Prof. Terry Smith

BA Mod, MA, D.PHIL

Contact Details

Professor of Biomedical Engineering Science
National Centre for Biomedical Engineering Science (NCBES)
Room 215
Orbsen Building
NUI Galway
University Road
Galway

T: +353 91 492022
E: terry.smith@nuigalway.ie
Professor
SCHOOL OF NATURAL SCIENCES
NUI GALWAY

T: Ext. 2022
E: terry.smith@nuigalway.ie
 
researcher

Biography

Professor Terry Smith obtained a BA. Moderatorship Degree in Microbiology, from Trinity College Dublin, in 1981. He was employed as a research scientist in the R&D division of the pharmaceutical company, G.D. Searle, High Wycombe, UK (1981 - 1984), before undertaking a Ph.D. degree at Oxford University.  His Ph.D. research investigated the molecular basis of the devastating human genetic disease, Duchenne's Muscular Dystrophy (DMD); he was awarded a D. Phil. degree from Oxford University in 1988. Having completed a Muscular Dystrophy Society post-doctoral Fellowship at Oxford (1987-1988), he was awarded a European Molecular Biology Organisation (EMBO) Long-term Post-doctoral Fellowship to work in the laboratory of Professor Oliver Smithies, 2007 Nobel Laureate in Medicine, at the University of North Carolina (UNC), Chapel Hill, where he worked on the development of an animal model for human atherosclerosis using mouse embryonic stem cells (1988 - 1990). In 1990, Prof. Smith took up a Senior Research Scientist and Team Leader position at the National Diagnostics Centre (BioResearch Ireland) at NUI Galway, where he headed up the DNA Diagnostics laboratory. In 1994, Prof. Smith was appointed General Manager of the National Diagnostics Centre, a post he held until 2001. 

Professor Smith was a founder member of the National Centre for Biomedical Engineering Science (NCBES), established at NUI Galway in 1999, and was appointed Professor of Biomedical Engineering Science and Director of the NCBES in January 2002.  He led the development, growth and evolution of the Centre's research programmes in Biomedical Science and Engineering.  As NCBES Director, he played a leadership role in the successful submission to the SFI CSET programme in 2003, leading to the establishment of the Regenerative Medicine Institute (REMEDI). He also played a key role in the establishment of the Network for Functional Biomaterials (NFB), in 2007, and the Alimentary Glycosciences Research Centre (AGRC) in 2009. Professor Smith led the NUI Galway research team in the Centre for BioAnalytical Sciences (CBAS), a partnership with Bristol Myers Squibb company and Dublin City University. He also led the negotiation of a four-year €7.3 million research collaboration in molecular diagnostics assay development and commercialisation, with Beckman Coulter Incorporated, 2008 - 2011), and he was Research Director of this programme until its completion.

Professor Smith was appointed Vice President for Research at NUI Galway in July 2008, a post he held until December 2012.  In this role, Professor Smith led the NUI Galway HEA PRTLI 5 Institutional submission in 2010, resulting in the University securing over €65 million from the HEA and private funders.  The most successful Institutional award in NUI Galway's history, the award, included funding for three research buildings (Biosciences; Arts Humanities and Social Sciences; and Translational Research) and a range of structured PhD programmes. He also played a lead role in the establishment of Bionnovate Ireland, a Medical Technologies training and innovation initiative, and the NUI Galway Hardiman Scholarship programme.  As VP Research, he led the University's strategic review of the Moore Institute and the Centre for Innovation for Structural Change (CISC), leading to the establishment of the Whitaker Institute for Business, the Social Sciences and Public Policy.

Prof. Smith's research at NUI Galway involves investigations of the molecular basis of disease, including in particular, infectious diseases and cancer, with a focus on the development and application of novel nucleic acid-based tests for disease diagnosis and therapeutic monitoring. He is a Co-PI with the SFI CSET Centre, the Biomedical Diagnostics Institute (BDI), where he leads two research programmes.  He has supervised 20 Ph.D. students to completion, and he directs a taught Masters in Biomedical Science programme, while he led the design and development of a two year part-time distance-learning masters in Biomedical Science programme that was initiated in 2006. He is the author/co-author of over 120 peer-reviewed papers in international journals, as well as being co-inventor of 8 granted patents from two patent families, with 49 other patent applications pending across 8 patent families.  Molecular Diagostics technologies co-invented by Terry Smith have been licensed to four companies, including two global in vitro diagnostics companies, and one Irish company, for commercial development.  He is a co-founder and Chief Executive Officer of an NUI Galway spin-out company, Advanced Molecular Systems Ltd. (AMS), incorporated in 2012.  AMS provides molecular diagnostic test development services to client companies, and currently employs four staff. 

Research Interests

My research is primarily focused on the use of functional genomics approaches to understand the molecular basis of human disease. This work involves the identification of genes, whose expression patterns are altered under disease conditions, determining their disease-association and analysing their functional significance. My main research interests in which I have active programmes are:
 
1. Nucleic acid-based diagnostics assay development for infectious disease pathogen detection

I have a long-standing, ongoing research programme focused on the design, development and clinical validation of nucleic acid-based diagnostics assays for infectious disease.  This is a research area, in which I am co-inventor of 8 granted patents, and over 50 filed patent applications.  Licenses have been granted to four IVD companies to exploit co-invented patented technologies.

2. Cancer small RNA biomarker discovery and nucleic acid-based diagnostic assay development

This ongoing research programmes aims to identify and detect small  regulatory 
RNA molecules and somatic cell mutations associated with cancer for diagnosis, therapeutic monitoring and disease management.
 

3. Molecular and cellular basis of complications of pregnancy and labour

This research involves investigation of the molecular and cellular basis of complications of pregnancy and parturition to understand the underlying mechanisms involved in the process of labour, in reproductive tissues, including in particular myometrium.
 
4. Cellular interactions between novel biomaterials and vascular cells.

Investigation of the molecular and cellular interactions between novel biomaterials with vascular cells and tissues has as a major goal, understanding and modulating the body's response to implant materials.

