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Prof. Matthew Griffin


Professor of Transplant Biology

Immunological Properties of Dendritic Cells in Acute Kidney Injury.
Interactions Between Dendritic Cells and T-cells in Acute Renal Obstruction.

Researcher in

Research Project Area: 

Immunological Properties of Dendritic Cells in Acute Kidney Injury
Interactions Between Dendritic Cells and T-cells in Acute Renal Obstruction

Positions Held: 

July 2008 - Present
Professor of Transplant Biology
National University of Ireland, Galway
Immunology related to kidney disease and transplantation

June 1999 - June 2008
Associate Professor of Medicine
Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Immunology related to vitamin D endocrine system and acute kidney disease.
Immunobiology of kidney transplantation

Jan 1997 - June 1999
Associate Research Fellow
The Ben May Institute, University of Chicago, Chicago, Illinois, USA
Basic immunology related to T-cell activation and regulation

July 1994 - Dec 1996
Nephrology Fellow
Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Pathobiology of Polycystic Kidney Disease.
Clinical Nephrology.

Awards & Honours: 

Charles Medals in Anatomy and Physiology, University College Cork

Final Year Prizes in Medicine, Paediatrics and Overall Marks, University College Cork

University College Cork Ainsworth Scholarship

Mayo Foundation Scholarship, Mayo Clinic, USA

Mayo Clinic Department of Medicine New Investigator Award

Standing Member NIDDK Subcommittee D

Selected Publications: 

Expression of polycystin in mouse metanephros and extra-metanephric tissues.
Kidney Int 1997 52:1196-1205.

Molecular basis of T cell inactivation by CTLA-4.
Science 1998, 282:2263-2266.

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
J Immunol 2000, 164:4433-4442.

Dendritic Cell Modulation by 1,25 dihydroxyvitamin D3 and its Analogs: A VDR-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo.
Proc Natl Acad Sci USA 2001, 98:6800-6805.

Regulation of RelB in dendritic cells by 1,25 dihydroxyvitamin D3 and its analogs.
J. Biol. Chem., 2003, 278: 49378 – 49385.

Antigen presentation by dendritic cells in the renal lymph nodes is linked with systemic and local injury to the kidney.
Kidney Int., 2005, 68:1096-1108

Regulation of relB in dendritic cells via modulated association of vitamin D receptor and histone deacetylase 3 with the promoter.
Proc Natl Acad Sci USA, 2005, 102:16007-16012

Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN).
Am J Transplant, 6:1025-1032, 2006.

Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury.
Kidney Int. 2007, 71:619-628 (Commentary by Nelson PJ, Kidney Int. 2007, 71:604-605.)

A role for dendritic cells in the inflammatory response and influx of IL-17 T-cells following acute renal obstruction.
Kidney Int, In Press 2008.

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