| Health / Biomedical / Clinical / Pre-clinical Sciences Projects | Lead Investigator | Link to project description |
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| Scaffold-mediated Spatiotemporal Multimodal Biomolecule Delivery to Treat Limb Ischemia | Abhay Pandit | Download PDF |
| Enhancing Sulphated Glycosaminoglycan (sGAG) Production using a Hyaluronan Nanoparticle-based Delivery System | Abhay Pandit | Download PDF |
| Optimised Functionalised Construct to Repair the Annulus Fibrosus (AF) of the Intervertebral Disc | Abhay Pandit | Download PDF |
| Functionalised Biomaterial Scaffold for Spinal Cord Repair | Abhay Pandit | Download PDF |
| Scaffold-mediated Spatiotemporal Multimodal Biomolecule Delivery to Treat Limb Ischemia | Abhay Pandit | Download PDF |
| Optimised Functionalised Construct to Repair the Annulus Fibrosus (AF) of the Intervertebral Disc | Abhay Pandit | Download PDF |
| Functionalised Biomaterial Scaffold for Spinal Cord Repair | Abhay Pandit | Download PDF |
| Mechanism of NGF-induced pro-survival signalling | Adrienne Gorman | Download PDF |
| Investigation into loss of p75 neurotrophin receptor in progression of prostate cancer | Adrienne Gorman | Download PDF |
| Investigation into role of p75 neurotrophin receptor in chronic lymphocytic leukemia | Adrienne Gorman | Download PDF |
| Unfolded Protein Response modulation of epithelial mesenchymal transit (EMT) | Afshin Samali | Download PDF |
| TARGETING MEVALONATE CASCADE IN BREAST CANCER | Afshin Samali | Download PDF |
| Assessment and management of disorders of consciousness in children | Agnes Shiel | Download PDF |
| Heterogeneity of Disorders of Consciousness | Agnes Shiel | Download PDF |
| Patterns of recovery after severe brain injury | Agnes Shiel | Download PDF |
| Constraint induced movement therapy in people with long term motor impairment after traumatic brain injury | Agnes Shiel | Download PDF |
| Disorders of consciousness in neurodegenerative conditions | Agnes Shiel | Download PDF |
| Efficacy and application of rehabilitation with people with dementia | Agnes Shiel | Download PDF |
| Introduction of a new antimicrobial (Fosfomycin) in community care: an observational study of the factors that influence prescribing of this new antimicrobial and longitudinal follow up of the impact of this introduction on the occurrence and spread of resistance. | Akke Vellinger | Download PDF |
| The impact of antibiotic guidelines in hospitals on the occurrence of resistance of hospital infections | Akke Vellinger | Download PDF |
| Validation of a novel breath test for the diagnosis of diabetes | Amir Shafat | Download PDF |
| Lifestyle and Insulin Resistance | Amir Shafat | Download PDF |
| Chromatin features contributing to stem cell properties in early animals | Andrew Flaus | Download PDF |
| Role of altered microhaemodynamics of the liver in the regeneration of liver: An intravital fluorescence microscopy (IVFM) study | Antony M Wheatley | Download PDF |
| Role of the innate immune system in liver regeration: role played by toll-like receptor pathways | Antony M Wheatley | Download PDF |
| Involvement of the hepatic microcirculation in the regeneration of the cirrhotic liver of the mouse | Antony M Wheatley | Download PDF |
| Role of the innate immune system on the microcirculation of the kidney following ischaemia-reperfusion (I-R) injury: An intravital fluorescence microscopy (IVFM) study | Antony M Wheatley | Download PDF |
| Role of the innate immune system gastrointestinal permeability: An intravital fluorescence microscopy (IVFM) study | Antony M Wheatley | Download PDF |
| Host cell responses to pathogenic bacteria – the role of the cellular stress pathways. | Aoife Boyd | Download PDF |
| Novel virulence factors of Vibrio parahaemolyticus | Aoife Boyd | Download PDF |
| Type III Secretion Systems of Vibrio parahaemolyticus | Aoife Boyd | Download PDF |
| Targeting IRE1 in Breast Cancer | Ashin Samali | Download PDF |
| The role of ER stress in innate immunity | Ashin Samali | Download PDF |
| Nanoparticle-Mediated Delivery of Superoxide Dismutase in Sepsis Induced Lung Injury | Brendan Higgins | Download PDF |
| A longitudinal study of Omega-3 Essential Fatty Acids (EFAs) and their association with grey and white matter in both healthy controls and individuals with bipolar disorder | Brian Hallahan | Download PDF |
| Deciphering the regulatory roles and mechanisms of non-coding miRNAs in thyroid cancer | Charles Spillane | Download PDF |