Peer Reviewed Journals

  Year Publication
(2017) 'Rapid Microarray Based Sandwich Assay for the Direct Detection of microRNAs'
Clancy E, Burke M, Arabkari V, Barry T, Kelly H, Dwyer RM, Kerin MJ. and Smith TJ (2017) 'Rapid Microarray Based Sandwich Assay for the Direct Detection of microRNAs'. Analytical And Bioanalytical Chemistry, [Details]
(2017) 'A novel molecular assay using hybridisation probes and melt curve analysis for CALR exon 9 mutation detection in myeloproliferative neoplasms'
Keaney T, O'Connor L, Krawczyk J, Abdelrahman MA, Hayat AH, Murray M, O'Dwyer M, Percy M, Langabeer S, Haslam K, Glynn B, Mullen C, Keady E, Lahiff S, Smith TJ. (2017) 'A novel molecular assay using hybridisation probes and melt curve analysis for CALR exon 9 mutation detection in myeloproliferative neoplasms'. J Clin Pathol, :1-7 [DOI] [Details]
(2017) 'Development of an on-disc isothermal in vitro amplification and detection of bacterial RNA'
Brennan, D,Coughlan, H,Clancy, E,Dimov, N,Barry, T,Kinahan, D,Ducree, J,Smith, TJ,Galvin, P (2017) 'Development of an on-disc isothermal in vitro amplification and detection of bacterial RNA'. Sensors And Actuators B-Chemical, 239 :235-242 [DOI] [Details]
(2016) 'Development and performance evaluation of a recombinase polymerase amplification assay for the rapid detection of group B streptococcus'
Clarke C;O'Connor L;Carré-Skinner H;Piepenburg O;Smith TJ; (2016) 'Development and performance evaluation of a recombinase polymerase amplification assay for the rapid detection of group B streptococcus'. BMC Microbiology, 16 (1) [DOI] [Details]
(2016) 'Ultrasensitive microarray bioassays using cyanine5 dye-doped silica nanoparticles'
Flynn, SP,Kelleher, SM,Acorn, JN,Kurzbuch, D,Daniels, S,McDonagh, C,Clancy, E,Smith, TJ,Nooney, R (2016) 'Ultrasensitive microarray bioassays using cyanine5 dye-doped silica nanoparticles'. Nanotechnology, 27 [DOI] [Details]
(2016) 'Development and performance evaluation of a recombinase polymerase amplification assay for the rapid detection of group B streptococcus'
Clarke, C,O'Connor, L,Carre-Skinner, H,Piepenburg, O,Smith, TJ (2016) 'Development and performance evaluation of a recombinase polymerase amplification assay for the rapid detection of group B streptococcus'. BMC Microbiology, 16 [DOI] [Details]
(2016) 'Development of internally controlled duplex real-time NASBA diagnostics assays for the detection of microorganisms associated with bacterial meningitis'
Clancy, E,Coughlan, H,Higgins, O,Boo, TW,Cormican, M,Barrett, L,Smith, TJ,Reddington, K,Barry, T (2016) 'Development of internally controlled duplex real-time NASBA diagnostics assays for the detection of microorganisms associated with bacterial meningitis'. Journal Of Microbiological Methods, 127 :197-202 [DOI] [Details]
(2016) 'Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells'
Chandran, S,Cairns, MT,O'Brien, M,O'Connell, E,Mashayekhi, K,Smith, TJ (2016) 'Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells'. Physiological Genomics, 48 :50-61 [DOI] [Details]
(2016) 'Development of internally controlled duplex real-time NASBA diagnostics assays for the detection of microorganisms associated with bacterial meningitis'
Clancy E, Coughlan H, Higgins O, Boo TW, Cormican M, Barrett L, Smith TJ, Reddington K, Barry T (2016) 'Development of internally controlled duplex real-time NASBA diagnostics assays for the detection of microorganisms associated with bacterial meningitis'. Journal Of Microbiological Methods, 127 [DOI] [Details]
(2015) 'Multivalent linkers for improved covalent binding of oligonucleotides to dye-doped silica nanoparticles'
Kelleher, SM,Nooney, RI,Flynn, SP,Clancy, E,Burke, M,Daly, S,Smith, TJ,Daniels, S,McDonagh, C (2015) 'Multivalent linkers for improved covalent binding of oligonucleotides to dye-doped silica nanoparticles'. Nanotechnology, 26 [DOI] [Details]
(2015) 'Solvent-selective routing for centrifugally automated solid-phase purification of RNA'
Dimov, N., Clancy, E., Gaughran, J., Boyle, D, McAuley, D., Glynn, M.T., Dwyer, R., Coughlan, H., Barry, T., Barrett, L.M., Smith, T.J. and Ducree, J. (2015) 'Solvent-selective routing for centrifugally automated solid-phase purification of RNA'. Microfluidics And Nanofluidics, 18 (5):859-871 [DOI] [ARAN Link] [Details]
(2015) 'Cross Platform Standardisation of an Experimental Pipeline for Use in the Identification of Dysregulated Human Circulating MiRNAs'
Kelly, H,Downing, T,Tuite, NL,Smith, TJ,Kerin, MJ,Dwyer, RM,Clancy, E,Barry, T,Reddington, K (2015) 'Cross Platform Standardisation of an Experimental Pipeline for Use in the Identification of Dysregulated Human Circulating MiRNAs'. Plos One, 10 [DOI] [Details]
(2015) 'Development of a rapid recombinase polymerase amplification assay for the detection of Streptococcus pneumoniae in whole blood'
Clancy, E,Higgins, O,Forrest, MS,Boo, TW,Cormican, M,Barry, T,Piepenburg, O,Smith, TJ (2015) 'Development of a rapid recombinase polymerase amplification assay for the detection of Streptococcus pneumoniae in whole blood'. BMC Infectious Diseases, 15 [DOI] [ARAN Link] [Details]
(2015) 'Comparative genome analysis identifies novel nucleic acid diagnostic targets for use in the specific detection of Haemophilus influenzae'
Coughlan, H,Reddington, K,Tuite, N,Boo, TW,Cormican, M,Barrett, L,Smith, TJ,Clancy, E,Barry, T (2015) 'Comparative genome analysis identifies novel nucleic acid diagnostic targets for use in the specific detection of Haemophilus influenzae'. Diagnostic Microbiology And Infectious Disease, 83 :112-116 [DOI] [Details]
(2015) 'Alignment-free clustering of transcription factor binding motifs using a genetic-k-medoids approach'
Broin, PO,Smith, TJ,Golden, AAJ (2015) 'Alignment-free clustering of transcription factor binding motifs using a genetic-k-medoids approach'. BMC Bioinformatics, 16 [DOI] [ARAN Link] [Details]
(2014) 'Transcriptomic effects of estradiol treatment on cultured human uterine smooth muscle cells'
Chandran, S,Cairns, MT,O'Brien, M,Smith, TJ (2014) 'Transcriptomic effects of estradiol treatment on cultured human uterine smooth muscle cells'. Molecular And Cellular Endocrinology, 393 :16-23 [DOI] [Details]
(2013) 'Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design'
Koehbach, J,O'Brien, M,Muttenthaler, M,Miazzo, M,Akcan, M,Elliott, AG,Daly, NL,Harvey, PJ,Arrowsmith, S,Gunasekera, S,Smith, TJ,Wray, S,Goransson, U,Dawson, PE,Craik, DJ,Freissmuth, M,Gruber, CW (2013) 'Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 110 (52):21183-21188 [DOI] [ARAN Link] [Details]
(2013) 'Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy'
O'Brien, M,Carbin, S,Morrison, JJ,Smith, TJ (2013) 'Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy'. Reproductive Biology And Endocrinology, 11 (79) [DOI] [ARAN Link] [Details]
(2012) 'Ultrathin and smooth poly(methyl methacrylate) (PMMA) films for label-free biomolecule detection with total internal reflection ellipsometry (TIRE)'
