Biochemistry Previous years seminar speakers‌ over the last 5 academic years.






Stefan Marciniak

Cambridge University

The role of endoplasmic reticulum microviscosity in alpha1-antitrypsin deficiency

Pavel Baranov


 Genetic decoding diversity: from single genes to the entire genetic codes

 Hans-Dieter Volk

 Charité/ Berlin Centre for Regenerative Therapies

 Impact of immunoaging on regenerative processes

 Gernot Längst

 University of Regensburg

 Targeting non-coding RNA to chromatin by triple helix formation

 Jean-Ehrland Ricci

 University of Nice

 Deciphering the link between metabolism and anti-cancer immunosurveillance

 Pascale Quignon

 University of Rennes   

 Like master like dog: The dog as a spontaneous genetic model

 Leonie Young


 Epigenetic and transcriptomic aberrations in advanced breast cancer

 Patrick Harrison


 Towards therapeutic gene editing for cystic fibrosis

 Lynne-Marie Postovit

 Cancer Research Institute of Northern Alberta

 Cellular plasticity in cancer: mechanisms of adaptation

 Mani Ramaswami


 Mechanisms of perpetual silencing: connecting molecules and modules to cognition

 Anja Göder

 University Medical Center Mainz

 Class I HDACs and phosphatase PP2A influence cell fate decisions upon replication stress

 Martin Lavin

 University of  Queensland

 ATM, role in repair of physiologically-induced DNA DSB and in protecting against lung disease

 Jessica Mar

 University of Queensland

 One of these cells is not like the other – how variability of gene expression highlights regulatory control

 Gerome Breen

 King's College London

 Genetic links to anxiety and depression

 Paul Murray

 UL / University of Birmingham

 The Epstein-Barr virus and the pathogenesis of B cell lymphoma

 Geert Kops

 Hubrecht Institute/ UMC Utrecht

 Make no  mistake: chromosomal instability and karyotype heterogeneity in cancer

 Paul Stothard

 University of Alberta

 Finding causative mutations in livestock: new bioinformatics tools for structural variant discovery and analysis

 Mikko Taipale

 University of Toronto

 Studying 1000 rare diseases at the same time

 David Shore

 University of Geneva 

 Replication fork barrier tolerance mechanisms in budding yeast

 Tomás Ryan


 Information storage in memory engrams

Francesco Ferrari

IFOM, Milan

Chromatin 3D organization and regulation of transcription



Luca Pellegrini

University of Cambridge

Molecular mechanisms of eukaryotic DNA replication, as revealed by structural studies

Olivier Micheau


Targeting TRAIL-R1 or TRAIL-R2 for cancer therapy, a cornelian choice!

Eric Alani


Identifying novel roles for DNA mismatch repair proteins in genetic recombination and repair.

Jop Kind

Hubrecht Institute

Untangling spatial genome organization: new insights from single-cell genomics

Michael Talkowski

Harvard Medical School

Genome structure and function across the neuropsychiatric spectrum

Aziz Aboobaker

University of Oxford

What can we learn from immortal worms? Planarians as model system for animal stem cell biology

Noah Filkenstein

University of Colorado 

Preserving the promise of higher education: our critical roles in excellence and access

John Schwabe

University of Leicester

Unravelling the complexities of histone deacetylase complexes - a structural and functional approach to understanding mechanisms of gene repression

Travis Stracker

Institute for Research in Biomedicine (IRB) Barcelona

Characterization of novel replication stress mediators in development and disease

Daniel Gaffney

Sanger Institute

Understanding the cellular functions of human genetic variation

Fabio Martinon

University of Lausanne

Mechanisms regulating the IRE1-XBP1 branch of the ER-stress response

Tracy Robson

Royal College of Surgeons in Ireland

Harnessing the anti-angiogenic and anti-cancer stem cell properties of FKBPL; discovery to clinic

Terry Orr-Weaver

Whitehead/ MIT

Developmental regulation of DNA replication to control cell size and gene copy number

Massimo Lopes

University of Zurich

Replication fork remodelling upon replication stress in cancer onset and therapy

Zuzana Storchová

TU Kaiserslautern

The consequences of aneuploidy: from Down's syndrome to cancer

Ivan Ahel

University of Oxford

ADP-ribosylation signaling in the regulation of genome stability

Gianpiero Cavalleri

Royal College of Surgeons in Ireland

Genomic insights into the population structure and history of the Irish Travellers

Jeremy Carlton

KCL and the Francis Crick Institute

ESCRT-III coordinates membrane remodelling during mitotic exit

Paul Modrich

Duke University Medical Center

Mechanisms in human DNA mismatch repair



Justin McCarthy


Beyond Alzheimer's disease-a new role for gamma-secretase proteases in cytokine signalling and apoptosis.

