Sanjeev Gupta

Dr Ralf Zwacka

 

Career History

 

Lecturer Above The Bar, NCBES, NUI Galway

 

 

 

Research Interests

 

TRAIL

 

Cancer

 

 

Research Overview

 

 

 

 

 

Selection of key publications:

 

Büneker CK, Yu R, Deedigan L, Mohr A, Zwacka RM. (2012) 'IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells'. Cancer Letters,

Albarenque SM, Zwacka RM, Mohr A. (2011) 'Both human and mouse mesenchymal stem cells promote breast cancer metastasis'. Stem Cell Research

Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Möller P, Zwacka RM, Debatin KM, Fulda S. (2010) 'TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors'. Clinical Cancer Research,

Mohr A, Albarenque SM, Deedigan L, Yu R, Reidy M, Fulda S, Zwacka RM. (2010) 'Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells'. Stem Cells

Richard Jäger and Ralf M. Zwacka (2010) 'The Enigmatic Roles of Caspases in Tumor Development'. Cancers

Büneker C, Mohr A, Zwacka RM (2009) 'The TRAIL-Receptor-1:TRAIL-Receptor-3 & -4 ratio is a predictor for TRAIL sensitivity of cancer cells'. Oncology Reports, 21 :1289-1295

Murray TV, McMahon JM, Howley BA, Stanley A, Ritter T, Mohr A, Zwacka R, Fearnhead HO (2008) 'A non-apoptotic role for caspase-9 in muscle differentiation'. Journal Of Cell Science, 121 :3786-3793

Mohr, A,Buneker, C,Gough, RP,Zwacka, RM (2008) 'MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release'. Oncogene, 27 :763-774

Mohr A, Lyons M, Deedigan L, Harte T, Shaw G, Howard L, Barry F, O'Brien T, Zwacka R. (2008) 'Mesenchymal Stem Cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model'. Journal Of Cellular And Molecular Medicine, 12 :2628-2643

Mohr A, Lyons M, Mohr W, Zwacka RM (2007) 'Gene therapy strategies for colorectal cancer'. Deutsche Medizinische Wochenschrift, 132 :567-570

La Ferla-Bruhl K, Westhoff MA, Karl S, Kasperczyk H, Zwacka RM, Debatin KM, Fulda S. NF-kappaB (2007) 'independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition'. ONCOGENE, 26 :571-582

Weiher H, Zwacka RM. (2007) 'Vitamin D3-24-Hydroxylase (CYP24) as a Potential Target for Intervention with Diabetic and Nondiabetic Nephropathy Clin Lab'. 53 :85-88

Mohr A, Zwacka RM (2007) 'In situ trapping of initiator caspases reveals intermediate surprises'. Cell Biology International, 31 :526-530

Braeuer SJ, Buneker C, Mohr A, Zwacka RM (2006) 'Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells'.Molecular Cancer Research, 4 :715-728

Kasperczyk H, La Ferla-Brühl K, Westhoff MA, Behrend L, Zwacka RM, Debatin K-M, Fulda S. (2005) 'Betulinic acid as new activator of NF-kB: Molecular mechanisms and implications for cancer therapy'. ONCOGENE, 24 :6945-6956

Behrend L, Mohr A, Dick T, Zwacka R (2005) 'MnSOD induces p53-dependent senescence in colorectal cancer cells'.MOLECULAR AND CELLULAR BIOLOGY, 25 :7758-7769

Mohr A, Zwacka RM, Jarmy G, Büneker C, Schrezenmeier H, Döhner K, Beltinger C, Wiesneth M, Debatin K-M, Stahnke K. (2005) 'Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis'. ONCOGENE, 24 :2421-2429

Mohr A, Henderson G, Dudus L, Herr I, Kuerschner T, Debatin K-M, Weiher H, Fisher K, Zwacka RM (2004) 'AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumour regression'. Gene Therapy, 11 :535-545

Mohr A, Zwacka RM, Debatin KM, Stahnke K (2004) 'A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release'. CELL DEATH AND DIFFERENTIATION, 11 :153-154

Behrend L, Henderson G, Zwacka RM (2003) 'Reactive oxygen species in oncogenic transformation'. BIOCHEMICAL SOCIETY TRANSACTIONS, 31 :1441-1444

Stark LA, Din FV, Zwacka RM, Dunlop MG (2001) 'Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells'. FASEB JOURNAL, 15 :1273-1275

Zhou W, Zhang Y, Hosch MS, Lang A, Zwacka RM, Engelhardt JF (2001) 'Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion'. HEPATOLOGY, 33 :902-914

Zanetti M, Zwacka R, Engelhardt J, Katusic Z, O'Brien T. (2001) 'Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia'. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 21 :195-200

Fritz E, Friedl AA, Zwacka RM, Eckardt-Schupp F, Meyn MS (2000) 'The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells'.MOLECULAR BIOLOGY OF THE CELL, 11 :2605-2616

Zwacka RM, Stark L, Dunlop MG (2000) 'NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal cancer cells'. 2 :334-343

Lam EW, Hammad HM, Zwacka R, Darby CJ, Baumgardner KR, Davidson BL, Oberley TD, Engelhardt JF, Oberley LW (2000) 'Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumours'. J DENTAL RESEARCH, 79 :1410-1417

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