Le NC, Gubala V, Clancy E, Barry T, Smith TJ, Williams DE (2012) 'Ultrathin and smooth poly(methyl methacrylate) (PMMA) films for label-free biomolecule detection with total internal reflection ellipsometry (TIRE)'. Biosensors & Bioelectronics, 36 (1):250-256 [DOI] [Details]
(2012) 'Uterine contractility of plants used to facilitate childbirth in Nigerian ethnomedicine'
Attah, AF,O'Brien, M,Koehbach, J,Sonibare, MA,Moody, JO,Smith, TJ,Gruber, CW (2012) 'Uterine contractility of plants used to facilitate childbirth in Nigerian ethnomedicine'. Journal Of Ethnopharmacology, 143 (1):377-382 [DOI] [Details]
(2012) 'Culture confirmation of Listeria monocytogenes using tmRNA as a diagnostics target'
Clancy, E,Glynn, B,Reddington, K,Smith, T,Barry, T (2012) 'Culture confirmation of Listeria monocytogenes using tmRNA as a diagnostics target'. Journal Of Microbiological Methods, 88 (3):427-429 [DOI] [Details]
(2012) 'Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells'
Prasad, BR,Mullins, G,Nikolskaya, N,Connolly, D,Smith, TJ,Gerard, VA,Byrne, SJ,Davies, GL,Gun'ko, YK,Rochev, Y (2012) 'Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells'. Journal Of Nanobiotechnology, 10 (4) [DOI] [ARAN Link] [Details]
(2010) 'Controlling Cellular activity by Manipulating Silicone surface roughness'
B.R. Prasad, M.A. Brook, T. Smith, S. Zhao, Y. Chen, H. Sheardown, R. D'souza, Y. Rochev (2010) 'Controlling Cellular activity by Manipulating Silicone surface roughness'. Colloids And Surfaces B: Biointerfaces, 78 :237-242 [DOI] [Details]
(2010) 'Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use'
Prasad, B. R.,Nikolskaya,N.,Connolly,D.,Smith, T.J>, Byrne,S.J., Gérard,V.A., Gun'ko,Y.K. & Rochev, Y. (2010) 'Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use'. Journal of Nanobiotechnology, 8 (7) [ARAN Link] [Details]
(2010) 'Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar)'
Guiry, A,Flynn, D,Hubert, S,O'Keeffe, AM,LeProvost, O,White, SL,Forde, PF,Davoren, P,Houeix, B,Smith, TJ,Cotter, D,Wilkins, NP,Cairns, MT (2010) 'Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar)'. BMC Genomics, 11 [DOI] [ARAN Link] [Details]
(2010) 'Ghrelin in the human myometrium'
O'Brien, M,Earley, P,Morrison, JJ,Smith, TJ (2010) 'Ghrelin in the human myometrium'. Reproductive Biology And Endocrinology, 8 [DOI] [ARAN Link] [Details]
(2009) 'Rapid detection of Listeria monocytogenes in food using culture enrichment combined with real-time PCR'
O'Grady, J,Ruttledge, M,Sedano-Balbas, S,Smith, TJ,Barry, T,Maher, M (2009) 'Rapid detection of Listeria monocytogenes in food using culture enrichment combined with real-time PCR'. Food Microbiology, 26 :4-7 [DOI] [Details]
(2009) 'Evaluation of Human Endothelial Cells Post Stent Deployment in a Cardiovascular Simulator In Vitro'
Punchard, MA,O'Cearbhaill, ED,Mackle, JN,McHugh, PE,Smith, TJ,Stenson-Cox, C,Barron, V (2009) 'Evaluation of Human Endothelial Cells Post Stent Deployment in a Cardiovascular Simulator In Vitro'. Annals Of Biomedical Engineering, 37 :1322-1330 [DOI] [Details]
(2009) 'Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin'
Fitzgibbon, J,Morrison, JJ,Smith, TJ,O'Brien, M (2009) 'Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin'. Reproductive Biology And Endocrinology, 7 [DOI] [ARAN Link] [Details]
(2009) 'Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data'
Talbot, AT,Pottinger, TG,Smith, TJ,Cairns, MT (2009) 'Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data'. Fish & Shellfish Immunology, 27 :309-317 [DOI] [ARAN Link] [Details]
(2009) 'Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs'
Wernecke M, Mullen C, Sharma V, Morrison J, Barry T, Maher M, Smith T (2009) 'Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs'. BMC Infectious Diseases, 9 [DOI] [ARAN Link] [Details]
(2009) 'tmRNA - a novel high-copy-number RNA diagnostic target - its application for Staphylococcus aureus detection using real-time NASBA'
O'Grady, J,Lacey, K,Glynn, B,Smith, TJ,Barry, T,Maher, M (2009) 'tmRNA - a novel high-copy-number RNA diagnostic target - its application for Staphylococcus aureus detection using real-time NASBA'. Fems Microbiology Letters, 301 :218-223 [DOI] [Details]
(2009) 'Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)'
Talbot, AT,Smith, TJ,Cairns, MT (2009) 'Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)'. Fish & Shellfish Immunology, 26 :589-598 [DOI] [ARAN Link] [Details]
(2008) 'Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labour'
O'Brien, M., Morrison, J. J., Smith, T. J. (2008) 'Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labour'. Biology of Reproduction, 78 (1):20-26 [DOI] [Details]
(2008) 'Rapid real-time PCR detection of Listeria monocytogenes in enriched food samples based on the ssr A gene, a novel diagnostic target'
O' Grady, J,Sedano-Balbas, S,Maher, M,Smith, T,Barry, T (2008) 'Rapid real-time PCR detection of Listeria monocytogenes in enriched food samples based on the ssr A gene, a novel diagnostic target'. Food Microbiology, 25 :75-84 [DOI] [Details]
(2008) 'Analysis of the effects of surface treatments on nickel release from nitinol wires and their impact on candidate gene expression in endothelial cells'
McLucas, E, Rochev, Y,Carroll, WM, Smith, TJ (2008) 'Analysis of the effects of surface treatments on nickel release from nitinol wires and their impact on candidate gene expression in endothelial cells'. Journal Of Materials Science-Materials In Medicine, 19 :975-980 [DOI] [Details]
(2008) 'Human coronary artery smooth muscle cell response to a novel PLA textile/fibrin gel composite scaffold'
Gundy, S,Manning, G,O'Connell, E,Ella, V,Harwoko, MS,Rochev, Y,Smith, T,Barron, V (2008) 'Human coronary artery smooth muscle cell response to a novel PLA textile/fibrin gel composite scaffold'. Acta Biomaterialia, 4 :1734-1744 [DOI] [Details]
(2008) 'Development of a co-culture system for tissue engineered vascular grafts'
Crouchley, CM,Barron, V,Punchard, M,O'Cearbhaill, E,Smith, T (2008) 'Development of a co-culture system for tissue engineered vascular grafts'. Bio-Medical Materials And Engineering, 18 :291-294 [DOI] [Details]
(2008) 'Reusable surface plasmon resonance assay for the specific detection of Streptococcus pneumoniae tmRNA'
Glynn, B,Lacey, K,O'Grady, J,Barry, T,Smith, TJ,Maher, M (2008) 'Reusable surface plasmon resonance assay for the specific detection of Streptococcus pneumoniae tmRNA'. Journal Of Rapid Methods And Automation In Microbiology, 16 :210-221 [Details]
(2008) 'Beta-adrenoceptor subtype expression in human placenta and umbilical arteries in normal and preeclamptic pregnancies'
Hynes PG, Friel AM, Smith TJ, Morrison JJ (2008) 'Beta-adrenoceptor subtype expression in human placenta and umbilical arteries in normal and preeclamptic pregnancies'. Hypertens Pregnancy, 27 (2):169-181 [DOI] [Details]