| Understanding the interplay between exercise and plant-derived nutraceuticals: Circulating miRNAs as biomarkers for personalised sports training regimes | Charles Spillane | Download PDF |
| Circulating miRNAs as biomarkers for high-altitude sports training regimes | Charles Spillane | Download PDF |
| Circulating miRNAs as biomarkers for differentiated sports training regimes for the young and elderly | Charles Spillane | Download PDF |
| Deciphering the regulatory roles and mechanisms of the non-coding microRNA mir-9 in breast cancer | Charles Spillane | Download PDF |
| Molecular genetic and epigenetic analysis of the regulatory role of the non-coding microRNA mir18a in breast and endometrial cancer | Charles Spillane | Download PDF |
| Ensuring the voice of young carers in developing relevant services and support | Colette Kelly | Download PDF |
| Molecular mechanisms of stress sensing in the food-borne bacterial pathogen Listeria monocytogenes | Conor O'Byrne | Download PDF |
| A functional metagenomic screen for stress adaptation mechanisms encoded by the microbiota in the human gut | Conor O'Byrne | Download PDF |
| Investigating the efficacy of selected progenitor cells to improve diabetic fracture healing. | Cynthia Coleman, | Download PDF |
| Use of novel marine extracts in reducing Campylobacter colonisation of broilers | Cyril Carroll | Download PDF |
| Host-pathogen interactions of Campylobacter jejuni | Cyril Carroll | Download PDF |
| Development of aantimicrobial resistance in Campylobacter jejuni biofilms. | Cyril Carroll | Download PDF |
| Effect of antimicrobials on Campylobacteri Biofilms | Cyril Carroll | Download PDF |
| Pattern Recognition in Clinical Neuroimaging of Psychiatric Disorders | Dara M Cannon | Download PDF |
| Diffusion Magnetic Resonance Imaging and Post-Mortem Investigation of White Matter Microstructural Organization in the Human Brain | Dara M Cannon | Download PDF |
| Epigenetic regulation of innate immune responses: | Declan Mckernan | Download PDF |
| In vitro cartilage organogenesis: The project aims to modulate the in vitro microenvironment of chondrocytes to build a host specific cartilage. | Dimitrios Zeugolis | Download PDF |
| In vitro corneal organogenesis: The project aims to modulate the in vitro microenvironment of corneal derived cells to build a corneal tissue in the lab. | Dimitrios Zeugolis | Download PDF |
| In vitro peripheral nerve organogenesis: The project aims to modulate the in vitro microenvironment of neural cells and fibroblasts to build a peripheral nerve implant. | Dimitrios Zeugolis | Download PDF |
| In vitro skin organogenesis: The project aims to modulate the in vitro microenvironment of skin derived cells to build a full thickness skin equivalent. | Dimitrios Zeugolis | Download PDF |
| In vitro tendon organogenesis: The project aims to modulate the in vitro microenvironment of tendon derived cells to build a tendon tissue in the lab. | Dimitrios Zeugolis | Download PDF |
| Biosensors for biomarkers | Donal Leech | Download PDF |
| Genes by environment interactions for modelling Parkinson’s disease. | Eilís Dowd | Download PDF |
| To investigate if basal-like breast tumours have a distinct pattern of DNA damage response or centrosome biology that can predict patient outcome and response to treatment | Emer Bourke | Download PDF |
| Development of treatment strategies to target and eradicate leukemic stem cells | Eva Szegezdi | Download PDF |
| Development of novel drugs for activating death receptor-mediated killing of tumours | Eva Szegezdi | Download PDF |
| Structure and molecular composition of human non-complicated diabetic skin | Fabio Quondamatteo | Download PDF |
| Role of autophagy gene AMBRA in tumorigenesis – Characterization of neoplasias | Fabio Quondamatteo | Download PDF |
| Structure and molecular composition of skin in a model of type 1 diabetes mellitus | Fabio Quondamatteo | Download PDF |
| An Investigation of Diabetes, Obesity and Autism | Geraldine Leader | Download PDF |
| An Investigation of Autism Spectrum Disorder in Adults and Older Adults. | Geraldine Leader | Download PDF |
| Functionalisation of cardiovascular stents for improved in vivo performance | Gerard Wall | Download PDF |
| Delivery of superoxide dismutase to the lung for therapy | Gerard Wall | Download PDF |
| Morphogenesis of the inner ear in Xenopus laevis | Gerhard Schlosser | Download PDF |
| Role of posttranslational modifications of the protein Eya1 for neurogenesis | Gerhard Schlosser | Download PDF |
