway-based SME Orbsen Therapeutics Ltd, we are interested in exploring the angiogenic potential and immunomodulatory effects of CD362-selected mesenchymal stromal cells (Cyndacel™) in rescuing ischemic complications.

Positions Held: 

2014 – Present Ph.D. Student, Regenerative Medicine Institute (REMEDI), NUI Galway

2012 – 2014 Postgraduate Researcher, Network of Excellence for Functional Biomaterials (NFB), NUI Galway

2008 – 2012 B.S.E. in Biomedical Engineering, Duke University, NC, USA

Selected Publications: 

V.N. Vernekar, C.S. Wallace, M. Wu, J.T. Chao, S. O’Connor, A. Raleigh, A.X. Liu, J.M. Haugh, W.M. Reichert, “Bi-Ligand Surfaces with Oriented and Patterned Protein for Real-Time Tracking of Cell Migration.” Colloids and Surfaces B: Biointerfaces. 123, 225-35. (2014)

J.T. Chao, M.J. Biggs, A.S. Pandit, “Diatoms: A Biotemplating Approach to Fabricating Drug Delivery Reservoirs.” Expert Opinion on Drug Delivery. 11(11), 1687-95. (2014)

J. O’Connor, Y. Lang, J. Chao, H. Cao, L. Collins, B.J. Rodriguez, P. Dockery, D.P. Finn, W. Wang, A. Pandit, “Generation of a Nano-structured Polymer-Silica Composite derived from a Marine Diatom via DE-ATRP Grafting.” Small. 10(3), 469-73. (2014)

Research Funding: 

Irish Research Council Enterprise Partnership Scheme Postgraduate Scholarship. 10/2014 - 09/2018 . €96,000.