Dr. Niall Colgan

B.Sc.,M.Sc., Ph.D

Contact Details

Lecturer
Physics

T: 091493393
E: niall.colgan@nuigalway.ie
 
researcher

Biography

Dr. Niall Colgan is a lecturer in medical physics and a clinical medical physicist.  His work has been applied in diagnostic imaging projects related to dementia, acquired brain injury, psychosis, neurological disorder, oncology, musculoskeletal and cardiac disease.  His primary research focus is magnetic resonance imaging, particularly MR metabolite imaging and diffusion MRI however he also has active research programs in ionizing imaging, computational modeling/simulation, Microscopy, data mining, clinical instrumentation and tissue mechanics. He has led research teams  in the area of preclinical imaging bio-markers  and preclinical drug trials and has directed and established clinical imaging research  facilities utilized in clinical research and trials. A particular interest is the development of imaging methods that will open up new possibilities for the diagnosis and evaluation of therapeutic efficacy. 

https://scholar.google.co.uk/citations?user=RPuNH60AAAAJ&hl=en


Research Interests

Research Interests

  • Medical physics
  • Diagnostic imaging (ionising and non-ionising)
  • Medical image processing
  • Biomechanics
  • Diagnostic biomarkers in acquired brain injury and dementia

Peer Reviewed Journals

  Year Publication
(2016) 'Testing and evaluation of image registration brachytherapy'
Sands, Gordon,Zuchora, Anysja,Brien, Aoife O.,Colgan, Niall,Moore, Margaret,Tuohy, Brendan (2016) 'Testing and evaluation of image registration brachytherapy'. Physica MedicaPhysica Medica, 32 (77):951-952 [Details]
(2016) 'Horizontal nystagmus and multiple sclerosis using 3-Tesla magnetic resonance imaging'
Iyer, PM,Fagan, AJ,Meaney, JF,Colgan, NC,Meredith, SD,Driscoll, DO,Curran, KM,Bradley, D,Redmond, J (2016) 'Horizontal nystagmus and multiple sclerosis using 3-Tesla magnetic resonance imaging'. Irish Journal of Medical Science (1971-)Irish Journal of Medical Science (1971-), :1-6 [Details]
(2016) 'Development and implementation of a DQE technique to assess image quality for digital radiology systems in the Saolta University Healthcare Group'
Donoghue, Matthew,Tuohy, Brendan,Colgan, Niall,Lavin, David,van der Putten, Wil (2016) 'Development and implementation of a DQE technique to assess image quality for digital radiology systems in the Saolta University Healthcare Group'. Physica MedicaPhysica Medica, 32 (77) [Details]
(2016) 'Imaging the accumulation and suppression of tau pathology using multiparametric MRI'
Holmes, Holly E,Colgan, Niall,Ismail, Ozama,Ma, Da,Powell, Nick M,O'Callaghan, James M,Harrison, Ian F,Johnson, Ross A,Murray, Tracey K,Ahmed, Zeshan (2016) 'Imaging the accumulation and suppression of tau pathology using multiparametric MRI'. Neurobiology of agingNeurobiology of aging, 39 :184-194 [Details]
(2016) 'Investigation of GlucoCEST as novel clinical MR biomarker of glucose metabolism'
Colgan, Niall Donoghue, Matthew Zuchora, Zdzislaw Tuohy, Brendan van der Putten, Wil (2016) 'Investigation of GlucoCEST as novel clinical MR biomarker of glucose metabolism'. Physica Medica, European Journal Of Medical Physics, [Details]
(2016) 'Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease'
Colgan, N,Siow, B,O'Callaghan, JM,Harrison, IF,Wells, JA,Holmes, HE,Ismail, O,Richardson, S,Alexander, DC,Collins, EC (2016) 'Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease'. NeuroImageNeuroImage, 125 :739-744 [Details]
(2016) 'Role of nuclear medicine methods in prostate cancer management'
Zuchora, Zdzislaw,Browne, Mark,Colgan, Niall (2016) 'Role of nuclear medicine methods in prostate cancer management'. Physica MedicaPhysica Medica, 32 (77):956-957 [Details]
(2015) 'In vivo imaging of tau pathology using multi-parametric quantitative MRI'
Wells, JA,O'Callaghan, JM,Holmes, HE,Powell, NM,Johnson, RA,Siow, B,Torrealdea, F,Ismail, O,Walker-Samuel, S,Golay, Xavier (2015) 'In vivo imaging of tau pathology using multi-parametric quantitative MRI'. NeuroimageNeuroimage, 111 :369-378 [Details]