| Does epistasis drive coevolution? | Gerhard Schlosser | Download PDF |
| P54nrb a novel player in the DNA damage response | Heinz Peter Nasheuer | Download PDF |
| Complex formation, mobility and concentration of DNA replication and DNA repair proteins in the cell cycle and after DNA damage | Heinz Peter Nasheuer | Download PDF |
| Cellular Small Non-Coding RNAs Highly Active in Inhibiting Polyoma Viral DNA Replication. | Heinz Peter Nasheuer | Download PDF |
| Distribution and abundance of H2AX in human mesenchymal stem cells. | Helen Dodson | Download PDF |
| The role of caspase-9 in differentiation | Howard Fearnhead | Download PDF |
| Caspase-mediated proteolysis during myoblast differentiation | Howard Fearnhead | Download PDF |
| Repurposing drugs for the treatment of Advanced Cancers | Howard Fearnhead | Download PDF |
| Development & evaluation of a novel biopolymer composite for healing of bone defects. | Jessica Hayes | Download PDF |
| Development of Biofunctionalised Implants for Orthopaedic Applications | Jessica Hayes | Download PDF |
| Does repeated methamphetamine exposure to rats produce lasting changes in central serotonergic circuitry and function? | John Kelly | Download PDF |
| Advanced Gene Therapy Vectors for ALI/ARDS | John Laffey | Download PDF |
| iPS therapy for ALI/ARDS | John Laffey | Download PDF |
| MSC Therapy for Lung Ischaemia/Reperfusion Injury | John Laffey | Download PDF |
| Investigation of the neurotoxic effects of methamphetamine | Karen Doyle | Download PDF |
| Investigation of the neuroprotective potential of neurotrophins for stroke | Karen Doyle | Download PDF |
| Investigation of the involvement of polyamines in the pathophysiology of stroke | Karen Doyle | Download PDF |
| Targeting Endo/Sarcoplasmic Reticulum Stress as a novel therapy for muscle disorders. | Karl Mccullagh | Download PDF |
| A gene therapy appproach to muscle disorders | Karl Mccullagh | Download PDF |
| Targeting Endo/Sarcoplasmic Reticulum Stress as a novel therapy for muscle disorders | Karl Mccullagh | Download PDF |
| GUT-Liver axis and inflammatory disease - role of concanavalin A mediated changes in gut permeability. | Leo Quinlan | Download PDF |
| Application of subsensory electrical noise as a neuromodulatory therapy in Motor disorders | Leo Quinlan | Download PDF |
| Application of subsensory electrical noise as a neuromodulatory therapy in the loss of sensory function | Leo Quinlan | Download PDF |
| Nongenomic steroid action on cellular structure and ion channel function in human reproductive tract - implications for fertility. | Leo Quinlan | Download PDF |
| Nongenomic steroid action on cellular structure and ion channel function in bovine reproductive tract - implications for fertility. | Leo Quinlan | Download PDF |
| Immune dysregulation in the postpartum cow and negative energy balance consequences for herd fertility | Leo Quinlan | Download PDF |
| Investigation of biomaterial in the treatment of interstitial cystitis. | Leo Quinlan | Download PDF |
| A biomaterials approach to treatment of overactive urinary bladder targeting purinergic pathways | Leo Quinlan | Download PDF |
| A biomaterials approach to treatment of overactive urinary bladder targeting purinergic signaling pathways. | Leo Quinlan | Download PDF |
| A biomaterials approach to treatment of pain in bladder disease targeting histamine inflammatory pathways | Leo Quinlan | Download PDF |
| GLYCOMARKERS FOR GASTROINTESTINAL CANCERS | Lokesh Joshi | Download PDF |
| Fibrin/conducting polymer hybrids for neuroelectrode functionalization | Manus Biggs | Download PDF |
| Bone mechanotransduction in health and disease | Manus Biggs | Download PDF |
| Osteoinductive ferroelectric polymers for bone tissue engineering | Manus Biggs | Download PDF |
| Bone regeneration through biomimetic ferroelectric nanofibers within collagen scaffolds | Manus Biggs | Download PDF |
| Applicants interested in conducintg doctoral research on the promotion of positive mental health and wellbeing are welcome to apply. | Margaret Barry | Download PDF |
| Applicants interested in conducintg doctoral research on the development and application Health Promotion of core competencies are welcome to apply. | Margaret Barry | Download PDF |
| Abnormal cognitive dynamics following premature birth | Mark Elliott | Download PDF |
| The role of Mesenchymal Stem Cells in Modulating Development of Osteoarthritis in the Damaged Joint | Mary Murphy | Download PDF |