Donald McDonnell

Duke University School of Medicine

Identification and exploitation of targetable vulnerabilities in endocrine therapy resistant breast and prostate cancers

Wojiech Niedzwiedz

Oxford University

Molecular mechanism of homologous recombination

Joe Jiricny

University of Zurich

Multifaceted mismatch repair

 Simonetta Piatti

 CRBM Montpellier

 The control of septin dynamics for cytokinesis in  budding yeast

 Anne-Helene Monsoro-Burq

 Institute Curie Paris

 Defining fates in the embryo: inducing the neural crest at the neural border

 Kazutoshi Mori

 Kyoto University

 The unfolded protein response: to mammals and beyond

 Donal OCarroll

 University of Edinburgh

 RNA and the immortal lineage

 Mark Martindale

 University of Florida

 I mesoderm. The origins and evolution of the middle germ layer

 Sue Vaughan

 Oxford Brookes University

 Using 3D microscopy to study the flagellum and cell morphogenesis in the protozoan parasite Trypanosoma brucei

 Helmut Pospiech

 Leibniz Institute on Aging
 Fritz Lipmann Institute (FLI)

 DNA replication stress – When replication goes mad

 Eric Brown

 University of Pennsylvania

 Genomic and proteomic signatures of replication stress

 Daniel Foltz

 Northwestern University, Chicago

 Epigenetic inheritance of human centromeres across cell cycle

Mike Williamson

Department of Molecular Biology and Biotechnology
University of Sheffield

How Proteins Recognise Polysaccharides - Shape not Subtle Stereochemistry

Marc Brehme

Joint Research Center for Computational Biomedicine
RWTH Aachen University

Towards a Global Atlas of Proteostasis Network Deregulation Topologies in the Human Diseasome

Kerry Bloom

UNC Chapel Hill

Building molecular springs that drive chromosome segregation

Niamh O Sullivan

Conway Institute, UCD

Investigating the role of ER protiens in motor neuron degeneration.

Paul Cotter

Teagasc, Moorepark, Cork

Diet, exercise and the gut microbiota; applying knowledge gained from studies with elite athletes

Johannes Krause

Max Planck Institute for the Science of Human History

The genomic history of the Ice Age Europeans

Anton Gartner

Univertsity of Dundee

About knives and worms, new mechanisms to maintain genome integrity

Karl Ekwall


Chd1 and Paf1C control chromatin changes during cell differentiation and quiescence

Olivier Gadal

University of Toulouse

Genetic analysis of RNA polymerase I: Life without specfic subunits

Kevin Hiom

University of Dundee

RNA processing and its impact on genome stability.

Sandra Van Schaeybroeck

Queens University Belfast

Targeted strategies in poor prognostic  molecular subgroups in colorectal cancer

Daniel Murphy

Beatson Institute for Cancer Research,
University of Glasgow

MYC driven metabolic stress is a cancer cell vulnerability

Scott Lujan

National Institute of Environmental Health Science
National Institute of Health  USA

Mapping the mechanisms of genome replication

Jason Swedlow

University of Dundee

The Image Data Resource, for Biological Image Data Access, Integration & Dissemination.

Gerard Brien

Dana-Faber Cancer Institute
Harvard Medical School

BRD9 is a butyryl-lysine reader and functional dependency in synovial sarcoma


Dawn O' Reilly

University of Oxford

The rising stars of the non-coding RNA world

Rebecca Taylor

MRC LMB Cambridge

Understanding the systemic effects of neuronal UPR activation

Laurence Pelletier

LTRI/ University of Toronto

A dynamic protein interaction landscape of the human centrosome- cilium interface

Jordan Raff

University of Oxford

How to build a centrosome

Fanni Gergely

CRUK Cambridge Research Institute

Centrosomes and spindle poles: a productive partnership

Miguel Godinho Ferreira

Gulbenkian, Lisbon

The role of telomeres in cancer and ageing in zebrafish

Palma Rocchi

Marseille Cancerology Research Center, 
Aix-Marseille Université

Targeting Hsp27 stress-induced signaling pathways to restore androgen sensitivity of castration-resistant prostate cancer

Ian Mills

University of Oslo  & Queens University Belfast

Metabolic changes and stress modulation in prostate cancer

Vincenzo  D'Angiolella

CRUK/MRC Oxford Institute for Radiation Oncology

Oncogenic Cullin-Ring ubiquitin Ligases(CRLs): novel targets?  

Stephen Tait

University of Glasgow

Targeting apoptosis in cancer - a double-edged sword

Adele Marston

University of Edinburgh

Pericentromeres and chromosome segregation in mitosis and meiosis

Hitoshi Kurumizaka

Waseda University

Structural basis of chromatin dynamics regulated by histone variants

Alan Irvine


'Genetics and the skin: discoveries and possible recoveries?