(2015) 'Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease'
Wells, Jack A,Holmes, Holly E,O'Callaghan, James M,Colgan, Niall,Ismail, Ozama,Fisher, Elizabeth MC,Siow, Bernard,Murray, Tracey K,Schwarz, Adam J,O'Neill, Michael J (2015) 'Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease'. Journal of Cerebral Blood Flow & MetabolismJournal of Cerebral Blood Flow & Metabolism, 35 (33):359-362 [Details]
(2015) 'A multi-scale MRI approach to investigate novel drug treatment strategies in mouse models of Alzheimer's disease'
Ismail, Ozama,Holmes, Holly,Colgan, Niall,Ma, Da,Wells, Jack A,Powell, Nicholas M,O'Callaghan, James M,Harrison, Ian F,Walker-Samuel, Simon,Cardoso, Jorge M (2015) 'A multi-scale MRI approach to investigate novel drug treatment strategies in mouse models of Alzheimer's disease'. Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationAlzheimer's & Dementia: The Journal of the Alzheimer's Association, 11 (77) [Details]
(2015) 'Glymphatic clearance impaired in a mouse model of tauopathy: Captured using contrast-enhanced MRI'
Harrison, Ian F,Machhada, Asif,Colgan, Niall,Ismail, Ozama,O'Callaghan, James M,Holmes, Holly,Wells, Jack A,Gourine, Alexander V,Murray, Tracey K,Ahmed, Zeshan (2015) 'Glymphatic clearance impaired in a mouse model of tauopathy: Captured using contrast-enhanced MRI'. Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationAlzheimer's & Dementia: The Journal of the Alzheimer's Association, 11 (77) [Details]
(2015) 'In vivo imaging of tau pathology using multi-parametric quantitative MRI'
Ismail, O,Walker-Samuel, S,Golay, X,Rega, M,Richardson, S,Modat, M,Cardoso, MJ,Ourselin, S,Schwarz, AJ,Ahmed, Zeshan (2015) 'In vivo imaging of tau pathology using multi-parametric quantitative MRI'. Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationAlzheimer's & Dementia: The Journal of the Alzheimer's Association, [Details]
(2015) 'Imaging the efficacy of microtubule stabilizing agent epothilone d in the rtg4510 mouse model of tauopathy'
Ismail, Ozama,Harrison, Ian F,Holmes, Holly,Colgan, Niall,Wells, Jack A,O'Callaghan, James M,Powell, Nicholas M,Ma, Da,Ourselin, Sebastien,Walker-Samuel, Simon (2015) 'Imaging the efficacy of microtubule stabilizing agent epothilone d in the rtg4510 mouse model of tauopathy'. Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationAlzheimer's & Dementia: The Journal of the Alzheimer's Association, 11 (77) [Details]
(2014) 'AN IMAGING STRATEGY TO CHARACTERISE TAU PATHOLOGY IN VIVO IN A MODEL OF ALZHEIMER'S DISEASE USING MULTI-PARAMETRIC MRI'
Holmes, Holly E,Ismail, Ozama,Wells, Jack,O'Callaghan, James,Powell, Nicholas,Murray, Tracey,Ahmed, Zehshan,O'Neill, Michael,Collins, Emily,Johnson, Ross (2014) 'AN IMAGING STRATEGY TO CHARACTERISE TAU PATHOLOGY IN VIVO IN A MODEL OF ALZHEIMER'S DISEASE USING MULTI-PARAMETRIC MRI'. Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationAlzheimer's & Dementia: The Journal of the Alzheimer's Association, 10 (44) [Details]
(2014) 'Neurite Orientation Dispersion and Density Imaging (NODDI) to Investigate Tau Pathology in a TG4510 Mouse Model of Alzheimer’s'
Colgan, N,Siow, BM,O'Callaghan, JM,Wells, J,Holmes, H,Powell, NM,Ismail, O,Richardson, S,Alexander, DC,Collins, EC (2014) 'Neurite Orientation Dispersion and Density Imaging (NODDI) to Investigate Tau Pathology in a TG4510 Mouse Model of Alzheimer’s'. [Details]
(2014) 'BRAIN TEXTURE ANALYSIS AS A BIOMARKER FOR TAUOPATHY IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER'S'
Colgan, Niall,Ganeshan, Balaji,Ismail, Ozama,Holmes, Holly,Powell, Nicholas,Wells, Jack,O'Callaghan, James,Collins, Emily,Johnson, Ross,O'Neill, Michael (2014) 'BRAIN TEXTURE ANALYSIS AS A BIOMARKER FOR TAUOPATHY IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER'S'. Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationAlzheimer's & Dementia: The Journal of the Alzheimer's Association, 4 (1010) [Details]
(2014) 'AN IMAGING STRATEGY TO CHARACTERISE TAU PATHOLOGY IN VIVO IN A MODEL OF ALZHEIMER'S DISEASE USING MULTI-PARAMETRIC MRI'