| Development of Strategies for Optimised Engraftment and Chondrogenic Differentiation of Mesenchymal Stem Cells for Cartilage Repair in Osteoarthritis | Mary Murphy | Download PDF |
| Cross-cultural analysis of women’s stories of birth. | Marypat O Malley-Keighran | Download PDF |
| Cross cultural analysis of mediated discourses of cosmetic surgery & dermatology | Marypat O Malley-Keighran | Download PDF |
| Cross cultural analysis of women’s experiences of cosmetic surgery & dermatology | Marypat O Malley-Keighran | Download PDF |
| Mesenchymal stem cells modulation of innate immune response to allogeneic pancreatic islets | Matthew Griffin | Download PDF |
| Dendritic cells and the intra-renal T-cell repertoire in kidney disease | Matthew Griffin | Download PDF |
| Mesenchymal stem cell and vitamin D re-programming of macrophages in kidney disease | Matthew Griffin | Download PDF |
| Development of a zebrafish model of the congenital heart disorder, arrhythmogenic right ventricular cardiomyopathy (ARVC). | Maura Grealy | Download PDF |
| Personalised Intensive Care Medicine Using Probabilistic Model-Based Data Analytics | Michael Madden | Download PDF |
| New Techniques for Analysis of Intensive Care Unit Data | Michael Madden | Download PDF |
| The identification of new inhibitors of cellular adhesion and trafficking in multiple myeloma | Michael O’Dwyer | Download PDF |
| Circulating microRNAs in Breast Cancer | Michael Kerin | Download PDF |
| Glia: the glue that link depression and pain | Michelle Roche | Download PDF |
| Endocannabinoid modulation of neuroinflammation | Michelle Roche | Download PDF |
| A conditional approach to probing ATR function during DNA synthesis | Noel Francis Lowndes | Download PDF |
| The role of molecular motor proteins in DNA repair: | Noel Francis Lowndes | Download PDF |
| The role of RNA binding protein in the cellular responses to DNA damage | Noel Francis Lowndes | Download PDF |
| The role of chromatin remodelling in the cellular responses to DNA damage | Noel Francis Lowndes | Download PDF |
| Identification and characterisation of novel proteins involved in the DNA damage response pathways after UV-irradiation | Noel Franics Lowndes | Download PDF |
| Noise induced hearing loss in younger people through over exposure to music through headphones and earphones is growing in its importance as a major health concern. | Padriag Molloy | Download PDF |
| The cellular effects of endocrine disrupting chemicals on the female reproductive system | Peter Dockery | Download PDF |
| Mechanisms of Triplet Repeat Instability in Eukaryotes. | Robert Lahue | Download PDF |
| Mesencyhmal Stem Cell (MSC)-mediated Gene Therapy for Breast Cancer | Roisin Dwyer | Download PDF |
| Generating and phenotyping Induced Pluripotent Stem (iPS) cells from ALS Patients. | Sanbing Shen | Download PDF |
| Generating Induced Pluripotent Stem (iPS) cell model for autism. | Sanbing Shen | Download PDF |
| Generating and phenotyping Induced Pluripotent Stem (iPS) cells for Fragile X syndrome. | Sanbing Shen | Download PDF |
| Phenotyping a novel knockout mouse on brain development and function. | Sanbing Shen | Download PDF |
| FUNCTION AND REGULATION OF microRNA BIOGENESIS DURING UNFOLDED PROTEIN RESPONSE | Sanjeev Gupta | Download PDF |
| Regulation of NCOA3 by miR-17 and its role in resistance to endocrine therapy of breast cancer | Sanjeev Gupta | Download PDF |
| IDENTIFICATION AND CHARACTERIZATION OF miRNAs A BIOMAKERS FOR BREAST CANCER | Sanjeev Gupta | Download PDF |
| Role of miR-17-92 cluster in regulating fate of cardiomyocytes during ischemia | Sanjeev Gupta | Download PDF |
| REGULATION OF DICER EXPRESSION BY ESTROGEN AND ITS ROLE IN RESISTANCE TO ENDOCRINE THERAPY OF BREAST CANCER | Sanjeev Gupta | Download PDF |
| This PhD project will involve participation in the international HBSC network (www.hbsc.org) with a focus on health and social inequalities in adolescent sexual health across Europe | Saoirse Nic Gabhainn | Download PDF |
| This PhD project will aim to develop participative research methods for use with children with chronic illness and disability, building on existing techniques developed in the research team, the applicant will develop and test methods for allowing children with disability a full voice in all matters that effect them. | Saoirse Nic Gabhainn | Download PDF |
| This PhD project will involve participation in the international HBSC network (www.hbsc.org) with a focus on early onset of risk behaviours such as substance use and sexual behaviour and the impact of such early onset on adolescent health. | Saoirse Nic Gabhainn | Download PDF |