(2008) 'Expression of RHOGTPase regulators in human myometrium'
O'Brien, M,Flynn, D,Mullins, B,Morrison, JJ,Smith, TJ (2008) 'Expression of RHOGTPase regulators in human myometrium'. Reproductive Biology And Endocrinology, 6 [DOI] [ARAN Link] [Details]
(2008) 'Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics'
Dimov, IK,Garcia-Cordero, JL,O'Grady, J,Poulsen, CR,Viguier, C,Kent, L,Daly, P,Lincoln, B,Maher, M,O'Kennedy, R,Smith, TJ,Ricco, AJ,Lee, LP (2008) 'Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics'. Lab On A Chip, 8 :2071-2078 [DOI] [Details]
(2008) 'Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor'
O'Brien, M,Morrison, JJ,Smith, TJ (2008) 'Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor'. Reproductive Sciences, 15 :382-393 [DOI] [ARAN Link] [Details]
(2008) 'Expression levels of mRNA for rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels'
Friel, AM,Hynes, PG,Sexton, DJ,Smith, TJ,Morrison, JJ (2008) 'Expression levels of mRNA for rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels'. Reproductive Sciences, 15 :179-188 [DOI] [Details]
(2008) 'The relaxant effect of nifedipine in human uterine smooth muscle and the BKCa channel'
Moynihan, AT,Smith, TJ,Morrison, JJ (2008) 'The relaxant effect of nifedipine in human uterine smooth muscle and the BKCa channel'. American Journal Of Obstetrics And Gynecology, 198 [DOI] [Details]
(2008) 'A note on the evaluation of a beta-casein variant in bovine breeds by allele-specific PCR and relevance to beta-casomorphin'
Keating, AF,Smith, TJ,Ross, RP,Cairns, MT (2008) 'A note on the evaluation of a beta-casein variant in bovine breeds by allele-specific PCR and relevance to beta-casomorphin'. Irish Journal Of Agricultural And Food Research, 47 :99-104 [ARAN Link] [Details]
(2007) 'Quantification of Bacterial tmRNA using in vitro Transcribed RNA Standards and Two-Step qRT-PCR'
Barry Glynn, Katrina Lacey, Joanna Reilly, Terry J Smith, Thomas Barry, and Majella Maher (2007) 'Quantification of Bacterial tmRNA using in vitro Transcribed RNA Standards and Two-Step qRT-PCR'. Research Journal Of Biological Sciences, 2 (5):564-570 [Details]
(2007) 'Bovine kappa-casein gene promoter haplotypes with potential implications for milk protein expression'
Keating, AF,Davoren, P,Smith, TJ,Ross, RP,Cairns, MT (2007) 'Bovine kappa-casein gene promoter haplotypes with potential implications for milk protein expression'. Journal Of Dairy Science, 90 :4092-4099 [DOI] [ARAN Link] [Details]
(2007) 'Expression and function of protease-activated receptor 4 in human myometrium'
Allen NM, O'Brien M, Friel AM, Smith TJ, Morrison JJ (2007) 'Expression and function of protease-activated receptor 4 in human myometrium'. American Journal Of Obstetrics And Gynecology, 196 (2):1690-1696 [DOI] [Details]
(2007) 'Differential expression of the metalloproteinase MMP3 and the alpha 5 integrin subunit in human myometrium at labour'
O'Brien, M,O'Shaughnessy, D,Ahamide, E,Morrison, JJ,Smith, TJ (2007) 'Differential expression of the metalloproteinase MMP3 and the alpha 5 integrin subunit in human myometrium at labour'. Molecular Human Reproduction, 13 :655-661 [DOI] [Details]
(2006) 'Global gene expression analysis of the effects of Vinblastine on endothelial cells, when eluted from a thermo-responsive polymer'
McLucas, E,Gallagher, H,Rochev, Y,Carroll, WM,Gorelov, A,Smith, TJ (2006) 'Global gene expression analysis of the effects of Vinblastine on endothelial cells, when eluted from a thermo-responsive polymer'. Journal Of Biomedical Materials Research Part A, 79A :246-253 [DOI] [ARAN Link] [Details]
(2006) 'Cloning and characterization of two genes encoding rainbow trout homologues of the IFITM protein family'
Johnson, MC,Sangrador-Vegas, A,Smith, TJ,Cairns, MT (2006) 'Cloning and characterization of two genes encoding rainbow trout homologues of the IFITM protein family'. Veterinary Immunology And Immunopathology, 110 :357-362 [DOI] [ARAN Link] [Details]
(2006) 'Effect of systemic progesterone concentration on the expression of progesterone-responsive genes in the bovine endometrium during the early luteal phase'
McNeill, RE,Sreenan, JM,Diskin, MG,Cairns, MT,Fitzpatrick, R,Smith, TJ,Morris, DG (2006) 'Effect of systemic progesterone concentration on the expression of progesterone-responsive genes in the bovine endometrium during the early luteal phase'. Reproduction Fertility And Development, 18 :573-583 [DOI] [Details]
(2006) 'An investigation into the effect of surface roughness of stainless steel on human umbilical vein endothelial cell gene expression'
McLucas, E,Moran, MT,Rochev, Y,Carroll, WM,Smith, TJ (2006) 'An investigation into the effect of surface roughness of stainless steel on human umbilical vein endothelial cell gene expression'. Endothelium-Journal Of Endothelial Cell Research, 13 :35-41 [DOI] [Details]
(2006) 'A Collagen-glycosaminoglycan Co-culture Model for Heart Valve Tissue Engineering Applications'
Flanagan, T.C., Wilkins, B., Black, A., Jockenhoevel, S. Smith, T.J. and Pandit, A.S. (2006) 'A Collagen-glycosaminoglycan Co-culture Model for Heart Valve Tissue Engineering Applications'. Biomaterials, 27 (10):2233-2246 [Details]
(2006) 'Self-organizing neural networks to support the discovery of DNA-binding motifs'
Mahony, S,Benos, PV,Smith, TJ,Golden, A (2006) 'Self-organizing neural networks to support the discovery of DNA-binding motifs'. Neural Networks, 19 :950-962 [DOI] [Details]
(2006) 'Reference models for mitral valve tissue engineering based on valve cell phenotype and extracellular matrix analysis'
Flanagan, TC,Black, A,O'Brien, M,Smith, TJ,Pandit, AS (2006) 'Reference models for mitral valve tissue engineering based on valve cell phenotype and extracellular matrix analysis'. Cells Tissues Organs, 183 :12-23 [DOI] [Details]
(2006) 'Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction'
Friel, AM,Sexton, DJ,O'Reilly, MW,Smith, TJ,Morrison, JJ (2006) 'Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction'. Reproduction, 132 :169-176 [DOI] [ARAN Link] [Details]
(2006) 'Inhibitory effect of leptin on human uterine contractility in vitro'
Moynihan, A. T., Hehir, M. P., Glavey, S. V. & Morrison, J. J. (2006) 'Inhibitory effect of leptin on human uterine contractility in vitro'. American Journal of Obstetrics & Gynaecology, 195 :504-509 [DOI] [Details]
(2006) 'Self-organizing neural networks to support the discovery of DNA-binding motifs'
S Mahony, PV Benos, TJ Smith, A Golden (2006) 'Self-organizing neural networks to support the discovery of DNA-binding motifs'. Neural Networks, 19 (6-7):950-962 [Details]
(2006) 'A single nucleotide polymorphism in the bovine beta-casein promoter region across different bovine breeds'
Keating, AF,Smith, TJ,Ross, RP,Cairns, MT (2006) 'A single nucleotide polymorphism in the bovine beta-casein promoter region across different bovine breeds'. Journal Of Dairy Research, 73 :193-196 [DOI] [ARAN Link] [Details]