Adrian Bracken


Polycomb family members in stem cells and cancer

Isidro Sanchez-Garcia

CSIC/ University of Salamanca

Cancer Stem Cells

 Gary Karpen 

 University of California Berkeley

 Biophysics meets chromatin: Does phase separation regulate heterochromatin formation and function? 


Mark O'Driscoll

University of Sussex

Novel human disorders of cell cycle control and receptor-mediated signal transduction

Frank Kooy

University of Antwerp

Fragile sites and human disease

Tomoyuki Tanaka

University of Dundee

Hidden functions of kinetochores: microtubule attachment and beyond


Queen's University Belfast

Targeting the inhibitors of death receptor-induces apoptosis

Ken Mills

Queen's University Belfast

Integrative genomic analysis to identify novel therapies in myeloid malignancies

Robin Allshire

University of Edinburgh

Establishing and maintaining specialised chromatin domains

Cathal Mahon

University of California

HIV host interactions - from systems to mechanisms

Seamus Martin

Trinity College Dublin

Cell death and inflammation: the how and the why

Sara Buonomo

EMBL Monterotondo

Relations between tri-dimensional nuclear organization and DNA replication timing

Guy Poirier

Laval University Quebec

Identification of poly(ADP-ribosyl)ated proteins complexes during DNA damage signalling: Identification of potential biomarkers

Fabrizio d’Adda di Fagagna

IFOM - FIRC Institute of Molecular Oncology, Milan

Molecular mechanisms of cellular senescence and a novel role of RNA in DNA damage response activation

Ivan Dikic

Goethe University Frankfurt

Ubiquitin networks in regulation of inflammation and autophagy

Phil Barker

University of Montreal

The p75NTR Neurotrophin Receptor: Jack of All Trades, Master of One or Two

Simon Boulton

CRUK London Research Institute

Genome stability and the control of recombination

Ken Wolfe

University College Dublin

Evolutionary rearrangement of yeast chromosomes

Edel Maria Harvey

Dublin City University

The role of histone post-translational modifications in eukaryotic evolution

Kristian Helin

University of Copenhagen

Epigenetic regulation of transcription and cell identity

Anja Groth

University of Copenhagen

Chromatin replication and epigenome maintenance

Lars Jansen

Gulbenkian Institute, Oeiras

Chromatin inheritance at the centromere and beyond

David Ron

University of Cambridge

Protein folding homeostasis in the endoplasmic reticulum

Eric Bullinger

University of Magdeburg

Understanding Biological Systems via Dynamical Modelling & Signal Analysis

Gary Gorbsky

Oklahoma Medical Research Foundation

Navigating the metaphase-anaphase transition in mitosis


Albert Einstein College of Medicine, New York.

Regulatory elements in the meta-epigenome


University of Oxford

Molecular mechanisms governing programmed and unscheduled genomic rearrangements

Nick Kent

Cardiff University

Sequencing chromatin architectures

Mark Petronczki

CRUK London Research Institute

Control of cytokinesis and the dark side of the force


Helder Maiato 

IMCB Porto 

A chromosome separation checkpoint 

Lisa Prendergast 

Institut Curie 

Switching states: How centromeres become mitotically competent

Constantinos Koumenis

University of Pennsylvania

The Unfolded Protein Response in malignancy: Problems and therapeutic opportunities

Behzad Kharabi 

University Hospital RWTH, Aachen

Don’t stress out! A lesson about ER stress and chaperones in hematological malignancies

Jeroen Raes

University of Leuven 

Studying the gut microbiome using metagenomics

Petr Cejka 

University of Zurich 

Homologous recombination: the beginning and the end 

Patrick Legembre 

University of Rennes 

Pro-oncogenic role of CD95 in Triple negative breast cancers and development of a therapeutic approach to block it 

Jacqueline Jacobs 

Netherlands Cancer Institute 

Control of DNA repair activity at mammalian telomeres 

Martin Leverkus 

University of Heidelberg 

Decisions, decisions:  Regulation of apoptotic and necroptotic cell death in skin cancer

Doug Higgs

University of Oxford

Switching genes on and off in haematopoiesis

Imre Berger 

EMBL Grenoble 

Insights into structure and assembly of a megadalton transcription regulator, human TFIID

Maria Carmo-Fonseca

University of Lisbon

Imaging pre-mRNA in real time

Luke O'Neill 


New frontiers in inflammation research 

Richard Meehan 

MRC Human Genetics Unit

Epigenetics and identity 

Aidan Doherty

University of Sussex

Unraveling the roles of primase-polymerases in genome repair and replication