| This PhD project will on migrant youth and their health, particularly how migrants are clustered together or separated from others from their countries of origin and the impact this has on youth health. | Saoirse Nic Gabhainn | Download PDF |
| This PhD project will focus on the health behaviours and socio-ecological context of vulnerable children – those who do not live with their parents. It will involve secondary data analysis of existing data sources and original qualitative data collection on health priorities of these youth. | Saoirse Nic Gabhainn | Download PDF |
| This PhD project will involve participation in the international HBSC network (www.hbsc.org) with a focus on the application of geographical information systems to adolescent health and well-being – to study the impact of location and physical context on child and adolescent health. | Saoirse Nic Gabhainn | Download PDF |
| This PhD project will focus on giving children and adolescents a voice in all aspects of the research process – involving young people from study inception, design, execution, analysis and presentation – with a view to documenting the contribution that young people can make and the challenges for researchers and the research process in including them. | Saoirse Nic Gabhainn | Download PDF |
| This PhD project will concentrate on the range of symptoms commonly reported by adolescents (such as headache, feeling irritable, feeling low) – how they are related to health outcomes and the contexts of health, how they are interpreted by adolescents, common medical responses to such symptoms and an analysis of the popular adolescent media about sympoms. | Saoirse Nic Gabhainn | Download PDF |
| Targeting stress pathways in prostate cancer | Sharon Glynn | Download PDF |
| Investigating chromatin modifications as a novel prognostic indicator in Prostate Cancer | Stephen Rea | Download PDF |
| Epigenetic mechanisms involved in chronic pain | Stephen Rea | Download PDF |
| Investigating the role of histone modifications in neuro-epigenetic memory | Stephen Rea | Download PDF |
| Development and application of rapid Point of Care (PoC) molecular diagnostics assays based on novel biomarkers for Cancer diagnosis and treatment monitoring | Terry Smith | Download PDF |
| Investigation of the transcriptomic effects of steroid hormone treatment on contractility associated gene expression linked to labour in a human uterine smooth muscle cell culture model | Terry Smith | Download PDF |
| Investigation of circulating miRNA profiles in women with gestational diabetes versus non-diabetic pregnant women using Next Generation Sequencing (NGS) approaches | Terry Smith | Download PDF |
| Investigation of circulating miRNA profiles in pregnant non-labouring and in-labour women using Next Generation Sequencing (NGS) approaches | Terry Smith | Download PDF |
| Understanding the immunomodulatory properties of mesenchymal stem cells on “licensing” of pathogenic T cells in the lung | Thomas Ritter | Download PDF |
| Regulating immunogenicity and tolerogenicity through cell surface glycosylation | Thomas Ritter | Download PDF |
| SeekTB/SeekNTM - Novel multi parametric Nucleic Acid Tests to Help in Global Effort to Control Tuberculosis and Non Tuberculosis Mycobacteria Infections | Thomas Barry | Download PDF |
| Development of a novel cell-free treatment protocol for cornea transplantation: Mesenchymal stem cell derived exosomes for the prevention of corneal graft rejection and characterisation of the underlying mechanisms | Thomas Ritter | Download PDF |
| Elucidating the mechanism of immunomodulation by syngeneic and allogeneic mesenchymal stem cells. | Thomas Ritter | Download PDF |
| Enhancement of in vivo therapeutic properties of differentiated allogeneic mesenchymal stem cells by genetic modification | Thomas Ritter | Download PDF |
| Application of novel immunoregulatory molecules in Cornea transplantation | Thomas Ritter | Download PDF |
| Phenotyping a novel knockout mouse as a model for human cardiovascular disease. | Timothy O'Brien | Download PDF |
| The role of chaperone proteins BiP and calreticulin in multiple sclerosis | Una Fitzgerald | Download PDF |
| Early development and acquisition of cellular commitment in Hydractinia | Uri Frank | Download PDF |
| Advanced biomaterials- based dressings containing stem cells for the treatment of diabetic foot ulcers | Wenxin Wang | Download PDF |