(2005) 'Transcription factor binding site identification using the Self-Organizing Map'
Mahony, S., Hendrix, D., Golden, A., Smith, T.J., Rokhsar, D.S. (2005) 'Transcription factor binding site identification using the Self-Organizing Map'. Bioinformatics, 1 (21(9)):1807-14 [ARAN Link] [Details]
(2005) 'Inhibitor of NF-kB in Rainbow Trout (Oncorhynchus Mykiss)'
Sangrador-Vegas A, Smith T.J., Cairns M.T. (2005) 'Inhibitor of NF-kB in Rainbow Trout (Oncorhynchus Mykiss)'. VETERINARY IMMUNOLOGY AND IMMUNOOPATHOLOGY, 103 (01-Feb):1-7 [Details]
(2005) 'Improved detection of DNA motifs using a self-organized clustering of familial binding profiles'
Mahony, S,Golden, A,Smith, TJ,Benos, PV (2005) 'Improved detection of DNA motifs using a self-organized clustering of familial binding profiles'. Bioinformatics, 21 :283-291 [DOI] [Details]
(2005) 'Self-organizing maps of position weight matrices for motif discovery in biological sequences'
Mahony, S,Hendrix, D,Smith, TJ,Golden, A (2005) 'Self-organizing maps of position weight matrices for motif discovery in biological sequences'. Artificial Intelligence Review, 24 :397-413 [DOI] [Details]
(2005) 'Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes'
Doheny, HC,Lynch, CM,Smith, TJ,Morrison, JJ (2005) 'Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes'. Journal Of Clinical Endocrinology & Metabolism, 90 :5786-5796 [DOI] [ARAN Link] [Details]
(2005) 'Isolation and characterization of the bovine Stearoyi-CoA desaturase promoter and analysis of polymorphisms in the promoter region in dairy cows'
Keating, AF,Stanton, C,Murphy, JJ,Smith, TJ,Ross, RP,Cairns, AT (2005) 'Isolation and characterization of the bovine Stearoyi-CoA desaturase promoter and analysis of polymorphisms in the promoter region in dairy cows'. Mammalian Genome, 16 :184-193 [DOI] [Details]
(2005) 'Cloning and characterization of a homologue of the alpha inhibitor of NF-kappa B in Rainbow trout (Oncorhynchus mykiss)'
Sangrador-Vegas, A,Smith, TJ,Cairns, MT (2005) 'Cloning and characterization of a homologue of the alpha inhibitor of NF-kappa B in Rainbow trout (Oncorhynchus mykiss)'. Veterinary Immunology And Immunopathology, 103 :1-7 [DOI] [Details]
(2005) 'Rho A/Rho kinase mRNA and protein levels in human myometrium during pregnancy and labor'
Friel, AM,Curley, M,Ravikumar, N,Smith, TJ,Morrison, JJ (2005) 'Rho A/Rho kinase mRNA and protein levels in human myometrium during pregnancy and labor'. Journal Of The Society For Gynecologic Investigation, 12 :20-27 [DOI] [Details]
(2005) 'Improved detection of DNA motifs using a self-organized clustering of familial binding profiles'
Mahony, S., Golden, A., Smith, T.J., Benos, P.V. (2005) 'Improved detection of DNA motifs using a self-organized clustering of familial binding profiles'. BIOINFORMATICS, 1 (21):283-291 [Details]
(2004) 'Analysis of Maxi-K a subunit splice variants in human myometrium'
Curley, M., Morrison, J.J. and Smith, T.J. (2004) 'Analysis of Maxi-K a subunit splice variants in human myometrium'. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2 (1) [ARAN Link] [Details]
(2004) 'Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) matrix metalloproteinase-9'
Johnson, MC,Sangrador-Vegas, A,Smith, TJ,Cairns, MT (2004) 'Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) matrix metalloproteinase-9'. Fish & Shellfish Immunology, 17 :499-503 [DOI] [Details]
(2004) 'Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models'
Mahony, S,McInerney, JO,Smith, TJ,Golden, A (2004) 'Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models'. BMC Bioinformatics, 5 [DOI] [ARAN Link] [Details]
(2004) 'Cannabinoids and the human uterus during pregnancy'
Dennedy MC, Friel AM, Houlihan DD, Broderick VM, Smith T, Morrison JJ. (2004) 'Cannabinoids and the human uterus during pregnancy'. American Journal Of Obstetrics And Gynecology, 190 (1):2-9 [Details]
(2003) 'Cystic fibrosis mutation frequencies in an Irish population'
Devaney, J,Glennon, M,Farrell, G,Ruttledge, M,Smith, T,Houghton, JA,Maher, M (2003) 'Cystic fibrosis mutation frequencies in an Irish population'. Clinical Genetics, 63 :121-125 [Details]
(2003) 'HFE alleles in an Irish cystic fibrosis population'
Devaney, J,Maher, M,Smith, T,Houghton, JA,Glennon, M (2003) 'HFE alleles in an Irish cystic fibrosis population'. Genetic Testing, 7 :155-158 [Details]
(2003) 'Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the BKCa channel'
Doheny, HC,Houlihan, DD,Ravikumar, N,Smith, TJ,Morrison, JJ (2003) 'Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the BKCa channel'. Journal Of Clinical Endocrinology & Metabolism, 88 :4310-4315 [DOI] [ARAN Link] [Details]
(2003) 'The RAD30 cancer susceptibility gene'
Carty MP, Glynn M, Maher M, Smith T, Yao J, Dixon K, McCann J, Rynn L, Flanagan A. (2003) 'The RAD30 cancer susceptibility gene'. Biochemical Society Transactions, 31 (1):252-256 [Details]
(2002) 'Detection and identification of Helicobacter pylori directly from gastric biopsies using polymerase chain reaction'
Ryan, KA,Moran, AP,Little, CL,Glennon, M,Smith, T,Maher, M (2002) 'Detection and identification of Helicobacter pylori directly from gastric biopsies using polymerase chain reaction'. Irish Journal Of Medical Science, 171 :117-117 [Details]
(2002) 'A survey of Johne's disease in imported animals in the Republic of Ireland'
O'Doherty, A,O'Grady, D,Smith, T,O'Farrell, KJ,Egan, J (2002) 'A survey of Johne's disease in imported animals in the Republic of Ireland'. Veterinary Record, 150 (20):634-636 [Details]
(2002) 'Survey of Johne's disease in imported animals in the Republic of Ireland'
O'Doherty, A,O'Grady, D,O'Farrell, K,Smith, T,Egan, J (2002) 'Survey of Johne's disease in imported animals in the Republic of Ireland'. Veterinary Record, 150 :634-636 [Details]
(2002) 'Molecular cloning of a novel CXC chemokine, RTCXC-1 and tissue factor in Rainbow Trout by use of suppression subtractive hybridisation'
Sangrador-Vegas, A., Lennington, J.B. and Smith, T.J. (2002) 'Molecular cloning of a novel CXC chemokine, RTCXC-1 and tissue factor in Rainbow Trout by use of suppression subtractive hybridisation'. CYTOKINE, 17 :66-70 [DOI] [Details]
(2002) 'Real-Time PCR assay for the detection of bovine material in meat and bone meal'
S. Lahiff, M. Glennon, J. Lyng, N. Shilton, T. Smith and M. Maher. (2002) 'Real-Time PCR assay for the detection of bovine material in meat and bone meal'. JOURNAL OF FOOD PROTECTION, 65 (7):1158-65 [Details]
(2002) 'Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium'
Curley, M,Cairns, MT,Friel, AM,McMeel, OM,Morrison, JJ,Smith, TJ (2002) 'Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium'. Molecular Human Reproduction, 8 :941-945 [Details]
(2002) 'A role for atlantic salmon HNF-3 in the regulation of Alantic salmon HNF-1'
