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SFI UREKA Site in Molecular Recognition
Translating Design into Application

Prof. Robert J. Woods , School of Chemistry

Prof. Woods's research examines the relationships between the conformations of carbohydrate molecules and biological recognition and activity, particularly the mechanisms involved in carbohydrate recognition in immunological events. The Woods's group utilizes the computational techniques of molecular dynamics and free energy perturbation simulations to study the conformational properties of oligosaccharides and carbohydrate-protein complexes.

Current research projects using these techniques include examinations of bacterial antigen-antibody interactions, as well as carbohydrate-lectin interactions. Carbohydrate antigens associated with Candida albicans, Salmonella paratyphi B and group B Streptococcus are being studied to understand the energetic contributions hydrophobic and hydrophilic interactions make to antibody binding energy.

 

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