Ismail, Ozama,Holmes, Holly,Wells, Jack,O'Callaghan, James,Powell, Nicholas,Murray, Tracey,Ahmed, Zehshan,O'Neill, Michael,Collins, Emily,Johnson, Ross (2014) 'AN IMAGING STRATEGY TO CHARACTERISE TAU PATHOLOGY IN VIVO IN A MODEL OF ALZHEIMER'S DISEASE USING MULTI-PARAMETRIC MRI'. Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationAlzheimer's & Dementia: The Journal of the Alzheimer's Association, 10 (44) [Details]
(2013) 'Morphometric Genomics: in vivo microMRI for 3D structural imaging of transgenic mice'
Holmes, H,Wells, J,O'Callaghan, J,Richardson, S,Siow, B,Powell, N,Ma, D,Modat, M,Colgan, N,Oursellin, S (2013) 'Morphometric Genomics: in vivo microMRI for 3D structural imaging of transgenic mice'. [Details]
(2012) 'Semiautomatic Region-of-Interest Validation at the Femur in 18F-Fluoride PET/CT'
Puri, Tanuj,Blake, Glen M,Curran, Kathleen M,Carr, Hamish,Moore, Amelia EB,Colgan, Niall,O’Connell, Martin J,Marsden, Paul K,Fogelman, Ignac,Frost, Michelle L (2012) 'Semiautomatic Region-of-Interest Validation at the Femur in 18F-Fluoride PET/CT'. Journal of nuclear medicine technologyJournal of nuclear medicine technology, 40 (33):168-174 [Details]
(2011) 'Cardiac Diffusion Tensor Imaging Registration'
Gil, C,Colgan, N,Bakermans, AJ,van Nierop, BJ,Strijkers, GJ,Curran, KM (2011) 'Cardiac Diffusion Tensor Imaging Registration'. Proceedings of the International Society for Magnetic Resonance in Medicine Proceedings of the International Society for Magnetic Resonance in Medicine, 19 [Details]
(2010) 'The Effect of Manual and Automatic 3D ROI Selection on the Representations of Neural Fibre Tracts. Visualization in Medicine and Life Sciences'
Colgan, Niall C,Meredith, S,Curran, KM (2010) 'The Effect of Manual and Automatic 3D ROI Selection on the Representations of Neural Fibre Tracts. Visualization in Medicine and Life Sciences'. Visualization in Medicine and Life SciencesVisualization in Medicine and Life Sciences, [Details]
(2010) 'Applying DTI white matter orientations to finite element head models to examine diffuse TBI under high rotational accelerations'
Colgan, Niall C.,Gilchrist, Michael D.,Curran, Kathleen M. (2010) 'Applying DTI white matter orientations to finite element head models to examine diffuse TBI under high rotational accelerations'. Progress in Biophysics and Molecular BiologyProgress in Biophysics and Molecular Biology, 103 (2–32–3):304-309 [Details]
(2010) 'Quantitative MRI analysis of brain volume changes due to controlled cortical impact'
Colgan, Niall C,Cronin, Michelle M,Gobbo, Oliviero L,O'Mara, Shane M,O'Connor, William T,Gilchrist, Michael D (2010) 'Quantitative MRI analysis of brain volume changes due to controlled cortical impact'. Journal of neurotraumaJournal of neurotrauma, 27 (77):1265-1274 [Details]
(2005) 'Controlled impact device for simulating TBI with an animal model'
Gilchrist, MD,Colgan, N,O'Connor, WT,Smyth, A,Kenny, C (2005) 'Controlled impact device for simulating TBI with an animal model'. Acta Neurobiologiae ExperimentalisActa Neurobiologiae Experimentalis, 5 (6565) [Details]

Conference Paper

  Year Publication
(2015) Characterising the effect of Doxycycline treatment on tau associated degeneration in rTg4510 mice.
Fisher, A,Heggenes, M,Meftah, S,Murray, T,Colgan, N,Ismail, O,Hutton, ML,Lythgoe, M,O'Neill, MJ,Ahmed, Z (2015) Characterising the effect of Doxycycline treatment on tau associated degeneration in rTg4510 mice. Conference Paper [Details]
(2011) BIOMECHANICAL ANALYSIS OF FLUID PERCUSSION MODEL OF BRAIN INJURY.
Mao, Haojie,Zhu, Feng,Jin, Xin,Clausen, Fredrik,Colgan, Niall,Gilchrist, Michael,Yang, King (2011) BIOMECHANICAL ANALYSIS OF FLUID PERCUSSION MODEL OF BRAIN INJURY. Conference Paper [Details]
(2009) Using cutting edge medical imaging to assist the teaching and understanding of neuroanatomy for medical students and medical researchers.
Meredith, S,Mascott, C,Colgan, N (2009) Using cutting edge medical imaging to assist the teaching and understanding of neuroanatomy for medical students and medical researchers. Conference Paper [Details]