Stenson, C., McNair, A., Curley, M., Smith, T., Gannon, F. (2002) 'A role for atlantic salmon HNF-3 in the regulation of Alantic salmon HNF-1'. MOLECULAR GENETICS AND GENOMICS, 266 :832-837 [DOI] [Details]
(2002) 'Expression and modulation of Rho kinase in human pregnant myometrium'
Moran, CJ,Friel, AM,Smith, TJ,Cairns, M,Morrison, JJ (2002) 'Expression and modulation of Rho kinase in human pregnant myometrium'. Molecular Human Reproduction, 8 :196-200 [Details]
(2002) 'Molecular cloning of an IL-8-like CXC chemokine and tissue factor in Rainbow trout (Oncorhynchus mykiss) by use of suppression subtractive hybridization'
Sangrador-Vegas, A,Lennington, JB,Smith, TJ (2002) 'Molecular cloning of an IL-8-like CXC chemokine and tissue factor in Rainbow trout (Oncorhynchus mykiss) by use of suppression subtractive hybridization'. Cytokine, 17 :66-70 [DOI] [Details]
(2002) 'Using RT-PCR to detect DAZ, RBMY and USP9Y RNA in testicular biopsy samples from azoospermic men'
Friel, A., Houghton, J.A., Glennon, M., Smith, T.J., Nolan, A. and Maher, M. (2002) 'Using RT-PCR to detect DAZ, RBMY and USP9Y RNA in testicular biopsy samples from azoospermic men'. INTERNATIONAL JOURNAL OF ANDROLOGY, 25 :59-64 [Details]
(2002) 'Postmortem stability of RNA isolated from bovine reproductive tissues'
Fitzpatrick R, Casey OM, Morris D, Smith T, Powell R, Sreenan JM. (2002) 'Postmortem stability of RNA isolated from bovine reproductive tissues'. BIOCHEM. BIOPHYS. ACTA, 20 (1574(1)):10-4 [Details]
(2002) 'Mycobacterium avium subsp. paratuberculosis in pasteurised and unpasteurised milk in the Republic of Ireland'
O'Doherty A., O'Grady D., Smith T., Egan J. (2002) 'Mycobacterium avium subsp. paratuberculosis in pasteurised and unpasteurised milk in the Republic of Ireland'. IRISH JOURNAL OF AGRICULTURE AND FOOD RESEARCH, 41 :117-121 [Details]
(2001) 'PCR-ELISA assays for the detection of Campylobacter jejuni and Campylobacter coli in poultry samples'
Grennan, B., O'Sullivan N., Fallon R., Carroll C., Smith T.J., Glennon M., and Maher M. (2001) 'PCR-ELISA assays for the detection of Campylobacter jejuni and Campylobacter coli in poultry samples'. BIOTECHNIQUES, 30 [Details]
(2001) '17 beta-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis'
Govoroun, M,McMeel, OM,Mecherouki, H,Smith, TJ,Guiguen, Y (2001) '17 beta-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis'. Endocrinology, 142 :1841-1848 [Details]
(2001) 'Gene structure and promoter function of a teleost ribosomal protein: a tilapia (Oreochromis mossambicus) L18 gene'
Molina, A,Iyengar, A,Marins, LF,Biemar, F,Hanley, S,Maclean, N,Smith, TJ,Martial, JA,Muller, M (2001) 'Gene structure and promoter function of a teleost ribosomal protein: a tilapia (Oreochromis mossambicus) L18 gene'. Biochimica Et Biophysica Acta-Gene Structure And Expression, 1520 :195-202 [Details]
(2001) 'Steroid enzyme gene expressions during natural and androgen-induced gonadal differentiation in the rainbow trout, Oncorhynchus mykiss'
Govoroun, M,McMeel, OM,D'Cotta, H,Ricordel, MJ,Smith, T,Fostier, A,Guiguen, Y (2001) 'Steroid enzyme gene expressions during natural and androgen-induced gonadal differentiation in the rainbow trout, Oncorhynchus mykiss'. Journal Of Experimental Zoology, 290 :558-566 [Details]
(2001) 'Evaluation of a PCR/DNA probe colorimetric membrane assay for the identification of Campylobacter spp. directly from stool specimens'
Collins E., Glennon, M., Hanley, S., Murray A-M., Cormican, M., Smith, T.J., and Maher M. (2001) 'Evaluation of a PCR/DNA probe colorimetric membrane assay for the identification of Campylobacter spp. directly from stool specimens'. JOURNAL OF CLINICAL MICROBIOLOGY, 39 (11):4163-65 [Details]
(2001) 'Molecular detection of Y chromosome microdeletions: An Irish study'
Friel, A., Houghton, J.A., Maher, M., Smith, T., Noel, S., Nolan, A., Egan, D. and Glennon, M. (2001) 'Molecular detection of Y chromosome microdeletions: An Irish study'. International Journal Of Andrology, 24 (1):31-36 [DOI] [Details]
(2001) 'Evaluation of clarithromycin resistance, and cagA and vacA genotyping of Helicobacter pylori strains from the west of Ireland using Line Probe (LiPA) assays'
RYAN, K.A., VAN DOORN, L.-J., MORAN, A.P., GLENNON, M., SMITH, T., & MAHER, M. (2001) 'Evaluation of clarithromycin resistance, and cagA and vacA genotyping of Helicobacter pylori strains from the west of Ireland using Line Probe (LiPA) assays'. JOURNAL OF CLINICAL MICROBIOLOGY, 39 :1978-1980 [Details]
(2001) 'Species-specific PCR for the identification of bovine, ovine, porcine and poultry species in meat and bone meal (MBM)'
Lahiff, S., Glennon, M., O'Brien, L., Lyng, J., Smith, T.J., Maher, M. and Shilton, N. (2001) 'Species-specific PCR for the identification of bovine, ovine, porcine and poultry species in meat and bone meal (MBM)'. MOLECULAR AND CELLULAR PROBES, 15 :27-35 [Details]
(2000) 'Genotyping of cagA and vacA, Lewis antigen status, and analysis of the poly-(C) tract in the alpha(1,3)-fucosyltransferase gene of Irish Helicobacter pylori isolates'
Ryan, KA,Moran, AP,Hynes, SO,Smith, T,Hyde, D,O'Morain, CA,Maher, M (2000) 'Genotyping of cagA and vacA, Lewis antigen status, and analysis of the poly-(C) tract in the alpha(1,3)-fucosyltransferase gene of Irish Helicobacter pylori isolates'. Fems Immunology And Medical Microbiology, 28 :113-119 [Details]
(2000) 'Synergistic activation of the Atlantic salmon hepatocyte nuclear factor (HNF) 1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin upstream promoter transcription factor I (COUP-TFI)'
McNair, A,Cereghini, S,Brand, H,Smith, T,Breillat, G,Gannon, F (2000) 'Synergistic activation of the Atlantic salmon hepatocyte nuclear factor (HNF) 1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin upstream promoter transcription factor I (COUP-TFI)'. Biochemical Journal, 352 :557-564 [Details]
(2000) 'Cloning and characterization of the Rainbow trout (Oncorhynchus mykiss) type II interleukin-1 receptor cDNA'
Sangrador-Vegas, A,Martin, SAM,O'Dea, PG,Smith, TJ (2000) 'Cloning and characterization of the Rainbow trout (Oncorhynchus mykiss) type II interleukin-1 receptor cDNA'. European Journal Of Biochemistry, 267 :7031-7037 [Details]
(2000) 'Molecular cloning of an Atlantic salmon nucleoside diphosphate kinase cDNA and its pattern of expression during embryogenesis'
Murphy, M,Harte, T,McInerney, J,Smith, TJ (2000) 'Molecular cloning of an Atlantic salmon nucleoside diphosphate kinase cDNA and its pattern of expression during embryogenesis'. Gene, 257 :139-148 [Details]
(2000) 'Detection and differentiation of Campylobactor jejuni and Campylobacter coli in broiler chicken samples using a PCR/DNA probe membrane based colorimetric detection assay'
O'Sullivan, N.A., Fallon, R., Carroll, C., Smith, T., and Maher, M. (2000) 'Detection and differentiation of Campylobactor jejuni and Campylobacter coli in broiler chicken samples using a PCR/DNA probe membrane based colorimetric detection assay'. MOLECULAR AND CELLULAR PROBES, 14 :7-16 [Details]
(2000) 'Rapid Polymerase Chain Reaction/DNA Probe Membrane-Based Assay for the Detection of Listeria and Listeria Monocytogenes in Food'
O’Connor, L., J. Joy, M. Kane, T.J. Smith and M. Maher (2000) 'Rapid Polymerase Chain Reaction/DNA Probe Membrane-Based Assay for the Detection of Listeria and Listeria Monocytogenes in Food'. Journal Of Food Protection, 63 (3):337-342 [Details]
(2000) 'Development of microsatellite PCR typing methodology for the sea louse, Lepeophtheirus salmonis'
Nolan, D., Martin, S., Kelly, Y., Glennon, K., Palmer, R., Smith, T.J., McCormack, G.P. & Powell, R. (2000) 'Development of microsatellite PCR typing methodology for the sea louse, Lepeophtheirus salmonis'. AQUACULTURE RESEARCH, 31 :1-8 [Details]
(2000) 'Molecular diagnostics in food safety: rapid detection of food-borne pathogens'
Smith, T.J., O'Connor, L., Glennon, M., and Maher, M. (2000) 'Molecular diagnostics in food safety: rapid detection of food-borne pathogens'. JOURNAL OF AGRICULTURAL AND FOOD RESEARCH, 39 :309-319 [Details]
(2000) 'Expression of cytochrome P450(11beta) (11beta-hydroxylase) gene during gonadal sex differentiation and spermatogenesis in rainbow trout, Oncorhynchus mykiss'
Liu, S., Govoroun. M., D'Cotta. H., Ricordel. M.J., Lareyre. J.J., McMeel. O.M., Smith. T.J., Nagahama, Y. and Guiguen, Y. (2000) 'Expression of cytochrome P450(11beta) (11beta-hydroxylase) gene during gonadal sex differentiation and spermatogenesis in rainbow trout, Oncorhynchus mykiss'. JOURNAL OF STEROID BIOCHEMISTRY, 75 :291-298 [Details]
(2000) 'Development of a PCR-based line probe assay for the identification of fungal pathogens'
Martin, C., Roberts, D., van der Weide, M., Rosseau, R., Jannes, G., Smith, T.J. and Maher, M. (2000) 'Development of a PCR-based line probe assay for the identification of fungal pathogens'. JOURNAL OF CLINICAL MICROBIOLOGY, 38 :3735-3742 [Details]
(2000) 'Atlantic salmon HNF-3/fork head; cDNA sequence, evolution, expression and functional analysis'
Stenson, C. McNair, A., Byrnes, L., Murphy, M., Smith, T. and F. Gannon (2000) 'Atlantic salmon HNF-3/fork head; cDNA sequence, evolution, expression and functional analysis'. DNA AND CELL BIOLOGY, 19 :59-68 [Details]
(1999) 'Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis'
Feeley, KM,Fullard, JF,Heneghan, MA,Smith, T,Maher, M,Murphy, RP,O'Gorman, TA (1999) 'Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis'. Journal Of Pathology, 188 :14-17 [Details]
(1999) 'Cloning and sequence analysis of rainbow trout LMP 2 cDNA and differential expression of the mRNA'
Davidson, J., Smith, T.J. and Martin, S. (1999) 'Cloning and sequence analysis of rainbow trout LMP 2 cDNA and differential expression of the mRNA'. Fish And Shellfish Immunology, 9 :621-632 [Details]
(1999) 'Differential expression of Atlantic salmon thyrotropin beta subunit mRNA and its cDNA sequence'
Martin, S.A.M., Wallner, W., Youngson, A.F. and Smith, T.J. (1999) 'Differential expression of Atlantic salmon thyrotropin beta subunit mRNA and its cDNA sequence'. Journal Of Fish Biology, 54 (4):757-766 [DOI] [Details]
(1999) 'Virulence factors CagA and VacA in an Irish H. pylori population'
RYAN, K.A., MORAN, A.P., SMITH, T., HYDE, D., O'MORAIN, C.A. & MAHER, M. (1999) 'Virulence factors CagA and VacA in an Irish H. pylori population'. Irish Journal Of Medical Science, 168 (3) [Details]
(1999) 'Virulence factors in an Irish Helicobacter pylori population including a subset of isolates from intestinal metaplasia patients'
RYAN, K.A., MORAN, A.P., HYNES, S.O., SMITH, T., HYDE, D., O'MORAIN, C.A. & MAHER, M. (1999) 'Virulence factors in an Irish Helicobacter pylori population including a subset of isolates from intestinal metaplasia patients'. GUT, 45 (3):A31-A32 [Details]
(1998) 'Isolation and functional analysis of the histone H3 promoter from Atlantic salmon (Salmo salar L.)'
Hanley, S,Smith, TI,Muller, F,Maclean, N,Uzbekova, S,Prunet, P,Breton, E (1998) 'Isolation and functional analysis of the histone H3 promoter from Atlantic salmon (Salmo salar L.)'. Molecular Marine Biology And Biotechnology, 7 :165-172 [Details]
(1997) 'PCR based DNA fingerprinting of Mycobacterium bovis'
Glennon, M., Jager, B., Dowdall, D., Maher, M., Dawson, M., Quigley, F., Costello, E., and Smith, T.J. (1997) 'PCR based DNA fingerprinting of Mycobacterium bovis'. VETERINARY MICROBIOLOGY, 54 :235-245 [Details]
(1997) 'Identification of a Splice Site Mutation (2789+5 G>A) Associated With Small Amounts of Normal CFTR mRNA and Mild Cystic Fibrosis'
Highsmith,W.E., Burch, L.H., Zhou, Z., Olsen, J.C., Strong, T.V., Smith, T.J., Friedman, K.J., Silverman, L.M., Boucher, R.C., Collins, F.S., and Knowles, M.R. (1997) 'Identification of a Splice Site Mutation (2789+5 G>A) Associated With Small Amounts of Normal CFTR mRNA and Mild Cystic Fibrosis'. Human Mutation, 9 (4):332-338 [DOI] [Details]
(1996) 'A Mycobacterium malmoense specific DNA probe from the 16S/23S rRNA intergenic region'
Glennon, M., Cormican, M., Ni Riain, U., Heginbotham, M., Gannon, F. and Smith, T.J. (1996) 'A Mycobacterium malmoense specific DNA probe from the 16S/23S rRNA intergenic region'. MOLECULAR AND CELLULAR PROBES, 10 :337-345 [Details]
(1996) 'Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting'
Toth, L.R., Smith, T.J., Jones,C., de Silva, H.V., Smithies, O., and Maeda, N. (1996) 'Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting'. GENE, 178 :161-168 [Details]
(1996) 'Evaluation of a novel PCR based diagnostic assay for the detection of Mycobacterium tuberculosis in sputum specimens'
Maher, M., Glennon, M., Martinazzo, E., Turchetti, E., Marcolini, S., Smith, T.J. and Dawson, M.T. (1996) 'Evaluation of a novel PCR based diagnostic assay for the detection of Mycobacterium tuberculosis in sputum specimens'. JOURNAL OF CLINICAL MICROBIOLOGY, 34 (9):2307-2308 [ARAN Link] [Details]
(1996) 'Application of a PCR based DNA probe for the rapid identification of Mycobacterium malmoense isolated from a case of cervical adenitis'
Glennon, M,Sheehan, S,McKiernan, J,Smith, T,Gannon, F,Cryan, B (1996) 'Application of a PCR based DNA probe for the rapid identification of Mycobacterium malmoense isolated from a case of cervical adenitis'. Journal Of Infection, 33 :231-233 [Details]
(1996) 'The sensitive detection of fluorescently labelled PCR products using an automated detection system'
Maher M., Dowdall D., Glennon M., Walshe S., Cormican M., Wiesner P., Gannon, F. and Smith, T.J. (1996) 'The sensitive detection of fluorescently labelled PCR products using an automated detection system'. MOLECULAR AND CELLULAR PROBES, 9 :265-276 [Details]
(1996) 'Evaluation of a novel PCR-based diagnostic assay for detection of Mycobacterium tuberculosis in sputum samples'
Maher, M,Glennon, M,Martinazzo, G,Turchetti, E,Marcolini, S,Smith, T,Dawson, MT (1996) 'Evaluation of a novel PCR-based diagnostic assay for detection of Mycobacterium tuberculosis in sputum samples'. Journal Of Clinical Microbiology, 34 :2307-2308 [Details]
(1995) 'RELATIONSHIP OF A NOVEL BACTERIAL FISH PATHOGEN TO STREPTOBACILLUS-MONILIFORMIS AND THE FUSOBACTERIA GROUP, BASED ON 16S RIBOSOMAL-RNA ANALYSIS'
MAHER, M,PALMER, R,GANNON, F,SMITH, T (1995) 'RELATIONSHIP OF A NOVEL BACTERIAL FISH PATHOGEN TO STREPTOBACILLUS-MONILIFORMIS AND THE FUSOBACTERIA GROUP, BASED ON 16S RIBOSOMAL-RNA ANALYSIS'. Systematic And Applied Microbiology, 18 :79-84 [Details]
(1994) 'The ribosomal RNA intrergenic spacer region: a target for the PCR based diagnosis of tuberculosis'
Glennon, M., Smith, T.J., Cormican, M., Noone, D., Barry, T., Maher, M., Dawson, M., Gilmartin, J.J. and Gannon, F (1994) 'The ribosomal RNA intrergenic spacer region: a target for the PCR based diagnosis of tuberculosis'. TUBERCLE AND LUNG DISEASE, 75 :353-360 [Details]
(1994) 'Important variables for Direct PCR Amplification from Blood'
Noone, D., Glennon, M., Gannon, F. and Smith, T.J. (1994) 'Important variables for Direct PCR Amplification from Blood'. THE GENETIC ENGINEER AND BIOTECHNOLOGIST, 14 :149-154 [Details]
(1994) 'Polymerase Chain Reaction Based fingerprinting of Enterobacter cloacae'
Ni Riain, U., Cormican, M., Flynn,J., Smith, T.J., and Glennon, M. (1994) 'Polymerase Chain Reaction Based fingerprinting of Enterobacter cloacae'. JOURNAL OF HOSPITAL INFECTION, 27 :237-240 [Details]
(1993) 'Detection of Mycobacterium bovis in bovine blood by combined PCR and DNA probe methods'
Barry, T., Glennon, M., Smith, T.J. and Gannon, F. (1993) 'Detection of Mycobacterium bovis in bovine blood by combined PCR and DNA probe methods'. VETERINARY RECORD, 132 :66-67 [Details]
(1993) 'Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice'
Homanics, G.E., Smith, T.J., Zhang, S. H., Lee, D., Oliver, P., Young, S.G. and Maeda, N (1993) 'Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 90 :2389-2393 [Details]
(1992) 'Improved method for direct PCR amplification from whole blood'
McCusker, J., Dawson, M., Noone, D., Gannon, F. and Smith, T.J. (1992) 'Improved method for direct PCR amplification from whole blood'. NUCLEIC ACIDS RESEARCH, 20 [Details]
(1991) 'Sequences of Junction fragments in the deletion-prone region of the dystrophin gene'
Love, D.R., England, S.B., Speer, A., Marsden, R.F., Bloomfield, J.F., Roche, A.L., Cross, G.S., Mountford, R.C., Smith, T.J., Davies, K.E. (1991) 'Sequences of Junction fragments in the deletion-prone region of the dystrophin gene'. GENOMICS, 10 :57-67 [Details]
(1990) 'Comparison of the sequence of the putative LDL receptor binding regions of Apolipoprotein B in human, pig, mouse and hamster'
Smith, T.J., Hautamaa, D., Maeda, N. (1990) 'Comparison of the sequence of the putative LDL receptor binding regions of Apolipoprotein B in human, pig, mouse and hamster'. GENE, 87 :309-310 [Details]
(1989) 'Molecular analysis of Duchenne and Becker muscular dystrophies'
Love, D.R., Forrest, S.M., Smith, T.J., England, S., Flint, T., Davies, K.E. (1989) 'Molecular analysis of Duchenne and Becker muscular dystrophies'. BRITISH MEDICAL BULLETIN, 45 :659-680 [Details]
(1988) 'Mild and severe muscular dystrophy associated with deletions in Xp21 of the human X chromosome'
Davies, K.E., Smith, T.J., Bundey, S., Read, A.P., Flint, T., Bell, M. and Speer, A. (1988) 'Mild and severe muscular dystrophy associated with deletions in Xp21 of the human X chromosome'. JOURNAL OF MEDICAL GENETICS, 25 :9-13 [Details]
(1988) 'Localisation of the endpoints of deletions in the 5' region of the Duchenne gene using a sequence isolated by chromosome jumping'
Kenwrick, S.J., Smith, T.J., England, S., Collins, F. and Davies, K.E. (1988) 'Localisation of the endpoints of deletions in the 5' region of the Duchenne gene using a sequence isolated by chromosome jumping'. NUCLEIC ACIDS RESEARCH, 16 :1305-1317 [Details]
(1987) 'Duchenne and Becker muscular dystrophy mutations: analysis using 2.6kb of muscle cDNA from the 5' end of the gene'
Smith, T.J., Forrest, S.M., Cross, G.S. and Davies, K.E. (1987) 'Duchenne and Becker muscular dystrophy mutations: analysis using 2.6kb of muscle cDNA from the 5' end of the gene'. NUCLEIC ACIDS RESEARCH, 15 :9761-9769 [Details]
(1987) 'Isolation of a conserved sequence deleted in Duchenne muscular dystrophy patients'
Smith, T.J., Wilson, L., Kenwrick, S.J., Forrest, S.M., Speer, A., Coutelle, Ch. and Davies, K.E. (1987) 'Isolation of a conserved sequence deleted in Duchenne muscular dystrophy patients'. NUCLEIC ACIDS RESEARCH, 15 :2167-2174 [Details]
(1987) 'Deletions of fetal and adult muscle cDNA in Duchenne and Becker muscular dystrophy patients'
Cross, G.S., Speer, A., Rosenthal, A., Forrest, S.M., Smith, T.J., Edwards, Y., Flint, T., Hill, D. and Davies, K.E. (1987) 'Deletions of fetal and adult muscle cDNA in Duchenne and Becker muscular dystrophy patients'. EMBO JOURNAL, 6 :3277-3283 [Details]
(1987) 'Effective strategy for prenatal prediction of Duchenne and Becker muscular dystrophy'
Forrest, S.M., Smith, T.J., Cross, G.S., Read, A.P., Thomas, N.S.T., Mountford, R.C., Harper, P.S., Geirsson, R.T. and Davies, K.E. (1987) 'Effective strategy for prenatal prediction of Duchenne and Becker muscular dystrophy'. LANCET, 2 :1294-1297 [Details]
(1986) 'Molecular analysis of human muscular dystrophies'
Davies, K.E., Forrest, S.M., Smith, T.J., Kenwrick, S.J., Ball, S., Dorkins, H., Patterson, M.N. (1986) 'Molecular analysis of human muscular dystrophies'. Muscle And Nerve, 10 :191-199 [Details]
(1986) 'Characterisation and incompatibility properties of ROM- derivatives of pBR322 based plasmids'
Nugent, M.E., Smith, T.J., Tacon, W.C.A. (1986) 'Characterisation and incompatibility properties of ROM- derivatives of pBR322 based plasmids'. JOURNAL OF GENETIC MICROBIOLOGY, 132 :1021-1026 [Details]
(1986) 'The cloning and sequence analysis of the aspC and tyrB genes from Escherichia coli K12'
Fotheringham, I.G., Dacey, S.A., Taylor, P.P., Smith, T.J., Hunter, M.G., Finlay, M.E., Primrose, S.B., Parker, D.M., Edwards, R.M. (1986) 'The cloning and sequence analysis of the aspC and tyrB genes from Escherichia coli K12'. JOURNAL OF BIOCHEMISTRY, 234 :593-604 [Details]

Book Chapters

  Year Publication
(2012) 'Evaluating the potential of quantum dots for in vitro biological studies: effects on gene expression using microarray analysis'
Prasad BR, O'Connell E, Smith TJ, Gérard VA, Gun'ko YK, Rochev Y (2012) 'Evaluating the potential of quantum dots for in vitro biological studies: effects on gene expression using microarray analysis' In: Nanoparticles in Biology and Medicine: Methods and Protocols. Clifton, N.J: Methods in Molecular Biology. [DOI]